产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
IL-1乙/IL-1F2抗体
目录 :
AF-401-NA
规格 :
100 ug (also 25 ug)
价格 :
479美元
克隆性 :
多克隆
宿主 :
domestic goat
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 中和反应, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 228
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 图 5l
  • 免疫印迹; 小鼠; 图 1b, 3b
Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 4e
Simpson D, Pang J, Weir A, Kong I, Fritsch M, Rashidi M, et al. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity. 2022;55:423-441.e9 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 2h
xd8 stergaard J, Jha J, Sharma A, Dai A, Choi J, de Haan J, et al. Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease. Clin Sci (Lond). 2022;136:167-180 pubmed 出版商
  • 免疫印迹; 小鼠; 图 1d
Ma M, Li G, Qi M, Jiang W, Zhou R. Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma. Front Immunol. 2021;12:718779 pubmed 出版商
  • 免疫组化; 小鼠; 1:200; 图 3e
Zou Y, Bhat O, Yuan X, Li G, Huang D, Guo Y, et al. Release and Actions of Inflammatory Exosomes in Pulmonary Emphysema: Potential Therapeutic Target of Acupuncture. J Inflamm Res. 2021;14:3501-3521 pubmed 出版商
  • 免疫组化; 人类; 图 1g
  • 免疫印迹; 人类; 图 1c
Chen Q, Liu X, Wang D, Zheng J, Chen L, Xie Q, et al. Periodontal Inflammation-Triggered by Periodontal Ligament Stem Cell Pyroptosis Exacerbates Periodontitis. Front Cell Dev Biol. 2021;9:663037 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:200; 图 3i
  • 免疫印迹; 大鼠; 1:2000; 图 5k
Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021;14: pubmed 出版商
  • 免疫印迹; 小鼠; 图 5a
Li J, Zhang H, Dong Y, Wang X, Wang G. Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice. Front Physiol. 2021;12:628122 pubmed 出版商
Bai Y, Min R, Chen P, Mei S, Deng F, Zheng Z, et al. Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2. Proc Natl Acad Sci U S A. 2023;120:e2306399120 pubmed 出版商
Zhang Z, Song J, Kwon S, Wang Z, Park S, Piao X, et al. Pirfenidone Inhibits Alveolar Bone Loss in Ligature-Induced Periodontitis by Suppressing the NF-κB Signaling Pathway in Mice. Int J Mol Sci. 2023;24: pubmed 出版商
Weerasinghe H, Simm C, Djajawi T, Tedja I, Lo T, Simpson D, et al. Candida auris uses metabolic strategies to escape and kill macrophages while avoiding robust activation of the NLRP3 inflammasome response. Cell Rep. 2023;42:112522 pubmed 出版商
Ren M, Chen J, Xu H, Li W, Wang T, Chi Z, et al. Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis. Int Immunopharmacol. 2023;120:110292 pubmed 出版商
Liu L, Feng L, Gao J, Hu J, Li A, Zhu Y, et al. Parthenolide targets NLRP3 to treat inflammasome-related diseases. Int Immunopharmacol. 2023;119:110229 pubmed 出版商
Huang L, Anas M, Xu J, Zhou B, Toth P, Krishnan Y, et al. Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury. elife. 2023;12: pubmed 出版商
Siopi E, Galerne M, Rivagorda M, Saha S, Moigneu C, Moriceau S, et al. Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice. Mol Psychiatry. 2023;28:3002-3012 pubmed 出版商
Kang J, Lee S, Seok J, Kim D, Ma G, Park J, et al. Novel Activity of ODZ10117, a STAT3 Inhibitor, for Regulation of NLRP3 Inflammasome Activation. Int J Mol Sci. 2023;24: pubmed 出版商
Ta A, Ricci Azevedo R, Vasudevan S, Wright S, Kumari P, Havira M, et al. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023;14:2035 pubmed 出版商
Bollenbecker S, Heitman K, Czaya B, Easter M, Hirsch M, Vang S, et al. Phosphate induces inflammation and exacerbates injury from cigarette smoke in the bronchial epithelium. Sci Rep. 2023;13:4898 pubmed 出版商
Li J, Lin Q, Shao X, Li S, Zhu X, Wu J, et al. HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome. Cell Death Dis. 2023;14:200 pubmed 出版商
Lin T, Jiang C, Sheng L, Wan L, Fan W, Li J, et al. Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5'-monophosphate-activated protein kinase/heme oxygenase-1 pathway. Neural Regen Res. 2023;18:2067-2074 pubmed 出版商
Chen Y, Pu J, Li X, Lian L, Ge C, Liu Z, et al. Aim2 Deficiency Ameliorates Lacrimal Gland Destruction and Corneal Epithelium Defects in an Experimental Dry Eye Model. Invest Ophthalmol Vis Sci. 2023;64:26 pubmed 出版商
Hooftman A, Peace C, Ryan D, Day E, Yang M, McGettrick A, et al. Macrophage fumarate hydratase restrains mtRNA-mediated interferon production. Nature. 2023;615:490-498 pubmed 出版商
Zhong W, Zhang J, Duan J, Zhang C, Ma S, Li Y, et al. TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury. J Transl Med. 2023;21:179 pubmed 出版商
Filippini A, Salvi V, Dattilo V, Magri C, Castrezzati S, Veerhuis R, et al. LRRK2 Kinase Inhibition Attenuates Astrocytic Activation in Response to Amyloid β1-42 Fibrils. Biomolecules. 2023;13: pubmed 出版商
Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination. J Neuroinflammation. 2023;20:41 pubmed 出版商
Shu X, Wei C, Tu W, Zhong K, Qi S, Wang A, et al. Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome. Cell Rep. 2023;42:112133 pubmed 出版商
Ramadan A, Cao Z, Gadjeva M, Zaidi T, Rathinam V, Panjwani N. The NLRP3 Inflammasome Is Required for Protection Against Pseudomonas Keratitis. Invest Ophthalmol Vis Sci. 2023;64:11 pubmed 出版商
