产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
Mouse Progranulin/PGRN Antibody
目录 :
AF2557-SP
规格 :
25微克
价格 :
135美元
克隆性 :
多克隆
宿主 :
家羊
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 18
参考文献
Frew J, Nygaard H. Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice. Acta Neuropathol Commun. 2021;9:57 pubmed 出版商
Sasaki T, Shimazawa M, Kanamori H, Yamada Y, Nishinaka A, Kuse Y, et al. Effects of progranulin on the pathological conditions in experimental myocardial infarction model. Sci Rep. 2020;10:11842 pubmed 出版商
Tang F, Zhao L, Zhao Y, Sun D, Zhu X, Mei L, et al. Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons. Cell Death Differ. 2020;: pubmed 出版商
Wang C, Zhang L, Ndong J, Hettinghouse A, Sun G, Chen C, et al. Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice. J Neuroinflammation. 2019;16:238 pubmed 出版商
Wei F, Jiang Z, Sun H, Pu J, Sun Y, Wang M, et al. Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling. PLoS Pathog. 2019;15:e1008062 pubmed 出版商
Zhou X, Paushter D, Pagan M, Kim D, Nunez Santos M, Lieberman R, et al. Progranulin deficiency leads to reduced glucocerebrosidase activity. PLoS ONE. 2019;14:e0212382 pubmed 出版商
Elia L, Mason A, Alijagic A, Finkbeiner S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway. J Neurosci. 2019;39:3332-3344 pubmed 出版商
Kuse Y, Ohuchi K, Nakamura S, Hara H, Shimazawa M. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018;24:536-545 pubmed
Nicholson A, Zhou X, Perkerson R, Parsons T, Chew J, Brooks M, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathol Commun. 2018;6:42 pubmed 出版商
Uesaka N, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, et al. Retrograde Signaling from Progranulin to Sort1 Counteracts Synapse Elimination in the Developing Cerebellum. Neuron. 2018;97:796-805.e5 pubmed 出版商
Fujita K, Chen X, Homma H, Tagawa K, Amano M, Saito A, et al. Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. Nat Commun. 2018;9:433 pubmed 出版商
Arrant A, Onyilo V, Unger D, Roberson E. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis. J Neurosci. 2018;38:2341-2358 pubmed 出版商
Sugihara H, Miyaji K, Yamanouchi K, Matsuwaki T, Nishihara M. Progranulin deficiency leads to prolonged persistence of macrophages, accompanied with myofiber hypertrophy in regenerating muscle. J Vet Med Sci. 2018;80:346-353 pubmed 出版商
Van Kampen J, Kay D. Progranulin gene delivery reduces plaque burden and synaptic atrophy in a mouse model of Alzheimer's disease. PLoS ONE. 2017;12:e0182896 pubmed 出版商
Zhou X, Paushter D, Feng T, Sun L, Reinheckel T, Hu F. Lysosomal processing of progranulin. Mol Neurodegener. 2017;12:62 pubmed 出版商
Petkau T, Blanco J, Leavitt B. Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice. Neurobiol Dis. 2017;106:14-22 pubmed 出版商
Beel S, Moisse M, Damme M, De Muynck L, Robberecht W, Van Den Bosch L, et al. Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo. Hum Mol Genet. 2017;26:2850-2863 pubmed 出版商
Kuse Y, Tsuruma K, Sugitani S, Izawa H, Ohno Y, Shimazawa M, et al. Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina. Sci Rep. 2016;6:23811 pubmed 出版商
图像
图像 1 :
安迪生物R&D AF2557-SP 图像 1
Detection of Mouse Progranulin/PGRN antibody by Western Blot.
产品信息
品牌 :
R&D Systems
master code :
AF2557
SKU号 :
AF2557-SP
产品名称 :
Mouse Progranulin/PGRN Antibody
描述 :
The Mouse Progranulin/PGRN Antibody from R&D Systems is a sheep polyclonal antibody to Progranulin/PGRN. This antibody reacts with mouse. The Mouse Progranulin/PGRN Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry.
靶标 :
Progranulin/PGRN
类别 :
一抗
单位尺寸 :
25微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
克隆性 :
多克隆
浓度 :
LYOPH
共轭标签 :
未共轭
宿主 :
羊
免疫原 :
Mouse myeloma cell line NS0-derived recombinant mouse Progranulin, Thr18-Leu589, Accession # P28798
抗体亚型 :
IgG
纯度 :
抗原亲和纯化
物种 :
小鼠
特异性 :
Detects mouse Progranulin in direct ELISAs and Western blots. In Western blots, approximately 15% cross-reactivity with recombinant human Progranulin is observed.
基因符号 :
Grn
accessionNumbers :
P28798
应用 :
免疫印迹, 免疫组化, 免疫细胞化学
美元2021 :
129
美元2022 :
135美元
别名 :
Acrogranin, CLN11, GEP, GP88, granulin precursor, GRN, PCDGF, PEPI, PGRN, Proepithelin
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.