公司名称 :
产品类型 :
产品名称 :
目录 :
规格 :
价格 :
克隆性 :
宿主 :
共轭标签 :
克隆名称 :
反应物种 :
人类, 小鼠, 大鼠
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 染色质免疫沉淀 , 免疫组化-石蜡切片, ChIP-Seq, 其他, 免疫印迹基因敲除验证, 免疫细胞化学基因敲除验证
更多信息或购买 :
文章摘录数: 930
  • 免疫印迹; 人类; 1:1000; 图 s11c
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, et al. An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity. Nat Commun. 2020;11:1310 pubmed 出版商
  • 免疫印迹; 人类; 图 4i
Pothuraju R, Rachagani S, Krishn S, Chaudhary S, Nimmakayala R, Siddiqui J, et al. Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance. Mol Cancer. 2020;19:37 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5a
El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed 出版商
  • 免疫印迹; 人类; 图 3s2d
Kabir S, Cidado J, Andersen C, Dick C, Lin P, Mitros T, et al. The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. elife. 2019;8: pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s2c
Wiel C, Le Gal K, Ibrahim M, Jahangir C, Kashif M, Yao H, et al. BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Cell. 2019;: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3g
Hari P, Millar F, Tarrats N, Birch J, Quintanilla A, Rink C, et al. The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype. Sci Adv. 2019;5:eaaw0254 pubmed 出版商
  • 免疫印迹; 人类; 1:10,000; 图 3i
Benyelles M, Episkopou H, O Donohue M, Kermasson L, Frange P, Poulain F, et al. Impaired telomere integrity and rRNA biogenesis in PARN-deficient patients and knock-out models. EMBO Mol Med. 2019;: pubmed 出版商
  • 免疫细胞化学; 人类; 图 s1a
  • 免疫印迹; 人类; 图 3a
Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix F, et al. Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence. Aging Cell. 2019;18:e12981 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2
Shin Y, Kim Y, Wen X, Cho N, Lee S, Kim W, et al. Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer. Clin Epigenetics. 2019;11:77 pubmed 出版商
  • 免疫沉淀; 小鼠; 图 s5b
Goodman D, Pretto C, Krepostman T, Carnahan K, Spindler K. Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). MBio. 2019;10: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s8a
Pillay N, Tighe A, Nelson L, Littler S, Coulson Gilmer C, Bah N, et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors. Cancer Cell. 2019;35:519-533.e8 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Chen H, Poran A, Unni A, Huang S, Elemento O, Snoeck H, et al. Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells. J Exp Med. 2019;216:674-687 pubmed 出版商
  • 免疫印迹; 人类; 图 ev2h
Zhao Y, Ding L, Wang D, Ye Z, He Y, Ma L, et al. EZH2 cooperates with gain-of-function p53 mutants to promote cancer growth and metastasis. EMBO J. 2019;38: pubmed 出版商
  • 免疫印迹; 人类; 图 3d
Wu Y, Li X, Yu J, Bjorkholm M, Xu D. ASF1a inhibition induces p53-dependent growth arrest and senescence of cancer cells. Cell Death Dis. 2019;10:76 pubmed 出版商
  • 免疫细胞化学; 人类; 图 e8a
  • 免疫印迹; 人类; 图 e1b, e1d, e1e
Nassour J, Radford R, Correia A, Fusté J, Schoell B, Jauch A, et al. Autophagic cell death restricts chromosomal instability during replicative crisis. Nature. 2019;565:659-663 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 3a
Sachs N, Papaspyropoulos A, Zomer van Ommen D, Heo I, Böttinger L, Klay D, et al. Long-term expanding human airway organoids for disease modeling. EMBO J. 2019;38: pubmed 出版商
  • 免疫印迹; 人类; 图 s3f
Mohni K, Wessel S, Zhao R, Wojciechowski A, Luzwick J, Layden H, et al. HMCES Maintains Genome Integrity by Shielding Abasic Sites in Single-Strand DNA. Cell. 2019;176:144-153.e13 pubmed 出版商
  • 免疫印迹; 人类; 图 3g
Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, et al. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner. Oncogene. 2019;38:2501-2515 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:2500; 图 1b, 4c, s3c
  • 免疫印迹; 人类; 1:2500; 图 1a, 2b, 2h
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Kim S, Jin H, Seo H, Lee H, Lee Y. Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death Differ. 2019;26:812-825 pubmed 出版商
  • 免疫组化; 人类; 1:100; 图 4j
  • 免疫印迹; 人类; 1:100; 图 4d
Jeon Y, Kim T, Park D, Nuovo G, Rhee S, Joshi P, et al. miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC. Nat Commun. 2018;9:5110 pubmed 出版商
  • 免疫印迹; 人类; 图 3k
Tan P, Ye Y, He L, Xie J, Jing J, Ma G, et al. TRIM59 promotes breast cancer motility by suppressing p62-selective autophagic degradation of PDCD10. PLoS Biol. 2018;16:e3000051 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5d
Ivanyi Nagy R, Ahmed S, Peter S, Ramani P, Ong P, Dreesen O, et al. The RNA interactome of human telomerase RNA reveals a coding-independent role for a histone mRNA in telomere homeostasis. elife. 2018;7: pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7a
Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, et al. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018;9:4394 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2j
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018;20:1181-1192 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s5b
Tajan M, Hock A, Blagih J, Robertson N, Labuschagne C, Kruiswijk F, et al. A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3. Cell Metab. 2018;28:721-736.e6 pubmed 出版商
  • 免疫印迹; 人类; 图 5c
Komori H, Goto Y, Kurayoshi K, Ozono E, Iwanaga R, Bradford A, et al. Differential requirement for dimerization partner DP between E2F-dependent activation of tumor suppressor and growth-related genes. Sci Rep. 2018;8:8438 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 s11c
Li F, Liu J, Bao R, Yan G, Feng X, Xu Y, et al. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018;9:508 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 1a
Gong L, Pan X, Lim C, de Polo A, Little J, Yuan Z. A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Oncogene. 2018;37:2150-2164 pubmed 出版商
  • 免疫印迹; 人类; 图 1e
Tanaka N, Zhao M, Tang L, Patel A, Xi Q, Van H, et al. Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1. Oncogene. 2018;37:1279-1292 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Wu J, Xiang S, Zhang M, Fang B, Huang H, Kwon O, et al. Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity. J Biol Chem. 2018;293:1976-1993 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Zhang F, Virshup D, Cheong J. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. 2018;37:363-376 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Reuther C, Heinzle V, Nölting S, Herterich S, Hahner S, Halilovic E, et al. The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. Neuroendocrinology. 2018;106:1-19 pubmed 出版商
  • 免疫细胞化学基因敲除验证; 人类; 图 2b
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 2c
Mircetic J, Dietrich A, Paszkowski Rogacz M, Krause M, Buchholz F. Development of a genetic sensor that eliminates p53 deficient cells. Nat Commun. 2017;8:1463 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Thaler S, Schmidt M, Roβwag S, Thiede G, Schad A, Sleeman J. Proteasome inhibitors prevent bi-directional HER2/estrogen-receptor cross-talk leading to cell death in endocrine and lapatinib-resistant HER2+/ER+ breast cancer cells. Oncotarget. 2017;8:72281-72301 pubmed 出版商
  • 免疫沉淀; 人类; 图 3e
  • 免疫印迹; 人类; 1:1000; 图 3a
Huang C, Wu S, Ji H, Yan X, Xie Y, Murai S, et al. Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library. Sci Adv. 2017;3:e1701383 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2d
  • 免疫印迹; 人类; 图 2g
Periyasamy M, Singh A, Gemma C, Kranjec C, Farzan R, Leach D, et al. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells. Nucleic Acids Res. 2017;45:11056-11069 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Giono L, Resnick Silverman L, Carvajal L, St Clair S, Manfredi J. Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase. Oncogene. 2017;36:6762-6773 pubmed 出版商
  • 免疫印迹; 人类; 图 s2b
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3e
Szoka L, Karna E, Hlebowicz Sarat K, Karaszewski J, Palka J. Exogenous proline stimulates type I collagen and HIF-1? expression and the process is attenuated by glutamine in human skin fibroblasts. Mol Cell Biochem. 2017;435:197-206 pubmed 出版商
  • 免疫印迹; 小鼠; 图 2f
Read M, Fong J, Modasia B, Fletcher A, Imruetaicharoenchoke W, Thompson R, et al. Elevated PTTG and PBF predicts poor patient outcome and modulates DNA damage response genes in thyroid cancer. Oncogene. 2017;36:5296-5308 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1f
  • 免疫印迹; 人类; 图 1f
Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4a
Yang X, Qi L, Lin F, Ou Z. The role of the chemokine receptor XCR1 in breast cancer cells. Breast Cancer (Dove Med Press). 2017;9:227-236 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
He L, Luo L, Zhu H, Yang H, Zhang Y, Wu H, et al. FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer. Mol Oncol. 2017;11:640-654 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s1d
Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed 出版商
  • 免疫印迹; 人类; 图 s1b
Fumagalli A, Drost J, Suijkerbuijk S, van Boxtel R, de Ligt J, Offerhaus G, et al. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proc Natl Acad Sci U S A. 2017;114:E2357-E2364 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Yan H, Zhang Y, Zhang Y, Ren X, Shen Y, Cheng M, et al. CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines. Biochim Biophys Acta Gene Regul Mech. 2017;1860:516-522 pubmed 出版商
  • 免疫印迹; 小鼠; 图 4a
Singh V, Katta S, Kumar S. WD-repeat protein WDR13 is a novel transcriptional regulator of c-Jun and modulates intestinal homeostasis in mice. BMC Cancer. 2017;17:148 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Shin S, Song J, Hwang B, Noh D, Park S, Kim W, et al. HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation. PLoS ONE. 2017;12:e0171860 pubmed 出版商
  • 免疫印迹; 小鼠; 图 6c
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed 出版商
  • 免疫沉淀; 人类; 图 3a
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类; 图 1a
Liu T, Krysiak K, Shirai C, Kim S, Shao J, Ndonwi M, et al. Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells. PLoS ONE. 2017;12:e0170470 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500; 图 6a
  • 免疫印迹; 人类; 图 5a
Coaxum S, Tiedeken J, Garrett Mayer E, Myers J, Rosenzweig S, Neskey D. The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer. Oncotarget. 2017;8:22991-23007 pubmed 出版商
  • 免疫印迹; 人类; 图 8a
Squillaro T, Antonucci I, Alessio N, Esposito A, Cipollaro M, Melone M, et al. Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes. J Cell Physiol. 2017;232:3454-3467 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;36:3274-3286 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2D
  • 免疫沉淀; 人类; 图 6D
Castellini L, Moon E, Razorenova O, Krieg A, von Eyben R, Giaccia A. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017;45:3674-3692 pubmed 出版商
  • 免疫印迹; 人类; 图 5f
Riverso M, Montagnani V, Stecca B. KLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. Oncogene. 2017;36:3322-3333 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 4h-s
