产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗Ki67抗原抗体
目录 :
34063
规格 :
100微升
价格 :
276美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
G067.1
反应物种 :
人类
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 34063 图像 1
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of Ki-67 in human cervical cancer tissue with #34063 diluted 1:100-1:200.
产品信息
目录号 :
34063
产品名称 :
抗Ki67抗原抗体
NAME+SKU :
抗Ki67抗原抗体(34063)
产品_TYPE :
抗体
描述 :
抗Ki67抗原小鼠单克隆抗体
SPECIFICITY SHORT :
Ki67抗原
物种活性 :
人类
靶标名 :
Ki67抗原
UniProt数据库 :
P46013
LOCATION :
Chromosome , Nucleus , Nucleus, nucleolus
蛋白名 :
Proliferation marker protein Ki-67
别称 :
Antigen identified by monoclonal antibody Ki-67, Antigen KI-67, Antigen Ki67
基因名称 :
MKI67
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
276美元
DISTIRBUTOR价格 :
193.2
SKU号规格1 :
34063
应用 :
免疫组化
应用INSTRUCTIONS :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
宿主 :
小鼠
格式 :
纯化
抗体亚型 :
IgG1
克隆编号 :
G067.1
免疫原 :
重组人类Ki67抗原
研究领域 :
Cancer research
配方 :
三羟甲基氨基甲烷缓冲液, pH值7.3-7.7, 1% BSA, 0.1% 叠氮化钠
缓冲液 :
三羟甲基氨基甲烷缓冲液
缓冲液pH值 :
pH值7.3-7.7
缓冲液抗MICROBIAL :
0.1% 叠氮化钠
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
Ki-67 is a nuclear, non-histone protein that is expressed only during active phases of the cell cycle (G1, S, G2, and M), but not in the resting phases of G0 and G1 early phase. Although it has been associated with ribosomal RNA transcription, it is strongly linked to cell proliferation and has been used as an effective marker in grading proliferation rate of tumors including those of brain, breast, cervix, and prostate.
FUNCTION :
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). {UniProtKB:E9PVX6, PubMed:10878551, PubMed:24867636, PubMed:27362226}.
STORAGE空调 :
These antibodies are stable for at least one (1) year at -20C to -70C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
特异性 :
Human Ki-67. Reactivity with other species has not been investigated.
图像Name_1 :
qed-bioscience-anti-ki-67-antibody-34063-1.jpg
应用1 :
免疫组化
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国