抗体

Malin Antibody

200-301-W58

100微克

单克隆

小鼠

未共轭

S85-18

免疫印迹, 酶联免疫吸附测定

Anti-Malin (MOUSE) Monoclonal Antibody - 200-301-W58

Malin Antibody

Anti-Malin antibody is suited for use in Western Blots and Immunocytochemistry. Expect a band approximately ~42 kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user.

0.02 M钾磷酸盐, 0.15 M氯化钠, pH值7.2

单克隆

S85-18

1毫克/毫升

by UV absorbance at 280 nm

(None)

100微克

微克

1:10,000

1:1000

Expiration date is one (1) year from date of opening.

IgG1

NHLRC1

小鼠

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Anti-Malin Antibody was created by repeated immunization of mice with a fusion protein of amino acids 2-125 of human Malin.

Wet Ice

Liquid (sterile filtered)

0.1%(w/v)叠氮化钠

Anti-Malin Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests 86% similarity to rat and 77% similarity to mouse.

人类

50%(v/v)甘油

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

IgG1

E3 ubiquitin-protein ligase NHLRC1, NHLRC 1, NHL repeat containing 1, EPM2A, EPM2B, MGC119262, MGC119264, MGC119265, NHL repeat containing protein 1

人类

Progressive myoclonic epilepsy type 2 (EPM2), also called Lafora disease, is an autosomal recessive disease characterized by grand mal seizures and/or myoclonus at about 15 years of age. Rapid and severe mental deterioration follows, often with psychotic features. Survival is less than 10 years after onset. Starch-like, endoplasmic reticulum-associated polyglucosans, called Lafora bodies, can be observed in brain, muscle, liver and heart. One cause of Lafora disease is due to mutations in NHLRC1, the gene encoding Malin. Forty-nine different mutations in NHLRC1 have been shown to cause EPM2. Malin, also called NHL repeat-containing protein 1, is a single subunit E3 ubiquitin ligase, containing 6 NHL repeats and 1 RING-type zinc finger. Malin’s RING domain is responsible for its ability to mediate ubiquitination. Malin interacts with and polyubiquitinates Laforin, a protein also implicated in EPM2. Malin localizes to the endoplasmic reticulum and, to a lesser extent, in the nucleus. Malin is expressed in brain, cerebellum, spinal cord, medulla, heart, liver, skeletal muscle and pancreas. Anti-Malin is ideal for researchers interested in Neuroscience, including Neuroleptic malignant syndrome, and pathways related to antigen processing, ubiquination and proteosome degradation.

重组蛋白

No

No

N末端

酶联免疫吸附测定, 免疫印迹

一抗

未共轭

Q6VVB1