产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
Anti-Rb Protein Antibody
目录 :
3101
规格 :
100微克
价格 :
352美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
4G2
反应物种 :
人类
更多信息或购买 :
图像
图像 1 :
Specificity and Applications
产品信息
目录号 :
3101
产品名称 :
Anti-Rb Protein Antibody
NAME+SKU :
Anti-Rb Protein Antibody (3101)
产品_TYPE :
抗体
描述 :
Anti-Rb Protein Mouse Monoclonal Antibody
SPECIFICITY SHORT :
Rb Protein
ASSOCIATED PRODUCTS :
Associated Clone Specificity Notes Catalog No. Clone No. Amino Acid Specificity ELISA Western Blot Immuno-Precipitation Immuno-Histochemistry . 3101 . 4G2 . 41-330 . . . . . 3102 . 4H6 . 121-140 . . . . . 3103 . 7F12 . 280-300 . . . . - . 3104 . 1G5 . 371-390 . . . . . 3105 . 1E5 . 511-530 . . . . - . 3106 . 1D1 . 571-590 . . . . - . 3107 . 3C8 . 886-905 . . . .
物种活性 :
人类
靶标名 :
Rb Protein
UniProt数据库 :
P06400
LOCATION :
Nucleus
蛋白名 :
Retinoblastoma-associated protein
别称 :
p105-Rb, p110-RB1, pRb, Rb, pp110
基因名称 :
视网膜成神经细胞瘤相关蛋白
登录号 :
NP_000312
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
352美元
DISTIRBUTOR价格 :
246.4
SKU号规格1 :
3101
应用 :
免疫印迹, 免疫沉淀, 免疫组化, 酶联免疫吸附测定
宿主 :
小鼠
格式 :
纯化
纯化 :
Purified by Protein G affinity chromatography.
抗体亚型 :
IgG1
克隆编号 :
4G2
免疫原 :
重组视网膜母细胞瘤
研究领域 :
Cancer Research
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
FUNCTION :
Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity). {UniProtKB:P13405, UniProtKB:P33568, PubMed:10499802, PubMed:15084261}.; (Microbial infection) In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity. {PubMed:1316611, PubMed:17974914, PubMed:18701596, PubMed:2839300, PubMed:8892909}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze-thaw cycles.
特异性 :
重组大鼠PSD95
图像Name_1 :
qed-bioscience-anti-rb-protein-antibody-3101-1.jpg
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国