p53 K372 me1抗体
抗p53 K372 me1(兔)抗体-200-401
p53 K372 me1抗体
Anti-p53 K372 me1 Antibody is suitable for Chromatin Immunoprecipitation and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 47kDa in the appropriate cell lysate or extract.
0.01 M钠磷酸盐, 0.25 M氯化钠, pH值7.2
by UV absorbance at 280 nm
5 μg per IP
Expiration date is one (1) year from date of opening.
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Anti-p53 K372 me1 Antibody was produced in rabbits by repeated immunizations with a synthetic peptide of human p53 methylated at K372.
Liquid (sterile filtered)
Anti-p53 K372 me1 Antibody was purified by Protein G chromatography. Cross reactivity with other species was not tested.
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, transcription factor p53, TRP53, LSF1
The transcription factor p53 is a tumor suppressor that regulates the cellular response to diverse cellular stresses. Upon activation, p53 induces several target genes which leads to cell cycle arrest and DNA repair, or alternatively, to apoptosis. In unstressed cells, p53 is kept inactive by the ubiquitin ligase MDM2 which inhibits the activity and promotes the degradation. p53 is a short-lived protein which is activated and stabilized via different post-translational modifications. One of these modifications, methylation of lysine 372 has been shown to positively affect the stability of p53. Mutations in p53 are involved in a vast majority of human cancers. Anti-p53 K372 me1 Antibody is ideal for research in Gene Expression, Cell Cycle Control, Apoptosis and Cancer.
Western Blot of anti-p53 K372 me1 antibody
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Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部，为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立，利用In vitro及In vivo方法制备并纯化单抗及多抗，这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究：Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。