产品简要
公司名称 :
Rockland Immunochemicals
产品类型 :
抗体
产品名称 :
TIRAP抗体
目录 :
200-401-A67
规格 :
100微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化
更多信息或购买 :
产品信息
目录号 :
200-401-A67
名称 :
抗TIRAP(兔)抗体-200-401
显示名称 :
TIRAP抗体
应用注释 :
Anti-TIRAP antibody has been tested for use in ELISA, immunohistochemistry, IF, and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band at ~34 kDa in size corresponding to TIRAP by western blotting in the appropriate cell lysate or extract.
缓冲液 :
0.02 M钾磷酸盐, 0.15 M氯化钠, pH值7.2
克隆性 :
多克隆
浓度值 :
1.0毫克/毫升
浓度定义 :
by UV absorbance at 280 nm
共轭 :
(None)
规格 :
100微克
默认单元 :
微克
ELISA稀释浓度 :
1:10, 000 - 1:40, 000
免疫组化稀释度 :
2微克/毫升
免疫荧光显微镜稀释浓度 :
10µg/毫升
免疫印迹稀释浓度 :
1:500 - 1:3, 000
有效期 :
Expiration date is one (1) year from date of opening.
格式 :
IgG
基因名称 :
TIRAP
宿主动物 :
一般免责声明 :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
免疫原 :
TIRAP Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the C-terminus of mouse TIRAP.
包装类型 :
干冰
物理状态 :
Liquid (sterile filtered)
防腐剂 :
0.01%(w/v)叠氮化钠
纯度和特异性 :
Anti-TIRAP Antibody was purified from monospecific antiserum. This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above. A BLAST analysis was used to suggest cross-reactivity with TIRAP with Human, Mouse and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with TIRAP from other sources has not been determined.
物种活性 :
人类, 小鼠, 大鼠
储存 :
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
同义词 :
Adapter protein wyatt antibody, FLJ42305 antibody, MAL antibody, MyD88 adapter like protein antibody, TIR domain containing adapter protein antibody, Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody
靶物种 :
小鼠
背景 :
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses.  These proteins act through adaptor molecules such as TIRAP (Toll-interleukin 1 receptor domain-containing adaptor protein) and MyD88 to activate various kinases and transcription factors.  In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 or TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.  Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling. Anti-TIRAP antibody is ideal for investigators involved cytokines and growth factors research.
免疫原类型 :
多肽
低内毒素 :
No
样品尺寸 :
No
靶活性结构域 :
C末端
应用文本 :
酶联免疫吸附测定, 免疫组化, IF显微镜, 免疫印迹
其他 :
User Optimized
类别 :
一抗
共轭名称 :
未共轭
UniProt数据库 :
Q99JY1
NCBI :
NP_001171318.1
最初图像名称 :
Western Blot of TIRAP antibody.
更多信息或购买 :
公司信息
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
orders@rockland-inc.com
https://www.rockland.com/
800-656-7625
公司总部: 美国
Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部,为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立,利用In vitro及In vivo方法制备并纯化单抗及多抗,这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究:Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。