Lin G, Li N, Li D, Chen L, Deng H, Wang S, et al. Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps. Int Immunopharmacol. 2023;116:109819 pubmed 出版商
Reynolds M, Hong H, Michmerhuizen B, Lawrence A, Zhang L, Knight J, et al. Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation. Sci Adv. 2023;9:eade8701 pubmed 出版商
Gonz xe1 lez Cofrade L, P Green J, Cuadrado I, Amesty x, Oramas Royo S, David Brough -, et al. Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors. Bioorg Chem. 2023;132:106362 pubmed 出版商
Xu H, Li W, Hong S, Shao J, Chen J, Chattipakorn N, et al. Tabersonine, a natural NLRP3 inhibitor, suppresses inflammasome activation in macrophages and attenuate NLRP3-driven diseases in mice. Acta Pharmacol Sin. 2023;44:1252-1261 pubmed 出版商
Zhu Y, Zhang H, Mao H, Zhong S, Huang Y, Chen S, et al. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell Death Differ. 2023;30:168-183 pubmed 出版商
Lee G, Ahn H, Yun J, Park J, Lee E, Oh S, et al. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022;12:22484 pubmed 出版商
Juin S, Pushpakumar S, Tyagi S, Sen U. Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes. Sci Rep. 2022;12:21707 pubmed 出版商
Branco L, Amaral M, Boekhoff H, de Lima A, Farias I, Lage S, et al. Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion. Cell Death Dis. 2022;13:1029 pubmed 出版商
Oh C, Li L, Verma A, Reuven A, Miao E, Bliska J, et al. Neutrophil inflammasomes sense the subcellular delivery route of translocated bacterial effectors and toxins. Cell Rep. 2022;41:111688 pubmed 出版商
Wu Y, Mo S, Chen I, Hsieh F, Hsieh S, Zhang J, et al. Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells. Sci Adv. 2022;8:eabn9912 pubmed 出版商
Mangan M, Gorki F, Krause K, Heinz A, Pankow A, Ebert T, et al. Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever. PLoS Biol. 2022;20:e3001351 pubmed 出版商
Kim S, Shin M, Kim S. Lipocalin 2 activates the NLRP3 inflammasome via LPS‑induced NF‑κB signaling and plays a role as a pro‑inflammatory regulator in murine macrophages. Mol Med Rep. 2022;26: pubmed 出版商
Lin Q, Zhang D, Zhang J, Luo W, Xu Z, Yao J, et al. Identification of lncRNA DLEU2 as a potential diagnostic biomarker and anti-inflammatory target for ulcerative colitis. Front Pharmacol. 2022;13:991448 pubmed 出版商
Sharma P, Karnam K, Mahale A, Sedmaki K, Krishna Venuganti V, Kulkarni O. HDAC5 RNA interference ameliorates acute renal injury by upregulating KLF2 and inhibiting NALP3 expression in a mouse model of oxalate nephropathy. Int Immunopharmacol. 2022;112:109264 pubmed 出版商
Abdelrahman A, Bunch K, Sandow P, Cheng P, Caldwell R, Caldwell R. Systemic Administration of Pegylated Arginase-1 Attenuates the Progression of Diabetic Retinopathy. Cells. 2022;11: pubmed 出版商
Duhalde Vega M, Olivera D, Gast xe3 o Davanzo G, Bertullo M, Noya V, Fabiano de Souza G, et al. PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease. Sci Adv. 2022;8:eabn6545 pubmed 出版商
de Castro Silva I, Bianchi A, Deshpande N, Sharma P, Mehra S, Garrido V, et al. Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study. elife. 2022;11: pubmed 出版商
Ruwanpura S, McLeod L, Dousha L, Seow H, West A, West A, et al. Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema. Proc Natl Acad Sci U S A. 2022;119:e2201494119 pubmed 出版商
Shi H, Zhu Y, Xing C, Li S, Bao Z, Lei L, et al. An injectable thermosensitive hydrogel for dual delivery of diclofenac and Avastin® to effectively suppress inflammatory corneal neovascularization. Int J Pharm. 2022;625:122081 pubmed 出版商
Dong A, Yang Y, Jiang S, Yao X, Qi D, Mao C, et al. Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease. Acta Pharmacol Sin. 2022;: pubmed 出版商
López Rodríguez A, Decouty Perez C, Farr xe9 Alins V, Palomino Antol xed n A, Narros Fern xe1 ndez P, Egea J. Activation of NLRP3 Is Required for a Functional and Beneficial Microglia Response after Brain Trauma. Pharmaceutics. 2022;14: pubmed 出版商
Ma J, Lee E, Yoon S, Min H, Oh J, Hwang I, et al. Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model. EBioMedicine. 2022;82:104184 pubmed 出版商
Chen W, Chen S, Yan C, Zhang Y, Zhang R, Chen M, et al. Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion. Nat Immunol. 2022;: pubmed 出版商
Yu W, Wang Z, Yu X, Zhao Y, Xie Z, Zhang K, et al. Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters. Nat Commun. 2022;13:3544 pubmed 出版商
Zhang Q, Liu W, Wang H, Zhou H, Bulek K, Chen X, et al. TH17 cells promote CNS inflammation by sensing danger signals via Mincle. Nat Commun. 2022;13:2406 pubmed 出版商
Zhou L, Yang S, Zou X. Farrerol Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting Macrophages and NLRP3. Front Pharmacol. 2022;13:879232 pubmed 出版商
Billingham L, Stoolman J, Vasan K, Rodriguez A, Poor T, Szibor M, et al. Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol. 2022;23:692-704 pubmed 出版商
Jung E, Suh K, Han J, Kim H, Kang H, Choi W, et al. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21:e13623 pubmed 出版商
