产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗E钙粘蛋白抗体
目录 :
34060
规格 :
100微升
价格 :
195美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
G564.1
反应物种 :
人类
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 34060 图像 1
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of E-cadherin in human breast with #34060 diluted 1:100-1:200.
产品信息
目录号 :
34060
产品名称 :
抗E钙粘蛋白抗体
NAME+SKU :
抗E钙粘蛋白抗体(34060)
产品_TYPE :
抗体
描述 :
抗E钙粘蛋白小鼠单克隆抗体
SPECIFICITY SHORT :
E钙粘蛋白
物种活性 :
人类
靶标名 :
E钙粘蛋白
UniProt数据库 :
P12830
LOCATION :
Cell junction, adherens junction , Cell membrane , Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
蛋白名 :
钙粘蛋白1
别称 :
CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD antigen CD324 [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
基因名称 :
CDH1
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
195美元
DISTIRBUTOR价格 :
136.5
SKU号规格1 :
34060
应用 :
免疫组化
应用INSTRUCTIONS :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
宿主 :
小鼠
格式 :
纯化
抗体亚型 :
IgG1
克隆编号 :
G564.1
免疫原 :
重组人类E钙粘蛋白
研究领域 :
Cancer research
配方 :
三羟甲基氨基甲烷缓冲液, pH值7.3-7.7, 1% BSA, 0.1% 叠氮化钠
缓冲液 :
三羟甲基氨基甲烷缓冲液
缓冲液pH值 :
pH值7.3-7.7
缓冲液抗MICROBIAL :
0.1% 叠氮化钠
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
E-cadherin is a calcium-dependent intercellular adhesion molecule encoded by the CDH1 gene and present on epithelial cells. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer. When compared with invasive ductal carcinoma, E-cadherin expression is markedly reduced or absent in the great majority of invasive lobular carcinomas when studied by immunohistochemistry.
FUNCTION :
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {PubMed:11976333, PubMed:16417575}.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {PubMed:16417575}.; (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {PubMed:10406800, PubMed:17540170, PubMed:8601315}.
STORAGE空调 :
存放在2-8C。 不冻结
特异性 :
Human E-cadherin. Reactivity with other species has not been investigated.
图像Name_1 :
qed-bioscience-anti-e-cadherin-antibody-34060-1.jpg
应用1 :
免疫组化
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国