产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类v-erb-b2成红细胞白血病病毒致瘤基因2/Her2 Fc嵌合体蛋白, CF
目录 :
1129-ER-01M
规格 :
1毫克
价格 :
4250美元
更多信息或购买 :
文章摘录数: 45
参考文献
Dengl S, Mayer K, Bormann F, Duerr H, Hoffmann E, Nussbaum B, et al. Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices. Nat Commun. 2020;11:4974 pubmed 出版商
Kondo T, Iwatani Y, Matsuoka K, Fujino T, Umemoto S, Yokomaku Y, et al. Antibody-like proteins that capture and neutralize SARS-CoV-2. Sci Adv. 2020;6: pubmed 出版商
Wege A, Kirchhammer N, Kazandjian L, Prassl S, Brandt M, Piendl G, et al. A novel rabbit derived anti-HER2 antibody with pronounced therapeutic effectiveness on HER2-positive breast cancer cells in vitro and in humanized tumor mice (HTM). J Transl Med. 2020;18:316 pubmed 出版商
Hegde M, Joseph S, Pashankar F, Derenzo C, Sanber K, Navai S, et al. Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma. Nat Commun. 2020;11:3549 pubmed 出版商
Crauwels M, Van Vaerenbergh N, Kulaya N, Vincke C, D Huyvetter M, Devoogdt N, et al. Reshaping nanobodies for affinity purification on protein a. N Biotechnol. 2020;57:20-28 pubmed 出版商
Kadonosono T, Yimchuen W, Ota Y, See K, Furuta T, Shiozawa T, et al. Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use. Sci Rep. 2020;10:891 pubmed 出版商
Parker C, Jacobs T, Huckaby J, Harit D, Lai S. Efficient and Highly Specific Gene Transfer Using Mutated Lentiviral Vectors Redirected with Bispecific Antibodies. MBio. 2020;11: pubmed 出版商
Liberelle M, Magnez R, Thuru X, Bencheikh Y, Ravez S, Quenon C, et al. MUC4-ErbB2 Oncogenic Complex: Binding studies using Microscale Thermophoresis. Sci Rep. 2019;9:16678 pubmed 出版商
Medina Echeverz J, Hinterberger M, Testori M, Geiger M, Giessel R, Bathke B, et al. Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies. Nat Commun. 2019;10:5041 pubmed 出版商
Ahn S, Li J, Sun C, Gao K, Hirabayashi K, Li H, et al. Cancer Immunotherapy with T Cells Carrying Bispecific Receptors That Mimic Antibodies. Cancer Immunol Res. 2019;7:773-783 pubmed 出版商
Tobin S, Wakefield D, Jones V, Liu X, Schmolze D, Jovanovic Talisman T. Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2. Sci Rep. 2018;8:15154 pubmed 出版商
Helsen C, Hammill J, Lau V, Mwawasi K, Afsahi A, Bezverbnaya K, et al. The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity. Nat Commun. 2018;9:3049 pubmed 出版商
Pruszyński M, Kang C, Koumarianou E, Vaidyanathan G, Zalutsky M. d-Amino Acid Peptide Residualizing Agents for Protein Radioiodination: Effect of Aspartate for Glutamate Substitution. Molecules. 2018;23: pubmed 出版商
Kahl M, Settele F, Knick P, Haupts U, Bosse Doenecke E. Mabfilin and Fabfilin - New antibody-scaffold fusion formats for multispecific targeting concepts. Protein Expr Purif. 2018;149:51-65 pubmed 出版商
Tolmachev V, Grönroos T, Yim C, Garousi J, Yue Y, Grimm S, et al. Molecular design of radiocopper-labelled Affibody molecules. Sci Rep. 2018;8:6542 pubmed 出版商
Correa I, Ilieva K, Crescioli S, Lombardi S, Figini M, Cheung A, et al. Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells. Front Immunol. 2018;9:493 pubmed 出版商
Nguyen A, Le K, Maynard J. Identification of high affinity HER2 binding antibodies using CHO Fab surface display. Protein Eng Des Sel. 2018;31:91-101 pubmed 出版商
