产品简要
公司名称 :
安迪生物R&D
产品类型 :
抗体
产品名称 :
小鼠IL-17/IL-17A抗体
目录 :
MAB421-SP
规格 :
25微克
价格 :
135美元
克隆性 :
单克隆
宿主 :
大鼠
共轭标签 :
未共轭
克隆名称 :
50104
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 中和反应
更多信息或购买 :
文章摘录数: 85
参考文献
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Garth J, Reeder K, Godwin M, Mackel J, Dunaway C, Blackburn J, et al. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection. J Immunol. 2017;199:2140-2148 pubmed 出版商
Davicino R, Méndez Huergo S, Eliçabe R, Stupirski J, Autenrieth I, Di Genaro M, et al. Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity. J Immunol. 2017;199:1382-1392 pubmed 出版商
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Okuyama H, Tominaga A, Fukuoka S, Taguchi T, Kusumoto Y, Ono S. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-?. Oncol Rep. 2017;37:684-694 pubmed 出版商
Qiu A, Bian Z, Mao P, Liu Q. IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling. Exp Mol Med. 2016;48:e280 pubmed 出版商
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Ishizuka M, Miyazaki Y, Masuo M, Suhara K, Tateishi T, Yasui M, et al. Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis. PLoS ONE. 2015;10:e0137978 pubmed 出版商
Liu Y, Li K, Yang L, Tang S, Wang X, Cao G, et al. Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia. PLoS ONE. 2015;10:e0136214 pubmed 出版商
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Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency. J Immunol. 2015;194:5407-16 pubmed 出版商
Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, et al. Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A. PLoS ONE. 2015;10:e0123010 pubmed 出版商
Kim Y, Lim H, Jung H, Wetsel R, Chung Y. Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS ONE. 2015;10:e0120294 pubmed 出版商
Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, et al. Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice. Immunobiology. 2015;220:54-9 pubmed 出版商
Tilahun A, Chowdhary V, David C, Rajagopalan G. Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome. J Immunol. 2014;193:2919-30 pubmed 出版商
Mathews J, Williams A, Brand J, Wurmbrand A, Chen L, Ninin F, et al. γδ T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFα. PLoS ONE. 2014;9:e97707 pubmed 出版商
Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, et al. Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gin. J Biol Chem. 2014;289:15621-30 pubmed 出版商
Klein M, Brouwer M, Angele B, Geldhoff M, Marquez G, Varona R, et al. Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis. PLoS ONE. 2014;9:e93057 pubmed 出版商
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Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, et al. IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-?-activated macrophage programming. J Immunol. 2014;192:704-13 pubmed 出版商
Chong S, Tan K, Wong F, Chua Y, Tang Y, Ng L, et al. CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells. J Invest Dermatol. 2014;134:666-676 pubmed 出版商
Bonnegarde Bernard A, Jee J, Fial M, Aeffner F, Cormet Boyaka E, Davis I, et al. IKK? in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunol. 2014;7:257-67 pubmed 出版商
Wu S, Yu J, Liu F, Miaw S, Wu Hsieh B. Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum. J Immunol. 2013;190:3427-37 pubmed 出版商
Singh T, Schön M, Wallbrecht K, Gruber Wackernagel A, Wang X, Wolf P. Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis. PLoS ONE. 2013;8:e51752 pubmed 出版商
Ano S, Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, et al. Transcription factors GATA-3 and ROR?t are important for determining the phenotype of allergic airway inflammation in a murine model of asthma. J Immunol. 2013;190:1056-65 pubmed 出版商
Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T, et al. Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis. J Immunol. 2013;190:621-9 pubmed 出版商
Noto Llana M, Sarnacki S, Vázquez M, Gartner A, Giacomodonato M, Cerquetti M. Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice. Infect Immun. 2012;80:2231-9 pubmed 出版商
Khader S, Guglani L, Rangel Moreno J, Gopal R, Junecko B, Fountain J, et al. IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. J Immunol. 2011;187:5402-7 pubmed 出版商
Park S, Gupta D, Kim C, Dziarski R. Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS ONE. 2011;6:e24961 pubmed 出版商