  • 免疫细胞化学; 人类; 图 4a-f
  • 免疫印迹; 人类; 图 2a
De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, et al. Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation. J Pathol. 2017;242:24-38 pubmed 出版商
  • 免疫印迹; 人类; 图 2d
Wamsley J, Issaeva N, An H, Lu X, Donehower L, Yarbrough W. LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro. Cell Cycle. 2017;16:213-223 pubmed 出版商
  • 免疫印迹; 人类; 1:250; 图 1a
Marmisolle I, Martínez J, Liu J, Mastrogiovanni M, Fergusson M, Rovira I, et al. Reciprocal regulation of acetyl-CoA carboxylase 1 and senescence in human fibroblasts involves oxidant mediated p38 MAPK activation. Arch Biochem Biophys. 2017;613:12-22 pubmed 出版商
  • 免疫印迹; 人类; 图 6e
Chhabra A, Mukherji B, Batra D. Activation induced cell death (AICD) of human melanoma antigen-specific TCR engineered CD8 T cells involves JNK, Bim and p53. Expert Opin Ther Targets. 2017;21:117-129 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 4f
Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed 出版商
  • 免疫沉淀; 人类; 图 2a
Qi D, Cobrinik D. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation. Oncogene. 2017;36:1760-1769 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Liu T, Xiong J, Yi S, Zhang H, Zhou S, Gu L, et al. FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene. 2017;36:1678-1686 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Scott T, Wicker C, Suganya R, Dhar B, Pittman T, Horbinski C, et al. Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin. Mol Carcinog. 2017;56:325-336 pubmed 出版商
  • 免疫组化; 人类; 1:500; 图 4a
  • 免疫印迹; 人类; 图 1b
D Brot A, Kurtz P, Regan E, Jakubowski B, Abrams J. A platform for interrogating cancer-associated p53 alleles. Oncogene. 2017;36:286-291 pubmed 出版商
  • 免疫印迹; 人类; 图 7a
Xu S, Huang J, Chen M, Zeng M, Zou F, Chen D, et al. Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation. Oncotarget. 2017;8:12705-12716 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 1:1000; 图 1b
  • 染色质免疫沉淀 ; 人类; 图 2e
Chao T, Zhou X, Cao B, Liao P, Liu H, Chen Y, et al. Pleckstrin homology domain-containing protein PHLDB3 supports cancer growth via a negative feedback loop involving p53. Nat Commun. 2016;7:13755 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 图 5a
  • 免疫印迹; 人类; 图 1a
Bhagirath D, Zhao X, Mirza S, West W, Band H, Band V. Mutant PIK3CA Induces EMT in a Cell Type Specific Manner. PLoS ONE. 2016;11:e0167064 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 8c
McKenzie C, D Avino P. Investigating cytokinesis failure as a strategy in cancer therapy. Oncotarget. 2016;7:87323-87341 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Gotoh T, Kim J, Liu J, Vila Caballer M, Stauffer P, Tyson J, et al. Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2. Proc Natl Acad Sci U S A. 2016;113:13516-13521 pubmed
  • 免疫细胞化学; 人类; 图 2d
  • 免疫印迹; 人类; 图 1b
Tian X, Dai S, Sun J, Jiang S, Sui C, Meng F, et al. Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53. Cell Physiol Biochem. 2016;39:2088-2098 pubmed
  • 染色质免疫沉淀 ; 人类; 图 4
Alfano L, Costa C, Caporaso A, Antonini D, Giordano A, Pentimalli F. HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget. 2016;7:78127-78139 pubmed 出版商
  • 免疫沉淀; 人类; 图 1d
  • 免疫组化; 人类; 1:2000; 图 4e
  • 免疫印迹; 人类; 1:3000; 图 s8
Parrales A, Ranjan A, Iyer S, Padhye S, Weir S, Roy A, et al. DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway. Nat Cell Biol. 2016;18:1233-1243 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 2b
  • 免疫印迹; 人类; 1:1000; 图 2a
Dong P, Xiong Y, Watari H, Hanley S, Konno Y, Ihira K, et al. Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124. Sci Rep. 2016;6:35480 pubmed 出版商
  • 免疫印迹; 人类; 图 3b
Lu F, Wu X, Yin F, Chia Fang Lee C, Yu M, Mihaylov I, et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open. 2016;5:1449-1460 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer Sci. 2016;107:1877-1887 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 2b
Barillari G, Palladino C, Bacigalupo I, Leone P, Falchi M, Ensoli B. Entrance of the Tat protein of HIV-1 into human uterine cervical carcinoma cells causes upregulation of HPV-E6 expression and a decrease in p53 protein levels. Oncol Lett. 2016;12:2389-2394 pubmed
  • 免疫印迹; 小鼠; 图 1e
Zhuang J, Kamp W, Li J, Liu C, Kang J, Wang P, et al. Forkhead Box O3A (FOXO3) and the Mitochondrial Disulfide Relay Carrier (CHCHD4) Regulate p53 Protein Nuclear Activity in Response to Exercise. J Biol Chem. 2016;291:24819-24827 pubmed
  • 免疫印迹; 人类; 1:500; 图 4a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed 出版商
  • 免疫印迹; 人类; 图 5f
Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, et al. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016;76:6950-6963 pubmed
  • 免疫印迹; 人类; 图 3
Wu H, Li S, Hu J, Yu X, Xu H, Chen Z, et al. Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells. J Exp Clin Cancer Res. 2016;35:145 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Minemura H, Takagi K, Sato A, Takahashi H, Miki Y, Shibahara Y, et al. CITED2 in breast carcinoma as a potent prognostic predictor associated with proliferation, migration and chemoresistance. Cancer Sci. 2016;107:1898-1908 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s3c
  • 免疫印迹; 小鼠; 图 4j
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Kozakai Y, Kamada R, Furuta J, Kiyota Y, Chuman Y, Sakaguchi K. PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin. Sci Rep. 2016;6:33272 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 1a
Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, et al. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016;22:1180-1186 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Weber A, Drobnitzky N, Devery A, Bokobza S, Adams R, Maughan T, et al. Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer. Oncotarget. 2016;7:60807-60822 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14:3777-84 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 7
Fernández Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed 出版商
  • 免疫印迹; 人类; 图 s10
Bauer M, Joerger A, Fersht A. 2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells. Proc Natl Acad Sci U S A. 2016;113:E5271-80 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Park J, Yang S, Park J, Ka S, Kim J, Kong Y, et al. Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun. 2016;7:12513 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 3b
  • 免疫印迹; 人类; 图 2a
Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, et al. Identification of cellular senescence-specific genes by comparative transcriptomics. Sci Rep. 2016;6:31758 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Luo H, Cowen L, Yu G, Jiang W, Tang Y. SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov. 2016;2:15042 pubmed 出版商
  • 免疫组化-石蜡切片; 大鼠; 1:100; 图 5
Al Maghrebi M, Renno W. Altered expression profile of glycolytic enzymes during testicular ischemia reperfusion injury is associated with the p53/TIGAR pathway: effect of fructose 1,6-diphosphate. Peerj. 2016;4:e2195 pubmed 出版商
  • ChIP-Seq; 小鼠; 图 1a
Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, et al. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 2016;22:861-8 pubmed 出版商
  • ChIP-Seq; 人类; 图 4a
  • 免疫沉淀; 人类; 图 5a
  • 免疫细胞化学; 人类; 图 s5h, s5i
  • 免疫印迹; 人类; 图 3c
  • 免疫印迹基因敲除验证; 小鼠; 图 3e
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 图 1d
Itahana Y, Zhang J, Göke J, Vardy L, Han R, Iwamoto K, et al. Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells. Sci Rep. 2016;6:28112 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s5
Hong A, Tseng Y, Cowley G, Jonas O, Cheah J, Kynnap B, et al. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016;7:11987 pubmed 出版商
  • 免疫细胞化学; 人类; 图 7
  • 免疫印迹; 人类; 1:200; 图 10a
Pomo J, Taylor R, Gullapalli R. Influence of TP53 and CDH1 genes in hepatocellular cancer spheroid formation and culture: a model system to understand cancer cell growth mechanics. Cancer Cell Int. 2016;16:44 pubmed 出版商
  • 免疫印迹基因敲除验证; 小鼠; 图 4
  • 染色质免疫沉淀 ; 小鼠; 图 4
  • 免疫印迹基因敲除验证; 人类; 图 1
  • 染色质免疫沉淀 ; 人类; 图 1
Zhou X, Hao Q, Liao P, Luo S, Zhang M, Hu G, et al. Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator. elife. 2016;5: pubmed 出版商
  • 免疫沉淀; 人类; 1:100; 图 5
  • 免疫印迹; 人类; 1:1000; 图 1
Alaee M, Danesh G, Pasdar M. Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53. PLoS ONE. 2016;11:e0154323 pubmed 出版商
  • 免疫印迹; 人类; 图 s4a
Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Chen Y, Pan K, Wang P, Cao Z, Wang W, Wang S, et al. HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. J Biol Chem. 2016;291:12688-705 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Beard J, Tenga A, Hills J, Hoyer J, Cherian M, Wang Y, et al. The orphan nuclear receptor NR4A2 is part of a p53-microRNA-34 network. Sci Rep. 2016;6:25108 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Chiang T, le Sage C, Larrieu D, Demir M, Jackson S. CRISPR-Cas9(D10A) nickase-based genotypic and phenotypic screening to enhance genome editing. Sci Rep. 2016;6:24356 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Xia Z, Huang X, Chen K, Wang H, Xiao J, He K, et al. Proapoptotic Role of Potassium Ions in Liver Cells. Biomed Res Int. 2016;2016:1729135 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 3
Perez R, Shen H, Duan L, Kim R, Kim T, Park N, et al. Modeling the Etiology of p53-mutated Cancer Cells. J Biol Chem. 2016;291:10131-47 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Dai Y, Wang L, Tang J, Cao P, Luo Z, Sun J, et al. Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress. Oncotarget. 2016;7:25478-92 pubmed 出版商
  • 免疫印迹; 人类; 图 6a
Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016;415:197-205 pubmed 出版商
  • 免疫印迹; 人类; 图 7g
Jin H, Lee K, Kim Y, Oh H, Maeng Y, Kim T, et al. Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. Oncogene. 2016;35:5106-18 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Mori F, Ferraiuolo M, Santoro R, Sacconi A, Goeman F, Pallocca M, et al. Multitargeting activity of miR-24 inhibits long-term melatonin anticancer effects. Oncotarget. 2016;7:20532-48 pubmed 出版商
  • 免疫印迹; 人类; 图 s8
Chen S, FORRESTER W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016;351:1204-8 pubmed 出版商
  • 流式细胞仪; 人类; 图 6f
  • 免疫印迹; 人类; 1:500; 图 1a
Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 3
Shin M, He Y, Marrogi E, Piperdi S, Ren L, Khanna C, et al. A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells. PLoS Genet. 2016;12:e1005884 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 5
Swetzig W, Wang J, Das G. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 2016;7:16049-69 pubmed 出版商
  • 免疫印迹; 人类; 图 s2
Talarico C, Dattilo V, D Antona L, Barone A, Amodio N, Belviso S, et al. SI113, a SGK1 inhibitor, potentiates the effects of radiotherapy, modulates the response to oxidative stress and induces cytotoxic autophagy in human glioblastoma multiforme cells. Oncotarget. 2016;7:15868-84 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6
