产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
Anti-Her2/Neu Antibody
目录 :
34061
规格 :
100微升
价格 :
237美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
G002.1
反应物种 :
人类
更多信息或购买 :
图像
图像 1 :
QED Bioscience 34061 图像 1
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of Her2/Neu in human breast carcinoma with #34061 diluted 1:100-1:200.
产品信息
目录号 :
34061
产品名称 :
Anti-Her2/Neu Antibody
NAME+SKU :
Anti-Her2/Neu Antibody (34061)
产品_TYPE :
抗体
描述 :
Anti-Her2/Neu Mouse Monoclonal Antibody
SPECIFICITY SHORT :
Her2/Neu
物种活性 :
人类
靶标名 :
Her2/Neu
UniProt数据库 :
P04626
LOCATION :
[Isoform 1]: Cell membrane , Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794).
蛋白名 :
Receptor tyrosine-protein kinase erbB-2
别称 :
EC 2.7.10.1, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD antigen CD340
基因名称 :
v-erb-b2成红细胞白血病病毒致瘤基因2
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
237美元
DISTIRBUTOR价格 :
165.9
SKU号规格1 :
34061
应用 :
免疫组化
应用INSTRUCTIONS :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
宿主 :
小鼠
格式 :
纯化
抗体亚型 :
IgG2a
克隆编号 :
G002.1
免疫原 :
Recombinant human Her2/Neu.
研究领域 :
Cancer research
配方 :
三羟甲基氨基甲烷缓冲液, pH值7.3-7.7, 1% BSA, 0.1% 叠氮化钠
缓冲液 :
三羟甲基氨基甲烷缓冲液
缓冲液pH值 :
pH值7.3-7.7
缓冲液抗MICROBIAL :
0.1% 叠氮化钠
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
The Her2/Neu (c-erB-2) proto-oncogene product is a trans-membrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the Her2/Neu protein has been associated with ductal breast cancer as well as with pulmonary and gastric adenocarcinomas. A correlation between Her2/Neu and p53 has also been reported as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.
FUNCTION :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. {PubMed:10358079, PubMed:15380516, PubMed:21555369}.
STORAGE空调 :
存放在2-8C。 不冻结
特异性 :
Human Her2/Neu. Reactivity with other species has not been investigated.
图像Name_1 :
qed-bioscience-anti-her2-neu-antibody-34061-1.jpg
应用1 :
免疫组化
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国