抗体

抗肿瘤坏死因子α抗体

21303

200微克

305美元

单克隆

小鼠

未共轭

F6C5

抗肿瘤坏死因子α抗体

抗肿瘤坏死因子α抗体(21303)

抗体

抗肿瘤坏死因子α小鼠单克隆抗体

肿瘤坏死因子α

人类

肿瘤坏死因子α

P01375

Cell membrane , Single-pass type II membrane protein

肿瘤坏死因子

Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a [Cleaved into: Tumor necrosis factor, membrane form

肿瘤坏死因子

单克隆

液体

Lot Specific

200微克

305美元

213.5

21303

酶联免疫吸附测定, 免疫组化

These antibodies may be used in immunoassays or in immunohisto- chemistry to detect and/or quantitate TNFalpha. 21301 and 21302 may be used in biological assays to inhibit activity of TNFalpha. Other applications are under investigation.

小鼠

纯化

经免疫亲和层析纯化

IgG1

F6C5

重组人类TNFalpha

生长因子, 细胞因子, 受体

PBS含0.1% 叠氮化钠

磷酸盐缓冲液

0.1% 叠氮化钠

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819). {UniProtKB:P06804, PubMed:12794819, PubMed:16829952, PubMed:22517918, PubMed:23396208}.; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {PubMed:16829952}.

Dilute in PBS or medium which is identical to that used in the assay system.

These antibodies are stable for at least one (1) year at -20C to -70C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

21303 recognizes a different epitope on TNFalpha than 21301 and 21302.21301 and 21302 can inhibit the biological activity of recombinant and native TNFalpha.