产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类VEGFR2/激酶插入区受体Fc嵌合体蛋白
目录 :
357-KD-050
规格 :
50微克
价格 :
405美元
更多信息或购买 :
文章摘录数: 38
参考文献 |
---|
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris M, et al. Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration. MAbs. 2017;9:269-284 pubmed 出版商
|
Inoo K, Inagaki R, Fujiwara K, Sasawatari S, Kamigaki T, Nakagawa S, et al. Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research. Mol Ther Oncolytics. 2016;3:16024 pubmed
|
Pan Q, Chathery Y, Wu Y, Rathore N, Tong R, Peale F, et al. Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting. J Biol Chem. 2007;282:24049-56 pubmed
|
Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, et al. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med. 2007;204:1431-40 pubmed
|
Backer M, Levashova Z, Patel V, Jehning B, Claffey K, Blankenberg F, et al. Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes. Nat Med. 2007;13:504-9 pubmed
|
Lake A, Vassy R, Di Benedetto M, Lavigne D, Le Visage C, Perret G, et al. Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1. J Biol Chem. 2006;281:37844-52 pubmed
|
Ren W, Markel D, Zhang R, Peng X, Wu B, Monica H, et al. Association between UHMWPE particle-induced inflammatory osteoclastogenesis and expression of RANKL, VEGF, and Flt-1 in vivo. Biomaterials. 2006;27:5161-9 pubmed
|
Getmanova E, Chen Y, Bloom L, Gokemeijer J, Shamah S, Warikoo V, et al. Antagonists to human and mouse vascular endothelial growth factor receptor 2 generated by directed protein evolution in vitro. Chem Biol. 2006;13:549-56 pubmed
|
Oliner J, Min H, Leal J, Yu D, Rao S, You E, et al. Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. Cancer Cell. 2004;6:507-16 pubmed
|
Seo K, Lee H, Jung B, Ko H, Choi J, Park S, et al. Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. Cancer Res. 2004;64:6482-8 pubmed
|
产品信息
品牌 :
R&D Systems
master code :
357-KD
SKU号 :
357-KD-050
产品名称 :
重组人类VEGFR2/激酶插入区受体Fc嵌合体蛋白
描述 :
The Recombinant Human VEGFR2/KDR Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Human VEGFR2/KDR Fc Chimera Protein has been validated for the following applications: Bioactivity.
靶标 :
VEGFR2/KDR/Flk-1
类别 :
蛋白和酶
单位尺寸 :
50微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
共轭标签 :
未共轭
纯度 :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
160-170 kDa, reducing conditions
理论上的分子量 :
110 kDa (monomer)
基因符号 :
激酶插入区受体
功能细节 :
Measured by its ability to inhibit the VEGF-dependent proliferation of HUVEC human umbilical vein endothelial cells. The ED50 for this effect is 10-40 ng/mL in the presence of 10 ng/mL recombinant human VEGF165.
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAC16450
应用 :
Bioactivity
来源 :
NS0-derived Recombinant Human VEGFR2/KDR Fc Chimera Protein
美元 :
405美元
别名 :
CD309, CD309 antigen, EC 2.7.10, EC 2.7.10.1, Fetal liver kinase 1, fetal liver kinase-1, Flk1, Flk-1, FLK1tyrosine kinase growth factor receptor, KDR, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), KRD1, Ly73, Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, vascular endothelial growth factor receptor 2, VEGF R2, VEGFR, VEGFR2, VEGFR-2
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.