产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗神经生长因子受体(神经生长因子受体)抗体
目录 :
34064
规格 :
100微升
价格 :
276美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
G637.1
反应物种 :
人类
更多信息或购买 :
图像
图像 1 :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of NGFR in human prostate with #34064 diluted 1:100-1:200.
产品信息
目录号 :
34064
产品名称 :
抗神经生长因子受体(神经生长因子受体)抗体
NAME+SKU :
抗神经生长因子受体(神经生长因子受体)抗体(34064)
产品_TYPE :
抗体
描述 :
抗神经生长因子受体(神经生长因子受体)小鼠单克隆抗体
SPECIFICITY SHORT :
神经生长因子受体(神经生长因子受体)
物种活性 :
人类
靶标名 :
神经生长因子受体(神经生长因子受体)
UniProt数据库 :
P08138
LOCATION :
Cell membrane , Perikaryon , Cell projection, growth cone , Cell projection, dendritic spine
蛋白名 :
Tumor necrosis factor receptor superfamily member 16
别称 :
Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, NGF receptor, p75 ICD, CD antigen CD271
基因名称 :
神经生长因子受体
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
276美元
DISTIRBUTOR价格 :
193.2
SKU号规格1 :
34064
应用 :
免疫组化
应用INSTRUCTIONS :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
宿主 :
小鼠
格式 :
纯化
抗体亚型 :
IgG1
克隆编号 :
G637.1
免疫原 :
重组人类神经生长因子受体
研究领域 :
Cancer research
配方 :
三羟甲基氨基甲烷缓冲液, pH值7.3-7.7, 1% BSA, 0.1% 叠氮化钠
缓冲液 :
三羟甲基氨基甲烷缓冲液
缓冲液pH值 :
pH值7.3-7.7
缓冲液抗MICROBIAL :
0.1% 叠氮化钠
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
Nerve Growth Factor Receptor (NGFR), also known as p75, P-75NTR or CD271, is a neurotrophin receptor belonging to the tumor necrosis factor receptor family. NGFR is expressed on Schwann cells and neurons as well as a number of other non-neuronal cell types, and it functions during central and peripheral nervous system development to regulate neuronal growth, migration, differentiation, and cell death. Nerve Growth Factor Receptor is also expressed on melanocytes, melanomas, neuroblastomas, pheochromocytomas, neurobromas, neurotized nevi (type C melanocytes), and other neural crest cell or tumor derivatives.
FUNCTION :
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {UniProtKB:Q9Z0W1, PubMed:14966521, PubMed:23785138, PubMed:24908487, PubMed:26646181, PubMed:3022937}.
STORAGE空调 :
存放在2-8C。 不冻结
特异性 :
Human NGFR. Reactivity with other species has not been investigated.
图像Name_1 :
qed-bioscience-anti-nerve-growth-factor-receptor-ngfr-antibody-34064-1.jpg
应用1 :
免疫组化
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国