产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗成纤维细胞生长因子受体1(FGFR1)抗体
目录 :
30101
规格 :
250微克
价格 :
596美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
M19B2
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
30101
产品名称 :
抗成纤维细胞生长因子受体1(FGFR1)抗体
NAME+SKU :
抗成纤维细胞生长因子受体1(FGFR1)抗体(30101)
产品_TYPE :
抗体
描述 :
抗成纤维细胞生长因子受体1小鼠单克隆抗体
SPECIFICITY SHORT :
成纤维细胞生长因子受体1
物种活性 :
人类
靶标名 :
成纤维细胞生长因子受体1(FGFR1)
UniProt数据库 :
P11362
LOCATION :
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
蛋白名 :
成纤维细胞生长因子受体1
别称 :
FGFR-1, EC 2.7.10.1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD antigen CD331
基因名称 :
FGFR1
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
250微克
标价规格1 :
596美元
DISTIRBUTOR价格 :
417.2
SKU号规格1 :
30101
应用 :
免疫印迹, 免疫组化, 免疫沉淀
应用INSTRUCTIONS :
Western blotting: at 1 ug/ml recognizes 10 ng recombinant bacterial, baculo-viral, or native FGFr1. Immunoprecipitation: native, recombinant, and ligand-labeled FGFr1. Immunohistochemistry: paraformalde-hyde fixed cells.
宿主 :
小鼠
格式 :
纯化
纯化 :
Purified by Protein G affinity chromatography.
抗体亚型 :
IgG1
克隆编号 :
M19B2
免疫原 :
Recombinant human ectodomain of FGFr1beta expressed in E. coli beginning with proline 23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH- terminal glu-phe sequences.
研究领域 :
生长因子, 细胞因子, 受体
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
FUNCTION :
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {UniProtKB:P16092, PubMed:10830168, PubMed:11353842, PubMed:12181353, PubMed:1379697, PubMed:1379698, PubMed:15117958, PubMed:16597617, PubMed:17311277, PubMed:17623664, PubMed:18480409, PubMed:19224897, PubMed:19261810, PubMed:19665973, PubMed:20133753, PubMed:20139426, PubMed:21765395, PubMed:8622701, PubMed:8663044}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This product is stable for at least 1 year at -20C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.
特异性 :
30101 reacts with both alpha and beta isoforms. Epitope is within the NH2-terminus of Ig loop II sequence lys145 and glu159 between the acidic box and heparin-binding sequence of FGFr1.
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国