产品简要
公司名称 :
Rockland Immunochemicals
产品类型 :
抗体
产品名称 :
磷酸酶张力蛋白同源基因抗体
目录 :
600-401-DU4
规格 :
100微克
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
人类, 小鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录号 :
600-401-DU4
名称 :
抗磷酸酶张力蛋白同源基因(兔)抗体-600-401
显示名称 :
磷酸酶张力蛋白同源基因抗体
应用注释 :
Anti-PTEN Antibody has been tested for use in ELISA, Western Blotting and Immunoprecipitation. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 47 kDa in Western Blots of specific cell lysates and tissues.
缓冲液 :
0.01 M钠磷酸盐, 0.25 M氯化钠, pH值7.2
克隆性 :
多克隆
浓度值 :
1毫克/毫升
浓度定义 :
by UV absorbance at 280 nm
共轭 :
(None)
规格 :
100微克
默认单元 :
微克
ELISA稀释浓度 :
1:10,000
免疫印迹稀释浓度 :
1微克/毫升
有效期 :
Expiration date is one (1) year from date of opening.
格式 :
IgG
基因名称 :
磷酸酶张力蛋白同源基因
宿主动物 :
一般免责声明 :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
免疫原 :
Anti-PTEN antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human PTEN.
包装类型 :
干冰
物理状态 :
Liquid (sterile filtered)
防腐剂 :
0.02%(w/v)叠氮化钠
纯度和特异性 :
Anti-PTEN Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PTEN from other sources has not been determined.
物种活性 :
人类, 小鼠
储存 :
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
同义词 :
PTEN Antibody, BZS, DEC, CWS1, GLM2, MHAM, TEP1, MMAC1, PTEN1, 10q23del, Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1
靶物种 :
人类
背景 :
PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.
免疫原类型 :
多肽
低内毒素 :
No
样品尺寸 :
No
靶活性结构域 :
C末端
应用文本 :
酶联免疫吸附测定, 免疫印迹
类别 :
一抗
共轭名称 :
未共轭
UniProt数据库 :
P60484
NCBI :
P60484
最初图像名称 :
Western Blot of PTEN Antibody
更多信息或购买 :
公司信息
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
orders@rockland-inc.com
https://www.rockland.com/
800-656-7625
公司总部: 美国
Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部,为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立,利用In vitro及In vivo方法制备并纯化单抗及多抗,这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究:Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。