产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类LAP(TGF乙1)蛋白
目录 :
246-LP
规格 :
25微克
价格 :
379美元
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 21
参考文献
Zhou M, Niu J, Wang J, Gao H, Shahbaz M, Niu Z, et al. Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1. J Cancer. 2020;11:3803-3815 pubmed 出版商
Basta J, Robbins L, Stout L, Prinsen M, Griggs D, Rauchman M. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury. Physiol Rep. 2020;8:e14329 pubmed 出版商
Tsui P, Higazi D, Wu Y, Dunmore R, Solier E, Kasali T, et al. The TGF-? inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan. MAbs. 2017;9:104-113 pubmed 出版商
Jones K, Ballesteros A, Mentink Kane M, Warren J, Rattila S, Malech H, et al. PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-?1 Pathway. PLoS ONE. 2016;11:e0158050 pubmed 出版商
Fan M, Zhu Q, Li H, Ra H, Majumdar S, Gulick D, et al. Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice. J Biol Chem. 2016;291:8070-89 pubmed 出版商
Turner C, Badu Nkansah K, Crowley D, van der Flier A, Hynes R. α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development. 2015;142:797-808 pubmed 出版商
Fedele C, Singh A, Zerlanko B, Iozzo R, Languino L. The αvβ6 integrin is transferred intercellularly via exosomes. J Biol Chem. 2015;290:4545-51 pubmed 出版商
Ballesteros A, Mentink Kane M, Warren J, Kaplan G, Dveksler G. Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). J Biol Chem. 2015;290:4422-31 pubmed 出版商
Guha R, Das S, Ghosh J, Sundar S, Dujardin J, Roy S. Antimony resistant Leishmania donovani but not sensitive ones drives greater frequency of potent T-regulatory cells upon interaction with human PBMCs: role of IL-10 and TGF-β in early immune response. PLoS Negl Trop Dis. 2014;8:e2995 pubmed 出版商
Dutta A, Li J, Lu H, Akech J, Pratap J, Wang T, et al. Integrin ?v?6 promotes an osteolytic program in cancer cells by upregulating MMP2. Cancer Res. 2014;74:1598-608 pubmed 出版商
Mele V, Muraro M, Calabrese D, Pfaff D, Amatruda N, Amicarella F, et al. Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-?. Int J Cancer. 2014;134:2583-94 pubmed 出版商
Willet J, Pichitsiri W, Jenkinson S, Brain J, Wood K, Alhasan A, et al. Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β. J Leukoc Biol. 2013;93:471-8 pubmed 出版商
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, et al. Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell. 2011;147:1146-58 pubmed 出版商
Oida T, Weiner H. Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß. J Immunol. 2010;185:3529-35 pubmed 出版商
Tran D, Glass D, Uzel G, Darnell D, Spalding C, Holland S, et al. Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function. J Immunol. 2009;182:2929-38 pubmed 出版商
Savage N, De Boer T, Walburg K, Joosten S, van Meijgaarden K, Geluk A, et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol. 2008;181:2220-6 pubmed
Rojas A, Meherem S, Kim Y, Washington M, Willis J, Markowitz S, et al. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer. 2008;123:14-21 pubmed 出版商
Van Aarsen L, Leone D, Ho S, Dolinski B, McCoon P, Lepage D, et al. Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res. 2008;68:561-70 pubmed 出版商
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Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, et al. TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol. 2004;172:834-42 pubmed
Zhang Y, McCormick L, Gilliam A. Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol. 2003;121:713-9 pubmed
产品信息
品牌 :
R&D Systems
master code :
246-LP
SKU号 :
246-LP-025
产品名称 :
重组人类LAP(TGF乙1)蛋白
描述 :
The Recombinant Human LAP (TGF-beta 1) Protein from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human LAP (TGF-beta 1) Protein has been validated for the following applications: Bioactivity.
靶标 :
LAP(TGF乙1)
类别 :
蛋白和酶
单位尺寸 :
25微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
共轭标签 :
未共轭
纯度 :
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
28-36 kDa, reducing 60-70 kDa, non-reducing conditions (variably glycosylated)
理论上的分子量 :
27 kDa (monomer)
基因符号 :
转化生长因子1
功能细节 :
Measured by its ability to inhibit TGF-beta 1 activity on HT-2 mouse T cells. Tsang, M. et al . (1995) Cytokine 7 :389. The ED50 for this effect is 50-300 ng/mL in the presence of 1 ng/mL of Recombinant Human TGF-beta 1 (Catalog # 240-B ).
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
catalog number base :
246-LP
accessionNumbers :
P01137.2
应用 :
Bioactivity
来源 :
Spodoptera frugiperda , Sf 21 (baculovirus)-derived human LAP (TGF-beta 1) protein Leu30-Arg278 (Cys33Ser)
2020美元 :
379
2021美元 :
379美元
别名 :
CED, DPD1, LAP, LAP(β肿瘤生长因子1), TGFB, 转化生长因子1, β肿瘤生长因子, 转化生长因子β1
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.