产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
人类TGF乙1蛋白
目录 :
100-B
规格 :
1 ug (also 10 ug)
价格 :
299美元
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 40
参考文献
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Zeng Z, Yang H, Wang Y, Ren J, Dai Y, Dai C. Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression. Sci Rep. 2017;7:46146 pubmed 出版商
Ren J, Li J, Liu X, Feng Y, Gui Y, Yang J, et al. Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling. Sci Rep. 2016;6:23968 pubmed 出版商
Li J, Ren J, Liu X, Jiang L, He W, Yuan W, et al. Rictor/mTORC2 signaling mediates TGFβ1-induced fibroblast activation and kidney fibrosis. Kidney Int. 2015;88:515-27 pubmed 出版商
Dayer C, Stamenkovic I. Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation. J Biol Chem. 2015;290:13763-78 pubmed 出版商
Shapero K, Wylie Sears J, Levine R, Mayer J, Bischoff J. Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. J Mol Cell Cardiol. 2015;80:175-85 pubmed 出版商
Bernard M, Dieudé M, Yang B, Hamelin K, Underwood K, Hébert M. Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy. 2014;10:2193-207 pubmed 出版商
Klingberg F, Chow M, Koehler A, Boo S, Buscemi L, Quinn T, et al. Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. J Cell Biol. 2014;207:283-97 pubmed 出版商
Patsialou A, Wang Y, Pignatelli J, Chen X, Entenberg D, Oktay M, et al. Autocrine CSF1R signaling mediates switching between invasion and proliferation downstream of TGF? in claudin-low breast tumor cells. Oncogene. 2015;34:2721-31 pubmed 出版商
Duan W, Yu X, Huang X, Yu J, Lan H. Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. Am J Pathol. 2014;184:2275-84 pubmed 出版商
Xu L, Golshirazian I, Asbury B, Li Y. Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA. Histol Histopathol. 2014;29:609-18 pubmed 出版商
Jiang L, Xu L, Mao J, Li J, Fang L, Zhou Y, et al. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis. J Am Soc Nephrol. 2013;24:1114-26 pubmed 出版商
Bruchard M, Mignot G, Derangère V, Chalmin F, Chevriaux A, Vegran F, et al. Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth. Nat Med. 2013;19:57-64 pubmed 出版商
Zhu Y, Colak T, Shenoy M, Liu L, Mehta K, Pai R, et al. Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis. Mol Pain. 2012;8:65 pubmed 出版商
Zhang N, Bevan M. TGF-? signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. Nat Immunol. 2012;13:667-73 pubmed 出版商
Kawamura T, Ogawa Y, Nakamura Y, Nakamizo S, Ohta Y, Nakano H, et al. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency. J Clin Invest. 2012;122:722-32 pubmed 出版商
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产品信息
品牌 :
R&D Systems
master code :
100-B
SKU号 :
100-B-001
产品名称 :
人类TGF乙1蛋白
描述 :
The Human TGF-beta 1 Protein from R&D Systems is derived from Human Platelets. The Human TGF-beta 1 Protein has been validated for the following applications: Bioactivity.
靶标 :
TGF乙1
类别 :
蛋白和酶
单位尺寸 :
1 ug (also 10 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
共轭标签 :
未共轭
纯度 :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
物种 :
人类
观察到的分子量 :
12 kDa, reducing conditions
基因符号 :
转化生长因子1
功能细节 :
Measured by its ability to inhibit the IL-4-dependent proliferation of HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 0.04-0.2 ng/mL.
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
100-B
应用 :
Bioactivity
来源 :
Human platelet-derived TGF-beta 1 protein The human platelets used for the isolation of this product were certified by the supplier to be HIV-1 and HBsAg negative at the time of shipment. Human blood products should always be treated in accordance with universal handling precautions.
extended description :
Item is in-process of being discontinued
2020美元 :
299
2021美元 :
299美元
产品细节 :
Item is in-process of being discontinued
别名 :
CEDLAP, DPD1, latency-associated peptide, TGF beta, TGF beta1, TGFB, TGFB1, TGFbeta, TGFbeta 1, TGF-beta 1 protein, TGF-beta-1, transforming growth factor beta-1, transforming growth factor, beta 1
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.