抗体

NMDA NR2B亚单位抗体

600-401-C87

10微克

多克隆

domestic rabbit

未共轭

人类, 小鼠, 大鼠

免疫印迹, 免疫组化, 免疫沉淀

抗NMDA NR2B亚单位(兔)抗体-600-401

NMDA NR2B亚单位抗体

Anti-NMDA NR2B subunit (Rabbit) antibody is suitable for use in Western Blotting, Immunoprecipitation and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band or approximately 180 kDa in size corresponding to the NR2B subunit of the NMDA receptor in the appropriate cell lysate or extract.

多克隆

Titrated value sufficient to run approximately 10 mini blots.

(None)

10微克

微克

1:1000-1:2000

3μl per 200μg lysate

1:1000

Expiration date is one (1) year from date of opening.

IgG

Grin2b

兔

This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.

Anti-NMDA NR2B Antibody was produced by repeated immunizations with a fusion protein from the C-terminal region NR2B subunit.

Ambient

冻干

Anti-NMDA 2B antibody is directed against NMDA receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. The antibody recognizes human, mouse and rat forms of the NR2B subunits of NMDAR. Immunolabeling is blocked by pre-adsorption of antibody with the fusion protein used to generate the antibody. No reactivity towards the NR2A and NR2C subunits was seen. This antibody is lyophilized from 5 mM ammonium bicarbonate.

Neutral PBS

50µL

大鼠, 小鼠, 人类

Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.

Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, Grin2b

大鼠

NMDA 2B antibody detects NMDA 2B receptor protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS. The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned and it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. The NMDAR is also potentiated by protein phosphorylation. Anti-NMDA 2B antibody is ideal for investigators involved in Cell Signaling, Neuroscience, and Signal Transduction research

重组蛋白

No

No

C末端

免疫组化, 免疫沉淀, 免疫印迹

User Optimized

一抗

未共轭

Q00960

NP_036706.1

Western blot of NMDA NR2B Subunit Antibody