重组人类DcR3/TNFRSF6B Fc嵌合体蛋白, CF | 安迪生物R&D 142-DC-100 产品信息

产品简要

公司名称 :

安迪生物R&D

产品类型 :

蛋白

产品名称 :

重组人类DcR3/TNFRSF6B Fc嵌合体蛋白, CF

142-直流

规格 :

100微克

价格 :

458美元

更多信息或购买 :

安迪生物R&D 产品网页

文章摘录数: 11

参考文献
Zwolak A, Chan S, Harvilla P, Mahady S, Armstrong A, Luistro L, et al. A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3. Sci Rep. 2022;12:20538 pubmed 出版商
Peng Y, Peng C, Lin Y, Lin G, Huang S, Chen S, et al. Decoy Receptor 3 Promotes Preosteoclast Cell Death via Reactive Oxygen Species-Induced Fas Ligand Expression and the IL-1α/IL-1 Receptor Antagonist Pathway. Mediators Inflamm. 2020;2020:1237281 pubmed 出版商
Idelson M, Alper R, Obolensky A, Yachimovich Cohen N, Rachmilewitz J, Ejzenberg A, et al. Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells. Stem Cell Reports. 2018;11:681-695 pubmed 出版商
Clarke A, Poulton L, Shim D, Mabon D, Butt D, Pollard M, et al. An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease. MAbs. 2018;10:664-677 pubmed 出版商
Connor J, Felder M, Kapur A, Onujiogu N. DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1. BMC Cancer. 2012;12:176 pubmed 出版商
Tso G, Law H, Tu W, Chan G, Lau Y. Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells. Stem Cells. 2010;28:939-54 pubmed 出版商
Morishige T, Yoshioka Y, Inakura H, Tanabe A, Yao X, Tsunoda S, et al. Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy. Biomaterials. 2010;31:3357-63 pubmed 出版商
Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, et al. Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients. Leukemia. 2009;23:2139-46 pubmed 出版商
Mueller A, Pedre X, Killian S, David M, Steinbrecher A. The Decoy Receptor 3 (DcR3, TNFRSF6B) suppresses Th17 immune responses and is abundant in human cerebrospinal fluid. J Neuroimmunol. 2009;209:57-64 pubmed 出版商
Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, et al. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 2007;178:192-200 pubmed
Edwards J, Sun S, Locklin R, Shipman C, Adamopoulos I, Athanasou N, et al. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum. 2006;54:1451-62 pubmed

产品信息

品牌 :

R&D Systems, a Bio-Techne Brand

catalog number base :

142-直流

SKU号 :

142-直流

产品名称 :

重组人类DcR3/TNFRSF6B Fc嵌合体蛋白, CF

描述 :

The Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.

靶标 :

DcR3/TNFRSF6B

类别 :

蛋白和酶

单位尺寸 :

100微克

缓冲液 :

Lyophilized from a 0.2 µm filtered solution in MES and NaCl.

共轭标签 :

未共轭

纯度 :

>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

物种 :

人类

观察到的分子量 :

60-65 kDa, reducing conditions

理论上的分子量 :

57 kDa (monomer)

基因符号 :

TNFRSF6B

功能细节 :

Measured by its ability to inhibit Fas Ligand-induced apoptosis of Jurkat human acute T cell leukemia cells. Cheng, J. et al . (1994) Science 263 :1759. The ED50 for this effect is 0.03-0.15 µg/mL in the presence of 20 ng/mL rhFas Ligand.

内毒素说明 :

<0.10 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

O95407

应用 :

Bioactivity

来源 :

Sf 21 (baculovirus)-derived Recombinant Human DcR3/TNFRSF6B Fc Chimera Protein

美元 :

458美元

别名 :

DCR3Decoy receptor for Fas ligand, Decoy receptor 3, M68, M68DJ583P15.1.1, TNFRSF6B, TR6, TR6DcR3, tumor necrosis factor receptor superfamily member 6B, tumor necrosis factor receptor superfamily, member 6b, decoy

储存 :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.

更多信息或购买 :

安迪生物R&D 产品网页

公司信息

安迪生物R&D

上海市长宁区延安西路726号华敏翰尊国际大厦24A1

info@rndsystemschina.com.cn

http://www.rndsystemschina.com.cn

21 52380373

公司总部: 美国

R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.