This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类PDGF-BB蛋白, CF
目录 :
220-BB-010
规格 :
10 ug (also 50 ug, 200 ug, 1 mg)
价格 :
259美元
文章摘录数: 131
参考文献
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Wang K, Yu J, Wang B, Wang H, Shi Z, Li G. miR-29a Regulates the Proliferation and Migration of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans of the Lower Extremities. Kidney Blood Press Res. 2019;44:1219-1232 pubmed 出版商
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Higashi Y, Mummidi S, Sukhanov S, Yoshida T, Noda M, Delafontaine P, et al. Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK suppression. Cell Signal. 2019;57:10-20 pubmed 出版商
Motegi S, Fujiwara C, Sekiguchi A, Yamazaki S, Yokoyama Y, Yasuda M, et al. Possible contribution of PDGF-BB-induced autophagy in dermatofibrosarcoma protuberans: Autophagy marker Atg5 could be a differential marker between dermatofibrosarcoma protuberans and dermatofibroma. J Dermatol Sci. 2019;93:139-141 pubmed 出版商
Li H, Zhao J, Liu B, Luo J, Li Z, Qin X, et al. MicroRNA-320 targeting neuropilin 1 inhibits proliferation and migration of vascular smooth muscle cells and neointimal formation. Int J Med Sci. 2019;16:106-114 pubmed 出版商
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Bergström B, Carlsten H, Ekwall A. Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Res Ther. 2018;20:49 pubmed 出版商
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Heo J, Yang H, Rhee W, Kang H. Vascular Smooth Muscle Cell-Derived Exosomal MicroRNAs Regulate Endothelial Cell Migration Under PDGF Stimulation. Cells. 2020;9: pubmed 出版商
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Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J. Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE. 2015;10:e0121939 pubmed 出版商
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Lo H, Lai T, Li C, Wu W. TNF-? induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin. 2014;35:339-50 pubmed 出版商
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Bastiaans J, van Meurs J, van Holten Neelen C, Nagtzaam N, van Hagen P, Chambers R, et al. Thrombin induces epithelial-mesenchymal transition and collagen production by retinal pigment epithelial cells via autocrine PDGF-receptor signaling. Invest Ophthalmol Vis Sci. 2013;54:8306-14 pubmed 出版商
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Gadepalli R, Kotla S, Heckle M, Verma S, Singh N, Rao G. Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. J Biol Chem. 2013;288:30815-31 pubmed 出版商
Karki R, Kim S, Kim D. Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation. Exp Cell Res. 2013;319:3238-50 pubmed 出版商
Hollborn M, Chen R, Wiedemann P, Reichenbach A, Bringmann A, Kohen L. Cytotoxic effects of curcumin in human retinal pigment epithelial cells. PLoS ONE. 2013;8:e59603 pubmed 出版商
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Cheng J, Cheng H, Tsai I, Jiang M. ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis. Lab Invest. 2013;93:422-33 pubmed 出版商
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Evans I, Yamaji M, Britton G, Pellet Many C, Lockie C, Zachary I, et al. Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells. Mol Cell Biol. 2011;31:1174-85 pubmed 出版商
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Shan L, Redhu N, Saleh A, Halayko A, Chakir J, Gounni A. Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. J Immunol. 2010;184:7134-43 pubmed 出版商
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Ball S, Bayley C, Shuttleworth C, Kielty C. Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem J. 2010;427:29-40 pubmed 出版商
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Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, et al. Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells. Kidney Int. 2009;75:1173-1183 pubmed 出版商
van Steensel L, Paridaens D, Schrijver B, Dingjan G, van Daele P, van Hagen P, et al. Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest Ophthalmol Vis Sci. 2009;50:3091-8 pubmed 出版商
Rice J, Veal J, Fadden R, Barabasz A, Partridge J, Barta T, et al. Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis. Arthritis Rheum. 2008;58:3765-75 pubmed 出版商
Jiang M, Bujo H, Ohwaki K, Unoki H, Yamazaki H, Kanaki T, et al. Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice. J Clin Invest. 2008;118:2733-46 pubmed 出版商
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He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, et al. Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008;49:4078-88 pubmed 出版商
Tomanek R, Hansen H, Christensen L. Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth. Arterioscler Thromb Vasc Biol. 2008;28:1237-43 pubmed 出版商
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Li R, Maminishkis A, Wang F, Miller S. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest Ophthalmol Vis Sci. 2007;48:5722-32 pubmed
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产品信息
品牌 :
R&D Systems
MasterCode :
220-BB
SKU号 :
220-BB-010
产品名称 :
重组人类PDGF-BB蛋白, CF
单位尺寸 :
10 ug (also 50 ug, 200 ug, 1 mg)
描述 :
The Recombinant Human PDGF-BB Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human PDGF-BB Protein, CF has been validated for the following applications: Bioactivity.
靶标 :
PDGF-BB
类别 :
蛋白和酶
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA.
共轭标签 :
未共轭
纯度 :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
物种 :
人类
观察到的分子量 :
12 kDa, reducing conditions
理论上的分子量 :
12.3 kDa (monomer)
基因符号 :
PDGFB
功能细节 :
Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells. Raines, E.W. et al . (1985) Methods Enzymol. 109 :749. The ED50 for this effect is 1.5-6 ng/mL. The specific activity of Recombinant Human PDGF-BB is approximately 1.9 x 106 IU/mg, which is calibrated against recombinant human PDGF-BB WHO International Standard (NIBSC code: 94/728). Specific activity is for reference purposes only and is not routinely tested.
内毒素说明 :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q6FHE7
应用 :
Bioactivity
source long :
E. coli -derived human PDGF-BB protein Ser82-Thr190
source short :
大肠杆菌
美元 :
259美元
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.