Kim H, Go H, Akira S, Chung D. TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice. J Immunol. 2011;187:4007-17 pubmed 出版商
Breslow J, Meissler J, Hartzell R, Spence P, Truant A, Gaughan J, et al. Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Infect Immun. 2011;79:3317-27 pubmed 出版商
Ma Y, Aymeric L, Locher C, Mattarollo S, Delahaye N, Pereira P, et al. Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J Exp Med. 2011;208:491-503 pubmed 出版商
Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W. Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. PLoS ONE. 2010;5:e13349 pubmed 出版商
Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, et al. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J Immunol. 2010;185:5820-7 pubmed 出版商
Wondimu Z, Santodomingo Garzon T, Le T, Swain M. Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Am J Pathol. 2010;177:2334-46 pubmed 出版商
Eliçabe R, Cargnelutti E, Serer M, Stege P, Valdez S, Toscano M, et al. Lack of TNFR p55 results in heightened expression of IFN-? and IL-17 during the development of reactive arthritis. J Immunol. 2010;185:4485-95 pubmed 出版商
De Latour R, Visconte V, Takaku T, Wu C, Erie A, Sarcon A, et al. Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood. 2010;116:4175-84 pubmed 出版商
Cruz A, Fraga A, Fountain J, Rangel Moreno J, Torrado E, Saraiva M, et al. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010;207:1609-16 pubmed 出版商
Redford P, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, et al. Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Eur J Immunol. 2010;40:2200-10 pubmed 出版商
De Luca A, Zelante T, D Angelo C, Zagarella S, Fallarino F, Spreca A, et al. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 2010;3:361-73 pubmed 出版商
Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, et al. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J Immunol. 2010;184:6367-77 pubmed 出版商
Horvat J, Starkey M, Kim R, Beagley K, Preston J, Gibson P, et al. Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. J Immunol. 2010;184:4159-69 pubmed 出版商
Li L, Huang L, Vergis A, Ye H, Bajwa A, Narayan V, et al. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest. 2010;120:331-42 pubmed 出版商
Han G, Wang R, Chen G, Wang J, Xu R, Wang L, et al. Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Immunology. 2010;129:197-206 pubmed 出版商
He R, Kim H, Yoon J, Oyoshi M, MacGinnitie A, Goya S, et al. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009;124:761-70.e1 pubmed 出版商
Bai H, Cheng J, Gao X, Joyee A, Fan Y, Wang S, et al. IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. J Immunol. 2009;183:5886-95 pubmed 出版商
Tigno Aranjuez J, Jaini R, Tuohy V, Lehmann P, Tary Lehmann M. Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells. J Immunol. 2009;183:5654-61 pubmed 出版商
Oyoshi M, Elkhal A, Kumar L, Scott J, Koduru S, He R, et al. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009;106:14954-9 pubmed 出版商
Wu S, Rhee K, Albesiano E, RABIZADEH S, Wu X, Yen H, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 2009;15:1016-22 pubmed 出版商
Park S, Lee K, Kim S, Min K, Choe Y, Moon H, et al. Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. J Immunol. 2009;183:3259-67 pubmed 出版商
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton M, et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol. 2009;183:1291-300 pubmed 出版商
Yuan X, Ansari M, D Addio F, Paez Cortez J, Schmitt I, Donnarumma M, et al. Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Proc Natl Acad Sci U S A. 2009;106:10734-9 pubmed 出版商
Hamada H, Garcia Hernandez M, Reome J, Misra S, Strutt T, McKinstry K, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. J Immunol. 2009;182:3469-81 pubmed 出版商
Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, et al. Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice. Cytokine. 2009;46:79-91 pubmed 出版商
Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, et al. Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Biochem Biophys Res Commun. 2009;382:252-8 pubmed 出版商
Chauhan S, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban D, et al. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J Immunol. 2009;182:1247-52 pubmed
