产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类NKp44 Fc嵌合体蛋白, CF
目录 :
2249-NK-050
规格 :
50微克
价格 :
423美元
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 15
参考文献
Murayama Y, Kasahara Y, Kubo N, Shin C, Imamura M, Oike N, et al. NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma. Transl Oncol. 2022;25:101521 pubmed 出版商
Lim S, Moon Y, Shin M, Kim T, Chae S, Yee C, et al. Hypoxia-Driven HIF-1α Activation Reprograms Pre-Activated NK Cells towards Highly Potent Effector Phenotypes via ERK/STAT3 Pathways. Cancers (Basel). 2021;13: pubmed 出版商
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed 出版商
Gross C, Schulte Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz Fejfár A, Schwab N, et al. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A. 2016;113:E2973-82 pubmed 出版商
Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Hübscher D, et al. Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1. PLoS ONE. 2015;10:e0125544 pubmed 出版商
Mou X, Zhou Y, Jiang P, Zhou T, Jiang Q, Xu C, et al. The regulatory effect of UL-16 binding protein-3 expression on the cytotoxicity of NK cells in cancer patients. Sci Rep. 2014;4:6138 pubmed 出版商
Robinet P, Baychelier F, Fontaine T, Picard C, Debre P, Vieillard V, et al. A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells. J Immunol. 2014;192:5332-42 pubmed 出版商
Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, et al. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog. 2013;9:e1003257 pubmed 出版商
Varchetta S, Brunetta E, Roberto A, Mikulak J, Hudspeth K, Mondelli M, et al. Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes. PLoS ONE. 2012;7:e45821 pubmed 出版商
Bellucci R, Nguyen H, Martin A, Heinrichs S, Schinzel A, Hahn W, et al. Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest. 2012;122:2369-83 pubmed 出版商
MADRID A, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012;86:8693-704 pubmed 出版商
Esin S, Batoni G, Counoupas C, Stringaro A, Brancatisano F, Colone M, et al. Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect Immun. 2008;76:1719-27 pubmed 出版商
Shi J, Tricot G, Garg T, Malaviarachchi P, Szmania S, Kellum R, et al. Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood. 2008;111:1309-17 pubmed
Banerjee P, Feuer G, Barker E. Human T-cell leukemia virus type 1 (HTLV-1) p12I down-modulates ICAM-1 and -2 and reduces adherence of natural killer cells, thereby protecting HTLV-1-infected primary CD4+ T cells from autologous natural killer cell-mediated cytotoxicity despite the. J Virol. 2007;81:9707-17 pubmed
Ward J, Bonaparte M, Sacks J, Guterman J, Fogli M, Mavilio D, et al. HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood. 2007;110:1207-14 pubmed
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
2249-NK
SKU号 :
2249-NK-050
产品名称 :
重组人类NKp44 Fc嵌合体蛋白, CF
描述 :
The Recombinant Human NKp44 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Human NKp44 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity.
靶标 :
NKp44/NCR2
类别 :
蛋白和酶
单位尺寸 :
50微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS.
共轭标签 :
未共轭
纯度 :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
物种 :
人类
观察到的分子量 :
61-67 kDa, reducing conditions
理论上的分子量 :
45 kDa (monomer)
基因符号 :
NCR2
功能细节 :
Measured by its ability to bind HeLa human cervical epithelial carcinoma cells in a flow cytometry assay. When 400 ng of rhNKp44 Fc chimera is added to 2 x 105 Hela cells, 25% cells bind to the protein.
内毒素说明 :
<0.01 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
CAB31968.1
应用 :
Bioactivity
来源 :
NS0-derived Recombinant Human NKp44 Fc Chimera Protein
美元 :
423美元
别名 :
CD336, CD336 antigen, LY95, LY95lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44), lymphocyte antigen 95 (activating NK-receptor; NK-p44), Lymphocyte antigen 95 homolog, natural cytotoxicity triggering receptor 2, Natural killer cell p44-related protein, NCR2, NK cell activating receptor (NKp44), NK cell-activating receptor, NKP44, NK-p44dJ149M18.1
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.