Liu R, Li S, Garcia E, Glubrecht D, Poon H, Easaw J, et al. Association between cytoplasmic CRABP2, altered retinoic acid signaling, and poor prognosis in glioblastoma. Glia. 2016;64:963-76 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
  • 免疫印迹; 小鼠; 图 ev1f
Liu X, Tan Y, Zhang C, Zhang Y, Zhang L, Ren P, et al. NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2. EMBO Rep. 2016;17:349-66 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Xie X, Lozano G, Siddik Z. Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene. 2016;35:4798-806 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 3b
Mignacca L, Saint Germain E, Benoit A, Bourdeau V, Moro A, Ferbeyre G. Sponges against miR-19 and miR-155 reactivate the p53-Socs1 axis in hematopoietic cancers. Cytokine. 2016;82:80-6 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200; 图 st3
  • 免疫印迹; 人类; 1:1000; 图 st3
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 9a
Vaughan C, Pearsall I, Singh S, Windle B, Deb S, Grossman S, et al. Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter. Oncotarget. 2016;7:12426-46 pubmed 出版商
  • 免疫印迹; 人类; 图 1c
Heo J, Kim W, Choi K, Bae S, Jeong J, Kim K. XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence. Oncotarget. 2016;7:5118-30 pubmed 出版商
  • 免疫印迹; 人类; 图 4d
Chavoshi S, Egorova O, Lacdao I, Farhadi S, Sheng Y, Saridakis V. Identification of Kaposi Sarcoma Herpesvirus (KSHV) vIRF1 Protein as a Novel Interaction Partner of Human Deubiquitinase USP7. J Biol Chem. 2016;291:6281-91 pubmed 出版商
  • 其他; 人类; 图 st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 6g
  • 免疫细胞化学; 人类; 图 2c
  • 免疫印迹; 人类
Soragni A, Janzen D, Johnson L, Lindgren A, Thai Quynh Nguyen A, Tiourin E, et al. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016;29:90-103 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Han M, Lee D, Woo S, Seo B, Min K, Kim S, et al. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. Sci Rep. 2016;6:18642 pubmed 出版商
  • 免疫印迹; 人类; 图 2a
Berges C, Chatterjee M, Topp M, Einsele H. Targeting polo-like kinase 1 suppresses essential functions of alloreactive T cells. Immunol Res. 2016;64:687-98 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Du C, Wu H, Leng R. UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation. Oncotarget. 2016;7:2823-36 pubmed 出版商
  • 免疫组化; 人类; 1:200; 表 4
Pages M, Lacroix L, Tauziède Espariat A, Castel D, Daudigeos Dubus E, Ridola V, et al. Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion. Acta Neuropathol Commun. 2015;3:85 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:200; 图 4
  • 免疫印迹; 人类; 1:500; 图 4
Fleury H, Communal L, Carmona E, Portelance L, Arcand S, Rahimi K, et al. Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease. Genes Cancer. 2015;6:378-398 pubmed
  • 免疫组化; 人类; 图 8a
Gravina G, Mancini A, Sanità P, Vitale F, Marampon F, Ventura L, et al. KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin [corrected] in prostate cancer models. BMC Cancer. 2015;15:941 pubmed 出版商
  • 免疫印迹; 人类; 1:5000; 图 3
Dewaele M, Tabaglio T, Willekens K, Bezzi M, Teo S, Low D, et al. Antisense oligonucleotide-mediated MDM4 exon 6 skipping impairs tumor growth. J Clin Invest. 2016;126:68-84 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
  • 免疫印迹; 人类; 图 5
Ivanschitz L, Takahashi Y, Jollivet F, Ayrault O, Le Bras M, de Thé H. PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence. Proc Natl Acad Sci U S A. 2015;112:14278-83 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 4b
Carpentieri A, Cozzoli E, Scimeca M, Bonanno E, Sardanelli A, Gambacurta A. Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. Cell Death Dis. 2015;6:e1974 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 4d
Kanu N, Zhang T, Burrell R, Chakraborty A, Cronshaw J, DaCosta C, et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2016;35:4009-19 pubmed 出版商
  • 免疫印迹; 人类; 图 s4
Xiao D, Ren P, Su H, Yue M, Xiu R, Hu Y, et al. Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2. Oncotarget. 2015;6:40655-66 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Antoniali G, Marcuzzi F, Casarano E, Tell G. Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis. DNA Repair (Amst). 2015;35:90-105 pubmed 出版商
  • 免疫组化; 人类; 1:200; 图 1
Chene G, Ouellet V, Rahimi K, Barrès V, Meunier L, de Ladurantaye M, et al. Expression of Stem Cell Markers in Preinvasive Tubal Lesions of Ovarian Carcinoma. Biomed Res Int. 2015;2015:808531 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, et al. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015;4:e173 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 4
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, et al. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med. 2015;21:1364-71 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 5f
Ramlee M, Yan T, Cheung A, Chuah C, Li S. High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis. Sci Rep. 2015;5:15587 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Tonsing Carter E, Bailey B, Saadatzadeh M, Ding J, Wang H, Sinn A, et al. Potentiation of Carboplatin-Mediated DNA Damage by the Mdm2 Modulator Nutlin-3a in a Humanized Orthotopic Breast-to-Lung Metastatic Model. Mol Cancer Ther. 2015;14:2850-63 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 4
Lauková J, Kozubík A, Hofmanová J, Nekvindová J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Habiger C, Jäger G, Walter M, Iftner T, Stubenrauch F. Interferon Kappa Inhibits Human Papillomavirus 31 Transcription by Inducing Sp100 Proteins. J Virol. 2016;90:694-704 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫印迹; 人类; 图 1
Laezza C, D Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S, et al. p53 regulates the mevalonate pathway in human glioblastoma multiforme. Cell Death Dis. 2015;6:e1909 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2
  • 免疫沉淀; 人类; 图 3
  • 免疫细胞化学; 人类; 图 4
Ye M, Tang Y, Tang S, Liu J, Wu K, Yao S, et al. STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation. Oncotarget. 2015;6:34718-31 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s6
Hu D, Gur M, Zhou Z, Gamper A, Hung M, Fujita N, et al. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015;6:8419 pubmed 出版商
  • 免疫印迹; 人类; 图 11
Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s3
O Loghlen A, Brookes S, Martin N, Rapisarda V, Peters G, Gil J. CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). Aging Cell. 2015;14:1113-21 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Li Z, Hao Q, Luo J, Xiong J, Zhang S, Wang T, et al. USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. Oncogene. 2016;35:2902-12 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Kramer H, Lai C, Patel H, Periyasamy M, Lin M, Feller S, et al. LRH-1 drives colon cancer cell growth by repressing the expression of the CDKN1A gene in a p53-dependent manner. Nucleic Acids Res. 2016;44:582-94 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 1a
Ho D, Kim H, Kim J, Sim H, Ahn H, Kim J, et al. Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Mol Brain. 2015;8:54 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Lee N, Kwon J, Kim Y, Kim S, Park S, Xu W, et al. Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition. Oncotarget. 2015;6:30130-48 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Bailey M, Singh T, Mero P, Moffat J, Hieter P. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 2015;201:885-95 pubmed 出版商
  • 免疫印迹; 人类; 图 st2
Tiffen J, Gunatilake D, Gallagher S, Gowrishankar K, Heinemann A, Cullinane C, et al. Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes. Oncotarget. 2015;6:27023-36 pubmed 出版商
  • 免疫印迹; 小鼠; 图 5
Zhao C, Su Y, Zhang J, Feng Q, Qu L, Wang L, et al. Fibrinogen-derived fibrinostatin inhibits tumor growth through anti-angiogenesis. Cancer Sci. 2015;106:1596-606 pubmed 出版商
  • 免疫印迹; 人类
Tan B, Mu R, Chang Y, Wang Y, Wu M, Tu H, et al. RNF4 negatively regulates NF-κB signaling by down-regulating TAB2. FEBS Lett. 2015;589:2850-8 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Khan I, Zakaria M, Kumar M, Mani P, Chattopadhyay P, Sarkar D, et al. A novel placental like alkaline phosphatase promoter driven transcriptional silencing combined with single chain variable fragment antibody based virosomal delivery for neoplastic cell targeting [corrected]. J Transl Med. 2015;13:254 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Subbaiah V, Zhang Y, Rajagopalan D, Abdullah L, Yeo Teh N, Tomaić V, et al. E3 ligase EDD1/UBR5 is utilized by the HPV E6 oncogene to destabilize tumor suppressor TIP60. Oncogene. 2016;35:2062-74 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2a
Yoon K, Byun S, Kwon E, Hwang S, Chu K, Hiraki M, et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015;349:1261669 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 s7c
Coutts A, La Thangue N. Actin nucleation by WH2 domains at the autophagosome. Nat Commun. 2015;6:7888 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Shatz M, Shats I, Menendez D, Resnick M. p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways. Oncotarget. 2015;6:16963-80 pubmed
  • 免疫印迹; 人类; 图 1
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed 出版商
  • 免疫印迹; 人类
Succoio M, Comegna M, D Ambrosio C, Scaloni A, Cimino F, Faraonio R. Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. J Proteomics. 2015;128:18-29 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Navarro F, Lieberman J. miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS ONE. 2015;10:e0132767 pubmed 出版商
  • 免疫印迹; 人类; 图 2b
Zhu J, Zhao C, Zhuang T, Jonsson P, Sinha I, Williams C, et al. RING finger protein 31 promotes p53 degradation in breast cancer cells. Oncogene. 2016;35:1955-64 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, et al. The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells. PLoS ONE. 2015;10:e0132052 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3
Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed 出版商
  • 免疫印迹; 人类; 图 4g
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, et al. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015;14:2090-102 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Sadaie M, Dillon C, Narita M, Young A, Cairney C, Godwin L, et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell. 2015;26:2971-85 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Seo G, Ho M, Bui N, Kim Y, Koh D, Lim Y, et al. Novel naphthochalcone derivative accelerate dermal wound healing through induction of epithelial-mesenchymal transition of keratinocyte. J Biomed Sci. 2015;22:47 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Marchesini M, Matocci R, Tasselli L, Cambiaghi V, Orleth A, Furia L, et al. PML is required for telomere stability in non-neoplastic human cells. Oncogene. 2016;35:1811-21 pubmed 出版商
  • 免疫印迹; 人类; 图 s1.