Li F, Lin L, He Y, Sun G, Dong D, Wu B. BMAL1 regulates Propionibacterium acnes-induced skin inflammation via REV-ERBα in mice. Int J Biol Sci. 2022;18:2597-2608 pubmed 出版商
Molnár K, Nógrádi B, Kristóf R, Mészáros A, Pajer K, Siklos L, et al. Motoneuronal inflammasome activation triggers excessive neuroinflammation and impedes regeneration after sciatic nerve injury. J Neuroinflammation. 2022;19:68 pubmed 出版商
Rego C, Francisco A, Boeno C, Paloschi M, Lopes J, Silva M, et al. Inflammasome NLRP3 activation induced by Convulxin, a C-type lectin-like isolated from Crotalus durissus terrificus snake venom. Sci Rep. 2022;12:4706 pubmed 出版商
Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, et al. Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling. elife. 2022;11: pubmed 出版商
Mohamed M, Gupta K, Goldufsky J, Roy R, Callaghan L, Wetzel D, et al. CrkII/Abl phosphorylation cascade is critical for NLRC4 inflammasome activity and is blocked by Pseudomonas aeruginosa ExoT. Nat Commun. 2022;13:1295 pubmed 出版商
Eislmayr K, Bestehorn A, Morelli L, Borroni M, Walle L, Lamkanfi M, et al. Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection. Sci Adv. 2022;8:eabj7293 pubmed 出版商
Wang Y, Liu T, Shen C, Lin S, Hung C, Hsu L, et al. K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy. Cell Rep. 2022;38:110354 pubmed 出版商
Jiao Y, Nan J, Mu B, Zhang Y, Zhou N, Yang S, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022;232:114194 pubmed 出版商
Xu T, Yu W, Fang H, Wang Z, Chi Z, Guo X, et al. Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation. Cell Death Differ. 2022;29:1582-1595 pubmed 出版商
Toth K, Lénárt N, Berki P, Fekete R, Szabadits E, Pósfai B, et al. The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. PLoS Biol. 2022;20:e3001526 pubmed 出版商
Wang S, Jing K, Wu H, Li X, Yang C, Li T, et al. Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy. Oxid Med Cell Longev. 2022;2022:2812493 pubmed 出版商
Murthy S, Baruah S, Bowen J, Keck K, Wagner B, Buettner G, et al. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming. J Leukoc Biol. 2022;112:457-473 pubmed 出版商
Szab xf3 D, Tod P, G xf6 l xf6 ncs xe9 r F, Rom xe1 n V, Lendvai B, Otrokocsi L, et al. Maternal P2X7 receptor inhibition prevents autism-like phenotype in male mouse offspring through the NLRP3-IL-1β pathway. Brain Behav Immun. 2022;101:318-332 pubmed 出版商
Williams N, Ryan D, Costa A, Mills E, Jedrychowski M, Cloonan S, et al. Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages. J Biol Chem. 2022;298:101501 pubmed 出版商
Yuan K, Zheng J, Shen X, Wu Y, Han Y, Jin X, et al. Sensory nerves promote corneal inflammation resolution via CGRP mediated transformation of macrophages to the M2 phenotype through the PI3K/AKT signaling pathway. Int Immunopharmacol. 2022;102:108426 pubmed 出版商
Munoz M, Fletcher E, Skinner O, Jurczyluk J, Kristianto E, Hodson M, et al. Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages. elife. 2021;10: pubmed 出版商
Wei Z, Zhan X, Ding K, Xu G, Shi W, Ren L, et al. Dihydrotanshinone I Specifically Inhibits NLRP3 Inflammasome Activation and Protects Against Septic Shock In Vivo. Front Pharmacol. 2021;12:750815 pubmed 出版商
Chen P, Bai Q, Wu Y, Zeng Q, Song X, Guo Y, et al. The Essential Oil of Artemisia argyi H.Lév. and Vaniot Attenuates NLRP3 Inflammasome Activation in THP-1 Cells. Front Pharmacol. 2021;12:712907 pubmed 出版商
Ahn H, Lee H, Lee G, Park J, Sung H, Lee E, et al. Parabens disrupt non-canonical inflammasome activation. Int Immunopharmacol. 2021;101:108196 pubmed 出版商
Wen B, Dang Y, Wu S, Huang Y, Ma K, Xu Y, et al. Antiatherosclerotic effect of dehydrocorydaline on ApoE-/- mice: inhibition of macrophage inflammation. Acta Pharmacol Sin. 2021;: pubmed 出版商
Jiang S, Maphis N, Binder J, Chisholm D, Weston L, DURAN W, et al. Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep. 2021;36:109720 pubmed 出版商
Tang Y, Kline K, Zhong X, Xiao Y, Lian H, Peng J, et al. Chronic colitis upregulates microRNAs suppressing brain-derived neurotrophic factor in the adult heart. PLoS ONE. 2021;16:e0257280 pubmed 出版商
Xiong S, Zhang L, Richner J, Class J, Rehman J, Malik A. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021;41:2773-2785 pubmed 出版商
Reimers D, Vallejo Muñoz M, Casarejos M, Jimenez Escrig A, Gonzalo Gobernado R, Bazán E. Immunohistochemical Study of ASC Expression and Distribution in the Hippocampus of an Aged Murine Model of Alzheimer's Disease. Int J Mol Sci. 2021;22: pubmed 出版商
Li X, Zhang X, Xia J, Zhang L, Chen B, Lian G, et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep. 2021;36:109607 pubmed 出版商
Ortiz Romero P, González Simón A, Egea G, Perez Jurado L, Campuzano V. Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams-Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression. Front Pharmacol. 2021;12:670785 pubmed 出版商
Ahn H, Lee G, Kim J, Park J, Kang S, Yoon S, et al. NLRP3 Triggers Attenuate Lipocalin-2 Expression Independent with Inflammasome Activation. Cells. 2021;10: pubmed 出版商
