产品简要
公司名称 :
QED Bioscience
产品类型 :
抗体
产品名称 :
抗转谷氨酰胺酶2(TG2)抗体
目录 :
90021
规格 :
100微克
价格 :
498美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
7D2
反应物种 :
人类
更多信息或购买 :
图像
图像 1 :
QED Bioscience 90021 图像 1
Immunoblotting: use at 1-5ug/ml. A band of ~80kDa is detected. Detection of TG2 in human erythroctyes with #90021.
产品信息
目录号 :
90021
产品名称 :
抗转谷氨酰胺酶2(TG2)抗体
NAME+SKU :
抗转谷氨酰胺酶2(TG2)抗体(90021)
产品_TYPE :
抗体
描述 :
抗转谷氨酰胺酶2(TG2)小鼠单克隆抗体
SPECIFICITY SHORT :
转谷氨酰胺酶2(TG2)
物种活性 :
人类, 豚鼠
靶标名 :
转谷氨酰胺酶2(TG2)
UniProt数据库 :
P21980
LOCATION :
Cytoplasm, cytosol , Nucleus , Chromosome , Secreted, extracellular space, extracellular matrix , Cell membrane , Mitochondrion
蛋白名 :
蛋白谷氨酸γ-谷氨酰转移酶2
别称 :
EC 2.3.2.13, Erythrocyte transglutaminase, Heart G alpha(h, hhG alpha(h, Isopeptidase TGM2, EC 3.4.-.-, Protein G alpha(h, G(h, Protein-glutamine deamidase TGM2, EC 3.5.1.44, Protein-glutamine dopaminyltransferase TGM2, EC 2.3.1.-, Protein-glutamine histaminyltransferase TGM2, EC 2.3.1.-, Protein-glutamine noradrenalinyltransferase TGM2, EC 2.3.1.-, Protein-glutamine serotonyltransferase TGM2, EC 2.3.1.-, Tissue transglutaminase, tTG, tTgase, Transglutaminase C, TG(C, TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase II, TGase II, Transglutaminase-2, TG2, TGase-2, hTG2
基因名称 :
TGM2
克隆性 :
单克隆
形式 :
冻干
浓度 :
1.0毫克/毫升
规格1 :
100微克
标价规格1 :
498美元
DISTIRBUTOR价格 :
348.6
SKU号规格1 :
90021
应用 :
免疫印迹, 免疫细胞化学
应用INSTRUCTIONS :
Immunoblotting: use at 1-5ug/ml. A band of ~80kDa is detected. Immunocytochemistry: use at 2- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
宿主 :
小鼠
格式 :
纯化
纯化 :
经免疫亲和层析纯化
抗体亚型 :
IgG3
克隆编号 :
7D2
免疫原 :
纯化TG2来自豚鼠肝(登录号。 P21980)
研究领域 :
配方 :
冻干, 0.1M三羟甲基氨基甲烷, 0.1M甘氨酸, 2% 蔗糖, 1毫克/毫升
缓冲液 :
三羟甲基氨基甲烷缓冲液
靶标背景 :
Transglutaminase 2 (TG2) is a multi- domain, multi-functional enzyme that post-translationally modifies proteins by catalyzing the formation of inter- molecular isopeptide bonds between glutamine and lysine side-chains. It plays a role in diverse biological functions, including extracellular matrix formation, integrin mediated signaling, and signal transduction involving 7- transmembrane receptors. While some of the roles of TG2 under normal physiological conditions remain obscure, the protein is believed to participate in the pathogenesis of several unrelated diseases including celiac sprue, neurodegenerative diseases, and certain types of cancer.
FUNCTION :
Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (PubMed:9252372, PubMed:23941696, PubMed:31991788). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:1683874, PubMed:7935379, PubMed:9252372, PubMed:27270573). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:23941696, PubMed:24349085, PubMed:29618516, PubMed:30458214). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (PubMed:7649299, PubMed:7592956, PubMed:18092889). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (PubMed:12506096). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (PubMed:7935379, PubMed:9252372). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:23797785, PubMed:30867594). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (PubMed:30867594, PubMed:32273471). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (PubMed:30867594). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (PubMed:32273471). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (PubMed:9623982, PubMed:20547769). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (PubMed:9623982). May also act as an isopeptidase cleaving the previously formed cross-links (PubMed:26250429, PubMed:27131890). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (PubMed:8943303). {UniProtKB:P08587, UniProtKB:P21981, PubMed:12506096, PubMed:1683874, PubMed:18092889, PubMed:20547769, PubMed:23797785, PubMed:23941696, PubMed:24349085, PubMed:26250429, PubMed:27131890, PubMed:29618516, PubMed:30458214, PubMed:30867594, PubMed:31991788, PubMed:32273471, PubMed:7592956, PubMed:7649299, PubMed:7935379, PubMed:8943303, PubMed:9252372, PubMed:9623982, PubMed:27270573}.; [Isoform 2]: Has cytotoxic activity: is able to induce apoptosis independently of its acyltransferase activity. {PubMed:17116873}.
STORAGE空调 :
This product is stable for at least one (1) year at -20C to -70C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.
特异性 :
这抗体识别豚鼠和人类TG2
图像Name_1 :
qed-bioscience-anti-transglutaminase-2-tg2-antibody-90021-1.jpg
应用1 :
免疫印迹
更多信息或购买 :
公司信息
QED Bioscience
10919 Technology Place, Suite C San Diego, CA 92127
info@qedbio.com
http://www.qedbio.com
800-929-2114 858-675-2405
公司总部: 美国