Hayashi M, Cesare A, Rivera T, Karlseder J. Cell death during crisis is mediated by mitotic telomere deprotection. Nature. 2015;522:492-6 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Pickard A, McDade S, McFarland M, McCluggage W, Wheeler C, McCance D. HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures. PLoS Pathog. 2015;11:e1004988 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2
Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, et al. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nat Commun. 2015;6:7505 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s2
Dettmer U, Newman A, Soldner F, Luth E, Kim N, von Saucken V, et al. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nat Commun. 2015;6:7314 pubmed 出版商
  • 免疫组化; 人类
Zhao J, Zhao D, Poage G, Mazumdar A, Zhang Y, Hill J, et al. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015;125:2707-20 pubmed 出版商
  • 免疫印迹; 人类; 图 3a
Petroni M, Sardina F, Heil C, Sahún Roncero M, Colicchia V, Veschi V, et al. The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress. Cell Death Differ. 2016;23:197-206 pubmed 出版商
  • 免疫印迹; 人类; 图 2A
Amente S, Milazzo G, Sorrentino M, Ambrosio S, Di Palo G, Lania L, et al. Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. Oncotarget. 2015;6:14572-83 pubmed
  • 免疫细胞化学; 人类; 1:50; 图 7d
  • 免疫印迹; 人类; 1:1000; 图 3a
Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, et al. p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. J Mol Cell Cardiol. 2015;85:183-98 pubmed 出版商
  • 免疫印迹; 人类
Neo S, Itahana Y, Alagu J, Kitagawa M, Guo A, Lee S, et al. TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification. Mol Cell Biol. 2015;35:2851-63 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 6
García Cano J, Ambroise G, Pascual Serra R, Carrión M, Serrano Oviedo L, Ortega Muelas M, et al. Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance. Oncotarget. 2015;6:15551-65 pubmed
  • 免疫印迹; 人类; 1:1000; 图 1
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Chen B, Zaveri P, Longtine M, Nelson D. N-myc downstream-regulated gene 1 (NDRG1) mediates pomegranate juice protection from apoptosis in hypoxic BeWo cells but not in primary human trophoblasts. Placenta. 2015;36:847-53 pubmed 出版商
  • 免疫细胞化学; 人类; 1:500
  • 免疫印迹; 人类; 1:1000
Tembe V, Martino Echarri E, Marzec K, Mok M, Brodie K, Mills K, et al. The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cell Signal. 2015;27:1763-71 pubmed 出版商
  • 免疫印迹; 人类; 图 s7f
Kloet D, Polderman P, Eijkelenboom A, Smits L, van Triest M, van den Berg M, et al. FOXO target gene CTDSP2 regulates cell cycle progression through Ras and p21(Cip1/Waf1). Biochem J. 2015;469:289-98 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5
Zhou Y, Han C, Li D, Yu Z, Li F, Li F, et al. Cyclin-dependent kinase 11(p110) (CDK11(p110)) is crucial for human breast cancer cell proliferation and growth. Sci Rep. 2015;5:10433 pubmed 出版商
  • 免疫印迹; 人类
Li Y, Wang W, Xu X, Sun S, Xu X, Qu X. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. Biomed Res Int. 2015;2015:491205 pubmed 出版商
  • 免疫细胞化学; 人类; 1:250
Andries V, Vandepoele K, Staes K, Berx G, Bogaert P, Van Isterdael G, et al. NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest. BMC Cancer. 2015;15:391 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Bhagirath D, Zhao X, West W, Qiu F, Band H, Band V. Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes. Oncotarget. 2015;6:9018-30 pubmed
  • 免疫印迹; 人类
Mishra A, Kumar R, Tyagi A, Kohaar I, Hedau S, Bharti A, et al. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015;9:525 pubmed 出版商
  • 免疫印迹; 人类; 1:10000
Wright J, Atwan Z, Morris S, Leppard K. The Human Adenovirus Type 5 L4 Promoter Is Negatively Regulated by TFII-I and L4-33K. J Virol. 2015;89:7053-63 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 5
Isogai T, van der Kammen R, Innocenti M. SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton. Sci Rep. 2015;5:9802 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 2
Drost J, van Jaarsveld R, Ponsioen B, Zimberlin C, van Boxtel R, Buijs A, et al. Sequential cancer mutations in cultured human intestinal stem cells. Nature. 2015;521:43-7 pubmed 出版商
  • 免疫组化-石蜡切片; 人类; 1:100; 图 1
Bian C, Li Z, Xu Y, Wang J, Xu L, Shen H. Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study. World J Surg Oncol. 2015;13:128 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Seiki T, Nagasaka K, Kranjec C, Kawana K, Maeda D, Nakamura H, et al. HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy. BMC Cancer. 2015;15:230 pubmed 出版商
  • 免疫印迹; 人类; 图 4g
Barfeld S, Fazli L, Persson M, Marjavaara L, Urbanucci A, Kaukoniemi K, et al. Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer. Oncotarget. 2015;6:12587-602 pubmed
  • 免疫印迹; 人类; 图 1
Cho J, Lee S, Oh A, Yoon M, Woo T, Park B. NF2 blocks Snail-mediated p53 suppression in mesothelioma. Oncotarget. 2015;6:10073-85 pubmed
  • 免疫组化-石蜡切片; 人类; 图 1
  • 免疫印迹; 人类; 1:500; 图 5
Zhao W, Chen R, Zhao M, Li L, Fan L, Che X. High glucose promotes gastric cancer chemoresistance in vivo and in vitro. Mol Med Rep. 2015;12:843-50 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 6c
Xu T, Fan B, Lv C, Xiao D. Slug mediates nasopharyngeal carcinoma radioresistance via downregulation of PUMA in a p53-dependent and -independent manner. Oncol Rep. 2015;33:2631-8 pubmed 出版商
  • 免疫印迹; 人类
Markkanen E, Fischer R, Ledentcova M, Kessler B, Dianov G. Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability. Nucleic Acids Res. 2015;43:3667-79 pubmed 出版商
  • 免疫印迹基因敲除验证; 人类; 图 1
Zhou Q, Derti A, Ruddy D, Rakiec D, Kao I, Lira M, et al. A chemical genetics approach for the functional assessment of novel cancer genes. Cancer Res. 2015;75:1949-58 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 5g
Aubry S, Shin W, Crary J, Lefort R, Qureshi Y, Lefebvre C, et al. Assembly and interrogation of Alzheimer's disease genetic networks reveal novel regulators of progression. PLoS ONE. 2015;10:e0120352 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Khoronenkova S, Dianov G. ATM prevents DSB formation by coordinating SSB repair and cell cycle progression. Proc Natl Acad Sci U S A. 2015;112:3997-4002 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Katagiri N, Kuroda T, Kishimoto H, Hayashi Y, Kumazawa T, Kimura K. The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription. Sci Rep. 2015;5:8903 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Luo Z, Feng X, Wang H, Xu W, Zhao Y, Ma W, et al. Mir-23a induces telomere dysfunction and cellular senescence by inhibiting TRF2 expression. Aging Cell. 2015;14:391-9 pubmed 出版商
  • 免疫细胞化学; 人类
Ehm P, Nalaskowski M, Wundenberg T, Jücker M. The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies. Nucleus. 2015;6:154-64 pubmed 出版商
  • 免疫印迹; 人类; 1:200
Tamilzhalagan S, Muthuswami M, Periasamy J, Lee M, Rha S, Tan P, et al. Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. Cell Signal. 2015;27:1075-86 pubmed 出版商
  • 免疫印迹; 人类; 图 s1
Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, et al. The cerebral cavernous malformation 3 gene is necessary for senescence induction. Aging Cell. 2015;14:274-83 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Lewinska A, Wnuk M, Grabowska W, Zabek T, Semik E, Sikora E, et al. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015;233:227-38 pubmed 出版商
  • 免疫印迹; 人类
Laura M, de la Cruz Herrera C, Ferreirós A, Baz Martínez M, Lang V, Vidal A, et al. KSHV latent protein LANA2 inhibits sumo2 modification of p53. Cell Cycle. 2015;14:277-82 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Lecona E, Narendra V, Reinberg D. USP7 cooperates with SCML2 to regulate the activity of PRC1. Mol Cell Biol. 2015;35:1157-68 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 4c
  • 免疫组化-石蜡切片; 小鼠; 图 9c
Wang L, Liu R, Ye P, Wong C, Chen G, Zhou P, et al. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015;6:5909 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Stolz A, Ertych N, Bastians H. A phenotypic screen identifies microtubule plus end assembly regulators that can function in mitotic spindle orientation. Cell Cycle. 2015;14:827-37 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 8
Pérès E, Gérault A, Valable S, Roussel S, Toutain J, Divoux D, et al. Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe. Oncotarget. 2015;6:2101-19 pubmed
  • 免疫印迹; 人类; 图 6
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed 出版商
  • 免疫印迹; 人类
Ghorbani A, Jeddi Tehrani M, Saidpour A, Safa M, Bayat A, Zand H. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58-66 pubmed 出版商
  • 免疫印迹; 人类
Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X. Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. J Biol Chem. 2015;290:2024-33 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Wei Z, Guo H, Liu Z, Zhang X, Liu Q, Qian Y, et al. CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. Free Radic Biol Med. 2015;79:1-13 pubmed 出版商
  • 免疫印迹; 人类
Kuo P, Huang C, Lee C, Chang H, Hsieh S, Chung Y, et al. BCAS2 promotes prostate cancer cells proliferation by enhancing AR mRNA transcription and protein stability. Br J Cancer. 2015;112:391-402 pubmed 出版商
  • 免疫印迹; 人类
Kim H, Jung G. Reactive oxygen species increase HEPN1 expression via activation of the XBP1 transcription factor. FEBS Lett. 2014;588:4413-21 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类; 1:1000
Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 s1
Park J, Lee S, Yang S, Yoo H, Park J, Seong M, et al. Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage. Nat Commun. 2014;5:5483 pubmed 出版商
