产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗钙网蛋白抗体
目录 :
56259
规格 :
100微升
价格 :
308美元
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠, , ,
更多信息或购买 :
产品信息
目录号 :
56259
产品名称 :
抗钙网蛋白抗体
NAME+SKU :
抗钙网蛋白抗体(56259)
产品_TYPE :
抗体
描述 :
抗钙网蛋白抗体兔多克隆抗体
SPECIFICITY SHORT :
钙网蛋白抗体
物种活性 :
Human, mouse, rat, bovine, canine, chicken, guinea pig, monkey, pig, hamster, rabbit, sheep
靶标名 :
钙网蛋白
UniProt数据库 :
P27797
LOCATION :
Endoplasmic reticulum lumen , Cytoplasm, cytosol , Secreted, extracellular space, extracellular matrix , Cell surface , Sarcoplasmic reticulum lumen , Cytoplasmic vesicle, secretory vesicle, Cortical granule , Cytolytic granule
蛋白名 :
钙网蛋白
别称 :
CRP55, Calregulin, Endoplasmic reticulum resident protein 60, ERp60, HACBP, grp60
基因名称 :
CALR
克隆性 :
多克隆
形式 :
液体
浓度 :
Lot Specific
规格1 :
100微升
标价规格1 :
308美元
DISTIRBUTOR价格 :
215.6
SKU号规格1 :
56259
应用 :
免疫印迹
应用INSTRUCTIONS :
Immunoblotting: use at 1:5,000-1:10,000 dilution. A band of ~63 kDa is detected. These are recommended concentrations. User should determine optimal concentrations for their application. Positive control: HeLa cell lysate.
宿主 :
格式 :
血清
免疫原 :
人类钙网蛋白合成肽,KLH偶联
研究领域 :
神经科学
配方 :
Whole Antiserum
缓冲液 :
Whole Antiserum
靶标背景 :
Calreticulin is a multifunctional highly conserved Ca+2-binding protein that is localized primarily in the endoplasmic reticulum (ER) but has also been detected in the nucleus and nuclear envelope. Like many other ER proteins, it has the conserved ER retention KDEL sequence (Lys-Asp-Glu-Leu) at its C-terminus. Calreticulin is made up of three domains: 1 180 residue N-terminal domain, a proline- rich P-domain (aa 189-288) that binds Ca+2 with high affinity and shares homology with calnexin and calmegin, and a 110 residue C-terminal domain that binds Ca+2 with low affinity but high capacity. Calreticulin appears to be involved in calcium storage and regulation, has molecular chaperone activity, and has been shown to be induced in response to various types of cell stress.
FUNCTION :
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {UniProtKB:P28491, UniProtKB:Q8K3H7, PubMed:11149926, PubMed:7876246}.
稀释INSTRUCTIONS :
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE空调 :
This antibody is stable for at least one (1) year at -20C. Avoid repeated freezing and thawing.
特异性 :
This antibody recognizes human, mouse, rat, bovine, canine, chicken, guinea pig, monkey, pig, hamster, rabbit, and sheep calreticulin.
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国