产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗纤连蛋白抗体
目录 :
42042
规格 :
400微克
价格 :
469美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
FN30-8
反应物种 :
人类
更多信息或购买 :
产品信息
目录号 :
42042
产品名称 :
抗纤连蛋白抗体
NAME+SKU :
抗纤连蛋白抗体(42042)
产品_TYPE :
抗体
描述 :
抗人类纤连蛋白小鼠单克隆抗体
SPECIFICITY SHORT :
人类纤连蛋白
物种活性 :
人类
靶标名 :
纤维连接蛋白
UniProt数据库 :
P02751
LOCATION :
Secreted, extracellular space, extracellular matrix
蛋白名 :
纤维连接蛋白
别称 :
FN, Cold-insoluble globulin, CIG [Cleaved into: Anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3]
基因名称 :
FN1
克隆性 :
单克隆
形式 :
冻干
浓度 :
Lot Specific
规格1 :
400微克
标价规格1 :
469美元
DISTIRBUTOR价格 :
328.3
SKU号规格1 :
42042
应用 :
免疫印迹, 酶联免疫吸附测定, 抑制作用
应用INSTRUCTIONS :
ELISA: 1-10ug/ml with immobilized antigen. Western Blot: 1-10ug/ml, reducing or non-reducing conditions. Cell Adhesion Inhibition Assay: 0.1-1.0ug/ml on 10ug/ml fibronectin-coated microwells inhibits adhesion of trypsinized NRK cells. Immunohistochemistry: 1-10ug/ml, paraffin-embedded or frozen tissue sections with Proteinase K treatment for antigen retrieval. These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
宿主 :
小鼠
格式 :
纯化
抗体亚型 :
IgG1
克隆编号 :
FN30-8
免疫原 :
人类血浆纤连蛋白
研究领域 :
细胞粘附
配方 :
PBS, pH值7.4, 1% BSA, 冻干
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
缓冲液蛋白稳定剂 :
1% 牛血清白蛋白
靶标背景 :
Fibronectin is a 440kDa glycoprotein of the extracellular matrix that binds to integrins, collagen, fibrin, and heparan sulfate proteoglycans. Fibronectin plays a major role in cell adhesion, growth, migration, and differentiation, and it is important for processes such as wound healing and embryonic development. Altered fibronectin expression, degradation, and organization has been associated with a number of pathologies, including cancer and fibrosis.
FUNCTION :
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {UniProtKB:P11276, PubMed:3024962, PubMed:34089617, PubMed:3593230, PubMed:3900070, PubMed:7989369}.; [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {PubMed:11209058, PubMed:15665290, PubMed:19379667, PubMed:8114919}.
稀释INSTRUCTIONS :
Dissolve lyophilized antibody in 200ul of distilled water (final concentration 2.0mg/ml).
STORAGE空调 :
The stock solution (2.0mg/ml) can be stored in aliquots at -20C for 1 year or can be stored at 4C for 6 months after adding 0.1% sodium azide. Prepare dilutions of stock solution immediately before use. Do not store diluted stock solution. Avoid repeated freeze-thaw cycles.
特异性 :
This antibody recognizes an epitope in the cell-binding domain of human fibronectin and can inhibit cell adhesion.
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国