  • 免疫组化; 人类; 1:100
Voorneveld P, Kodach L, Jacobs R, van Noesel C, Peppelenbosch M, Korkmaz K, et al. The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. Br J Cancer. 2015;112:122-30 pubmed 出版商
  • 免疫印迹; 人类
Wang D, Zhang P, Gao K, Tang Y, Jin X, Zhang Y, et al. PLK1 and β-TrCP-dependent ubiquitination and degradation of Rap1GAP controls cell proliferation. PLoS ONE. 2014;9:e110296 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Hühn D, Kousholt A, Sørensen C, Sartori A. miR-19, a component of the oncogenic miR-17∼92 cluster, targets the DNA-end resection factor CtIP. Oncogene. 2015;34:3977-84 pubmed 出版商
  • 免疫印迹; 人类; 图 4a
Choi H, Choi Y, Kang H, Lim E, Park S, Lee H, et al. PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet. 2015;24:1127-41 pubmed 出版商
  • 免疫印迹; 人类
Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. 2014;5:7540-8 pubmed
  • 免疫印迹; 人类; 图 1
Iannetti A, Ledoux A, Tudhope S, Sellier H, Zhao B, Mowla S, et al. Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet. 2014;10:e1004642 pubmed 出版商
  • 免疫印迹; 人类
Fan Y, Meley D, Pizer B, Sée V. Mir-34a mimics are potential therapeutic agents for p53-mutated and chemo-resistant brain tumour cells. PLoS ONE. 2014;9:e108514 pubmed 出版商
  • 染色质免疫沉淀 ; 人类; 图 5b
  • 免疫印迹; 人类; 图 1a
  • 免疫印迹; 小鼠; 图 1f
Chen D, Ming L, Zou F, Peng Y, Van Houten B, Yu J, et al. TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity. Oncotarget. 2014;5:8107-22 pubmed
  • 免疫细胞化学; 人类; 图 4
Santos J, Gil J. TRIM28/KAP1 regulates senescence. Immunol Lett. 2014;162:281-9 pubmed 出版商
  • 免疫印迹; 人类
Alpay K, Farshchian M, Tuomela J, Sandholm J, Aittokallio K, Siljamäki E, et al. Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantrone. PLoS ONE. 2014;9:e105526 pubmed 出版商
  • 免疫组化; 人类; 1:5000
Wennerström A, Lothe I, Sandhu V, Kure E, Myklebost O, Munthe E. Generation and characterisation of novel pancreatic adenocarcinoma xenograft models and corresponding primary cell lines. PLoS ONE. 2014;9:e103873 pubmed 出版商
  • 免疫印迹; 人类; 0.2 ug/ml
Jacob A, Singh R, Comiskey D, Rouhier M, Mohammad F, Bebee T, et al. Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways. PLoS ONE. 2014;9:e104444 pubmed 出版商
  • 免疫印迹; 人类
Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed 出版商
  • 免疫印迹; 人类; 1:2000; 图 5h
Zhang P, Wei Y, Wang L, Debeb B, Yuan Y, Zhang J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014;16:864-75 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Suico M, Fukuda R, Miyakita R, Koyama K, Taura M, Shuto T, et al. The transcription factor MEF/Elf4 is dually modulated by p53-MDM2 axis and MEF-MDM2 autoregulatory mechanism. J Biol Chem. 2014;289:26143-54 pubmed 出版商
  • 免疫印迹; 人类
Clewell R, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen P, et al. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicol Sci. 2014;142:56-73 pubmed 出版商
  • 免疫印迹; 人类
Watanabe T, Nakamura S, Ono T, Ui S, Yagi S, Kagawa H, et al. Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochem Biophys Res Commun. 2014;451:93-100 pubmed 出版商
  • 免疫印迹; 人类
Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. elife. 2014;3:e02907 pubmed 出版商
  • 免疫印迹; 人类
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, et al. AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation. Biochem Biophys Res Commun. 2014;450:1498-504 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Patel A, Burton D, Halvorsen K, Balkan W, Reiner T, Perez Stable C, et al. MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways. Oncogene. 2015;34:2586-96 pubmed 出版商
  • 免疫印迹; 人类
Weilbacher A, Gutekunst M, Oren M, Aulitzky W, van der Kuip H. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell Death Dis. 2014;5:e1318 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Oi N, Yuan J, Malakhova M, Luo K, Ryu J, Zhang L, et al. Resveratrol induces apoptosis by directly targeting Ras-GTPase-activating protein SH3 domain-binding protein 1. Oncogene. 2015;34:2660-71 pubmed 出版商
  • 免疫印迹; 人类
Yang H, Hwangbo K, Zheng M, Cho J, Son J, Kim H, et al. Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts. Arch Pharm Res. 2015;38:876-84 pubmed 出版商
  • 免疫印迹; 人类
Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama K. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 2014;34:3321-40 pubmed 出版商
  • 免疫印迹; 人类; 图 1b
Luo X, Suzuki M, Ghandhi S, Amundson S, Boothman D. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS ONE. 2014;9:e99983 pubmed 出版商
  • 免疫印迹; 人类; 图 6
Otani K, Dong Y, Li X, Lu J, Zhang N, Xu L, et al. Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol. 2014;234:302-15 pubmed 出版商
  • 免疫印迹; 小鼠
  • 免疫印迹; 人类
Mahadevan D, Morales C, Cooke L, Manziello A, Mount D, Persky D, et al. Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2. PLoS ONE. 2014;9:e95184 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Zeng L, Holly J, Perks C. Effects of physiological levels of the green tea extract epigallocatechin-3-gallate on breast cancer cells. Front Endocrinol (Lausanne). 2014;5:61 pubmed 出版商
  • 免疫印迹; 人类
Lu H, Fang E, Sykora P, Kulikowicz T, Zhang Y, Becker K, et al. Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice. Cell Death Dis. 2014;5:e1226 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s1
Abuali G, Chaisaklert W, Stelloo E, Pazarentzos E, Hwang M, Qize D, et al. The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis. Oncogene. 2015;34:1718-28 pubmed 出版商
  • 免疫印迹; 人类
Li B, Iglesias Pedraz J, Chen L, Yin F, Cadenas E, Reddy S, et al. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014;13:367-78 pubmed
  • 免疫印迹; 人类
Ram R, Mendiratta S, Bodemann B, Torres M, Eskiocak U, White M. RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progression. Mol Cell Biol. 2014;34:2350-8 pubmed 出版商
  • 染色质免疫沉淀 ; 人类
Munne P, Gu Y, Tumiati M, Gao P, Koopal S, Uusivirta S, et al. TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli. Sci Rep. 2014;4:4663 pubmed 出版商
  • 免疫印迹; 人类; 图 2
Gad H, Koolmeister T, Jemth A, Eshtad S, Jacques S, Ström C, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014;508:215-21 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫印迹; 人类
Wong P, Yeoh C, Ahmad A, Chelala C, Gillett C, Speirs V, et al. Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer. Oncogene. 2014;33:4579-88 pubmed 出版商
  • 免疫印迹; 人类; 图 5b
Levay K, Slepak V. Regulation of Cop9 signalosome activity by the EF-hand Ca2+-binding protein tescalcin. J Cell Sci. 2014;127:2448-59 pubmed 出版商
  • 免疫细胞化学; 人类; 1:300
  • 免疫印迹; 人类
Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed 出版商
  • 免疫印迹; 人类
Fiori M, Barbini C, Haas T, Marroncelli N, Patrizii M, Biffoni M, et al. Antitumor effect of miR-197 targeting in p53 wild-type lung cancer. Cell Death Differ. 2014;21:774-82 pubmed 出版商
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Facciuto F, Bugnon Valdano M, Marziali F, Massimi P, Banks L, Cavatorta A, et al. Human papillomavirus (HPV)-18 E6 oncoprotein interferes with the epithelial cell polarity Par3 protein. Mol Oncol. 2014;8:533-43 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Heyne K, Förster J, Schüle R, Roemer K. Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2. Nucleic Acids Res. 2014;42:3565-79 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Qi M, Zhang J, Zeng W, Chen X. DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner. Biochim Biophys Acta. 2014;1839:62-9 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed 出版商
  • 免疫印迹; 人类
Zaganjor E, Osborne J, Weil L, Díaz Martínez L, Gonzales J, Singel S, et al. Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells. Oncogene. 2014;33:5457-66 pubmed 出版商
  • 免疫沉淀; 人类
  • 免疫细胞化学; 人类
  • 免疫印迹; 人类
Zhang R, Misra V. Effects of cyclic AMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. Cell Cycle. 2014;13:279-92 pubmed 出版商
  • 免疫印迹; 人类
Meijer A, Kruyt F, van der Zee A, Hollema H, Le P, Ten Hoor K, et al. Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br J Cancer. 2013;109:2685-95 pubmed 出版商
  • 免疫印迹; 人类
Gubanova E, Issaeva N, Gokturk C, Djureinovic T, Helleday T. SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways. Cell Cycle. 2013;12:3770-80 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2
Hou A, Voorhoeve P, Lan W, Tin M, Tong L. Comparison of gene expression profiles in primary and immortalized human pterygium fibroblast cells. Exp Cell Res. 2013;319:2781-9 pubmed 出版商
  • 免疫印迹; 人类
Sy S, Jiang J, O W, Deng Y, Huen M. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks. Nucleic Acids Res. 2013;41:8572-80 pubmed 出版商
  • 免疫印迹; 人类
García Regalado A, Vargas M, Garcia Carranca A, Arechaga Ocampo E, Gonzalez De la Rosa C. Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells. Mol Cancer. 2013;12:44 pubmed 出版商
  • 免疫印迹; 小鼠
Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed 出版商
  • 免疫印迹; 人类
Ranaweera R, Yang X. Auto-ubiquitination of Mdm2 enhances its substrate ubiquitin ligase activity. J Biol Chem. 2013;288:18939-46 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5
Contreras A, Mebratu Y, Delgado M, Montaño G, Hu C, Ryter S, et al. Deacetylation of p53 induces autophagy by suppressing Bmf expression. J Cell Biol. 2013;201:427-37 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Moreno A, Soleto I, García Sanz P, Moreno Bueno G, Palmero I. ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth. Oncogene. 2014;33:1945-53 pubmed 出版商
  • 免疫印迹; 人类
Kojima K, Kornblau S, Ruvolo V, Dilip A, Duvvuri S, Davis R, et al. Prognostic impact and targeting of CRM1 in acute myeloid leukemia. Blood. 2013;121:4166-74 pubmed 出版商
  • 免疫印迹; 人类; 图 5
