抗体

抗NIK(CT)抗体

1129

100微克

455美元

多克隆

domestic rabbit

未共轭

抗NIK(CT)抗体

抗NIK(CT)抗体(1129)

抗体

抗NIK(CT)兔多克隆抗体

NIK(CT)

人类

NIK(CT)

Q99558

细胞质

丝裂原活化蛋白激酶激酶激酶 14

EC 2.7.11.25, NF-kappa-beta-inducing kinase, HsNIK, Serine/threonine-protein kinase NIK

MAP3K14

NP_003945.2

多克隆

液体

1.0毫克/毫升

100微克

455美元

318.5

1129

免疫印迹

ELISA Immunoblotting Recommended concentration: 2-4ug/ml. Optimal dilution should be determined by enduser. Positive control: Whole cell lysate of NIK-transfected 293 cells.

兔

纯化

Purified by immuno-affinity chromatography on the peptide immunogen.

合成多肽对应于氨基酸931-947人的NIK(登录号。 Q99558)

神经科学

PBS, 1毫克/毫升, pH值7.4, 0.02% 叠氮化钠

磷酸盐缓冲液

pH值7.4

0.02% 叠氮化钠

Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS, and mitogens. A serine/threonine protein kinase which mediates NF-kappaB activation by IL-1, TNFalpha, and CD95 has been identified and designated NIK (for NF-kappaB inducing kinase). NIK is an activator of IkappaB kinase alpha and beta (IKKalpha and IKKbeta). Therefore, NIK is a key molecule in the NF-kappaB signaling pathway leading to the expression of a variety of gene products in response to pro-inflammatory cytokines and bacterial products.

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. {PubMed:15084608}.

Dilute in PBS or medium which is identical to that used in the assay system.

This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze- thaw cycles.

这抗体识别人类NIK