产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
人类/小鼠/大鼠HIF-1甲/缺氧诱导因子1A抗体
目录 :
MAB1536
规格 :
100 ug (also 25 ug)
价格 :
369美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
241809
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫沉淀, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 43
出版应用/物种/样本/稀释参考文献
  • 免疫组化-石蜡切片; 小鼠; 图 4e
Chi Y, Remšík J, Kiseliovas V, Derderian C, Sener U, Alghader M, et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science. 2020;369:276-282 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Labrousse Arias D, Martínez Alonso E, Corral Escariz M, Bienes Martínez R, Berridy J, Serrano Oviedo L, et al. VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1. J Cell Biol. 2017;216:835-847 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2a
Oh E, Kim J, Kim J, Kim S, Lee J, Hong S, et al. NQO1 inhibits proteasome-mediated degradation of HIF-1α. Nat Commun. 2016;7:13593 pubmed 出版商
  • 免疫印迹; 人类; 图 7d
Scott D, Rhee D, Duda D, Kelsall I, Olszewski J, Paulo J, et al. Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation. Cell. 2016;166:1198-1214.e24 pubmed 出版商
  • 免疫印迹; 大鼠; 图 5a
Suyama K, Silagi E, Choi H, Sakabe K, Mochida J, Shapiro I, et al. Circadian factors BMAL1 and ROR? control HIF-1? transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health. Oncotarget. 2016;7:23056-71 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7a
Sharma B, Kolhe R, Black S, Keller J, Mivechi N, Satyanarayana A. Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells. FASEB J. 2016;30:262-75 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1
Ferreira J, Soares A, Ramalho J, Pereira P, Girao H. K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy. Sci Rep. 2015;5:10210 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Sun Y, George J, Rocha S. Dose-dependent effects of allopurinol on human foreskin fibroblast cells and human umbilical vein endothelial cells under hypoxia. PLoS ONE. 2015;10:e0123649 pubmed 出版商
  • 免疫印迹; 小鼠
Liu H, Xue W, Ge G, Luo X, Li Y, Xiang H, et al. Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1? in MSCs. Biochem Biophys Res Commun. 2010;401:509-15 pubmed 出版商
  • 免疫印迹; 小鼠
Hickey M, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, et al. The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest. 2010;120:827-39 pubmed 出版商
  • 免疫印迹; 人类
Monnier Y, Farmer P, Bieler G, Imaizumi N, Sengstag T, Alghisi G, et al. CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. Cancer Res. 2008;68:7323-31 pubmed 出版商
  • 免疫组化; 小鼠
Taniguchi H, Mohri I, Okabe Arahori H, Kanekiyo T, Kagitani Shimono K, Wada K, et al. Early induction of neuronal lipocalin-type prostaglandin D synthase after hypoxic-ischemic injury in developing brains. Neurosci Lett. 2007;420:39-44 pubmed
Toriuchi K, Kakita H, Tamura T, Takeshita S, Yamada Y, Aoyama M. Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions. J Neuroinflammation. 2020;17:141 pubmed 出版商
Sevilla Montero J, Bienes Martínez R, Labrousse Arias D, Fuertes Yebra E, Ordoñez A, Calzada M. pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines. Sci Rep. 2020;10:1175 pubmed 出版商
Rattila S, Dunk C, Im M, Grichenko O, Zhou Y, Yanez Mo M, et al. Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions. Cells. 2019;8: pubmed 出版商
Jalili Firoozinezhad S, Prantil Baun R, Jiang A, Potla R, Mammoto T, Weaver J, et al. Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip. Cell Death Dis. 2018;9:223 pubmed 出版商
Rao K, Sethi K, Ischia J, Gibson L, Galea L, Xiao L, et al. Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent. PLoS ONE. 2017;12:e0180028 pubmed 出版商
Park C, Ivanova I, Kenneth N. XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys63-linked polyubiquitination. Nucleic Acids Res. 2017;45:9336-9347 pubmed 出版商
Fischer A, Miles S. Silencing HIF-1? induces TET2 expression and augments ascorbic acid induced 5-hydroxymethylation of DNA in human metastatic melanoma cells. Biochem Biophys Res Commun. 2017;490:176-181 pubmed 出版商
Hernansanz Agustín P, Ramos E, Navarro E, Parada E, Sánchez López N, Peláez Aguado L, et al. Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia. Redox Biol. 2017;12:1040-1051 pubmed 出版商
Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, et al. Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency. Cell Metab. 2017;25:1103-1117.e6 pubmed 出版商
Wang P, Lan C, Xiong S, Zhao X, Shan Y, Hu R, et al. HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget. 2017;8:28074-28092 pubmed 出版商
van Gijsel Bonnello M, Baranger K, Benech P, Rivera S, Khrestchatisky M, De Reggi M, et al. Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer's disease: Alleviation by pantethine. PLoS ONE. 2017;12:e0175369 pubmed 出版商
