产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗PSAP抗体
目录 :
34070
规格 :
100微升
价格 :
229美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
G655.1
反应物种 :
人类
更多信息或购买 :
QED Bioscience 产品网页
图像
图像 1 :
QED Bioscience 34070 图像 1
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of PSAP in human prostate with #34070 diluted 1:100-1:200.
产品信息
目录号 :
34070
产品名称 :
抗PSAP抗体
NAME+SKU :
抗PSAP抗体(34070)
产品_TYPE :
抗体
描述 :
抗PSAP小鼠单克隆抗体
SPECIFICITY SHORT :
PSAP
物种活性 :
人类
靶标名 :
PSAP
UniProt数据库 :
P07602
LOCATION :
溶酶体
蛋白名 :
Prosaposin
别称 :
Proactivator polypeptide [Cleaved into: Saposin-A
基因名称 :
PSAP
克隆性 :
单克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
229美元
DISTIRBUTOR价格 :
160.3
SKU号规格1 :
34070
应用 :
免疫组化
应用INSTRUCTIONS :
Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
宿主 :
小鼠
格式 :
纯化
纯化 :
经免疫亲和层析纯化
抗体亚型 :
IgG1
克隆编号 :
G655.1
免疫原 :
重组人类PSAP
研究领域 :
Cancer research
配方 :
三羟甲基氨基甲烷缓冲液, pH值7.3-7.7, 1% BSA
缓冲液 :
三羟甲基氨基甲烷缓冲液
缓冲液pH值 :
pH值7.3-7.7
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
Prostatic Specific Acid Phosphatase (PSAP) is an enzyme found in the glandular epithelium of the prostate. PSAP levels are elevated in hyperplastic prostate and prostate carcinoma with the highest levels being detected in metastasized prostate cancer. Moderate overexpression of PSAP is also characteristic of diseases of the bone (such as Paget’s disease or hyperparathyroidism), diseases of blood cells (such as sickle-cell disease), multiple myeloma, or lysosomal storage diseases such as Gaucher’s disease.
FUNCTION :
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.; Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).; [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {UniProtKB:Q61207, PubMed:10383054}.; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
STORAGE空调 :
存放在2-8C。 不冻结
特异性 :
Human PSAP. Reactivity with other species has not been investigated.
图像Name_1 :
qed-bioscience-anti-psap-antibody-34070-1.jpg
应用1 :
免疫组化
更多信息或购买 :
QED Bioscience 产品网页
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国