产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组小鼠蝶素b2 Fc嵌合体蛋白, CF
目录 :
496-EB-200
规格 :
200微克
价格 :
341美元
更多信息或购买 :
文章摘录数: 46
参考文献
Chang C, Banerjee S, Park S, Zhang X, Cotnoir White D, Opperman K, et al. Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function. bioRxiv. 2023;: pubmed 出版商
Yang M, Zhu W, Truong T, Pickering B, Babiuk S, Kobasa D, et al. Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays. Viruses. 2022;14: pubmed 出版商
Bhatia S, Nguyen D, Darragh L, Van Court B, Sharma J, Knitz M, et al. EphB4 and ephrinB2 act in opposition in the head and neck tumor microenvironment. Nat Commun. 2022;13:3535 pubmed 出版商
Ortega V, Zamora J, Monreal I, Hoffman D, Ezzatpour S, Johnston G, et al. Novel Roles of the Nipah Virus Attachment Glycoprotein and Its Mobility in Early and Late Membrane Fusion Steps. MBio. 2022;13:e0322221 pubmed 出版商
Chen D, Hughes E, Saunders T, Wu J, Vasquez M, Makinen T, et al. Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells. JCI Insight. 2022;7: pubmed 出版商
Donato C, Kunz L, Castro Giner F, Paasinen Sohns A, Strittmatter K, Szczerba B, et al. Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells. Cell Rep. 2020;32:108105 pubmed 出版商
Ge Y, Feng K, Liu X, Chen H, Sun Z, Wang C, et al. The Recombinant Protein EphB4-Fc Changes the Ti Particle-Mediated Imbalance of OPG/RANKL via EphrinB2/EphB4 Signaling Pathway and Inhibits the Release of Proinflammatory Factors In Vivo. Oxid Med Cell Longev. 2020;2020:1404915 pubmed 出版商
Laing E, Navaratnarajah C, Cheliout Da Silva S, Petzing S, Xu Y, Sterling S, et al. Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus. Proc Natl Acad Sci U S A. 2019;116:20707-20715 pubmed 出版商
Voigt K, Hoffmann M, Drexler J, Müller M, Drosten C, Herrler G, et al. Fusogenicity of the Ghana Virus (Henipavirus: Ghanaian bat henipavirus) Fusion Protein is Controlled by the Cytoplasmic Domain of the Attachment Glycoprotein. Viruses. 2019;11: pubmed 出版商
Herrero D, Cañon S, Albericio G, Carmona R, Aguilar S, Manes S, et al. Age-related oxidative stress confines damage-responsive Bmi1+ cells to perivascular regions in the murine adult heart. Redox Biol. 2019;22:101156 pubmed 出版商
Baek J, Cheon Y, Kwak S, Jun H, Yoon K, Lee M, et al. Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Exp Mol Med. 2018;50:50 pubmed 出版商
Groppa E, Brkic S, Uccelli A, Wirth G, Korpisalo Pirinen P, Filippova M, et al. EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF. EMBO Rep. 2018;19: pubmed 出版商
Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock H, Maritzen T, et al. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2017;114:5533-5538 pubmed 出版商
Cisse M, Duplan E, Lorivel T, Dunys J, Bauer C, Meckler X, et al. The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model. Mol Psychiatry. 2017;22:1562-1575 pubmed 出版商
Wang M, Collins M, Foster T, Bai H, Hashimoto T, Santana J, et al. Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase. J Vasc Surg. 2017;65:179-189 pubmed 出版商
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed 出版商
Mimche P, Brady L, Keeton S, Fenne D, King T, Quicke K, et al. Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation. PLoS ONE. 2015;10:e0138835 pubmed 出版商
Zhang G, Brady J, Liang W, Wu Y, Henkemeyer M, Yan M. EphB4 forward signalling regulates lymphatic valve development. Nat Commun. 2015;6:6625 pubmed 出版商
Dong L, Gao F, Wang X, Miao Y, Wang S, Wu Y, et al. GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. J Neurosci. 2015;35:5409-21 pubmed 出版商
Lisle J, Mertens Walker I, Stephens C, Stansfield S, Clements J, Herington A, et al. Murine, but not human, ephrin-B2 can be efficiently cleaved by the serine protease kallikrein-4: implications for xenograft models of human prostate cancer. Exp Cell Res. 2015;333:136-46 pubmed 出版商
Liu Q, Bradel Tretheway B, Monreal A, Saludes J, Lu X, Nicola A, et al. Nipah virus attachment glycoprotein stalk C-terminal region links receptor binding to fusion triggering. J Virol. 2015;89:1838-50 pubmed 出版商
Schaupp A, Sabet O, Dudanova I, Ponserre M, Bastiaens P, Klein R. The composition of EphB2 clusters determines the strength in the cellular repulsion response. J Cell Biol. 2014;204:409-22 pubmed 出版商
Conway A, Schaffer D. Biomaterial microenvironments to support the generation of new neurons in the adult brain. Stem Cells. 2014;32:1220-9 pubmed 出版商
van Gils J, Ramkhelawon B, Fernandes L, Stewart M, Guo L, Seibert T, et al. Endothelial expression of guidance cues in vessel wall homeostasis dysregulation under proatherosclerotic conditions. Arterioscler Thromb Vasc Biol. 2013;33:911-9 pubmed 出版商
