产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
VEGFR2/KDR/Flk-1 Antibody
目录 :
AF357
规格 :
100 ug (also 25 ug)
价格 :
489美元
克隆性 :
多克隆
宿主 :
domestic goat
共轭标签 :
未共轭
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 中和反应, 免疫沉淀, 免疫组化-石蜡切片, proximity ligation assay
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 19
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 人类; 图 4c
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed 出版商
  • proximity ligation assay; 人类; 1:100; 图 4b
Morin E, Sjöberg E, Tjomsland V, Testini C, Lindskog C, Franklin O, et al. VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. J Pathol. 2018;246:311-322 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫细胞化学; 人类; 图 2
  • 免疫印迹; 人类; 图 1
Fearnley G, Smith G, Abdul Zani I, Yuldasheva N, Mughal N, Homer Vanniasinkam S, et al. VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis. Biol Open. 2016;5:571-83 pubmed 出版商
Ash D, Sudhahar V, Youn S, Okur M, Das A, O Bryan J, et al. The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2. Nat Commun. 2021;12:3091 pubmed 出版商
Kempers L, Wakayama Y, van der Bijl I, Furumaya C, De Cuyper I, Jongejan A, et al. The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis. Angiogenesis. 2021;24:695-714 pubmed 出版商
Dallinga M, Habani Y, Schimmel A, Dallinga Thie G, Van Noorden C, Klaassen I, et al. The Role of Heparan Sulfate and Neuropilin 2 in VEGFA Signaling in Human Endothelial Tip Cells and Non-Tip Cells during Angiogenesis In Vitro. Cells. 2021;10: pubmed 出版商
Burger S, Meng J, Zwanzig A, Beck M, Pankonin M, Wiedemann P, et al. Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons. Int J Mol Sci. 2020;22: pubmed 出版商
Hu Z, Cano I, Saez Torres K, LeBlanc M, Saint Geniez M, Ng Y, et al. Elements of the Endomucin Extracellular Domain Essential for VEGF-Induced VEGFR2 Activity. Cells. 2020;9: pubmed 出版商
Wei S, Huang Y, Hsieh M, Lin Y, Shyu W, Chen H, et al. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling. Cell Death Dis. 2020;11:307 pubmed 出版商
Fearnley G, Latham A, Hollstein M, Odell A, Ponnambalam S. ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis. Cell Signal. 2020;66:109481 pubmed 出版商
LeBlanc M, Saez Torres K, Cano I, Hu Z, Saint Geniez M, Ng Y, et al. Glycocalyx regulation of vascular endothelial growth factor receptor 2 activity. FASEB J. 2019;:fj201900011R pubmed 出版商
Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, et al. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nat Commun. 2019;10:2350 pubmed 出版商
Fearnley G, Abdul Zani I, Latham A, Hollstein M, Ladbury J, Wheatcroft S, et al. Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function. Biol Open. 2019;8: pubmed 出版商
Tiede C, Bedford R, Heseltine S, Smith G, Wijetunga I, Ross R, et al. Affimer proteins are versatile and renewable affinity reagents. elife. 2017;6: pubmed 出版商
Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed 出版商
Jin Y, Muhl L, Burmakin M, Wang Y, Duchez A, Betsholtz C, et al. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling. Nat Cell Biol. 2017;19:639-652 pubmed 出版商
Heinolainen K, Karaman S, D Amico G, Tammela T, Sormunen R, Eklund L, et al. VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling. Circ Res. 2017;120:1414-1425 pubmed 出版商
Alghanem A, Wilkinson E, Emmett M, Aljasir M, Holmes K, Rothermel B, et al. RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017;20:341-358 pubmed 出版商
Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, et al. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis. J Cell Sci. 2016;129:4091-4104 pubmed
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
AF357
SKU号 :
AF357
产品名称 :
VEGFR2/KDR/Flk-1 Antibody
描述 :
The Human VEGFR2/KDR/Flk-1 Antibody from R&D Systems is a goat polyclonal antibody to VEGFR2/KDR/Flk-1. This antibody reacts with human. The Human VEGFR2/KDR/Flk-1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Neutralization.
靶标 :
VEGFR2/KDR/Flk-1
类别 :
一抗
单位尺寸 :
100 ug (also 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
克隆性 :
多克隆
浓度 :
LYOPH
共轭标签 :
未共轭
宿主 :
山羊
免疫原 :
Mouse myeloma cell line NS0-derived recombinant human VEGFR2/KDR/Flk-1, Ala20-Glu764, Accession # AAC16450
抗体亚型 :
IgG
纯度 :
抗原亲和纯化
物种 :
人类
特异性 :
Detects human VEGFR2/KDR/Flk-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse VEGFR2 is observed and less than 10% cross-reactivity with recombinant human (rh) VEGFR1 and rhVEGFR3 is observed.
基因符号 :
激酶插入区受体
内毒素说明 :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
AAC16450
应用 :
免疫印迹, 免疫组化, 中和反应
美元 :
489美元
别名 :
CD309, CD309 antigen, EC 2.7.10, EC 2.7.10.1, Fetal liver kinase 1, fetal liver kinase-1, Flk1, Flk-1, FLK1tyrosine kinase growth factor receptor, KDR, Kinase insert domain receptor, kinase insert domain receptor (a type III receptor tyrosine kinase), KRD1, Ly73, Protein-tyrosine kinase receptor flk-1, soluble VEGFR2, vascular endothelial growth factor receptor 2, VEGF R2, VEGFR, VEGFR2, VEGFR-2
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.