产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类PDGF-DD蛋白, CF
目录 :
1159-SB-025/CF
规格 :
25微克
价格 :
394美元
更多信息或购买 :
文章摘录数: 16
参考文献
Akiyama T, Yasuda T, Uchihara T, Yasuda Yoshihara N, Tan B, Yonemura A, et al. Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors. Cancer Res. 2023;83:753-770 pubmed 出版商
Pham T, Najy A, Kim H. E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR. J Biol Chem. 2022;298:101981 pubmed 出版商
Li Z, Yu S, Liu Y, Hu X, Li Y, Xiao Z, et al. SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway. J Neuroinflammation. 2022;19:95 pubmed 出版商
Kim J, Baek S, Jeon E, Choi J, Jang E, Kim C. PDGFR-β signaling mediates HMGB1 release in mechanically stressed vascular smooth muscle cells. PLoS ONE. 2022;17:e0265191 pubmed 出版商
Yamamoto Y, Mukai A, Ikushima T, Urata Y, Kinoshita S, Hamuro J, et al. Pluripotent epigenetic regulator OBP-801 maintains filtering blebs in glaucoma filtration surgery model. Sci Rep. 2020;10:20936 pubmed 出版商
Mamer S, Chen S, Weddell J, Palasz A, Wittenkeller A, Kumar M, et al. Discovery of High-Affinity PDGF-VEGFR Interactions: Redefining RTK Dynamics. Sci Rep. 2017;7:16439 pubmed 出版商
Miller C, Pjanic M, Wang T, Nguyen T, Cohain A, Lee J, et al. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci. Nat Commun. 2016;7:12092 pubmed 出版商
Heim E, Marston J, Federman R, Edwards A, Karabadzhak A, Petti L, et al. Biologically active LIL proteins built with minimal chemical diversity. Proc Natl Acad Sci U S A. 2015;112:E4717-25 pubmed 出版商
Obenauf A, Zou Y, Ji A, Vanharanta S, Shu W, Shi H, et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 2015;520:368-72 pubmed 出版商
Petti L, Talbert Slagle K, Hochstrasser M, DiMaio D. A single amino acid substitution converts a transmembrane protein activator of the platelet-derived growth factor ? receptor into an inhibitor. J Biol Chem. 2013;288:27273-86 pubmed 出版商
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed 出版商
Martino M, Hubbell J. The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain. FASEB J. 2010;24:4711-21 pubmed 出版商
Crawford Y, Kasman I, Yu L, ZHONG C, Wu X, Modrusan Z, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell. 2009;15:21-34 pubmed 出版商
Rice J, Veal J, Fadden R, Barabasz A, Partridge J, Barta T, et al. Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum. 2008;58:3765-75 pubmed 出版商
Wågsäter D, Zhu C, Björck H, Eriksson P. Effects of PDGF-C and PDGF-D on monocyte migration and MMP-2 and MMP-9 expression. Atherosclerosis. 2009;202:415-23 pubmed 出版商
McCabe K, Bronner Fraser M. Essential role for PDGF signaling in ophthalmic trigeminal placode induction. Development. 2008;135:1863-74 pubmed 出版商
产品信息
品牌 :
R&D Systems
master code :
1159-SB/CF
SKU号 :
1159-SB-025/CF
产品名称 :
重组人类PDGF-DD蛋白, CF
描述 :
The Recombinant Human PDGF-DD Protein, CF from R&D Systems is derived from NS0. The Recombinant Human PDGF-DD Protein, CF has been validated for the following applications: Bioactivity.
靶标 :
PDGF-DD
类别 :
蛋白和酶
单位尺寸 :
25微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
共轭标签 :
未共轭
纯度 :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
19 kDa, reducing conditions
理论上的分子量 :
14 kDa (monomer)
基因符号 :
PDGFD
功能细节 :
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 15-75 ng/mL in a fluorometric assay using the redox sensitive dye, Resazurin (Catalog # AR002 ) and 2-5 ng/mL when measured by 3H-thymidine incorporation.
内毒素说明 :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q9GZP0.1
应用 :
Bioactivity
来源 :
NS0-derived Recombinant Human PDGF-DD Protein, CF
美元 :
394美元
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.