产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
趋化因子受体4抗体
目录 :
MAB170
规格 :
500 ug (also 25 ug)
价格 :
449美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
12G5
反应物种 :
人类
应用 :
中和反应, 流式细胞仪
更多信息或购买 :
文章摘录数: 31
参考文献
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Li S, Fong K, Gritsina G, Zhang A, Zhao J, Kim J, et al. Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer. Cancer Res. 2019;79:2580-2592 pubmed 出版商
Dinkel B, Kremer K, Rollins M, Medlyn M, Hedin K. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion. J Biol Chem. 2018;293:14022-14039 pubmed 出版商
Mills S, Howell L, Beekman A, Stokes L, Mueller A. Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4. Cell Signal. 2018;42:88-96 pubmed 出版商
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Wescott M, Kufareva I, Paes C, Goodman J, Thaker Y, Puffer B, et al. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016;113:9928-33 pubmed 出版商
Lopez Haber C, Barrio Real L, Casado Medrano V, Kazanietz M. Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol. 2016;36:2011-26 pubmed 出版商
Griffiths K, Dolezal O, Cao B, Nilsson S, See H, Pfleger K, et al. i-bodies, Human Single Domain Antibodies That Antagonize Chemokine Receptor CXCR4. J Biol Chem. 2016;291:12641-57 pubmed 出版商
Patrussi L, Capitani N, Martini V, Pizzi M, Trimarco V, Frezzato F, et al. Enhanced Chemokine Receptor Recycling and Impaired S1P1 Expression Promote Leukemic Cell Infiltration of Lymph Nodes in Chronic Lymphocytic Leukemia. Cancer Res. 2015;75:4153-63 pubmed 出版商
Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, et al. Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines. PLoS ONE. 2015;10:e0120069 pubmed 出版商
Zsiros E, Duttagupta P, Dangaj D, Li H, Frank R, Garrabrant T, et al. The Ovarian Cancer Chemokine Landscape Is Conducive to Homing of Vaccine-Primed and CD3/CD28-Costimulated T Cells Prepared for Adoptive Therapy. Clin Cancer Res. 2015;21:2840-50 pubmed 出版商
Lin Y, Yet S, Hsu Y, Wang G, Hung S. Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function. Stem Cells Transl Med. 2015;4:44-55 pubmed 出版商
Park B, Kook S, Lee S, Jeong J, Brufsky A, Lee B. An isoform of C/EBP?, LIP, regulates expression of the chemokine receptor CXCR4 and modulates breast cancer cell migration. J Biol Chem. 2013;288:28656-67 pubmed 出版商
Yasumoto K, Yamada T, Kawashima A, Wang W, Li Q, Donev I, et al. The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancer. Clin Cancer Res. 2011;17:3619-30 pubmed 出版商
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Kobune M, Kawano Y, Takahashi S, Takada K, Murase K, Iyama S, et al. Interaction with human stromal cells enhances CXCR4 expression and engraftment of cord blood Lin(-)CD34(-) cells. Exp Hematol. 2008;36:1121-31 pubmed 出版商
Kaminski A, Ma N, Donndorf P, Lindenblatt N, Feldmeier G, Ong L, et al. Endothelial NOS is required for SDF-1alpha/CXCR4-mediated peripheral endothelial adhesion of c-kit+ bone marrow stem cells. Lab Invest. 2008;88:58-69 pubmed
Ao M, Franco O, Park D, Raman D, Williams K, Hayward S. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res. 2007;67:4244-53 pubmed
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Deiva K, Khiati A, Hery C, Salim H, Leclerc P, Horellou P, et al. CCR5-, DC-SIGN-dependent endocytosis and delayed reverse transcription after human immunodeficiency virus type 1 infection in human astrocytes. AIDS Res Hum Retroviruses. 2006;22:1152-61 pubmed
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图像
图像 1 :
安迪生物R&D MAB170 图像 1
Detection of CXCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.
产品信息
品牌 :
R&D Systems
master code :
MAB170
SKU号 :
MAB170
产品名称 :
趋化因子受体4抗体
描述 :
The CXCR4 Antibody from MAB170 is a mab170 antibody to . The CXCR4 Antibody has been validated for the following applications: P61073.
靶标 :
趋化因子受体4
类别 :
一抗
单位尺寸 :
500 ug (also 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
克隆性 :
单克隆
克隆 :
12G5
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line, Accession # P61073
抗体亚型 :
IgG2a
纯度 :
蛋白质A或G纯化来自腹水
物种 :
人类
特异性 :
Detects human CXCR4
基因符号 :
趋化因子受体4
内毒素说明 :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
P61073
应用 :
Flow Cytometry, Neutralization, CyTOF-reported
美元 :
449美元
别名 :
CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.