Andrews P, He Z, Tzenov Y, Popadiuk C, Kao K. Evidence of a novel role for Pygopus in rRNA transcription. Biochem J. 2013;453:61-70 pubmed 出版商
  • 免疫细胞化学; 人类; 图 2
Martin N, Popov N, Aguilo F, O Loghlen A, Raguz S, Snijders A, et al. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. EMBO J. 2013;32:982-95 pubmed 出版商
  • 免疫印迹; 人类
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Penicud K, Behrens A. DMAP1 is an essential regulator of ATM activity and function. Oncogene. 2014;33:525-31 pubmed 出版商
  • 免疫印迹; 人类
Khoronenkova S, Dianov G. USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Res. 2013;41:1750-6 pubmed 出版商
  • 免疫印迹; 人类
Jullien L, Mestre M, Roux P, Gire V. Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response. Nucleic Acids Res. 2013;41:900-11 pubmed 出版商
  • 免疫印迹; 人类
Liu C, Chen C, Huang A, Li J. Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1. J Ethnopharmacol. 2011;137:503-11 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Benatti P, Dolfini D, Vigano A, Ravo M, Weisz A, Imbriano C. Specific inhibition of NF-Y subunits triggers different cell proliferation defects. Nucleic Acids Res. 2011;39:5356-68 pubmed 出版商
  • 免疫印迹; 人类
Li X, Wu L, Corsa C, Kunkel S, Dou Y. Two mammalian MOF complexes regulate transcription activation by distinct mechanisms. Mol Cell. 2009;36:290-301 pubmed 出版商
  • 免疫印迹; 人类
Wolff S, Erster S, Palacios G, Moll U. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res. 2008;18:733-44 pubmed 出版商
  • 免疫印迹; 人类
Sakasai R, Tibbetts R. RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage. J Biol Chem. 2008;283:13549-55 pubmed 出版商
  • 免疫印迹; 人类
Funes J, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, et al. Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A. 2007;104:6223-8 pubmed
Cai W, Su L, Liao L, Liu Z, Langbein L, Dulaimi E, et al. PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. Nat Commun. 2019;10:5800 pubmed 出版商
Joshi A, Van Wassenhove L, Logas K, Minhas P, Andreasson K, Weinberg K, et al. Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology. Acta Neuropathol Commun. 2019;7:190 pubmed 出版商
Yu A, Wang Z, Wu W, Chen K, Yan S, Mao Z. Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2. Aging (Albany NY). 2019;11:10220-10241 pubmed 出版商
Brückmann N, Bennedsen S, Duijf P, Terp M, Thomassen M, Larsen M, et al. A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence. Cell Death Dis. 2019;10:841 pubmed 出版商
Liu L, Yang J, Ji W, Wang C. Curcumin Inhibits Proliferation of Epstein-Barr Virus-Associated Human Nasopharyngeal Carcinoma Cells by Inhibiting EBV Nuclear Antigen 1 Expression. Biomed Res Int. 2019;2019:8592921 pubmed 出版商
Burocziova M, Burdova K, Martinikova A, Kaspárek P, Kleiblova P, Danielsen S, et al. Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell Death Dis. 2019;10:818 pubmed 出版商
Gul N, Karlsson J, Tängemo C, Linsefors S, Tuyizere S, Perkins R, et al. The MTH1 inhibitor TH588 is a microtubule-modulating agent that eliminates cancer cells by activating the mitotic surveillance pathway. Sci Rep. 2019;9:14667 pubmed 出版商
Zhang G, Kai J, Chen M, Ma Q, Zhong A, Xie S, et al. Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels. Oncol Lett. 2019;18:4194-4202 pubmed 出版商
Wang C, Vegna S, Jin H, Benedict B, Lieftink C, Ramirez C, et al. Inducing and exploiting vulnerabilities for the treatment of liver cancer. Nature. 2019;: pubmed 出版商
Sarraf S, Sideris D, Giagtzoglou N, Ni L, Kankel M, Sen A, et al. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Rep. 2019;29:225-235.e5 pubmed 出版商
Chen Y, Hao Q, Wang J, Li J, Huang C, Zhang Y, et al. Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53. Cell Death Dis. 2019;10:737 pubmed 出版商
Lee G, Hwang K, Choi K. Effects of Fludioxonil on the Cell Growth and Apoptosis in T and B Lymphocytes. Biomolecules. 2019;9: pubmed 出版商
Masamsetti V, Low R, Mak K, O Connor A, Riffkin C, Lamm N, et al. Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection. Nat Commun. 2019;10:4224 pubmed 出版商
Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone M, et al. The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. Aging (Albany NY). 2019;11:5817-5828 pubmed 出版商
Nam K, Yi S, Nam G, Noh J, Park J, Lee M, et al. Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer. BMC Cancer. 2019;19:773 pubmed 出版商
Tocci P, Cianfrocca R, Di Castro V, Rosanò L, Sacconi A, Donzelli S, et al. β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer. Nat Commun. 2019;10:3196 pubmed 出版商
Borghesan M, Fafián Labora J, Eleftheriadou O, Carpintero Fernández P, Pàez Ribes M, Vizcay Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019;27:3956-3971.e6 pubmed 出版商
Dabiri Y, Abu El Maaty M, Chan H, Wölker J, Ott I, Wolfl S, et al. p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer Cells. Front Oncol. 2019;9:438 pubmed 出版商
Matson J, House A, Grant G, Wu H, Perez J, Cook J. Intrinsic checkpoint deficiency during cell cycle re-entry from quiescence. J Cell Biol. 2019;: pubmed 出版商
Chen P, Zhao D, Li J, Liang X, Li J, Chang A, et al. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019;35:868-884.e6 pubmed 出版商
Sowamber R, Chehade R, Bitar M, Dodds L, Milea A, Slomovitz B, et al. CCAAT/enhancer binding protein delta (C/EBPδ) demonstrates a dichotomous role in tumour initiation and promotion of epithelial carcinoma. EBioMedicine. 2019;: pubmed 出版商
Cowman S, Fan Y, Pizer B, See V. Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells. BMC Cancer. 2019;19:300 pubmed 出版商
Aho E, Wang J, Gogliotti R, Howard G, Phan J, Acharya P, et al. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity. Cell Rep. 2019;26:2916-2928.e13 pubmed 出版商
He C, Lv X, Huang C, Angeletti P, Hua G, Dong J, et al. A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Rep. 2019;26:2636-2650.e5 pubmed 出版商
Terada Y, Jo N, Arakawa Y, Sakakura M, Yamada Y, Ukai T, et al. Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor. Cell Rep. 2019;26:2608-2621.e6 pubmed 出版商
Sundar D, Yu Y, Katiyar S, Putri J, Dhanjal J, Wang J, et al. Wild type p53 function in p53Y220C mutant harboring cells by treatment with Ashwagandha derived anticancer withanolides: bioinformatics and experimental evidence. J Exp Clin Cancer Res. 2019;38:103 pubmed 出版商
Jeon H, Ham S, Kim J, Jin X, Lee S, Shin Y, et al. Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model. Cell Death Differ. 2019;: pubmed 出版商
Yang Y, Ishak Gabra M, Hanse E, Lowman X, Tran T, Li H, et al. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nat Commun. 2019;10:809 pubmed 出版商
Ideno N, Yamaguchi H, Okumura T, Huang J, Brun M, Ho M, et al. A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination. Lab Invest. 2019;: pubmed 出版商
Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed 出版商
Yamaguchi M, Hankinson O. 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling. Int J Oncol. 2019;54:1422-1432 pubmed 出版商
Abaev Schneiderman E, Admoni Elisha L, Levy D. SETD3 is a positive regulator of DNA-damage-induced apoptosis. Cell Death Dis. 2019;10:74 pubmed 出版商
Hald Ø, Olsen L, Gallo Oller G, Elfman L, Løkke C, Kogner P, et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma. Oncogene. 2019;38:2800-2813 pubmed 出版商
Varela Eirin M, Varela Vazquez A, Guitián Caamaño A, Paíno C, Mato V, Largo R, et al. Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis. 2018;9:1166 pubmed 出版商
Ishak Gabra M, Yang Y, Lowman X, Reid M, Tran T, Kong M. IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018;7:93 pubmed 出版商
Lee S, Lee W, Kim N, Kang J, Kim K, Kim S, et al. Renal Cell Carcinoma Is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition. Cancers (Basel). 2018;10: pubmed 出版商
Arnandis T, Monteiro P, Adams S, Bridgeman V, Rajeeve V, Gadaleta E, et al. Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Dev Cell. 2018;47:409-424.e9 pubmed 出版商
Majerská J, Feretzaki M, Glousker G, Lingner J. Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1. Life Sci Alliance. 2018;1:e201800121 pubmed 出版商
Smirnov A, Cappello A, Lena A, Anemona L, Mauriello A, Di Daniele N, et al. ZNF185 is a p53 target gene following DNA damage. Aging (Albany NY). 2018;10:3308-3326 pubmed 出版商
Baek H, Kim S, Choi E, Kim J, Shin D, Park E, et al. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 2018;14:1755-1768 pubmed 出版商
Georges A, Marcon E, Greenblatt J, Frappier L. Identification and Characterization of USP7 Targets in Cancer Cells. Sci Rep. 2018;8:15833 pubmed 出版商
Liu C, Cai Z, Jin G, Peng D, Pan B, Zhang X, et al. Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance. Cell Discov. 2018;4:54 pubmed 出版商
Stone O, El Brolosy M, Wilhelm K, Liu X, Romão A, Grillo E, et al. Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nat Commun. 2018;9:4077 pubmed 出版商
Luff S, Kao C, Papoutsakis E. Role of p53 and transcription-independent p53-induced apoptosis in shear-stimulated megakaryocytic maturation, particle generation, and platelet biogenesis. PLoS ONE. 2018;13:e0203991 pubmed 出版商
Kim S, Lam T, Yook J, Ahn S. Antioxidant modifications induced by the new metformin derivative HL156A regulate metabolic reprogramming in SAMP1/kl (-/-) mice. Aging (Albany NY). 2018;10:2338-2355 pubmed 出版商
Griveau A, Wiel C, Le Calve B, Ziegler D, Djebali S, Warnier M, et al. Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes. Aging Cell. 2018;17:e12835 pubmed 出版商
Sriraman A, Dickmanns A, Najafova Z, Johnsen S, Dobbelstein M. CDK4 inhibition diminishes p53 activation by MDM2 antagonists. Cell Death Dis. 2018;9:918 pubmed 出版商
Chow T, Shi X, Wei J, Guan J, Stadler G, Huang B, et al. Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun. 2018;9:3583 pubmed 出版商
