抗体

抗成纤维细胞生长因子受体1(FGFR1)抗体

30102

250微克

596美元

单克隆

小鼠

未共轭

M5G10

抗成纤维细胞生长因子受体1(FGFR1)抗体

抗成纤维细胞生长因子受体1(FGFR1)抗体(30102)

抗体

抗成纤维细胞生长因子受体1小鼠单克隆抗体

成纤维细胞生长因子受体1

人类

成纤维细胞生长因子受体1(FGFR1)

P11362

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.

成纤维细胞生长因子受体1

FGFR-1, EC 2.7.10.1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr, CD antigen CD331

FGFR1

单克隆

液体

Lot Specific

250微克

596美元

417.2

30102

免疫印迹, 免疫组化, 免疫沉淀

Immunohistochemistry: 10ug/ml, paraffin- embedded tissue. Immunoblotting: 1ug/ml recognizes 10ng recombinant bacterial, baculoviral or native FGFR1. Immunoprecipitation: native, recombinant, and ligand-labeled FGFr1.

小鼠

纯化

Purified by Protein G affinity chromatography.

IgG1

M5G10

Recombinant human ectodomain of FGFR-1beta expressed in E. coli beginning with proline 23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.

生长因子, 细胞因子, 受体

PBS, pH值7.4

磷酸盐缓冲液

pH值7.4

The fibroblast growth factor (FGF) family is a group of multi-functional polypeptides that function in embryonic development, tissue repair, neuronal cell survival, cardiovascular disease, and tumorigenesis. The biological activities of FGF are mediated by cell surface receptors that have tyrosine kinase activity. FGFR-1 is activated by FGF-1 and FGF-2. In neoplastic cells, overexpression of FGF-1, FGF-2 and FGF receptors appear to contribute to cellular trans- formation and proliferation.

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. {UniProtKB:P16092, PubMed:10830168, PubMed:11353842, PubMed:12181353, PubMed:1379697, PubMed:1379698, PubMed:15117958, PubMed:16597617, PubMed:17311277, PubMed:17623664, PubMed:18480409, PubMed:19224897, PubMed:19261810, PubMed:19665973, PubMed:20133753, PubMed:20139426, PubMed:21765395, PubMed:8622701, PubMed:8663044}.

Dilute in PBS or medium which is identical to that used in the assay system.

These antibodies are stable for at least one (1) year at -20C to -70C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

This antibody reacts with both alpha (denatured) and beta isoforms. Epitope is within the sequence his241 and val267 between Ig loops II and III. Epitope is masked in undenatured FGFr1alpha.

qed-bioscience-anti-fibroblast-growth-factor-receptor-1-fgfr1-antibody-30102-1.jpg

免疫组化

qed-bioscience-anti-fibroblast-growth-factor-receptor-1-fgfr1-antibody-30102-2.jpg

免疫印迹