Soskis M, Ho H, Bloodgood B, Robichaux M, Malik A, Ataman B, et al. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012;15:1645-54 pubmed 出版商
Kawano H, Katayama Y, Minagawa K, Shimoyama M, Henkemeyer M, Matsui T. A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition. Eur J Immunol. 2012;42:1562-72 pubmed 出版商
Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, et al. EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes. J Immunol. 2011;187:5983-94 pubmed 出版商
Naska S, Lin D, Miller F, Kaplan D. p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse. Mol Cell Neurosci. 2010;45:108-20 pubmed 出版商
Genander M, Holmberg J, Frisen J. Ephrins negatively regulate cell proliferation in the epidermis and hair follicle. Stem Cells. 2010;28:1196-205 pubmed 出版商
Sawamiphak S, Seidel S, Essmann C, Wilkinson G, Pitulescu M, Acker T, et al. Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis. Nature. 2010;465:487-91 pubmed 出版商
Afshari F, Kwok J, Fawcett J. Astrocyte-produced ephrins inhibit schwann cell migration via VAV2 signaling. J Neurosci. 2010;30:4246-55 pubmed 出版商
He S, Kumar S, Zhou P, Krasnoperov V, Ryan S, Gill P, et al. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010;51:543-52 pubmed 出版商
Pennisi A, Ling W, Li X, Khan S, Shaughnessy J, Barlogie B, et al. The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth. Blood. 2009;114:1803-12 pubmed 出版商
Slack S, Battaglia A, Cibert Goton V, Gavazzi I. EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia. Neuroscience. 2008;156:175-83 pubmed 出版商
Månsson Broberg A, Siddiqui A, Genander M, Grinnemo K, Hao X, Andersson A, et al. Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation. Biochem Biophys Res Commun. 2008;373:355-9 pubmed 出版商
Masuda J, Usui R, Maru Y. Fibronectin type I repeat is a nonactivating ligand for EphA1 and inhibits ATF3-dependent angiogenesis. J Biol Chem. 2008;283:13148-55 pubmed 出版商
Nestor M, Mok L, Tulapurkar M, Thompson S. Plasticity of neuron-glial interactions mediated by astrocytic EphARs. J Neurosci. 2007;27:12817-28 pubmed
Negrete O, Chu D, Aguilar H, Lee B. Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage. J Virol. 2007;81:10804-14 pubmed
Chaudhari A, Mahfouz M, Fialho A, Yamada T, Granja A, Zhu Y, et al. Cupredoxin-cancer interrelationship: azurin binding with EphB2, interference in EphB2 tyrosine phosphorylation, and inhibition of cancer growth. Biochemistry. 2007;46:1799-810 pubmed
Yang N, Pasquale E, Owen L, Ethell I. The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem. 2006;281:32574-86 pubmed
Holmberg J, Genander M, Halford M, Annerén C, Sondell M, Chumley M, et al. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell. 2006;125:1151-63 pubmed
Masood R, Kumar S, Sinha U, Crowe D, Krasnoperov V, Reddy R, et al. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. Int J Cancer. 2006;119:1236-48 pubmed
Ricard J, Salinas J, Garcia L, Liebl D. EphrinB3 regulates cell proliferation and survival in adult neurogenesis. Mol Cell Neurosci. 2006;31:713-22 pubmed
Le Noble F, Moyon D, Pardanaud L, Yuan L, Djonov V, Matthijsen R, et al. Flow regulates arterial-venous differentiation in the chick embryo yolk sac. Development. 2004;131:361-75 pubmed
Füller T, Korff T, Kilian A, Dandekar G, Augustin H. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci. 2003;116:2461-70 pubmed
Sharfe N, Freywald A, Toro A, Dadi H, Roifman C. Ephrin stimulation modulates T cell chemotaxis. Eur J Immunol. 2002;32:3745-55 pubmed
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
496-EB
SKU号 :
496-EB-200
产品名称 :
重组小鼠蝶素b2 Fc嵌合体蛋白, CF
描述 :
The Recombinant Mouse Ephrin-B2 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Mouse Ephrin-B2 Fc Chimera Protein, CF has been validated for the following applications: Binding Activity.
靶标 :
蝶素b2
类别 :
蛋白和酶
单位尺寸 :
200微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS.
共轭标签 :
未共轭
纯度 :
>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
小鼠
观察到的分子量 :
60-65 kDa, reducing conditions
理论上的分子量 :
49.6 kDa (monomer)
基因符号 :
Efnb2
功能细节 :
Measured by its ability to compete with Biotinylated Recombinant Mouse Ephrin-B2 Fc Chimera (Catalog # BT496 ) for binding with immobilized Recombinant Mouse EphB2 Fc Chimera (Catalog # 467-B2 ) in a functional ELISA assay. Optimal dilutions should be determined by each laboratory for each application.
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
AAA82934
应用 :
结合活性
来源 :
NS0-derived Recombinant Mouse Ephrin-B2 Fc Chimera Protein
美元 :
341美元
别名 :
EFNB2, ELF-2, ephrin B2, EphrinB2, EPLG5, Htk-L, HTKL, LERK5, LERK-5, NLERK-1
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.