产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗ROR2抗体
目录 :
34045
规格 :
100微克
价格 :
413美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
ROR2 2535-2835
反应物种 :
人类, 小鼠
更多信息或购买 :
图像
图像 1 :
QED Bioscience 34045 图像 1
Immunoblotting: use at 1-10ug/ml. A band of ~105kDa is detected.
图像 2 :
QED Bioscience 34045 图像 2
Immunohistochemistry: use at 1-10ug/ml on paraformaldehyde-fixed, paraffin-embedded sections following antigen retrieval (microwave 12 min in citrate buffer, pH 6.0). Detection of ROR2 in LMS and GIST. Samples were scored 2 (strong staining), 1 (weak staining), or 0 (absence of staining). See reference Edris B. et al.
产品信息
目录号 :
34045
产品名称 :
抗ROR2抗体
NAME+SKU :
抗ROR2抗体(34045)
产品_TYPE :
抗体
描述 :
抗ROR2小鼠单克隆抗体
SPECIFICITY SHORT :
ROR2
物种活性 :
人类, 小鼠
靶标名 :
ROR2
UniProt数据库 :
Q01974
LOCATION :
Cell membrane , Single-pass type I membrane protein
蛋白名 :
Tyrosine-protein kinase transmembrane receptor ROR2
别称 :
EC 2.7.10.1, Neurotrophic tyrosine kinase, receptor-related 2
基因名称 :
ROR2
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微克
标价规格1 :
413美元
DISTIRBUTOR价格 :
289.1
SKU号规格1 :
34045
应用 :
免疫印迹, 免疫组化
应用INSTRUCTIONS :
Immunoblotting: use at 1-10ug/ml. A band of ~105kDa is detected. Immunohistochemistry: use at 1-10ug/ml on paraformaldehyde-fixed, paraffin-embedded sections following antigen retrieval (microwave 12 min in citrate buffer, pH 6.0). These are recommended concentrations. Enduser should determine optimal concentrations for their application.
宿主 :
小鼠
格式 :
纯化
纯化 :
经免疫亲和层析纯化
抗体亚型 :
IgG1
克隆编号 :
ROR2 2535-2835
免疫原 :
Bases 2535-2835 of mouse ROR2 fused in-frame to MBP and expressed in E. coli.
研究领域 :
Cancer research
配方 :
PBS, pH 7.4. Purified by Protein G affinity chromatography.
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
靶标背景 :
Receptor tyrosine kinases (RTKs) are cell surface receptors that regulate normal cellular processes through ligand-controlled tyrosine kinase activity. ROR2 is a membrane-bound RTK that is activated by Wnt signaling during normal bone and cartilage development. Recently, ROR2 has been shown to have pro-tumorigenic effects in osteosarcoma, melanoma, and renal cell carcinoma cell lines. ROR2 levels have also been described in soft-tissue sarcomas; specifically, in vitro studies revealed that invasive abilities of leiomyosarcoma (LMS) and gastrointestinal stromal tumor (GIST) are affected by ROR2 expression, and suppression of ROR2 reduces in vivo tumor mass in a xenotransplantation model of LMS.
FUNCTION :
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). {UniProtKB:Q9Z138, PubMed:17717073, PubMed:25029443}.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Avoid multiple freeze-thaw cycles.
特异性 :
Mouse and human ROR2. Does not cross-react with ROR1.
图像Name_1 :
qed-bioscience-anti-ror2-antibody-34045-1.jpg
应用1 :
免疫印迹
图像Name_2 :
qed-bioscience-anti-ror2-antibody-34045-2.jpg
应用2 :
免疫组化
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国