Egan P, van Nieuwenhuijze A, Campbell I, Wicks I. Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis. Arthritis Rheum. 2008;58:3720-9 pubmed 出版商
Koenders M, Devesa I, Marijnissen R, Abdollahi Roodsaz S, Boots A, Walgreen B, et al. Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Arthritis Rheum. 2008;58:3461-70 pubmed 出版商
Burrell B, Csencsits K, Lu G, Grabauskiene S, Bishop D. CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. J Immunol. 2008;181:3906-14 pubmed
Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, et al. Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease. Am J Respir Crit Care Med. 2008;178:379-88 pubmed 出版商
Lee K, Kang M, Lee Y, Kim Y, Kim D, Ko H, et al. A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Cell Immunol. 2008;251:50-5 pubmed 出版商
Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D Angelo C, et al. Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. J Immunol. 2008;180:4022-31 pubmed
Iwanami K, Matsumoto I, Tanaka Watanabe Y, Inoue A, Mihara M, Ohsugi Y, et al. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum. 2008;58:754-63 pubmed 出版商
Romani L, Fallarino F, De Luca A, Montagnoli C, D Angelo C, Zelante T, et al. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature. 2008;451:211-5 pubmed 出版商
Irmler I, Gajda M, Bräuer R. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. J Immunol. 2007;179:6228-36 pubmed
Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol. 2007;37:2695-706 pubmed
He R, Oyoshi M, Jin H, Geha R. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A. 2007;104:15817-22 pubmed
Harris T, Grosso J, Yen H, Xin H, Kortylewski M, Albesiano E, et al. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. J Immunol. 2007;179:4313-7 pubmed
Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna M, Hayashi H, et al. IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17. J Immunol. 2007;179:3917-25 pubmed
Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y. Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. J Immunol. 2007;178:4466-72 pubmed
Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, et al. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J Allergy Clin Immunol. 2007;119:662-70 pubmed
Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhäll C, et al. Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Am J Respir Cell Mol Biol. 2007;36:442-51 pubmed
Sergejeva S, Ivanov S, Lotvall J, Linden A. Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Am J Respir Cell Mol Biol. 2005;33:248-53 pubmed
Burchill M, Nardelli D, England D, DeCoster D, Christopherson J, Callister S, et al. Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Infect Immun. 2003;71:3437-42 pubmed
Miyamoto M, Prause O, Sjöstrand M, Laan M, Lotvall J, Linden A. Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. J Immunol. 2003;170:4665-72 pubmed
图像
图像 1 :
安迪生物R&D MAB421-SP 图像 1
Detection of Recombinant Mouse IL-17/IL-17A antibody by Western Blot.
产品信息
品牌 :
R&D Systems
master code :
MAB421
SKU号 :
MAB421-SP
产品名称 :
小鼠IL-17/IL-17A抗体
描述 :
The Mouse IL-17/IL-17A Antibody from R&D Systems is a rat monoclonal antibody to IL-17/IL-17A. This antibody reacts with mouse. The Mouse IL-17/IL-17A Antibody has been validated for the following applications: Western Blot, Neutralization.
靶标 :
IL-17/IL-17A
类别 :
一抗
单位尺寸 :
25微克
缓冲液 :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
克隆性 :
单克隆
克隆 :
50104
共轭标签 :
未共轭
宿主 :
大鼠
免疫原 :
E. coli -derived recombinant mouse IL-17, Thr22-Ala158, Accession # Q62386
抗体亚型 :
IgG2a
纯度 :
Protein A or G purified from hybridoma culture supernatant
物种 :
小鼠
特异性 :
Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant rat IL-17A and approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
基因符号 :
IL17A
内毒素说明 :
<0.10 EU per 1 µg of the antibody by the LAL method.
accessionNumbers :
Q62386
应用 :
免疫印迹, 中和反应
美元2021 :
129
美元2022 :
135美元
别名 :
CTLA8, CTLA-8, CTLA8cytotoxic T淋巴细胞 丝氨酸酯酶8, 细胞毒性T淋巴细胞 抗原8, 白细胞介素-17, IL17A, IL-17A, IL-17Acytotoxic T淋巴细胞 蛋白8, IL-17CTLA-8, IL17interleukin-17A, 白细胞介素17(细胞毒性T淋巴细胞 丝氨酸酯酶8), 白细胞介素17A
储存 :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
更多信息或购买 :
公司信息
安迪生物R&D
上海市长宁区延安西路726号华敏翰尊国际大厦24A1
info@rndsystemschina.com.cn
http://www.rndsystemschina.com.cn
21 52380373
公司总部: 美国
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.