产品简要
公司名称 :
Rockland Immunochemicals
产品类型 :
抗体
产品名称 :
SNAP25磷酸化S187抗体
目录 :
600-401-X28
规格 :
100微升
克隆性 :
多克隆
宿主 :
domestic rabbit
共轭标签 :
未共轭
反应物种 :
小鼠, 大鼠
应用 :
免疫印迹, 酶联免疫吸附测定
更多信息或购买 :
产品信息
目录号 :
600-401-X28
名称 :
抗SNAP25 pS187(兔)抗体-600-401
显示名称 :
SNAP25磷酸化S187抗体
应用注释 :
Anti-Phospho-Ser187 SNAP25 Antibody is suitable for Western Blots and is specific for the ~25 kDa SNAP25 protein phosphorylated at Ser187 in Western blots. Immunolabeling is completely blocked by blocked lambda-Phosphatase. Specific conditions for reactivity should be optimized by the end user.
缓冲液 :
0.01 M羟乙基哌嗪乙磺酸, 0.15 M氯化钠, pH值7.5
克隆性 :
多克隆
共轭 :
(None)
规格 :
100微升
默认单元 :
微升
ELISA稀释浓度 :
1:10,000
免疫印迹稀释浓度 :
1:1000
有效期 :
Expiration date is one (1) year from date of opening.
格式 :
IgG
基因名称 :
Snap25
宿主动物 :
一般免责声明 :
This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
免疫原 :
Anti-Phospho-Ser187 SNAP25 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Ser187 of rat SNAP25 conjugated to KLH.
包装类型 :
Wet Ice
物理状态 :
Liquid (sterile filtered)
纯度和特异性 :
Anti-Phospho-Ser187 SNAP25 Antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities. Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. This antibody is specific for phosphorylated SNAP25. Minimal reactivity occurs against non-phosphorylated SNAP25. Reactivity against SNAP25 occurs from rat sources. However, reactivity is also expected against guinea pig, human, non-human primate, zebra fish based on 100% sequence homology.
物种活性 :
小鼠, 大鼠
稳定剂 :
0.1毫克/毫升牛血清白蛋白(BSA)-不含IgG和蛋白酶, 50%(v/v)甘油
储存 :
Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilut
同义词 :
Synaptosomal-associated protein 25, SNAP-25, Super Protein, SUP, Synaptosoma-associated 25 kDa protein
靶物种 :
大鼠
背景 :
SNAP25 (Synaptosomal associated protein of 25 kDa) is a presynaptic plasma membrane protein that is widely distributed throughout the brain and involved in the regulation of neurotransmitter release. Decreased levels of SNAP25 have been found in the brains of patients with Down Syndrome and Alzheimer’s Disease. In addition, a significant reduction in the hippocampal expression of SNAP25 has also been found in patients with Schizophrenia. Increasing evidence suggests that SNAP-25 also modulates various ion channels, including voltage gated calcium channels (VGCCs). Activation of PKC results in the phosphorylation of SNAP-25 on ser187. Phosphorylation of SNAP25 on ser187 is believed to cause inhibition of VGCC. Since ser187 phosphorylation is transiently induced by neuronal activity, SNAP25 creates a negative feedback mechanism for controlling neuronal excitability. SNAP25 pS187 Antibody is ideal for researchers interested in neuroscience research.
免疫原类型 :
多肽
低内毒素 :
No
翻译后的修饰作用 :
磷酸化
样品尺寸 :
No
靶活性结构域 :
内部
应用文本 :
酶联免疫吸附测定, 免疫印迹
类别 :
一抗
共轭名称 :
未共轭
UniProt数据库 :
P60881
NCBI :
NP_001257504.1
更多信息或购买 :
公司信息
Rockland Immunochemicals
321 Jones Blvd
Pottstown, PA 19464
orders@rockland-inc.com
https://www.rockland.com/
800-656-7625
公司总部: 美国
Rockland Immunochemicals, Inc.位于宾夕法尼亚州的费城西部,为基础研究、应用研究及临床研究提供磷酸化位点特异性抗体及抗体相关研究工具。公司的技术平台是由一批经验丰富的科学家建立,利用In vitro及In vivo方法制备并纯化单抗及多抗,这些抗体应用于免疫印迹、ELISA、免疫组化、荧光检测、高通量筛选及诊断试剂盒生产等。常用一抗主要应用于以下研究:Akt通路、载脂蛋白、细胞凋亡/细胞周期、细胞因子、细胞信号、酶类、胞外基质、转录因子及泛素相关领域。