产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类/猕猴/猫CXCL12/SDF-1甲
目录 :
350-NS
规格 :
10 ug (also 50 ug)
价格 :
239美元
更多信息或购买 :
文章摘录数: 144
参考文献
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Park S, Jang H, Kim B, Hwang C, Jeong G, Park Y. Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device. PLoS ONE. 2017;12:e0184595 pubmed 出版商
Liu X, Liu Y, Huang X, Lin G, Xie C. Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease. Mol Med Rep. 2017;16:5294-5302 pubmed 出版商
Kobayashi D, Endo M, Ochi H, Hojo H, Miyasaka M, Hayasaka H. Regulation of CCR7-dependent cell migration through CCR7 homodimer formation. Sci Rep. 2017;7:8536 pubmed 出版商
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Logun M, Bisel N, Tanasse E, Zhao W, Gunasekera B, Mao L, et al. Glioma Cell Invasion is Significantly Enhanced in Composite Hydrogel Matrices Composed of Chondroitin 4- and 4,6-Sulfated Glycosaminoglycans. J Mater Chem B. 2016;4:6052-6064 pubmed 出版商
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Shi X, Guo L, Seedial S, Takayama T, Wang B, Zhang M, et al. Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia. Stem Cells. 2016;34:2744-2757 pubmed 出版商
Freund P, Porpaczy E, Le T, Gruber M, Pausz C, Staber P, et al. Cannabinoid Receptors Are Overexpressed in CLL but of Limited Potential for Therapeutic Exploitation. PLoS ONE. 2016;11:e0156693 pubmed 出版商
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Lopez Haber C, Barrio Real L, Casado Medrano V, Kazanietz M. Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol. 2016;36:2011-26 pubmed 出版商
Velasquez S, Malik S, Lutz S, Scemes E, Eugenin E. Pannexin1 Channels Are Required for Chemokine-Mediated Migration of CD4+ T Lymphocytes: Role in Inflammation and Experimental Autoimmune Encephalomyelitis. J Immunol. 2016;196:4338-47 pubmed 出版商
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Heinzmann D, Bangert A, Müller A, von Ungern Sternberg S, Emschermann F, Schönberger T, et al. The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis. PLoS ONE. 2015;10:e0124606 pubmed 出版商
Chang T, Poltoratsky V, Vancurova I. Bortezomib inhibits expression of TGF-β1, IL-10, and CXCR4, resulting in decreased survival and migration of cutaneous T cell lymphoma cells. J Immunol. 2015;194:2942-53 pubmed 出版商
Butschkau A, Wagner N, Genz B, Vollmar B. Protein z exerts pro-angiogenic effects and upregulates CXCR4. PLoS ONE. 2014;9:e113554 pubmed 出版商
Williams D, Anastos K, Morgello S, Berman J. JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+CD16+ monocytes in HIV-infected individuals. J Leukoc Biol. 2015;97:401-12 pubmed 出版商
Nelson M, Short A, Cole S, Gross A, Winter J, Eubank T, et al. Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber 'cell highways'. BMC Cancer. 2014;14:825 pubmed 出版商
Chigaev A, Smagley Y, Sklar L. Carbon monoxide down-regulates α4β1 integrin-specific ligand binding and cell adhesion: a possible mechanism for cell mobilization. BMC Immunol. 2014;15:52 pubmed 出版商
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Walsh T, Harper M, Poole A. SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal. 2015;27:37-46 pubmed 出版商
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Ugarte Berzal E, Bailon E, Amigo Jiménez I, Albar J, Garcia Marco J, Garcia Pardo A. A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem. 2014;289:15340-9 pubmed 出版商
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Krook M, Nicholls L, Scannell C, Chugh R, Thomas D, Lawlor E. Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma. Mol Cancer Res. 2014;12:953-64 pubmed 出版商
Zucco L, Zhang Q, Kuliszewski M, Kandic I, Faughnan M, Stewart D, et al. Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia. PLoS ONE. 2014;9:e89927 pubmed 出版商
Lessey Morillon E, Osborne L, Monaghan Benson E, Guilluy C, O Brien E, Superfine R, et al. The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration. J Immunol. 2014;192:3390-8 pubmed 出版商
Lo H, Lai T, Li C, Wu W. TNF-? induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin. 2014;35:339-50 pubmed 出版商
Gharaee Kermani M, Mehra R, Robinson D, Wei J, Macoska J. Complex cellular composition of solitary fibrous tumor of the prostate. Am J Pathol. 2014;184:732-9 pubmed 出版商
Ruiz E, Oeztuerk Winder F, Ventura J. A paracrine network regulates the cross-talk between human lung stem cells and the stroma. Nat Commun. 2014;5:3175 pubmed 出版商
Vermi W, Micheletti A, Lonardi S, Costantini C, Calzetti F, Nascimbeni R, et al. slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells. Nat Commun. 2014;5:3029 pubmed 出版商
Smith A, Bowers S, Stratman A, Davis G. Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE. 2013;8:e85147 pubmed 出版商
Hoque M, Windus L, Lovitt C, Avery V. PCaAnalyser: a 2D-image analysis based module for effective determination of prostate cancer progression in 3D culture. PLoS ONE. 2013;8:e79865 pubmed 出版商
Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M, et al. The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization. Blood. 2014;123:1032-9 pubmed 出版商
