产品简要
公司名称 :
Rockland Immunochemicals
产品类型 :
抗体
产品名称 :
NMDA R1, Splice Variant C2 Antibody
目录 :
600-401-D86
规格 :
25微克
价格 :
366美元
克隆性 :
多克隆
宿主 :
共轭标签 :
未共轭
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 免疫组化
更多信息或购买 :
产品信息
目录号 :
600-401-D86
名称 :
Anti-NMDA R1, Splice Variant C2 (Rabbit) Antibody - 600-401-D86
显示名称 :
NMDA R1, Splice Variant C2 Antibody
应用注释 :
Anti-NMDA R1, Splice Variant C2 (Rabbit) Antibody is suitable for use in Western Blotting and IHC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 120 kDa in size corresponding to the NMDA Receptor containing the C2 splice variant insert in the appropriate cell lysate or extract.
克隆性 :
多克隆
浓度值 :
Titrated value sufficient to run approximately 10 mini blots.
共轭 :
(None)
规格 :
25微克
默认单元 :
微克
免疫组化稀释度 :
1:1000-2000
免疫印迹稀释浓度 :
1:1000
有效期 :
Expiration date is one (1) year from date of opening.
格式 :
IgG
基因名称 :
Grin1
宿主动物 :
一般免责声明 :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
免疫原 :
Anti-NMDA R1, Splice Variant C2 Antibody was produced by repeated immunizations with a synthetic peptide corresponding to amino acid residues specific to the NR1 subunit, C2 splice variant insert.
包装类型 :
Ambient
物理状态 :
冻干
纯度和特异性 :
Anti-NMDA R1, Splice Variant C2 antibody is directed against NMDA R1 receptor protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. This antibody does not recognize the NR1 subunits of the NMDA receptor that do not contain the C2 insert. Reactivity is expected from the following species based on 100% sequence homology: human.
重组缓冲液 :
Neutral PBS
重组体积 :
50µL
物种活性 :
大鼠, 小鼠
储存 :
Store vial at 4° C prior to restoration.   For extended storage aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing.  Centrifuge product if not completely clear after standing at room temperature.  Dilute only prior to immediate use.
同义词 :
Glutamate [NMDA] receptor subunit zeta-1,N-methyl-D-aspartate receptor subunit NR1, NMD-R1, Grin1
靶物种 :
大鼠
背景 :
NMDA R1, Splice Variant C2 antibody detects NMDA R1 receptor protein. The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA Receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death. There are a number of different splice variants of the NR1 subunit. Differential splicing of three exons in the NR1 subunit generates up to eight NR1 subunit splice variants and 7 of these have been identified in cDNA libraries. These exons encode a 21 amino acid N-terminal domain (N1) and adjacent sequences in the C-terminus (C1 and C2). Splicing out the C2 cassette eliminates the first stop codon and produces a new reading frame that generates a new sequence of 22 amino acids (C2'). Considerable attention has been focused on the distribution and expression of these splice variants that may affect the functional properties and regulation of the NMDAR. Anti-NMDA R1, Splice Variant C2 Antibody is ideal for investigators involved in Neuroscience and Signal Transduction research.
一般参考 :
Carroll RC and Zukin RS (2002). NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity. Trends Neurosci 25:571-577. Foldes RL, Rampersad V and Kamboj RK (1994). Cloning and sequence analysis of additional splice variants encoding human N-methyl-D-aspartate receptor (hNR1) subunits. Gene 147:303-304. Grosshans DR, Clayton DA, Coultrap SJ and Browning MD (2002). LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1. Nat Neurosci 5:27-33. Wenthold RJ, Prybylowski K, Standley S, Sans N and Petralia RS (2003). Trafficking of NMDA receptors. Annu Rev Pharmacol Toxicol 43:335-358. Zukin RS and Bennett MVL (1995). Alternatively spliced isoforms of the NMDARI receptor subunit. Trends Neurosci 18:306-313. Fan M, Fernandes H, Zhang L, Hayden M and Raymond L (2007). Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's DiseaseJ. Neurosci., 27: 3768 - 3779.
免疫原类型 :
多肽
低内毒素 :
No
样品尺寸 :
No
靶活性结构域 :
内部
应用文本 :
免疫组化, 免疫印迹
其他 :
User Optimized
类别 :
一抗
共轭名称 :
未共轭
2020价格 :
366美元
UniProt数据库 :
P35439
NCBI :
NP_058706.1
最初图像名称 :
Western blot of Anti-NMDA R1, Splice Variant C2 (Rabbit) Antibody - 600-401-D86
更多信息或购买 :
公司信息
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
orders@rockland-inc.com
https://rockland-inc.com
800-656-7625
公司总部: 美国
Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部,为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立,利用In vitro及In vivo方法制备并纯化单抗及多抗,这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究:Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。