产品简要
公司名称 :
安迪生物R&D
产品类型 :
蛋白
产品名称 :
重组人类金属蛋白酶组织抑制剂-3蛋白, CF
目录 :
973-TM-010
规格 :
10微克
价格 :
499美元
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 24
参考文献
Mwaura A, Riaz M, Maoga J, Mecha E, Omwandho C, Scheiner Bobis G, et al. Role of Betaglycan in TGF-β Signaling and Wound Healing in Human Endometriotic Epithelial Cells and in Endometriosis. Biology (Basel). 2022;11: pubmed 出版商
Abu El Asrar A, Ahmad A, Nawaz M, Siddiquei M, De Zutter A, Vanbrabant L, et al. Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation. Front Physiol. 2021;12:807747 pubmed 出版商
Santamaria S, Martin D, Dong X, Yamamoto K, Apte S, Ahnstr xf6 m J. Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8. J Biol Chem. 2021;297:101323 pubmed 出版商
Cassuto J, Folestad A, Göthlin J, Malchau H, Kärrholm J. Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants. Bone Rep. 2020;13:100715 pubmed 出版商
Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee C, Happel M, et al. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 2020;9: pubmed 出版商
Su C, Chang Y, Chien M, Hsieh Y, Chen M, Lin C, et al. Loss of TIMP3 by promoter methylation of Sp1 binding site promotes oral cancer metastasis. Cell Death Dis. 2019;10:793 pubmed 出版商
Nielsen M, Andersen M, Rittig N, Rødgaard Hansen S, Grønbaek H, Moestrup S, et al. The macrophage-related biomarkers sCD163 and sCD206 are released by different shedding mechanisms. J Leukoc Biol. 2019;106:1129-1138 pubmed 出版商
Ruiz Gómez G, Vogel S, Moller S, Pisabarro M, Hempel U. Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level. Sci Rep. 2019;9:4905 pubmed 出版商
Zhai H, Qi X, Li Z, Zhang W, Li C, Ji L, et al. TIMP‑3 suppresses the proliferation and migration of SMCs from the aortic neck of atherosclerotic AAA in rabbits, via decreased MMP‑2 and MMP‑9 activity, and reduced TNF‑α expression. Mol Med Rep. 2018;18:2061-2067 pubmed 出版商
Dave J, Mirabella T, Weatherbee S, Greif D. Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain. Dev Cell. 2018;44:665-678.e6 pubmed 出版商
Ohrvik H, Logeman B, Turk B, Reinheckel T, Thiele D. Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. J Biol Chem. 2016;291:13905-16 pubmed 出版商
Wong K, Zhu F, Khatri I, Huo Q, Spaner D, Gorczynski R. Characterization of CD200 Ectodomain Shedding. PLoS ONE. 2016;11:e0152073 pubmed 出版商
Sanz R, Ferraro G, Fournier A. IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015;290:4330-42 pubmed 出版商
Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, et al. ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface. Cytokine. 2015;71:238-45 pubmed 出版商
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed 出版商
Fröhlich C, Klitgaard M, Noer J, Kotzsch A, Nehammer C, Kronqvist P, et al. ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. Biochem J. 2013;452:97-109 pubmed 出版商
Golubkov V, Strongin A. Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7). J Biol Chem. 2012;287:42009-18 pubmed 出版商
Krstic D, Rodríguez M, Knuesel I. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS ONE. 2012;7:e47793 pubmed 出版商
Dierker T, Dreier R, Petersen A, Bordych C, Grobe K. Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem. 2009;284:8013-22 pubmed 出版商
Sun Q, Weber C, Sohail A, Bernardo M, Toth M, Zhao H, et al. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. J Biol Chem. 2007;282:21998-2010 pubmed
Fisher K, Pop A, Koh W, Anthis N, Saunders W, Davis G. Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. Mol Cancer. 2006;5:69 pubmed
Saunders W, Bohnsack B, Faske J, Anthis N, Bayless K, Hirschi K, et al. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol. 2006;175:179-91 pubmed
Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan Vague I, Nalbone G, et al. The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res. 2006;312:3969-80 pubmed
Von Tresckow B, Kallen K, Von Strandmann E, Borchmann P, Lange H, Engert A, et al. Depletion of cellular cholesterol and lipid rafts increases shedding of CD30. J Immunol. 2004;172:4324-31 pubmed
产品信息
品牌 :
R&D Systems
master code :
973-TM
SKU号 :
973-TM-010
产品名称 :
重组人类金属蛋白酶组织抑制剂-3蛋白, CF
描述 :
The Recombinant Human TIMP-3 Protein, CF from R&D Systems is derived from NS0. The Recombinant Human TIMP-3 Protein, CF has been validated for the following applications: Inhibition Activity.
靶标 :
金属蛋白酶组织抑制剂-3
类别 :
蛋白和酶
单位尺寸 :
10微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in Tris and NaCl.
共轭标签 :
未共轭
纯度 :
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
物种 :
人类
观察到的分子量 :
26 kDa, reducing conditions
理论上的分子量 :
22 kDa
基因符号 :
TIMP3
功能细节 :
Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (Catalog # ES001 ). The IC50 value is approximately 3 nM, under conditions the described conditions.
内毒素说明 :
<1.0 EU per 1 µg of the protein by the LAL method.
accessionNumbers :
P35625
应用 :
抑制作用活性
来源 :
NS0-derived Recombinant Human TIMP-3 Protein, CF
美元 :
499美元
别名 :
HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.