Wen W, Xie S, Xin X, Geng M, Ding J, Chen Y. Oligomannurarate sulfate inhibits CXCL12/SDF-1-mediated proliferation and invasion of human tumor cells in vitro. Acta Pharmacol Sin. 2013;34:1554-9 pubmed 出版商
Westerweel P, Teraa M, Rafii S, Jaspers J, White I, Hooper A, et al. Impaired endothelial progenitor cell mobilization and dysfunctional bone marrow stroma in diabetes mellitus. PLoS ONE. 2013;8:e60357 pubmed 出版商
Cheng C, Chang S, Chueh Y, Huang T, Huang P, Cheng S, et al. Distinct angiogenesis roles and surface markers of early and late endothelial progenitor cells revealed by functional group analyses. BMC Genomics. 2013;14:182 pubmed 出版商
Akimoto K, Kimura K, Nagano M, Takano S, To a Salazar G, Yamashita T, et al. Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation. Stem Cells Dev. 2013;22:1370-86 pubmed 出版商
Rossi E, Sanz Rodriguez F, Eleno N, Düwell A, Blanco F, Langa C, et al. Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration. Blood. 2013;121:403-15 pubmed 出版商
Jawad M, Yu N, Seedhouse C, Tandon K, Russell N, Pallis M. Targeting of CD34+CD38- cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in Acute Myeloid Leukaemia. BMC Cancer. 2012;12:431 pubmed 出版商
Wilson T, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, et al. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 2012;487:505-9 pubmed 出版商
Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, et al. Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood. 2012;120:1877-87 pubmed 出版商
Badr G, Lefevre E, Mohany M. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE. 2011;6:e23741 pubmed 出版商
Fujio M, Yamamoto A, Ando Y, Shohara R, Kinoshita K, Kaneko T, et al. Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors. Bone. 2011;49:693-700 pubmed 出版商
Fujita Sato S, Ito S, Isobe T, Ohyama T, Wakabayashi K, Morishita K, et al. Structural basis of digoxin that antagonizes RORgamma t receptor activity and suppresses Th17 cell differentiation and interleukin (IL)-17 production. J Biol Chem. 2011;286:31409-17 pubmed 出版商
Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev I, et al. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res. 2011;17:3619-30 pubmed 出版商
Benamar K, Palma J, Cowan A, Geller E, Adler M. Analgesic efficacy of buprenorphine in the presence of high levels of SDF-1?/CXCL12 in the brain. Drug Alcohol Depend. 2011;114:246-8 pubmed 出版商
Burton V, Butler L, McGettrick H, Stone P, Jeffery H, Savage C, et al. Delay of migrating leukocytes by the basement membrane deposited by endothelial cells in long-term culture. Exp Cell Res. 2011;317:276-92 pubmed 出版商
Berahovich R, Zabel B, Penfold M, Lewén S, Wang Y, Miao Z, et al. CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 2010;185:5130-9 pubmed 出版商
Hachehouche L, Chetoui N, Aoudjit F. Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen. Mol Immunol. 2010;47:1866-9 pubmed 出版商
Charles J, Di Domizio J, Salameire D, Bendriss Vermare N, Aspord C, Muhammad R, et al. Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. J Invest Dermatol. 2010;130:1646-56 pubmed 出版商
Sengupta N, Afzal A, Caballero S, Chang K, Shaw L, Pang J, et al. Paracrine modulation of CXCR4 by IGF-1 and VEGF: implications for choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:2697-704 pubmed 出版商
Stratman A, Malotte K, Mahan R, Davis M, Davis G. Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood. 2009;114:5091-101 pubmed 出版商
Kenig S, Alonso M, Mueller M, Lah T. Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. Cancer Lett. 2010;289:53-61 pubmed 出版商
Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur J, Hollenberg M, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J. 2009;23:2928-41 pubmed 出版商
Boniface K, Bak Jensen K, Li Y, Blumenschein W, McGeachy M, McClanahan T, et al. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009;206:535-48 pubmed 出版商
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产品信息
品牌 :
R&D Systems
master code :
350-NS
SKU号 :
350-NS-010
产品名称 :
重组人类/猕猴/猫CXCL12/SDF-1甲
描述 :
The Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha from R&D Systems is derived from E. coli. The Recombinant Human/Rhesus Macaque/Feline CXCL12/SDF-1 alpha has been validated for the following applications: Bioactivity.
靶标 :
CXCL12/SDF-1甲
类别 :
蛋白和酶
单位尺寸 :
10 ug (also 50 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
共轭标签 :
未共轭
纯度 :
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
物种 :
人类, 猫, 猕猴
观察到的分子量 :
7 kDa, reducing conditions.
理论上的分子量 :
8.0 kDa
基因符号 :
CXCL12
功能细节 :
Measured by its ability to chemoattract 5-10 day cultured human peripheral blood lymphocytes (PBL). The ED50 for this effect is 3-9 ng/mL. Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR4. The ED50 for this effect is 0.15-0.6 ng/mL.
内毒素说明 :
<0.01 EU per 1 µg of the protein by the LAL method.
catalog number base :
350-NS
accessionNumbers :
P48061
应用 :
Bioactivity
来源 :
E. coli -derived CXCL12/SDF-1 alpha protein Lys22-Lys89
2020美元 :
239
2021美元 :
239美元
别名 :
CXCL12 chemokine (C-X-C motif) ligand 12, IRH, PBSF, SCYB12, SDF1, SDF-1, SDF1 alpha, SDF1a, SDF1B, TLSF, TPAR1
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.