Wu X, Lv J, Zhang S, Yi X, Xu Z, Zhi Y, et al. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta Pharmacol Sin. 2021;: pubmed 出版商
Rastogi S, Ellinwood S, Augenstreich J, Mayer Barber K, Briken V. Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF. PLoS Pathog. 2021;17:e1009712 pubmed 出版商
Nizami S, Millar V, Arunasalam K, Zarganes Tzitzikas T, Brough D, Tresadern G, et al. A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation. Sci Rep. 2021;11:15319 pubmed 出版商
Lin C, Shen Y, Chang C, Guo X, Young Y, Lai T, et al. Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation. Nat Commun. 2021;12:3878 pubmed 出版商
Timblin G, Tharp K, Ford B, Winchester J, Wang J, Zhu S, et al. Mitohormesis reprogrammes macrophage metabolism to enforce tolerance. Nat Metab. 2021;3:618-635 pubmed 出版商
Ratitong B, Marshall M, Pearlman E. β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles. Cell Rep. 2021;35:109139 pubmed 出版商
Vijayaraj S, Feltham R, Rashidi M, Frank D, Liu Z, Simpson D, et al. The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. Nat Commun. 2021;12:2713 pubmed 出版商
Xia S, Zhang Z, Magupalli V, Pablo J, Dong Y, Vora S, et al. Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature. 2021;593:607-611 pubmed 出版商
Wang X, Li Z, Bai Y, Zhang R, Meng R, Chen F, et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis. 2021;12:402 pubmed 出版商
Zhou B, Abbott D. Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases. Cell Rep. 2021;35:108998 pubmed 出版商
Zhang C, Yue H, Sun P, Hua L, Liang S, Ou Y, et al. Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities. Eur J Med Chem. 2021;219:113417 pubmed 出版商
Shimada A, Hasegawa Ishii S. Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice. Toxicol Rep. 2021;8:520-528 pubmed 出版商
Lee M, Lee Y, Wu D, Pae M. Luteolin inhibits NLRP3 inflammasome activation via blocking ASC oligomerization. J Nutr Biochem. 2021;92:108614 pubmed 出版商
Li Z, Cao Y, Li Y, Zhao Y, Chen X. Vaccine delivery alerts innate immune systems for more immunogenic vaccination. JCI Insight. 2021;6: pubmed 出版商
Mishima Y, Osaki T, Shimada A, Kamiya S, Hasegawa Ishii S. Sex-dependent differences in the gut microbiota following chronic nasal inflammation in adult mice. Sci Rep. 2021;11:4640 pubmed 出版商
Shi Y, Lv Q, Zheng M, Sun H, Shi F. NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages. Int Immunopharmacol. 2021;92:107358 pubmed 出版商
Estfanous S, Krause K, Anne M, Eltobgy M, Caution K, Abu Khweek A, et al. Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo. Sci Rep. 2021;11:855 pubmed 出版商
Lin Q, Li S, Jiang N, Jin H, Shao X, Zhu X, et al. Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy. Autophagy. 2021;17:2975-2990 pubmed 出版商
Kajino Sakamoto R, Fujishita T, Taketo M, Aoki M. Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells. Oncogene. 2021;40:408-420 pubmed 出版商
Zhao Q, Bi Y, Guo J, Liu Y, Zhong J, Pan L, et al. Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation. Acta Pharmacol Sin. 2021;42:975-986 pubmed 出版商
Farré Alins V, Narros Fernández P, Palomino Antolin A, Decouty Pérez C, López Rodríguez A, Parada E, et al. Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux. Antioxidants (Basel). 2020;9: pubmed 出版商
Nógrádi B, Nyúl Tóth Á, Kozma M, Molnár K, Patai R, Siklos L, et al. Upregulation of Nucleotide-Binding Oligomerization Domain-, LRR- and Pyrin Domain-Containing Protein 3 in Motoneurons Following Peripheral Nerve Injury in Mice. Front Pharmacol. 2020;11:584184 pubmed 出版商
Nilsson J, Hörnberg M, Schmidt Christensen A, Linde K, Nilsson M, Carlus M, et al. NKT cells promote both type 1 and type 2 inflammatory responses in a mouse model of liver fibrosis. Sci Rep. 2020;10:21778 pubmed 出版商
Wang W, Hu D, Feng Y, Wu C, Song Y, Liu W, et al. Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC Biol. 2020;18:182 pubmed 出版商
Sweet D, Vasudevan N, Fan L, Booth C, Keerthy K, Liao X, et al. Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation. Nat Commun. 2020;11:5872 pubmed 出版商
Ahn H, Lee G. Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity. Sci Rep. 2020;10:19091 pubmed 出版商
Matsuoka T, Yoshimatsu G, Sakata N, Kawakami R, Tanaka T, Yamada T, et al. Inhibition of NLRP3 inflammasome by MCC950 improves the metabolic outcome of islet transplantation by suppressing IL-1β and islet cellular death. Sci Rep. 2020;10:17920 pubmed 出版商
Ming S, Zeng L, Guo Y, Zhang S, Li G, Ma Y, et al. The Human-Specific STING Agonist G10 Activates Type I Interferon and the NLRP3 Inflammasome in Porcine Cells. Front Immunol. 2020;11:575818 pubmed 出版商
Kim Y, Kwak M, Lee B, Shin J, Aum S, Park I, et al. Secretory autophagy machinery and vesicular trafficking are involved in HMGB1 secretion. Autophagy. 2020;:1-18 pubmed 出版商
Volchuk A, Ye A, Chi L, Steinberg B, Goldenberg N. Indirect regulation of HMGB1 release by gasdermin D. Nat Commun. 2020;11:4561 pubmed 出版商
Deo P, Chow S, Han M, Speir M, Huang C, Schittenhelm R, et al. Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation. Nat Microbiol. 2020;5:1418-1427 pubmed 出版商
