产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗HNF4甲(磷酸化Ser304)抗体
目录 :
43043
规格 :
100微升
价格 :
345美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
更多信息或购买 :
产品信息
目录号 :
43043
产品名称 :
抗HNF4甲(磷酸化Ser304)抗体
NAME+SKU :
抗HNF4甲(磷酸化Ser304)抗体(43043)
产品_TYPE :
抗体
描述 :
抗HNF4甲(磷酸化Ser304)兔多克隆抗体
SPECIFICITY SHORT :
HNF4甲(磷酸化Ser304)
物种活性 :
人类, 小鼠, 大鼠
靶标名 :
HNF4甲(磷酸化Ser304)
靶抗原修饰 :
磷酸化ser304
UniProt数据库 :
P41235
LOCATION :
Nucleus.
蛋白名 :
肝细胞核因子4甲
基因名称 :
HNF4A
克隆性 :
多克隆
形式 :
液体
浓度 :
1.0毫克/毫升
规格1 :
100微升
标价规格1 :
345美元
DISTIRBUTOR价格 :
241.5
SKU号规格1 :
43043
应用 :
免疫印迹
应用INSTRUCTIONS :
Immunoblotting: use at dilution of 1:1,000. A band of ~52kDa is detected.
These are recommended working dilutions. Enduser should determine optimal dilutions for their applications
宿主 :
兔
格式 :
纯化
纯化 :
经免疫亲和层析纯化
免疫原 :
Peptide sequence that includes phosphorylation site of serine 304 (L-R-S(p)-Q-V) derived from human HNF4alpha and conjugated to KLH.
研究领域 :
磷酸化特异性抗体
配方 :
PBS (without Mg2 and Ca2 ), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
缓冲液 :
磷酸盐缓冲液
缓冲液pH值 :
pH值7.4
缓冲液抗MICROBIAL :
0.02% 叠氮化钠
缓冲液CRYOPRESERVATIVE :
50% 甘油
靶标背景 :
Hepatocyte nuclear factor 4 alpha (HNF4alpha) is a nuclear transcription factor that binds DNA as a homodimer and controls the expression of several genes including hepatocyte nuclear factor 1, a transcripton factor that regulates expression of several hepatic genes. HNF4alpha has been implicated in development of liver, kidney, and intestines. Mutations in the HNF4alpha gene have been associated with monogenic autosomal-dominant non-insulin-dependent diabetes mellitus type 1. Alternative splicing of this gene results in multiple transcript variants.
FUNCTION :
Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {UniProtKB:P49698, PubMed:30530698, PubMed:30597922}.
稀释INSTRUCTIONS :
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE空调 :
Lyophilized product may be stored long-term at 4C in a dry environment. After reconstitution, if not intended for use within 30 days, prepare appropriate aliquots and store at -20C.
特异性 :
This antibody detects endogenous human, mouse, and rat HNF4alpha only when phosphorylated at serine 304.
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com800-929-2114 858-675-2405
公司总部: 美国