Lee J, Kang H, Bae J, Kim K, Lee K, Lim K, et al. Evaluation of analytical similarity between trastuzumab biosimilar CT-P6 and reference product using statistical analyses. MAbs. 2018;10:547-571 pubmed 出版商
Bielamowicz K, Fousek K, Byrd T, Samaha H, Mukherjee M, Aware N, et al. Trivalent CAR T-cells Overcome Interpatient Antigenic Variability in Glioblastoma. Neuro Oncol. 2017;: pubmed 出版商
Yun M, Kim D, Lee J, Kim H, Kim H, Pyo A, et al. A High-Affinity Repebody for Molecular Imaging of EGFR-Expressing Malignant Tumors. Theranostics. 2017;7:2620-2633 pubmed 出版商
Shinozaki N, Hashimoto R, Fukui K, Uchiyama S. Efficient generation of single domain antibodies with high affinities and enhanced thermal stabilities. Sci Rep. 2017;7:5794 pubmed 出版商
Petrović B, Gianni T, Gatta V, Campadelli Fiume G. Insertion of a ligand to HER2 in gB retargets HSV tropism and obviates the need for activation of the other entry glycoproteins. PLoS Pathog. 2017;13:e1006352 pubmed 出版商
Tobias J, Jasinska J, Baier K, Kundi M, Ede N, Zielinski C, et al. Enhanced and long term immunogenicity of a Her-2/neu multi-epitope vaccine conjugated to the carrier CRM197 in conjunction with the adjuvant Montanide. BMC Cancer. 2017;17:118 pubmed 出版商
Leung I, Jarvik N, Sidhu S. A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents. J Mol Biol. 2017;429:115-127 pubmed 出版商
Dai P, Zhang C, Welborn M, Shepherd J, Zhu T, Van Voorhis T, et al. Salt Effect Accelerates Site-Selective Cysteine Bioconjugation. ACS Cent Sci. 2016;2:637-646 pubmed
Hegde M, Mukherjee M, Grada Z, Pignata A, Landi D, Navai S, et al. Tandem CAR T cells targeting HER2 and IL13R?2 mitigate tumor antigen escape. J Clin Invest. 2016;126:3036-52 pubmed 出版商
Selis F, Focà G, Sandomenico A, Marra C, Di Mauro C, Saccani Jotti G, et al. Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen. Int J Mol Sci. 2016;17:491 pubmed 出版商
Kanojia D, Balyasnikova I, Morshed R, Frank R, Yu D, Zhang L, et al. Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases. Stem Cells. 2015;33:2985-94 pubmed 出版商
Leung K, Batey S, Rowlands R, Isaac S, Jones P, Drewett V, et al. A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis. Mol Ther. 2015;23:1722-1733 pubmed 出版商
Zhou Q, Uhlig K, Muth A, Kimpel J, Lévy C, Münch R, et al. Exclusive Transduction of Human CD4+ T Cells upon Systemic Delivery of CD4-Targeted Lentiviral Vectors. J Immunol. 2015;195:2493-501 pubmed 出版商
Vanseggelen H, Hammill J, Dvorkin Gheva A, Tantalo D, Kwiecien J, Denisova G, et al. T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice. Mol Ther. 2015;23:1600-10 pubmed 出版商
Lin C, Pan I, Li Y, Pan Y, Lin M, Lu Y, et al. The adjuvant effects of high-molecule-weight polysaccharides purified from Antrodia cinnamomea on dendritic cell function and DNA vaccines. PLoS ONE. 2015;10:e0116191 pubmed 出版商
Liu Z, Leng E, Gunasekaran K, Pentony M, Shen M, Howard M, et al. A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism. J Biol Chem. 2015;290:7535-62 pubmed 出版商
Schönfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, et al. Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Mol Ther. 2015;23:330-8 pubmed 出版商