Tucey T, Verma J, Olivier F, Lo T, Robertson A, Naderer T, et al. Metabolic competition between host and pathogen dictates inflammasome responses to fungal infection. PLoS Pathog. 2020;16:e1008695 pubmed 出版商
von Herrmann K, Anderson F, Martinez E, Young A, Havrda M. Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice. J Neuroinflammation. 2020;17:213 pubmed 出版商
Park Y, Remmers E, Lee W, Ombrello A, Chung L, Shilei Z, et al. Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis. Nat Immunol. 2020;21:857-867 pubmed 出版商
Bulek K, Zhao J, Liao Y, Rana N, Corridoni D, Antanaviciute A, et al. Epithelial-derived gasdermin D mediates nonlytic IL-1β release during experimental colitis. J Clin Invest. 2020;130:4218-4234 pubmed 出版商
Huang Y, Wang H, Hao Y, Lin H, Dong M, Ye J, et al. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nat Cell Biol. 2020;22:716-727 pubmed 出版商
Xiong S, Hong Z, Huang L, Tsukasaki Y, Nepal S, Di A, et al. IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury. J Clin Invest. 2020;130:3684-3698 pubmed 出版商
Wang Y, Li H, Li F. ELMO2 association with Gαi2 regulates pancreatic cancer cell chemotaxis and metastasis. Peerj. 2020;8:e8910 pubmed 出版商
Donado C, Cao A, Simmons D, Croker B, Brennan P, Brenner M. A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling. Cell Rep. 2020;31:107466 pubmed 出版商
Cao F, Tian X, Li Z, Lv Y, Han J, Zhuang R, et al. Suppression of NLRP3 Inflammasome by Erythropoietin via the EPOR/JAK2/STAT3 Pathway Contributes to Attenuation of Acute Lung Injury in Mice. Front Pharmacol. 2020;11:306 pubmed 出版商
Tozaki Saitoh H, Sasaki I, Yamashita T, Hosoi M, Kato T, Tsuda M. Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors. J Pharmacol Sci. 2020;143:133-140 pubmed 出版商
Hamarsheh S, Osswald L, Saller B, Unger S, De Feo D, Vinnakota J, et al. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation. Nat Commun. 2020;11:1659 pubmed 出版商
Li Q, Cao Y, Dang C, Han B, Han R, Ma H, et al. Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke. EMBO Mol Med. 2020;12:e11002 pubmed 出版商
Kim B, Kim B, Kook Y, Kim B. Mycobacterium abscessus infection leads to enhanced production of type 1 interferon and NLRP3 inflammasome activation in murine macrophages via mitochondrial oxidative stress. PLoS Pathog. 2020;16:e1008294 pubmed 出版商
Nakata R, Nakamura Y, Hosomi S, Okuda H, Nishida Y, Sugita N, et al. Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. Sci Rep. 2020;10:4883 pubmed 出版商
Subbarao S, Sanchez Garrido J, Krishnan N, Shenoy A, Robertson B. Genetic and pharmacological inhibition of inflammasomes reduces the survival of Mycobacterium tuberculosis strains in macrophages. Sci Rep. 2020;10:3709 pubmed 出版商
Zasłona Z, Flis E, Wilk M, Carroll R, Palsson McDermott E, Hughes M, et al. Caspase-11 promotes allergic airway inflammation. Nat Commun. 2020;11:1055 pubmed 出版商
das Gupta K, Shakespear M, Curson J, Murthy A, Iyer A, Hodson M, et al. Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2. Cell Rep. 2020;30:2712-2728.e8 pubmed 出版商
Liu B, Lu Y, Chen X, Muthuraj P, Li X, Pattabiraman M, et al. Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Nutrients. 2020;12: pubmed 出版商
Wooff Y, Fernando N, Wong J, Dietrich C, Aggio Bruce R, Chu Tan J, et al. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration. Sci Rep. 2020;10:2263 pubmed 出版商
Fox D, Mathur A, Xue Y, Liu Y, Tan W, Feng S, et al. Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome. Nat Commun. 2020;11:760 pubmed 出版商
Wang J, Liu H, Xie G, Cai W, Xu J. Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020;21:685-694 pubmed 出版商
Kim J, Ahn H, Yu S, Ahn J, Ko H, Kweon M, et al. IκBζ controls NLRP3 inflammasome activation via upregulation of the Nlrp3 gene. Cytokine. 2020;127:154983 pubmed 出版商
Bhatta A, Atianand M, Jiang Z, Crabtree J, Blin J, Fitzgerald K. A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome. J Immunol. 2020;204:428-437 pubmed 出版商
Speir M, Nowell C, Chen A, O Donnell J, Shamie I, Lakin P, et al. Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation. Nat Immunol. 2020;21:54-64 pubmed 出版商
Di Gioia M, Spreafico R, Springstead J, Mendelson M, Joehanes R, Levy D, et al. Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation. Nat Immunol. 2020;21:42-53 pubmed 出版商
Yoshizaki T, Itoh S, Yamaguchi S, Numata T, Nambu A, Kimura N, et al. IL-25 exacerbates autoimmune aortitis in IL-1 receptor antagonist-deficient mice. Sci Rep. 2019;9:17067 pubmed 出版商
Chen Y, Wang H, Shen J, Deng R, Yao X, Guo Q, et al. Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist. J Immunol. 2019;203:2712-2723 pubmed 出版商
Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al. Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation. Cell Rep. 2019;29:151-161.e5 pubmed 出版商
Wang P, Qi X, Xu G, Liu J, Guo J, Li X, et al. CCL28 promotes locomotor recovery after spinal cord injury via recruiting regulatory T cells. Aging (Albany NY). 2019;11:7402-7415 pubmed 出版商
