产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
Recombinant Human TLR4/MD-2 Complex Protein, CF
目录 :
3146-TM-050/CF
规格 :
50微克
价格 :
377美元
更多信息或购买 :
文章摘录数: 20
参考文献
Xu H, Chen G, Wu Y, Xie L, Tan Z, Liu B, et al. Ginsenoside Ro, an oleanolic saponin of Panax ginseng, exerts anti-inflammatory effect by direct inhibiting toll like receptor 4 signaling pathway. J Ginseng Res. 2022;46:156-166 pubmed 出版商
Tsubokawa D, Kikuchi T, Lee J, Kusakabe T, Yamamoto Y, Maruyama H. Venestatin from parasitic helminths interferes with receptor for advanced glycation end products (RAGE)-mediated immune responses to promote larval migration. PLoS Pathog. 2021;17:e1009649 pubmed 出版商
Iannucci A, Caneparo V, Raviola S, Debernardi I, Colangelo D, Miggiano R, et al. Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding. PLoS Pathog. 2020;16:e1008811 pubmed 出版商
Jaeckle E, Brauchle E, Nottrodt N, Wehner M, Lensing R, Gillner A, et al. Towards automation in biologics production via Raman micro-spectroscopy, laser-induced forward cell transfer and surface-enhanced Raman spectroscopy. J Biotechnol. 2020;323:313-321 pubmed 出版商
Bahraoui E, Serrero M, Planès R. HIV-1 Tat - TLR4/MD2 interaction drives the expression of IDO-1 in monocytes derived dendritic cells through NF-κB dependent pathway. Sci Rep. 2020;10:8177 pubmed 出版商
Kasus Jacobi A, Land C, Stock A, Washburn J, Pereira H. Antimicrobial Peptides Derived from the Immune Defense Protein CAP37 Inhibit TLR4 Activation by S100A9. Invest Ophthalmol Vis Sci. 2020;61:16 pubmed 出版商
Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch S, et al. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest. 2018;128:1852-1866 pubmed 出版商
Sun S, He M, Wang Y, Yang H, Al Abed Y. Folic acid derived-P5779 mimetics regulate DAMP-mediated inflammation through disruption of HMGB1:TLR4:MD-2 axes. PLoS ONE. 2018;13:e0193028 pubmed 出版商
Honegr J, Dolezal R, Malinak D, Benkova M, Soukup O, Almeida J, et al. Rational Design of a New Class of Toll-Like Receptor 4 (TLR4) Tryptamine Related Agonists by Means of the Structure- and Ligand-Based Virtual Screening for Vaccine Adjuvant Discovery. Molecules. 2018;23: pubmed 出版商
Durai P, Shin H, Achek A, Kwon H, Govindaraj R, Panneerselvam S, et al. Toll-like receptor 2 antagonists identified through virtual screening and experimental validation. FEBS J. 2017;284:2264-2283 pubmed 出版商
Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby Teglund A, Smeds E, et al. Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo. PLoS Pathog. 2015;11:e1005319 pubmed 出版商
Loyau J, Malinge P, Daubeuf B, Shang L, Elson G, Kosco Vilbois M, et al. Maximizing the potency of an anti-TLR4 monoclonal antibody by exploiting proximity to Fcγ receptors. MAbs. 2014;6:1621-30 pubmed 出版商
Jung I, Shin S, Lee M, Kang T, Han H, Lee S, et al. Enhancement of tumor-specific T cell-mediated immunity in dendritic cell-based vaccines by Mycobacterium tuberculosis heat shock protein X. J Immunol. 2014;193:1233-45 pubmed 出版商
Shang L, Daubeuf B, Triantafilou M, Olden R, Dépis F, Raby A, et al. Selective antibody intervention of Toll-like receptor 4 activation through Fc ? receptor tethering. J Biol Chem. 2014;289:15309-18 pubmed 出版商
Chen Y, Shiau A, Wang S, Yang J, Chang S, Wu C, et al. Zhankuic acid A isolated from Taiwanofungus camphoratus is a novel selective TLR4/MD-2 antagonist with anti-inflammatory properties. J Immunol. 2014;192:2778-86 pubmed 出版商
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med. 2012;18:1279-85 pubmed 出版商
Feng C, Stamatos N, Dragan A, Medvedev A, Whitford M, Zhang L, et al. Sialyl residues modulate LPS-mediated signaling through the Toll-like receptor 4 complex. PLoS ONE. 2012;7:e32359 pubmed 出版商
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, et al. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. PLoS ONE. 2011;6:e23132 pubmed 出版商
Chambers M, Whelan A, Spallek R, Singh M, Coddeville B, Guerardel Y, et al. Non-acylated Mycobacterium bovis glycoprotein MPB83 binds to TLR1/2 and stimulates production of matrix metalloproteinase 9. Biochem Biophys Res Commun. 2010;400:403-8 pubmed 出版商
Zunt S, Burton L, Goldblatt L, Dobbins E, Srinivasan M. Soluble forms of Toll-like receptor 4 are present in human saliva and modulate tumour necrosis factor-alpha secretion by macrophage-like cells. Clin Exp Immunol. 2009;156:285-93 pubmed 出版商
产品信息
品牌 :
R&D Systems
master code :
3146-TM/CF
SKU号 :
3146-TM-050/CF
产品名称 :
Recombinant Human TLR4/MD-2 Complex Protein, CF
描述 :
The Recombinant Human TLR4/MD-2 Complex Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TLR4/MD-2 Complex Protein, CF has been validated for the following applications: Bioactivity.
靶标 :
TLR4/MD2 Complex
类别 :
蛋白和酶
sizes available :
50微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS.
共轭标签 :
未共轭
纯度 :
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
物种 :
人类
观察到的分子量 :
95 kDa and 34 kDa, reducing conditions
理论上的分子量 :
70.6 kDa (TLR4), 19.2 kDa (MD-2)
基因符号 :
Toll样受体4
功能细节 :
Measured by its ability to inhibit LPS-induced TNF-alpha secretion by PMA-differentiated U937 human histiocytic lymphoma cells. 20 µg/mL of recombinant human TLR4/MD-2 will inhibit 60% of the TNF-alpha secretion induced by LPS.
内毒素说明 :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
O00206.2(Toll样受体4)Q9Y6Y9.1(MD-2)
应用 :
Bioactivity
来源 :
NS0-derived Recombinant Human TLR4/MD-2 Complex Protein, CF
美元 :
377
美元2023 :
377美元
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.