Choppara S, Ganga S, Manne R, Dutta P, Singh S, Santra M. The SCFFBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence. J Biol Chem. 2018;293:16291-16306 pubmed 出版商
Bach D, Luu T, Kim D, An Y, Park S, Park H, et al. BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells. Mol Ther Nucleic Acids. 2018;12:817-828 pubmed 出版商
Lei K, Sun R, Chen L, Diplas B, Moure C, Wang W, et al. Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells. Sci Rep. 2018;8:12507 pubmed 出版商
Mattioli E, Andrenacci D, Garofalo C, Prencipe S, Scotlandi K, Remondini D, et al. Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Aging Cell. 2018;17:e12824 pubmed 出版商
Schulz Heddergott R, Stark N, Edmunds S, Li J, Conradi L, Bohnenberger H, et al. Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion. Cancer Cell. 2018;34:298-314.e7 pubmed 出版商
Noh J, Kim K, Idda M, Martindale J, Yang X, Abdelmohsen K, et al. GRSF1 suppresses cell senescence. Aging (Albany NY). 2018;10:1856-1866 pubmed 出版商
Chen B, Wang J, Wang J, Wang H, Gu X, Tang L, et al. A regulatory circuitry comprising TP53, miR-29 family, and SETDB1 in non-small cell lung cancer. Biosci Rep. 2018;38: pubmed 出版商
Fujiwara Y, Saito M, Robles A, Nishida M, Takeshita F, Watanabe M, et al. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network. EBioMedicine. 2018;33:33-48 pubmed 出版商
Stolte B, Iniguez A, Dharia N, Robichaud A, Conway A, Morgan A, et al. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018;215:2137-2155 pubmed 出版商
Zamponi E, Zamponi N, Coskun P, Quassollo G, Lorenzo A, Cannas S, et al. Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells. Aging Cell. 2018;17:e12812 pubmed 出版商
Georgilis A, Klotz S, Hanley C, Herranz N, Weirich B, Morancho B, et al. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell. 2018;34:85-102.e9 pubmed 出版商
Román Rosales A, Garcia Villa E, Herrera L, Gariglio P, Diaz Chavez J. Mutant p53 gain of function induces HER2 over-expression in cancer cells. BMC Cancer. 2018;18:709 pubmed 出版商
Rahnamoun H, Hong J, Sun Z, Lee J, Lu H, Lauberth S. Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. J Biol Chem. 2018;293:13234-13246 pubmed 出版商
Wang B, Lam T, Soh M, Ye Z, Chen J, Ren E. Influenza A Virus Facilitates Its Infectivity by Activating p53 to Inhibit the Expression of Interferon-Induced Transmembrane Proteins. Front Immunol. 2018;9:1193 pubmed 出版商
Plafker K, Zyla K, Berry W, Plafker S. Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Redox Biol. 2018;17:411-422 pubmed 出版商
Otsuka K, Yamamoto Y, Ochiya T. Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer. Oncotarget. 2018;9:24718-24730 pubmed 出版商
Arboatti A, Lambertucci F, Sedlmeier M, Pisani G, Monti J, Alvarez M, et al. Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice. Biomed Res Int. 2018;2018:9472939 pubmed 出版商
Ménard M, Costechareyre C, Ichim G, Blachier J, Neves D, Jarrosson Wuilleme L, et al. Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth. PLoS Biol. 2018;16:e2002912 pubmed 出版商
Kim J, Kim J, Lee J, Park M. Oct4 suppresses IR‑induced premature senescence in breast cancer cells through STAT3- and NF‑κB-mediated IL‑24 production. Int J Oncol. 2018;53:47-58 pubmed 出版商
Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed 出版商
Syn N, Lim P, Kong L, Wang L, Wong A, Lim C, et al. Pan-CDK inhibition augments cisplatin lethality in nasopharyngeal carcinoma cell lines and xenograft models. Signal Transduct Target Ther. 2018;3:9 pubmed 出版商
Kim J, Lee M, Yu G, Kim S, Jang K, Yu H, et al. Alterations in the p53-SOCS2 axis contribute to tumor growth in colon cancer. Exp Mol Med. 2018;50:3 pubmed 出版商
Gong L, Liu F, Xiong Z, Qi R, Luo Z, Gong X, et al. Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes. Proc Natl Acad Sci U S A. 2018;115:E3987-E3995 pubmed 出版商
Fang Z, Cao B, Liao J, Deng J, Plummer K, Liao P, et al. SPIN1 promotes tumorigenesis by blocking the uL18 (universal large ribosomal subunit protein 18)-MDM2-p53 pathway in human cancer. elife. 2018;7: pubmed 出版商
Wang Q, Yu J, Kadungure T, Beyene J, Zhang H, Lu Q. ARMMs as a versatile platform for intracellular delivery of macromolecules. Nat Commun. 2018;9:960 pubmed 出版商
Bienkowska Haba M, Luszczek W, Myers J, Keiffer T, DiGiuseppe S, Polk P, et al. A new cell culture model to genetically dissect the complete human papillomavirus life cycle. PLoS Pathog. 2018;14:e1006846 pubmed 出版商
Eldakhakhny S, Zhou Q, Crosbie E, Sayan B. Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death Dis. 2018;9:127 pubmed 出版商
Dilworth D, Gudavicius G, Xu X, Boyce A, O Sullivan C, Serpa J, et al. The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability. Nucleic Acids Res. 2018;46:2459-2478 pubmed 出版商
Xiang Q, Ju H, Li Q, Mei S, Chen D, Choi Y, et al. Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. J Virol. 2018;92: pubmed 出版商
Fraile J, Campos Iglesias D, Rodriguez F, Astudillo A, Vilarrasa Blasi R, Verdaguer Dot N, et al. Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice. J Biol Chem. 2018;293:2183-2194 pubmed 出版商
Su Y, Chen R, Wang H, Song H, Zhang Q, Chen L, et al. Novel Targeting of Transcription and Metabolism in Glioblastoma. Clin Cancer Res. 2018;24:1124-1137 pubmed 出版商
Wu C, Esfandiari A, Ho Y, Wang N, Mahdi A, Aptullahoglu E, et al. Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. Br J Cancer. 2018;118:495-508 pubmed 出版商
Abdul A, De Silva B, Gary R. The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of β-catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018;7: pubmed 出版商
Canny M, Moatti N, Wan L, Fradet Turcotte A, Krasner D, Mateos Gomez P, et al. Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nat Biotechnol. 2018;36:95-102 pubmed 出版商
Zhuge W, Chen R, Vladimir K, Dong X, Zia K, Sun X, et al. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. Cancer Lett. 2018;412:46-58 pubmed 出版商
Kaushik S, Liu F, Veazey K, Gao G, Das P, Neves L, et al. Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML. Leukemia. 2018;32:499-509 pubmed 出版商
Wang Y, Liu X, Zhou L, Duong D, Bhuripanyo K, Zhao B, et al. Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer. Nat Commun. 2017;8:2232 pubmed 出版商
Liao P, Zeng S, Zhou X, Chen T, Zhou F, Cao B, et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell. 2017;68:1134-1146.e6 pubmed 出版商
Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Oncotarget. 2017;8:75924-75942 pubmed 出版商
Saint Germain E, Mignacca L, Vernier M, Bobbala D, Ilangumaran S, Ferbeyre G. SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes. Aging (Albany NY). 2017;9:2137-2162 pubmed 出版商
Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed 出版商
Yu F, Pillman K, Neilsen C, Toubia J, Lawrence D, Tsykin A, et al. Naturally existing isoforms of miR-222 have distinct functions. Nucleic Acids Res. 2017;45:11371-11385 pubmed 出版商
Rai T, Glass M, Cole J, Rather M, Marsden M, Neilson M, et al. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Res. 2017;45:11673-11683 pubmed 出版商
Kim H, Ham S, Jo M, Lee G, Lee Y, Shin J, et al. CRISPR-Cas9 Mediated Telomere Removal Leads to Mitochondrial Stress and Protein Aggregation. Int J Mol Sci. 2017;18: pubmed 出版商
Silvers M, Deja S, Singh N, Egnatchik R, Sudderth J, Luo X, et al. The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism. J Biol Chem. 2017;292:18203-18216 pubmed 出版商
Li P, Wuthrick E, Rappaport J, Kraft C, Lin J, Marszalowicz G, et al. GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. Cancer Res. 2017;77:5095-5106 pubmed 出版商
Conforti F, Zhang X, Rao G, De Pas T, Yonemori Y, Rodriguez J, et al. Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. Cancer Res. 2017;77:5614-5627 pubmed 出版商
Yang Z, Maciejowski J, de Lange T. Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb. Mol Cancer Res. 2017;15:1579-1586 pubmed 出版商
Ben Younes K, Body S, Costé Ã, Viailly P, Miloudi H, Coudre C, et al. A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. BMC Cancer. 2017;17:538 pubmed 出版商
Tanaka N, Patel A, Tang L, Silver N, Lindemann A, Takahashi H, et al. Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation. Clin Cancer Res. 2017;23:6541-6554 pubmed 出版商
Hata A, Rowley S, Archibald H, Gomez Caraballo M, Siddiqui F, Ji F, et al. Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers. Oncogene. 2017;36:6581-6591 pubmed 出版商
Oldenburg A, Briand N, Sørensen A, Cahyani I, Shah A, Moskaug J, et al. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. J Cell Biol. 2017;216:2731-2743 pubmed 出版商
Tan E, McGreal S, Graw S, Tessman R, Koppel S, Dhakal P, et al. Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism. J Biol Chem. 2017;292:14940-14962 pubmed 出版商
Pacini L, Ceraolo M, Venuti A, Melita G, Hasan U, Accardi R, et al. UV Radiation Activates Toll-Like Receptor 9 Expression in Primary Human Keratinocytes, an Event Inhibited by Human Papillomavirus 38 E6 and E7 Oncoproteins. J Virol. 2017;91: pubmed 出版商
Larsson C, Ali M, Pandzic T, Lindroth A, He L, Sjöblom T. Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition. BMC Cancer. 2017;17:487 pubmed 出版商
Zheng S, Koh X, Goh H, Rahmat S, Hwang L, Lane D. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res. 2017;77:4342-4354 pubmed 出版商
Ghosh S, Salot S, Sengupta S, Navalkar A, Ghosh D, Jacob R, et al. p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis. Cell Death Differ. 2017;24:1784-1798 pubmed 出版商
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed 出版商
Suleymanova N, Crudden C, Shibano T, Worrall C, Oprea I, Tica A, et al. Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene. 2017;36:5734-5744 pubmed 出版商