Nilvebrant J, Astrand M, Georgieva Kotseva M, Björnmalm M, Löfblom J, Hober S. Engineering of bispecific affinity proteins with high affinity for ERBB2 and adaptable binding to albumin. PLoS ONE. 2014;9:e103094 pubmed 出版商
Hussain S, Rodriguez Fernandez M, Braun G, Doyle F, Ruoslahti E. Quantity and accessibility for specific targeting of receptors in tumours. Sci Rep. 2014;4:5232 pubmed 出版商
Gu J, Yang J, Chang Q, Lu X, Wang J, Chen M, et al. Identification of anti-ErbB2 dual variable domain immunoglobulin (DVD-Ig™) proteins with unique activities. PLoS ONE. 2014;9:e97292 pubmed 出版商
Kang J, Poovassery J, Bansal P, You S, Manjarres I, Ober R, et al. Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells. MAbs. 2014;6:340-53 pubmed 出版商
Hegde M, Corder A, Chow K, Mukherjee M, Ashoori A, Kew Y, et al. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther. 2013;21:2087-101 pubmed 出版商
Frese K, Eisenmann M, Ostendorp R, Brocks B, Pabst S. An automated immunoassay for early specificity profiling of antibodies. MAbs. 2013;5:279-87 pubmed 出版商
Axup J, Bajjuri K, Ritland M, Hutchins B, Kim C, Kazane S, et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A. 2012;109:16101-6 pubmed 出版商
Feldwisch J, Tolmachev V, Lendel C, Herne N, Sjöberg A, Larsson B, et al. Design of an optimized scaffold for affibody molecules. J Mol Biol. 2010;398:232-47 pubmed 出版商
Serpe M, Umulis D, Ralston A, Chen J, Olson D, Avanesov A, et al. The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila. Dev Cell. 2008;14:940-53 pubmed 出版商
Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed 出版商
Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels W, et al. Regression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007;67:5957-64 pubmed
图像
图像 1 :
安迪生物R&D 1129-ER-01M 图像 1
Graph showing dose-dependent bioactivity of human ErbB2/ Her2 protein
产品信息
品牌 :
R&D Systems
MasterCode :
1129-ER
SKU号 :
1129-ER-01M
产品名称 :
重组人类v-erb-b2成红细胞白血病病毒致瘤基因2/Her2 Fc嵌合体蛋白, CF
单位尺寸 :
1毫克
描述 :
The Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human ErbB2/Her2 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
靶标 :
v-erb-b2成红细胞白血病病毒致瘤基因2/Her2
类别 :
蛋白和酶
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS.
共轭标签 :
未共轭
纯度 :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
125-130 kDa, reducing conditions 220-250 kDa, non-reducing conditions
理论上的分子量 :
96.8 kDa (monomer)
基因符号 :
v-erb-b2成红细胞白血病病毒致瘤基因2
功能细节 :
Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. Brodowicz, T. et al . (1997) Int. J. Cancer 73 :875. The ED50 for this effect is 0.3-1.2 µg/mL in the presence of 0.6 µg/mL Anti-Human ErbB2/Her2 Monoclonal Antibody (Trastuzumab, Catalog # MAB9589 ).
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
NP_004439
应用 :
Bioactivity
source long :
Mouse myeloma cell line, NS0-derived human ErbB2/Her2 protein Human Erb B2 (Thr23-Thr652) Accession # NP_004439 IEGRMD Human IgG1 (Pro100-Lys330) 6 His-tag N-terminus C-terminus
source short :
NS0
美元 :
4250美元
别名 :
CD340, CD340 antigen, c-erb B2/neu protein, EC 2.7.10, EGFR2, HER2, HER-2, HER2EC 2.7.10.1, herstatin, Metastatic lymph node gene 19 protein, MLN 19, MLN19, Neu Oncogene, NEUHER-2/neu, neuroblastoma/glioblastoma derived oncogene homolog, NGL, NGLTKR1, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.