产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗Ku80抗体
目录 :
12527
规格 :
100微克
价格 :
378美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
更多信息或购买 :
产品信息
目录号 :
12527
产品名称 :
抗Ku80抗体
NAME+SKU :
抗Ku80抗体(12527)
产品_TYPE :
抗体
描述 :
抗Ku80兔多克隆抗体
SPECIFICITY SHORT :
Ku80
物种活性 :
人类, 小鼠, 大鼠, 仓鼠
靶标名 :
Ku80
UniProt数据库 :
P13010
LOCATION :
Nucleus , Nucleus, nucleolus , Chromosome
蛋白名 :
X-ray repair cross-complementing protein 5
别称 :
EC 3.6.4.-, 86 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit, CTC85, CTCBF, DNA repair protein XRCC5, Ku80, Ku86, Lupus Ku autoantigen protein p86, Nuclear factor IV, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 5
基因名称 :
XRCC5
登录号 :
NP_066964
克隆性 :
多克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
378美元
DISTIRBUTOR价格 :
264.6
SKU号规格1 :
12527
应用 :
免疫印迹
应用INSTRUCTIONS :
Immunoblotting: use at 1:500 dilution. A band of approximately 80 kDa is detected. Positive control: A431 and AR42J whole cell lysates.
宿主 :
格式 :
纯化
纯化 :
经免疫亲和层析纯化
免疫原 :
Synthetic peptide corresponding to amino acids 419-440 (LVYVQLPFMEDLRQYMFSSLKN) of Ku80 conjugated to KLH at the N- terminus.
研究领域 :
脱氧核糖核酸
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
靶标背景 :
Telomere length maintenance, essential to chromosome stability and genome integrity, is regulated by telomerase and telomere-associated factors. The Ku proteins are eukaryotic nuclear proteins involved in DNA repair and telomere maintenance. They exist as a heterodimer of 70 and 80 kDa subunits (Ku 70 and Ku 80). Ku heterodimers bind to DNA ends at telomeres and at double-strand breaks where they interact with DNA-dependent protein kinase (DNA PK) and participate in targeting of DNA PK to DNA. The Ku proteins may participate in DNA repair and replication, cell signaling, proliferation, transcriptional activation, and apoptosis.
FUNCTION :
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA (PubMed:7957065, PubMed:8621488, PubMed:12145306, PubMed:11493912). Required for double-strand break repair and V(D)J rPubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:28712728, PubMed:32103174, PubMed:7957065, PubMed:8621488}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze- thaw cycles.
特异性 :
这抗体识别人类, 小鼠, 大鼠, 和仓鼠Ku80
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国