产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
IL-6R甲抗体
目录 :
MAB227-100
规格 :
100 ug (also 500 ug, 25 ug)
价格 :
469美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
17506
反应物种 :
人类
应用 :
免疫印迹, 酶联免疫吸附测定, 中和反应, 流式细胞仪
更多信息或购买 :
安迪生物R&D 产品网页
文章摘录数: 20
参考文献
Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed 出版商
Sugahara S, Hanaoka K, Emori T, Takeshita N, Fujii Y, Nakano M, et al. Peficitinib improves bone fragility by recovering bone turnover imbalance in arthritic mice. J Pharmacol Sci. 2022;148:134-141 pubmed 出版商
Kim E, Um H, Park J, Jung J, Kim J, Lee H, et al. TM4SF5-dependent crosstalk between hepatocytes and macrophages to reprogram the inflammatory environment. Cell Rep. 2021;37:110018 pubmed 出版商
Rolvering C, Zimmer A, Ginolhac A, Margue C, Kirchmeyer M, Servais F, et al. The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies. J Leukoc Biol. 2018;104:969-985 pubmed 出版商
Uchibori T, Matsuda K, Shimodaira T, Sugano M, Uehara T, Honda T. IL-6 trans-signaling is another pathway to upregulate Osteopontin. Cytokine. 2017;90:88-95 pubmed 出版商
Munir H, Luu N, Clarke L, Nash G, McGettrick H. Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium. PLoS ONE. 2016;11:e0155161 pubmed 出版商
Sommer A, Fabri M. Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS ONE. 2015;10:e0130395 pubmed 出版商
Resheq Y, Li K, Ward S, Wilhelm A, Garg A, Curbishley S, et al. Contact-dependent depletion of hydrogen peroxide by catalase is a novel mechanism of myeloid-derived suppressor cell induction operating in human hepatic stellate cells. J Immunol. 2015;194:2578-86 pubmed 出版商
Becker T, Boyd S, Mijatov B, Gowrishankar K, Snoyman S, Pupo G, et al. Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene. 2014;33:1158-66 pubmed 出版商
Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-? or IL-10 and are regulated by IL-1?. Nature. 2012;484:514-8 pubmed 出版商
Nieman K, Kenny H, Penicka C, Ladanyi A, Buell Gutbrod R, Zillhardt M, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011;17:1498-503 pubmed 出版商
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol. 2009;10:857-63 pubmed 出版商
Ara T, Song L, Shimada H, Keshelava N, Russell H, Metelitsa L, et al. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009;69:329-37 pubmed 出版商
Kolliputi N, Waxman A. IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol. 2009;40:314-24 pubmed 出版商
Acosta Rodriguez E, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8:942-9 pubmed
Ammit A, Moir L, Oliver B, Hughes J, Alkhouri H, Ge Q, et al. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L199-206 pubmed
Mozaffarian D, Rimm E, King I, Lawler R, McDonald G, Levy W. trans fatty acids and systemic inflammation in heart failure. Am J Clin Nutr. 2004;80:1521-5 pubmed
Hurst S, McLoughlin R, Monslow J, Owens S, Morgan L, Fuller G, et al. Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol. 2002;169:5244-51 pubmed
Erices A, Conget P, Rojas C, Minguell J. Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Exp Cell Res. 2002;280:24-32 pubmed
Hurst S, Wilkinson T, McLoughlin R, Jones S, Horiuchi S, Yamamoto N, et al. Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity. 2001;14:705-14 pubmed
图像
图像 1 :
安迪生物R&D MAB227-100 图像 1
Detection of Recombinant Human IL-6R alpha antibody by Western Blot.
产品信息
品牌 :
R&D Systems, a Bio-Techne Brand
catalog number base :
MAB227
SKU号 :
MAB227-100
产品名称 :
IL-6R甲抗体
描述 :
The Human IL-6R alpha Antibody from R&D Systems is a mouse monoclonal antibody to IL-6R alpha. This antibody reacts with human. The Human IL-6R alpha Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, ELISA Capture (Matched Antibody Pair).
靶标 :
IL-6R甲
类别 :
一抗
单位尺寸 :
100 ug (also 500 ug, 25 ug)
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
克隆性 :
单克隆
克隆 :
17506
共轭标签 :
未共轭
宿主 :
小鼠
免疫原 :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IL-6R alpha, Leu20-Asp339, Accession # P08887
抗体亚型 :
IgG1
纯度 :
Protein A or G purified from hybridoma culture supernatant
物种 :
人类
特异性 :
Detects human IL-6R alpha in ELISAs and Western blots. In ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) IL-1 alpha , recombinant mouse (rm) IL-1 alpha , rhIL-1 beta , rmIL-1 beta , rhIL-1ra, rhIL-2, rhIL-3, rmIL-3, rhIL-4, rmIL-4, rhIL-5, rmIL-5, rhIL-6, rmIL-6, rhIL-7, rmIL-7, rhIL-8, rhIL-9, rmIL-9, rhIL-10, or rhIL-11.
基因符号 :
IL6R
内毒素说明 :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
P08887
应用 :
Western Blot, Flow Cytometry, Neutralization, CyTOF-ready, ELISA Capture (Matched Antibody Pair)
美元 :
469美元
别名 :
CD126, gp80, IL-6 R甲, IL6Q, IL6R, IL6R甲, IL-6R-1, IL6RA, IL-6RA, IL6RQ, 白细胞介素-6受体
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
安迪生物R&D 产品网页
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.