产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
GLI-3抗体
目录 :
AF3690
规格 :
100 ug (also 25 ug)
价格 :
464美元
克隆性 :
多克隆
宿主 :
domestic goat
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 免疫细胞化学, 染色质免疫沉淀
更多信息或购买 :
文章摘录数: 39
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 1:1000; 图 3a
Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, et al. SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway. Cell Death Discov. 2021;7:120 pubmed 出版商
  • 免疫印迹; 小鼠; 图 3g
Koeniger A, Brichkina A, Nee I, Dempwolff L, Hupfer A, Galperin I, et al. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers (Basel). 2021;13: pubmed 出版商
Schmidt S, Luecken M, Tr xfc mbach D, Hembach S, Niedermeier K, Wenck N, et al. Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun. 2022;13:4819 pubmed 出版商
Sun J, Yoon J, Lee M, Lee H, Hwang Y, Daar I. Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development. Cell Rep. 2022;38:110312 pubmed 出版商
Sharma D, Mirando A, Leinroth A, Long J, Karner C, Hilton M. HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021;17:e1009982 pubmed 出版商
May E, Kalocsay M, D Auriac I, Schuster P, Gygi S, Nachury M, et al. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol. 2021;220: pubmed 出版商
Elliott K, Chen X, Salomone J, Chaturvedi P, Schultz P, Balchand S, et al. Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. elife. 2020;9: pubmed 出版商
Dias J, Alekseenko Z, Jeggari A, Boareto M, Vollmer J, Kozhevnikova M, et al. A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells. Sci Adv. 2020;6: pubmed 出版商
Chottekalapanda R, Kalik S, Gresack J, Ayala A, Gao M, Wang W, et al. AP-1 controls the p11-dependent antidepressant response. Mol Psychiatry. 2020;25:1364-1381 pubmed 出版商
Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, et al. TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nat Commun. 2020;11:2196 pubmed 出版商
Kim Y, Lee J, Seppala M, Cobourne M, Kim S. Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020;11:1994 pubmed 出版商
Liu P, Dodson M, Fang D, Chapman E, Zhang D. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol. 2020;18:e3000620 pubmed 出版商
Bastida M, Pérez Gómez R, Trofka A, Zhu J, Rada Iglesias A, Sheth R, et al. The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. 2020;117:1090-1096 pubmed 出版商
Taroc E, Naik A, Lin J, Peterson N, Keefe D, Genis E, et al. Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration. J Neurosci. 2020;40:311-326 pubmed 出版商
Martin Hurtado A, Martin Morales R, Robledinos Antón N, Blanco R, Palacios Blanco I, Lastres Becker I, et al. NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. Sci Rep. 2019;9:13896 pubmed 出版商
Ma P, Song N, Li Y, Zhang Q, Zhang L, Zhang L, et al. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep. 2019;28:541-553.e4 pubmed 出版商
Kiseleva A, Korobeynikov V, Nikonova A, Zhang P, Makhov P, Deneka A, et al. Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs. Clin Cancer Res. 2019;: pubmed 出版商
Choi Y, Halbritter J, Braun D, Schueler M, Schapiro D, Rim J, et al. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet. 2019;104:45-54 pubmed 出版商
Massa F, Tammaro R, Prado M, Cesana M, Lee B, Finley D, et al. The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2019;28:764-777 pubmed 出版商
He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, et al. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun. 2018;9:3310 pubmed 出版商
Hong S, Wang C, Huang Y, Chang Y, Chang Y, Pusapati G, et al. Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nat Commun. 2018;9:1732 pubmed 出版商
Rosengren T, Larsen L, Pedersen L, Christensen S, Møller L. TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms. Cell Mol Life Sci. 2018;75:2663-2680 pubmed 出版商
