抗体

抗E钙粘蛋白抗体

42027

100微克

484美元

单克隆

小鼠

未共轭

SHE78-7

抗E钙粘蛋白抗体

抗E钙粘蛋白抗体(42027)

抗体

抗人类E钙粘蛋白小鼠单克隆抗体

人类E钙粘蛋白

人类

E钙粘蛋白

P12830

Cell junction, adherens junction , Cell membrane , Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.

钙粘蛋白1

CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD antigen CD324 [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]

CDH1

单克隆

冻干

Lot Specific

100微克

484美元

338.8

42027

免疫印迹, 酶联免疫吸附测定, 免疫组化, IF, 流式细胞仪

ELISA: 2ug/ml. Western Blotting: 2ug/ml, reducing and non-reducing conditions. Flow Cytometry: 1ug/ml. Immunohistochemistry: 2ug/ml, paraffin- embedded and frozen tissue sections. Immunofluorescence: 1ug/ml. Cell-Cell Contact Inhibition Assays: 1ug/ml.

小鼠

纯化

IgG2a

SHE78-7

人类胎盘E钙粘蛋白

细胞粘附

PBS, pH值7.4, 冻干

磷酸盐缓冲液

pH值7.4

Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {PubMed:11976333, PubMed:16417575}.; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. {PubMed:16417575}.; (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. {PubMed:10406800, PubMed:17540170, PubMed:8601315}.

Reconstitute in distilled water to the final desired concentration.

This product does not contain preservative. The stock solution (2.0mg/ml) can be stored in aliquots at – 20C for 1 year or can be stored at 4C for 6 months after adding 0.1% sodium azide. Dilutions of stock solution should not be stored. Avoid repeated freeze- thaw cycles.

This antibody specifically reacts with human E-Cadherin, but does not react with rat E-Cadherin. This antibody inhibits E-Cadherin dependent cell-cell contact.