重组人类活性的SHP-2蛋白, CF | 安迪生物R&D 1894-SH-100 产品信息

产品简要

公司名称 :

安迪生物R&D

产品类型 :

蛋白

产品名称 :

重组人类活性的SHP-2蛋白, CF

1894-SH-100

规格 :

100 ug (also 1 mg)

价格 :

423美元

更多信息或购买 :

安迪生物R&D 产品网页

文章摘录数: 5

参考文献
Liu W, Zhao J, Guo X, Lu S, Li W, Li W. Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer. Eur J Med Chem. 2023;258:115585 pubmed 出版商
Solanki A, Arif E, Srivastava P, Furcht C, Rahman B, Wen P, et al. Phosphorylation of slit diaphragm proteins NEPHRIN and NEPH1 upon binding of HGF promotes podocyte repair. J Biol Chem. 2021;297:101079 pubmed 出版商
Fan Z, Tian Y, Chen Z, Liu L, Zhou Q, He J, et al. Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors. EMBO Mol Med. 2020;12:e11571 pubmed 出版商
Zehender A, Huang J, Györfi A, Matei A, Trinh Minh T, Xu X, et al. The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat Commun. 2018;9:3259 pubmed 出版商
Zang Q, Martinez B, Yao X, Maass D, Ma L, Wolf S, et al. Sepsis-induced cardiac mitochondrial dysfunction involves altered mitochondrial-localization of tyrosine kinase Src and tyrosine phosphatase SHP2. PLoS ONE. 2012;7:e43424 pubmed 出版商

产品信息

品牌 :

R&D Systems, a Bio-Techne Brand

catalog number base :

1894-SH

SKU号 :

1894-SH-100

产品名称 :

重组人类活性的SHP-2蛋白, CF

描述 :

The Recombinant Human Active SHP-2 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human Active SHP-2 Protein, CF has been validated for the following applications: Enzyme Activity.

靶标 :

SHP-2

类别 :

蛋白和酶

单位尺寸 :

100 ug (also 1 mg)

缓冲液 :

Supplied as a 0.2 µm filtered solution in Tris, NaCl, Glycerol and DTT.

共轭标签 :

未共轭

纯度 :

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.

物种 :

人类

观察到的分子量 :

63-70 kDa, reducing conditions

理论上的分子量 :

69 kDa

基因符号 :

PTPN11

功能细节 :

Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site (Catalog # ES006 ). The specific activity is 3 µmol/min/mg, measured under the described conditions.

内毒素说明 :

<1.0 EU per 1 µg of the protein by the LAL method.

accessionNumbers :

NP_002825.3

应用 :

酶活性

来源 :

E. coli-derived Recombinant Human Active SHP-2 Protein

美元 :

423美元

别名 :

BPTP3, EC 3.1.3.48, MGC14433, protein tyrosine phosphatase, non-receptor type 11, protein tyrosine phosphatase-2, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C, PTP1D, PTP-1D, PTP2C, PTP-2C, PTP2CNS1, PTPN11, SHP2, SHP-2, SHP2CFC, SHPTP2, SH-PTP2, SH-PTP2Noonan syndrome 1, SH-PTP3, tyrosine-protein phosphatase non-receptor type 11

储存 :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.

更多信息或购买 :

安迪生物R&D 产品网页

公司信息

安迪生物R&D

上海市长宁区延安西路726号华敏翰尊国际大厦24A1

info@rndsystemschina.com.cn

http://www.rndsystemschina.com.cn

21 52380373

公司总部: 美国

R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.