产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗雌激素受体β抗体
目录 :
3336
规格 :
100微克
价格 :
461美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
6A12
反应物种 :
人类
更多信息或购买 :
图像
图像 1 :
Non-transfected (–) and transfected (+) 293T whole cell extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with Estrogen Receptor beta antibody [6A12] (3336) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody was used to detect the primary antibody.
产品信息
目录号 :
3336
产品名称 :
抗雌激素受体β抗体
NAME+SKU :
抗雌激素受体β抗体(3336)
产品_TYPE :
抗体
描述 :
抗雌激素受体β小鼠单克隆抗体
SPECIFICITY SHORT :
雌激素受体β
物种活性 :
人类
靶标名 :
雌激素受体β
UniProt数据库 :
Q92731
LOCATION :
Nucleus
蛋白名 :
雌激素受体β
别称 :
ER-beta, Nuclear receptor subfamily 3 group A member 2
基因名称 :
ESR2
登录号 :
NP_001035365
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
461美元
DISTIRBUTOR价格 :
322.7
SKU号规格1 :
3336
应用 :
免疫印迹
应用INSTRUCTIONS :
Immunoblotting: use at 1-5 ug/ml.
Positive controls: Native receptor from human thymus, spleen, ovary, and testis or recombinant protein.
宿主 :
小鼠
格式 :
纯化
纯化 :
Purified by Protein G affinity chromatography.
抗体亚型 :
IgG2b
克隆编号 :
6A12
免疫原 :
6-His fusion protein containing the region encoding aa 1-153 of human estrogen receptor-beta (ER-beta) expressed in E. coli.
研究领域 :
Cancer Research
配方 :
PBS, pH值7.4
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
FUNCTION :
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). {PubMed:20074560, PubMed:29261182, PubMed:30113650, PubMed:9325313}.; [Isoform 2]: Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. {PubMed:9671811}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at ≤-20C. Avoid multiple freeze-thaw cycles.
特异性 :
This antibody recognizes human ER-beta, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-beta are very similar to ER-alpha with the ligand and DNA binding domains being highly conserved. The N-terminus of each receptor, which serves as their transactivation domain, are significantly different. Like ER-alpha, ER-beta binds to estrogen with a high affinity and regulates estrogen-specific gene activation through direct interaction with estrogen response elements.
图像Name_1 :
qed-bioscience-anti-estrogen-receptor-beta-antibody-3336-1.jpg
应用1 :
免疫印迹
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国