产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组大鼠GFR甲1 Fc嵌合体蛋白, CF
目录 :
560-GR-100/CF
规格 :
100微克
价格 :
423美元
更多信息或购买 :
文章摘录数: 14
参考文献
Boyer A, Zhang X, Levasseur A, Abou Nader N, St Jean G, Nagano M, et al. Constitutive activation of CTNNB1 results in a loss of spermatogonial stem cell activity in mice. PLoS ONE. 2021;16:e0251911 pubmed 出版商
Porokuokka L, Virtanen H, Lindén J, Sidorova Y, Danilova T, Lindahl M, et al. Gfra1 Underexpression Causes Hirschsprung's Disease and Associated Enterocolitis in Mice. Cell Mol Gastroenterol Hepatol. 2019;7:655-678 pubmed 出版商
Shindo T, Doi S, Nakashima A, Sasaki K, Arihiro K, Masaki T. TGF-?1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA. Sci Rep. 2018;8:14060 pubmed 出版商
Gassei K, Sheng Y, Fayomi A, Mital P, Sukhwani M, Lin C, et al. DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis. Biol Reprod. 2017;96:707-719 pubmed 出版商
Yuan J, Liu W, Zhu H, Chen Y, Zhang X, Li L, et al. Curcumin inhibits glial scar formation by suppressing astrocyte-induced inflammation and fibrosis in vitro and in vivo. Brain Res. 2017;1655:90-103 pubmed 出版商
Ibiza S, García Cassani B, Ribeiro H, Carvalho T, Almeida L, Marques R, et al. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence. Nature. 2016;535:440-443 pubmed 出版商
Fonseca Pereira D, Arroz Madeira S, Rodrigues Campos M, Barbosa I, Domingues R, Bento T, et al. The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function. Nature. 2014;514:98-101 pubmed 出版商
Sakuraba J, Shintani T, Tani S, Noda M. Substrate specificity of R3 receptor-like protein-tyrosine phosphatase subfamily toward receptor protein-tyrosine kinases. J Biol Chem. 2013;288:23421-31 pubmed 出版商
Euteneuer S, Yang K, Chavez E, Leichtle A, Loers G, Olshansky A, et al. Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM). Mol Cell Neurosci. 2013;54:30-43 pubmed 出版商
Kubota H, Wu X, Goodyear S, Avarbock M, Brinster R. Glial cell line-derived neurotrophic factor and endothelial cells promote self-renewal of rabbit germ cells with spermatogonial stem cell properties. FASEB J. 2011;25:2604-14 pubmed 出版商
Carmillo P, Dagø L, Day E, Worley D, Rossomando A, Walus L, et al. Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry. 2005;44:2545-54 pubmed
Schuetz G, Rosario M, Grimm J, Boeckers T, Gundelfinger E, Birchmeier W. The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol. 2004;167:945-52 pubmed
Cerchia L, Libri D, Carlomagno M, de Franciscis V. The soluble ectodomain of RetC634Y inhibits both the wild-type and the constitutively active Ret. Biochem J. 2003;372:897-903 pubmed
Peterziel H, Unsicker K, Krieglstein K. TGFbeta induces GDNF responsiveness in neurons by recruitment of GFRalpha1 to the plasma membrane. J Cell Biol. 2002;159:157-67 pubmed
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
560-GR/CF
SKU号 :
560-GR-100/CF
产品名称 :
重组大鼠GFR甲1 Fc嵌合体蛋白, CF
描述 :
The Recombinant Rat GFR alpha-1 Fc Chimera Protein, CF from R&D Systems is derived from NS0. The Recombinant Rat GFR alpha-1 Fc Chimera Protein, CF has been validated for the following applications: Bioactivity, Binding Activity.
靶标 :
GFR甲1/GDNF R甲1
类别 :
蛋白和酶
单位尺寸 :
100微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS.
共轭标签 :
未共轭
纯度 :
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
物种 :
大鼠
观察到的分子量 :
95 kDa, reducing conditions
理论上的分子量 :
74 kDa (monomer)
基因符号 :
Gfra1
功能细节 :
Measured by its ability to confer GDNF responsiveness to PC-12 rat adrenal pheochromocytoma cells using a neurite outgrowth assay. Treanor, J. et al . (1996) Nature 392 :80. The ED50 for this effect is approximately 0.3 µg/mL in the presence of 25 ng/mL of Recombinant Rat GDNF (Catalog # 512-GF ). Measured by its binding ability in a functional ELISA. Immobilized Recombinant Rat GDNF (Catalog # 512-GF ) at 1 µg/mL binds Recombinant Rat GFR alpha-1/GDNF R alpha-1 Fc Chimera with an apparent KD 5 nM.
内毒素说明 :
<0.10 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
Q62997
应用 :
Bioactivity, Binding Activity
来源 :
NS0-derived Recombinant Rat GFR alpha-1 Fc Chimera Protein
美元 :
423美元
别名 :
DKFZp313E1012, DKFZp686J0156, GDNF family receptor alpha 1, GDNF family receptor alpha-1, GDNF R alpha-1, GDNF receptor alpha-1, GDNFRAGFR-ALPHA-1, GDNFR-alpha-1, GDNFRMGC23045, GFR alpha1, GFRa-1, GFRA1, GFR-alpha-1, Glial cell line-derived neurotrophic factor receptor alpha, GPI-linked anchor protein, PI-linked cell-surface accessory protein, RET ligand 1, RET1L, RETL1FLJ10561, TGF-beta related neurotrophic factor receptor 1, TGF-beta-related neurotrophic factor receptor 1, TRNR1FLJ31546
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.