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed 出版商
Akula M, Ibrahim M, Ivarsson E, Khan O, Kumar I, Erlandsson M, et al. Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. Nat Commun. 2019;10:3975 pubmed 出版商
Mian Wu -, Zhang M, Ma Y, Liu F, Chen S, Lu J, et al. Chaetocin attenuates gout in mice through inhibiting HIF-1α and NLRP3 inflammasome-dependent IL-1β secretion in macrophages. Arch Biochem Biophys. 2019;: pubmed 出版商
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, et al. PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation. Redox Biol. 2019;26:101254 pubmed 出版商
Spalinger M, Schmidt T, Schwarzfischer M, Hering L, Atrott K, Lang S, et al. Protein tyrosine phosphatase non-receptor type 22 modulates colitis in a microbiota-dependent manner. J Clin Invest. 2019;129:2527-2541 pubmed 出版商
Phillips E, Lorch A, Durkes A, Goergen C. Early pathological characterization of murine dissecting abdominal aortic aneurysms. APL Bioeng. 2018;2:046106 pubmed 出版商
Da Costa L, Outlioua A, Anginot A, Akarid K, Arnoult D. RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Cell Death Dis. 2019;10:346 pubmed 出版商
Ojcius D, Jafari A, Yeruva L, Schindler C, Abdul Sater A. Dicer regulates activation of the NLRP3 inflammasome. PLoS ONE. 2019;14:e0215689 pubmed 出版商
Meng R, Gu L, Lu Y, Zhao K, Wu J, Wang H, et al. High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice. J Biol Chem. 2019;294:8872-8884 pubmed 出版商
Ahn H, Han B, Kim J, Kang S, Kim P, Jang K, et al. Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression. J Ginseng Res. 2019;43:291-299 pubmed 出版商
Zhang P, Cao L, Zhou R, Yang X, Wu M. The lncRNA Neat1 promotes activation of inflammasomes in macrophages. Nat Commun. 2019;10:1495 pubmed 出版商
Tapia V, Daniels M, Palazón Riquelme P, Dewhurst M, Luheshi N, Rivers Auty J, et al. The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes. J Biol Chem. 2019;294:8325-8335 pubmed 出版商
Lee J, Jung E, Heur M. Injury induces endothelial to mesenchymal transition in the mouse corneal endothelium in vivo via FGF2. Mol Vis. 2019;25:22-34 pubmed
Morita Takemura S, Nakahara K, Hasegawa Ishii S, Isonishi A, Tatsumi K, Okuda H, et al. Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance. J Neuroinflammation. 2019;16:39 pubmed 出版商
Erlich Z, Shlomovitz I, Edry Botzer L, Cohen H, Frank D, Wang H, et al. Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model. Nat Immunol. 2019;20:397-406 pubmed 出版商
Hwang W, Lan H, Cheng W, Huang S, Yang M. Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol. 2019;12:10 pubmed 出版商
Cui H, Banerjee S, Guo S, Xie N, Ge J, Jiang D, et al. Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury. JCI Insight. 2019;4: pubmed 出版商
Gunaratna R, Santos A, Luo L, Nagi C, Lambertz I, Spier M, et al. Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model. Oncogene. 2019;38:3535-3550 pubmed 出版商
Kurundkar D, Kurundkar A, Bone N, Becker E, Liu W, Chacko B, et al. SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury. JCI Insight. 2019;4: pubmed 出版商
Widmann C, Gandin C, Petit Paitel A, Lazdunski M, Heurteaux C. The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia. Sci Rep. 2018;8:18062 pubmed 出版商
Kaplanov I, Carmi Y, Kornetsky R, Shemesh A, Shurin G, Shurin M, et al. Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation. Proc Natl Acad Sci U S A. 2019;116:1361-1369 pubmed 出版商
Mathur A, Feng S, Hayward J, Ngo C, Fox D, Atmosukarto I, et al. A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome. Nat Microbiol. 2019;4:362-374 pubmed 出版商
Vince J, De Nardo D, Gao W, Vince A, Hall C, McArthur K, et al. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation. Cell Rep. 2018;25:2339-2353.e4 pubmed 出版商
Koch B, Barugahare A, Lo T, Huang C, Schittenhelm R, Powell D, et al. A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling. Cell Rep. 2018;25:2244-2258.e7 pubmed 出版商
Sharma D, Malik A, Guy C, Vogel P, Kanneganti T. TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. J Clin Invest. 2019;129:150-162 pubmed 出版商
Kasper L, König A, Koenig P, Gresnigt M, Westman J, Drummond R, et al. The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes. Nat Commun. 2018;9:4260 pubmed 出版商
Wang S, Lin Y, Yuan X, Li F, Guo L, Wu B. REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis. Nat Commun. 2018;9:4246 pubmed 出版商
Benjamin J, Moore D, Bennett C, Van Der Meer R, Royce A, Loveland R, et al. Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality. J Immunol. 2018;201:2873-2878 pubmed 出版商
Zhang Z, Shao X, Jiang N, Mou S, Gu L, Li S, et al. Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury. Cell Death Dis. 2018;9:983 pubmed 出版商
Chen Y, He X, Yuan X, Hong J, Bhat O, Li G, et al. NLRP3 Inflammasome Formation and Activation in Nonalcoholic Steatohepatitis: Therapeutic Target for Antimetabolic Syndrome Remedy FTZ. Oxid Med Cell Longev. 2018;2018:2901871 pubmed 出版商