Basavarajappa H, Sulaiman R, Qi X, Shetty T, Sheik Pran Babu S, Sishtla K, et al. Ferrochelatase is a therapeutic target for ocular neovascularization. EMBO Mol Med. 2017;9:786-801 pubmed 出版商
Wei Q, Bian Y, Yu F, Zhang Q, Zhang G, Li Y, et al. Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model. J Biomed Res. 2016;30:490-495 pubmed 出版商
Bhogaraju S, Kalayil S, Liu Y, Bonn F, Colby T, Matic I, et al. Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination. Cell. 2016;167:1636-1649.e13 pubmed 出版商
Gerriets V, Danzaki K, Kishton R, Eisner W, Nichols A, Saucillo D, et al. Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. Eur J Immunol. 2016;46:1970-83 pubmed 出版商
Kim Y, Nam H, Lee J, Park D, Kim C, Yu Y, et al. Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis. Nat Commun. 2016;7:10347 pubmed 出版商
Orr A, Vargas L, Turk C, Baaten J, Matzen J, Dardov V, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11:834-6 pubmed 出版商
Fischer C, Leithner K, Wohlkoenig C, Quehenberger F, Bertsch A, Olschewski A, et al. Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization. Mol Cancer. 2015;14:4 pubmed 出版商
Fujita N, Hirose Y, Tran C, Chiba K, Miyamoto T, Toyama Y, et al. HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells. FASEB J. 2014;28:2455-65 pubmed 出版商
Bruzzese L, Fromonot J, By Y, Durand Gorde J, Condo J, Kipson N, et al. NF-?B enhances hypoxia-driven T-cell immunosuppression via upregulation of adenosine A(2A) receptors. Cell Signal. 2014;26:1060-7 pubmed 出版商
Bett J, Ibrahim A, Garg A, Kelly V, Pedrioli P, Rocha S, et al. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Biochem J. 2013;451:185-94 pubmed 出版商
Kim H, Jeong J, Kim S, Park S, Chae H, Lee Y. Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-?B/HIF-1? signaling pathway. Sci Rep. 2013;3:1142 pubmed 出版商
Zhou J, Joplin D, Cross J, Templeton D. Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. PLoS ONE. 2012;7:e49744 pubmed 出版商
Zhdanov A, Dmitriev R, Papkovsky D. Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. Biosci Rep. 2012;32:587-95 pubmed 出版商
Naranjo Suarez S, Carlson B, Tsuji P, Yoo M, Gladyshev V, Hatfield D. HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS ONE. 2012;7:e30470 pubmed 出版商
Melvin A, Mudie S, Rocha S. The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. Mol Biol Cell. 2011;22:4171-81 pubmed 出版商
van Uden P, Kenneth N, Webster R, Müller H, Mudie S, Rocha S. Evolutionary conserved regulation of HIF-1β by NF-κB. PLoS Genet. 2011;7:e1001285 pubmed 出版商
Newton I, Kenneth N, Appleton P, Näthke I, Rocha S. Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. Mol Biol Cell. 2010;21:3630-8 pubmed 出版商
Pescador N, Villar D, Cifuentes D, Garcia Rocha M, Ortiz Barahona A, Vazquez S, et al. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS ONE. 2010;5:e9644 pubmed 出版商
Zahm A, Bucaro M, Srinivas V, Shapiro I, Adams C. Oxygen tension regulates preosteocyte maturation and mineralization. Bone. 2008;43:25-31 pubmed 出版商
Risbud M, Guttapalli A, Stokes D, Hawkins D, Danielson K, Schaer T, et al. Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem. 2006;98:152-9 pubmed
产品信息
品牌 :
R&D Systems
master code :
MAB1536
SKU号 :
MAB1536
产品名称 :
人类/小鼠/大鼠HIF-1甲/缺氧诱导因子1A抗体
描述 :
The Human/Mouse/Rat HIF-1 alpha/HIF1A Antibody from R&D Systems is a mouse monoclonal antibody to HIF-1 alpha. This antibody reacts with human, mouse, rat. The Human/Mouse/Rat HIF-1 alpha/HIF1A Antibody has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunoprecipitation, Knockout Validated.
靶标 :
HIF-1甲
类别 :
一抗
单位尺寸 :
100 ug (also 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
克隆性 :
单克隆
克隆 :
241809
浓度 :
LYOPH
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
E. coli -derived recombinant human HIF-1 alpha/HIF1A, Arg575-Asn826, Accession # Q16665.1
抗体亚型 :
IgG1
纯度 :
Protein A or G purified from hybridoma culture supernatant
物种 :
人类, 小鼠, 大鼠
特异性 :
Detects human, mouse, and rat HIF-1 alpha/HIF1A.
基因符号 :
缺氧诱导因子1A
catalog number base :
MAB1536
accessionNumbers :
Q16665.1
应用 :
Western Blot, Simple Western, Immunohistochemistry, Immunoprecipitation, Knockout Validated
2020美元 :
349
2021美元 :
369美元
别名 :
AINT, anti-HIF-1 alpha, anti-HIF1A, ARNT interacting protein, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, BHLHE78, Class E basic helix-loop-helix protein 78, HIF 1A, HIF1, HIF1 alpha, HIF-1 alpha, HIF-1a, HIF1A, HIF-1alpha, HIF-1-alpha, HIF1-alpha, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor), hypoxia-inducible factor 1-alpha, Member of PAS protein 1, member of PAS superfamily 1, MOP1, PAS domain-containing protein 8, PASD8
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.