Struchtrup A, Wiegering A, Stork B, Ruther U, Gerhardt C. The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts. Autophagy. 2018;14:567-583 pubmed 出版商
Gonnissen A, Isebaert S, Perneel C, McKee C, Van Utterbeeck F, Lerut E, et al. Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients. Am J Pathol. 2018;188:795-804 pubmed 出版商
Veistinen L, Mustonen T, Hasan M, Takatalo M, Kobayashi Y, Kesper D, et al. Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. Front Physiol. 2017;8:1036 pubmed 出版商
Guen V, Chavarria T, Kröger C, Ye X, Weinberg R, Lees J. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Proc Natl Acad Sci U S A. 2017;114:E10532-E10539 pubmed 出版商
Hasegawa D, Ochiai Shino H, Onodera S, Nakamura T, Saito A, Onda T, et al. Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE. 2017;12:e0186879 pubmed 出版商
Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed 出版商
Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-?2 nuclear import system. PLoS Biol. 2017;15:e2002063 pubmed 出版商
Hoelzl M, Heby Henricson K, Gerling M, Dias J, Kuiper R, Trünkle C, et al. Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017;429:132-146 pubmed 出版商
Arensdorf A, Dillard M, Menke J, Frank M, Rock C, Ogden S. Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation. Cell Rep. 2017;19:2074-2087 pubmed 出版商
Cai H, Liu A. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Dev Biol. 2017;432:72-85 pubmed 出版商
Phua S, Chiba S, Suzuki M, Su E, Roberson E, Pusapati G, et al. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017;168:264-279.e15 pubmed 出版商
Makino S, Fukumura R, Gondo Y. Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9. Sci Rep. 2016;6:39608 pubmed 出版商
Cai H, Liu A. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016;113:14751-14756 pubmed 出版商
Chang C, Chang Y, Millington G, Brugmann S. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS Genet. 2016;12:e1006351 pubmed 出版商
Luchetti G, Sircar R, Kong J, Nachtergaele S, Sagner A, Byrne E, et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. elife. 2016;5: pubmed 出版商
Tukachinsky H, Petrov K, Watanabe M, Salic A. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog. Proc Natl Acad Sci U S A. 2016;113:E5866-E5875 pubmed
Emechebe U, Kumar P P, Rozenberg J, Moore B, Firment A, Mirshahi T, et al. T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. elife. 2016;5: pubmed 出版商
图像
图像 1 :
安迪生物R&D AF3690 图像 1
Detection of Mouse GLI-3 antibody by Western Blot.
产品信息
品牌 :
R&D Systems
master code :
AF3690
SKU号 :
AF3690
产品名称 :
GLI-3抗体
描述 :
The Human/Mouse GLI-3 Antibody from R&D Systems is a goat polyclonal antibody to GLI-3. This antibody reacts with human, mouse. The Human/Mouse GLI-3 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry.
靶标 :
GLI-3
类别 :
一抗
单位尺寸 :
100 ug (also 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
克隆性 :
多克隆
浓度 :
LYOPH
共轭标签 :
未共轭
宿主 :
山羊
免疫原 :
E. coli -derived recombinant human GLI-3, Met1-Glu479, Accession # P10071
抗体亚型 :
IgG
纯度 :
免疫原亲和纯化
物种 :
人类, 小鼠
特异性 :
Detects human and mouse GLI-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) GLI-1 and rhGLI-2 is observed.
基因符号 :
GLI3
accessionNumbers :
P10071
应用 :
免疫印迹, 染色质免疫沉淀 (ChIP), 免疫细胞化学
美元 :
464美元
别名 :
ACLS, ACLSPAPAPHS, ADD, Bph, GCPS, GLI family zinc finger 3, GLI3, GLI3 form of 190 kDa, GLI3 full length protein, GLI3-190, GLI3FL, GLI-Kruppel family member GLI3, glioma-associated oncogene family zinc finger 3, Greig cephalopolysyndactyly syndrome, oncogene GLI3, PAP-A, PAPA1, PAPB, PAPBDNA-binding protein, Pdn, PHS, PPDIV, Xt, zinc finger protein GLI3
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.