Monteleone M, Stanley A, Chen K, Brown D, Bezbradica J, von Pein J, et al. Interleukin-1? Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. Cell Rep. 2018;24:1425-1433 pubmed 出版商
Marchetti C, Swartzwelter B, Koenders M, Azam T, Tengesdal I, Powers N, et al. NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis. Arthritis Res Ther. 2018;20:169 pubmed 出版商
Shahid M, Lee M, Yeon A, Cho E, Sairam V, Valdiviez L, et al. Menthol, a unique urinary volatile compound, is associated with chronic inflammation in interstitial cystitis. Sci Rep. 2018;8:10859 pubmed 出版商
He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, et al. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018;9:2550 pubmed 出版商
Lee E, Hwang I, Park S, Hong S, Hwang B, Cho Y, et al. MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration. Cell Death Differ. 2019;26:213-228 pubmed 出版商
Kwak S, Koppula S, In E, Sun X, Kim Y, Kim M, et al. Artemisia Extract Suppresses NLRP3 and AIM2 Inflammasome Activation by Inhibition of ASC Phosphorylation. Mediators Inflamm. 2018;2018:6054069 pubmed 出版商
Coleman L, Maile R, Jones S, Cairns B, Crews F. HMGB1/IL-1β complexes in plasma microvesicles modulate immune responses to burn injury. PLoS ONE. 2018;13:e0195335 pubmed 出版商
Kim Y, Koppula S, Shim D, In E, Kwak S, Kim M, et al. Inhibitory Effect and Mechanism of Arctium lappa Extract on NLRP3 Inflammasome Activation. Evid Based Complement Alternat Med. 2018;2018:6346734 pubmed 出版商
Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, et al. Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Circ Res. 2018;122:1661-1674 pubmed 出版商
Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, et al. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med. 2018;10: pubmed 出版商
Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed 出版商
Zhuang W, Wang C, Shi X, Qiu S, Zhang S, Xu B, et al. MCMV triggers ROS/NLRP3-associated inflammasome activation in the inner ear of mice and cultured spiral ganglion neurons, contributing to sensorineural hearing loss. Int J Mol Med. 2018;41:3448-3456 pubmed 出版商
Carroll R, Zasłona Z, Galván Peña S, Koppe E, Sévin D, Angiari S, et al. An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation. J Biol Chem. 2018;293:5509-5521 pubmed 出版商
Santos J, Dick M, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, et al. LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation. EMBO J. 2018;37: pubmed 出版商
Boucher D, Monteleone M, Coll R, Chen K, Ross C, Teo J, et al. Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. J Exp Med. 2018;215:827-840 pubmed 出版商
Kuriakose T, Zheng M, Neale G, Kanneganti T. IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. J Immunol. 2018;200:1489-1495 pubmed 出版商
Ross J, Queme L, Lamb J, Green K, Jankowski M. Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury. Biol Sex Differ. 2018;9:2 pubmed 出版商
Zenke K, Muroi M, Tanamoto K. AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner. Cell Signal. 2018;43:32-39 pubmed 出版商
Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed 出版商
Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald K. The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression. J Immunol. 2017;199:3249-3260 pubmed 出版商
Rivera J, Noueihed B, Madaan A, Lahaie I, Pan J, Belik J, et al. Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina. J Neuroinflammation. 2017;14:181 pubmed 出版商
Albalawi F, Lu W, Beckel J, Lim J, McCaughey S, Mitchell C. The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain. Front Cell Neurosci. 2017;11:227 pubmed 出版商
Nakanishi H, Kawashima Y, Kurima K, Chae J, Ross A, Pinto Patarroyo G, et al. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy. Proc Natl Acad Sci U S A. 2017;114:E7766-E7775 pubmed 出版商
McDonough E, Barrett C, Parang B, Mittal M, Smith J, Bradley A, et al. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight. 2017;2: pubmed 出版商
Brawek B, Liang Y, Savitska D, Li K, Fomin Thunemann N, Kovalchuk Y, et al. A new approach for ratiometric in vivo calcium imaging of microglia. Sci Rep. 2017;7:6030 pubmed 出版商
Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed 出版商
Wu T, Zhang J, Geng M, Tang S, Zhang W, Shu J. Nucleoside reverse transcriptase inhibitors (NRTIs) induce proinflammatory cytokines in the CNS via Wnt5a signaling. Sci Rep. 2017;7:4117 pubmed 出版商
Domingo Fernández R, Coll R, Kearney J, Breit S, O Neill L. The intracellular chloride channel proteins CLIC1 and CLIC4 induce IL-1? transcription and activate the NLRP3 inflammasome. J Biol Chem. 2017;292:12077-12087 pubmed 出版商
Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J, Tye H, et al. Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med. 2017;214:1737-1752 pubmed 出版商
Zhu Q, Kanneganti T. Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1?. J Immunol. 2017;198:4210-4215 pubmed 出版商
Ahn H, Jeon E, Kim J, Kang S, Yoon S, Ko H, et al. Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production. Sci Rep. 2017;7:1314 pubmed 出版商
Kanamori Y, Murakami M, Sugiyama M, Hashimoto O, Matsui T, Funaba M. Interleukin-1? (IL-1?) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein ? (C/EBP?) expression in hepatocytes. J Biol Chem. 2017;292:10275-10287 pubmed 出版商
Freeman L, Guo H, David C, Brickey W, JHA S, Ting J. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351-1370 pubmed 出版商
Choo M, Sano Y, Kim C, Yasuda K, Li X, Lin X, et al. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017;214:1297-1311 pubmed 出版商
Zhong Z, Zhai Y, Bu P, Shah S, Qiao L. Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice. Nat Commun. 2017;8:15004 pubmed 出版商
Youssef H, Stashenko P. Interleukin-1 and estrogen protect against disseminating dentoalveolar infections. Int J Oral Sci. 2017;9:16-23 pubmed 出版商
Moriwaki K, Balaji S, Bertin J, Gough P, Chan F. Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep. 2017;18:2441-2451 pubmed 出版商
Domiciano T, Wakita D, Jones H, Crother T, Verri W, Arditi M, et al. Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis. Sci Rep. 2017;7:41539 pubmed 出版商
Tsugita M, Morimoto N, Tashiro M, Kinoshita K, Nakayama M. SR-B1 Is a Silica Receptor that Mediates Canonical Inflammasome Activation. Cell Rep. 2017;18:1298-1311 pubmed 出版商
Tufanlı Ö, Telkoparan Akillilar P, Acosta Alvear D, Kocatürk B, Onat U, Hamid S, et al. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A. 2017;114:E1395-E1404 pubmed 出版商
Koh H, Kim Y, Kim J, Yun J, Jang K, Yang C. Toxoplasma gondii GRA7-Targeted ASC and PLD1 Promote Antibacterial Host Defense via PKCα. PLoS Pathog. 2017;13:e1006126 pubmed 出版商
Haldar S, Dru C, Mishra R, Tripathi M, Duong F, Angara B, et al. Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis. Sci Rep. 2016;6:39257 pubmed 出版商
Chavarria Smith J, Mitchell P, Ho A, Daugherty M, Vance R. Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation. PLoS Pathog. 2016;12:e1006052 pubmed 出版商
Mittal M, Tiruppathi C, Nepal S, Zhao Y, Grzych D, Soni D, et al. TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury. Proc Natl Acad Sci U S A. 2016;113:E8151-E8158 pubmed
Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed 出版商
Pereira M, Tourlomousis P, Wright J, P Monie T, Bryant C. CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages. Nat Commun. 2016;7:12874 pubmed 出版商
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed 出版商
Myles I, Zhao M, Nardone G, Olano L, Reckhow J, Saleem D, et al. CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells. J Leukoc Biol. 2017;101:307-320 pubmed 出版商
Cader M, Boroviak K, Zhang Q, Assadi G, Kempster S, Sewell G, et al. C13orf31 (FAMIN) is a central regulator of immunometabolic function. Nat Immunol. 2016;17:1046-56 pubmed 出版商
Braverman J, Sogi K, Benjamin D, Nomura D, Stanley S. HIF-1? Is an Essential Mediator of IFN-?-Dependent Immunity to Mycobacterium tuberculosis. J Immunol. 2016;197:1287-97 pubmed 出版商
Stein R, Kapplusch F, Heymann M, Russ S, Staroske W, Hedrich C, et al. Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division. J Biol Chem. 2016;291:18419-29 pubmed 出版商
Meng N, Xia M, Lu Y, Wang M, Boini K, Li P, et al. Activation of NLRP3 inflammasomes in mouse hepatic stellate cells during Schistosoma J. infection. Oncotarget. 2016;7:39316-39331 pubmed 出版商
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed 出版商
Du R, Tan J, Sun X, Lu M, Ding J, Hu G. Fluoxetine Inhibits NLRP3 Inflammasome Activation: Implication in Depression. Int J Neuropsychopharmacol. 2016;19: pubmed 出版商
Wang X, Shaw D, Sakhon O, Snyder G, Sundberg E, Santambrogio L, et al. The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infect Immun. 2016;84:1796-1805 pubmed 出版商
Marty Roix R, Vladimer G, Pouliot K, Weng D, Buglione Corbett R, West K, et al. Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants. J Biol Chem. 2016;291:1123-36 pubmed 出版商
图像
图像 1 :
安迪生物R&D AF-401-NA 图像 1
IL-1ss/IL-1F2 antibody in MCF-7 Human Cell Line by Immunocytochemistry (ICC).
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
AF-401-NA
SKU号 :
AF-401-NA
产品名称 :
IL-1乙/IL-1F2抗体
描述 :
The Mouse IL-1 beta/IL-1F2 Antibody from R&D Systems is a goat polyclonal antibody to IL-1 beta/IL-1F2. This antibody reacts with mouse. The Mouse IL-1 beta/IL-1F2 Antibody has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Neutralization, Immunocytochemistry.
靶标 :
IL-1乙/IL-1F2
类别 :
一抗
单位尺寸 :
100 ug (also 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
克隆性 :
多克隆
浓度 :
LYOPH
共轭标签 :
未共轭
宿主 :
山羊
免疫原 :
E. coli -derived recombinant mouse IL-1 beta/IL-1F2, Val118-Ser269, Accession # NP_032387
抗体亚型 :
IgG
纯度 :
抗原亲和纯化
物种 :
小鼠
特异性 :
Detects mouse IL-1 beta/IL-1F2 in direct ELISAs and Western blots.
基因符号 :
IL1B
内毒素说明 :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
NP_032387
应用 :
Western Blot, Simple Western, Immunohistochemistry, Neutralization, Immunocytochemistry
美元 :
479美元
别名 :
catabolin, IL-1, IL1 beta, IL-1 beta, IL-1b, IL1B, IL1-BETA, IL-1F2, IL1F2IL-1 beta, interleukin 1, beta, interleukin-1 beta, preinterleukin 1 beta, pro-interleukin-1-beta
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.