Shih C, Chang Y, Chen Y, Ma C, Chen H, Yang C, et al. The PPARγ-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence. Aging Cell. 2017;16:797-813 pubmed 出版商
Yang Z, Su Z, Dewitt J, Xie L, Chen Y, Li X, et al. Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy. EBioMedicine. 2017;19:49-59 pubmed 出版商
Woo T, Yoon M, Hong S, Choi J, Ha N, Sun H, et al. Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest. Oncotarget. 2017;8:23690-23701 pubmed 出版商
Wang S, Cao Z, Xue J, Li H, Jiang W, Cheng Y, et al. A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis. J Biol Chem. 2017;292:8207-8222 pubmed 出版商
Müllers E, Silva Cascales H, Burdova K, Macurek L, Lindqvist A. Residual Cdk1/2 activity after DNA damage promotes senescence. Aging Cell. 2017;16:575-584 pubmed 出版商
Garzon R, Savona M, Baz R, Andreeff M, Gabrail N, Gutierrez M, et al. A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia. Blood. 2017;129:3165-3174 pubmed 出版商
An L, Jiang Y, Ng H, Man E, Chen J, Khoo U, et al. Dual-utility NLS drives RNF169-dependent DNA damage responses. Proc Natl Acad Sci U S A. 2017;114:E2872-E2881 pubmed 出版商
Choi M, Min Y, Pyo J, Lee C, Jang C, Kim J. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br J Pharmacol. 2017;174:1810-1825 pubmed 出版商
Riddick G, Kotliarova S, Rodriguez V, Kim H, Linkous A, Storaska A, et al. A Core Regulatory Circuit in Glioblastoma Stem Cells Links MAPK Activation to a Transcriptional Program of Neural Stem Cell Identity. Sci Rep. 2017;7:43605 pubmed 出版商
Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, et al. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS ONE. 2017;12:e0173047 pubmed 出版商
Kim H, Jeong Y, Song I, Noh Y, Seo K, Kim M, et al. Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver. Sci Rep. 2017;7:43296 pubmed 出版商
Simon M, Mesmar F, Helguero L, Williams C. Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant. PLoS ONE. 2017;12:e0172832 pubmed 出版商
Correia L, Johnson J, McErlean P, Bauer J, Farah H, Rassl D, et al. SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer. Am J Respir Crit Care Med. 2017;195:1494-1508 pubmed 出版商
Prakash Bangalore M, Adhikarla S, Mukherjee O, Panicker M. Genotoxic Effects of Culture Media on Human Pluripotent Stem Cells. Sci Rep. 2017;7:42222 pubmed 出版商
Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017;292:4556-4570 pubmed 出版商
Hoppe Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, et al. Induction of dormancy in hypoxic human papillomavirus-positive cancer cells. Proc Natl Acad Sci U S A. 2017;114:E990-E998 pubmed 出版商
Iman V, Mohan S, Abdelwahab S, Karimian H, Nordin N, Fadaeinasab M, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2017;11:103-121 pubmed 出版商
Das D, Sengupta I, Sarkar N, Pal A, Saha D, Bandopadhyay M, et al. Anti-hepatitis B virus (HBV) response of imiquimod based toll like receptor 7 ligand in hbv-positive human hepatocelluar carcinoma cell line. BMC Infect Dis. 2017;17:76 pubmed 出版商
Yang H, Yu S, Wang W, Li X, Hou Y, Liu Z, et al. SHARPIN Facilitates p53 Degradation in Breast Cancer Cells. Neoplasia. 2017;19:84-92 pubmed 出版商
Ota A, Nakao H, Sawada Y, Karnan S, Wahiduzzaman M, Inoue T, et al. ?40p53? suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells. J Cell Sci. 2017;130:614-625 pubmed 出版商
Shao D, Han J, Hou X, Fry J, Behring J, Seta F, et al. Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. Antioxid Redox Signal. 2017;27:313-327 pubmed 出版商
Sokolova M, Turunen M, Mortusewicz O, Kivioja T, Herr P, Vähärautio A, et al. Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion. Cell Cycle. 2017;16:189-199 pubmed 出版商
Ohashi T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Imamura T, et al. Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma. Br J Cancer. 2017;116:218-226 pubmed 出版商
Prokesch A, Graef F, Madl T, Kahlhofer J, Heidenreich S, Schümann A, et al. Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis. FASEB J. 2017;31:732-742 pubmed 出版商
Wachter F, Morgan A, Godes M, Mourtada R, Bird G, Walensky L. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. 2017;36:2184-2190 pubmed 出版商
Tran T, Lowman X, Reid M, Mendez Dorantes C, Pan M, Yang Y, et al. Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction. Oncogene. 2017;36:1991-2001 pubmed 出版商
Sun P, Wu Q, Ruan G, Zheng X, Song Y, Zhun J, et al. Expression patterns of maspin and mutant p53 are associated with the development of gestational trophoblastic neoplasia. Oncol Lett. 2016;12:3135-3142 pubmed
Gong L, Pan X, Chen H, Rao L, Zeng Y, Hang H, et al. p53 isoform Δ133p53 promotes efficiency of induced pluripotent stem cells and ensures genomic integrity during reprogramming. Sci Rep. 2016;6:37281 pubmed 出版商
Gopas J, Stern E, Zurgil U, Ozer J, Ben Ari A, Shubinsky G, et al. Reed-Sternberg cells in Hodgkin's lymphoma present features of cellular senescence. Cell Death Dis. 2016;7:e2457 pubmed 出版商
Kuo W, Lo J, Ho T, Pai P, Chiang S, Chen P, et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016;7:e2455 pubmed 出版商
Lee N, Lee J, Kim W, Yun S, Youn Y, Park C, et al. Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors. Oncotarget. 2016;7:75307-75318 pubmed 出版商
Wang W, Ji G, Xiao X, Chen X, Qin W, Yang F, et al. Epigenetically regulated miR-145 suppresses colon cancer invasion and metastasis by targeting LASP1. Oncotarget. 2016;7:68674-68687 pubmed 出版商
Mallet J, Dorr M, Drigeard Desgarnier M, Bastien N, Gendron S, Rochette P. Faster DNA Repair of Ultraviolet-Induced Cyclobutane Pyrimidine Dimers and Lower Sensitivity to Apoptosis in Human Corneal Epithelial Cells than in Epidermal Keratinocytes. PLoS ONE. 2016;11:e0162212 pubmed 出版商
Li X, Zhao Y, Xia Q, Zheng L, Liu L, Zhao B, et al. Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding. Cell Death Dis. 2016;7:e2356 pubmed 出版商
Li Q, Zhu Y, Hou L, Wang J, Hu G, Fang X, et al. C23 promotes tumorigenesis via suppressing p53 activity. Oncotarget. 2016;7:58274-58285 pubmed 出版商
Drayman N, Ben nun Shaul O, Butin Israeli V, Srivastava R, Rubinstein A, Mock C, et al. p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget. 2016;7:52643-52660 pubmed 出版商
Chen Y, Liu Y, Wei H, Lv K, Fu P. Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells. Oncotarget. 2016;7:59604-59617 pubmed 出版商
Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, et al. Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell Death Differ. 2016;23:1615-27 pubmed 出版商
Brosh R, Hrynyk I, Shen J, Waghray A, Zheng N, Lemischka I. A dual molecular analogue tuner for dissecting protein function in mammalian cells. Nat Commun. 2016;7:11742 pubmed 出版商
Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed 出版商
López Mateo I, Arruabarrena Aristorena A, Artaza Irigaray C, López J, Calvo E, Belandia B. HEY1 functions are regulated by its phosphorylation at Ser-68. Biosci Rep. 2016;36: pubmed 出版商
Kang J, Lee J, Hong D, Lee S, Kim N, Lee W, et al. Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy. Cell Death Dis. 2016;7:e2163 pubmed 出版商
Yeo S, Itahana Y, Guo A, Han R, Iwamoto K, Nguyen H, et al. Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. elife. 2016;5:e07101 pubmed 出版商
Yang Y, Liu W, Ding R, Xiong L, Dou R, Zhang Y, et al. Comprehensive Expression Profiling and Functional Network Analysis of p53-Regulated MicroRNAs in HepG2 Cells Treated with Doxorubicin. PLoS ONE. 2016;11:e0149227 pubmed 出版商
Mollet I, Patel D, Govani F, Giess A, Paschalaki K, Periyasamy M, et al. Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes. PLoS ONE. 2016;11:e0147990 pubmed 出版商
Poletto M, Legrand A, Fletcher S, Dianov G. p53 coordinates base excision repair to prevent genomic instability. Nucleic Acids Res. 2016;44:3165-75 pubmed 出版商
Iyer S, Parrales A, Begani P, Narkar A, Adhikari A, Martinez L, et al. Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities. Oncotarget. 2016;7:5401-15 pubmed 出版商
Xie H, Li C, Dang Q, Chang L, Li L. Infiltrating mast cells increase prostate cancer chemotherapy and radiotherapy resistances via modulation of p38/p53/p21 and ATM signals. Oncotarget. 2016;7:1341-53 pubmed 出版商
Wright D, Marchal C, Hoang K, Ankney J, Nguyen S, Rushing A, et al. Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1. Oncotarget. 2016;7:1687-706 pubmed 出版商
Lankenau M, Patel R, Liyanarachchi S, Maharry S, Hoag K, Duggan M, et al. MicroRNA-3151 inactivates TP53 in BRAF-mutated human malignancies. Proc Natl Acad Sci U S A. 2015;112:E6744-51 pubmed 出版商
Bogen D, Wei J, Azorsa D, Ormanoglu P, Buehler E, Guha R, et al. Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma. Oncotarget. 2015;6:35247-62 pubmed 出版商
Li X, Zhou J, Chan Z, Chooi J, Chen Z, Chng W. PRIMA-1met (APR-246) inhibits growth of colorectal cancer cells with different p53 status through distinct mechanisms. Oncotarget. 2015;6:36689-99 pubmed 出版商
Zhu J, Liu S, Ye F, Shen Y, Tie Y, Zhu J, et al. Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells. PLoS ONE. 2015;10:e0139790 pubmed 出版商
Li Y, Saini P, Sriraman A, Dobbelstein M. Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors. Oncotarget. 2015;6:32339-52 pubmed 出版商
Carter B, Mak P, Mak D, Ruvolo V, Schober W, McQueen T, et al. Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34+ proliferating and quiescent chronic myeloid leukemia blast crisis cells. Oncotarget. 2015;6:30487-99 pubmed 出版商
Laroche A, Tran Cong K, Chaire V, Lagarde P, Hostein I, Coindre J, et al. Heterogeneous Mechanisms of Secondary Resistance and Clonal Selection in Sarcoma during Treatment with Nutlin. PLoS ONE. 2015;10:e0137794 pubmed 出版商
Sui X, Zhu J, Tang H, Wang C, Zhou J, Han W, et al. p53 controls colorectal cancer cell invasion by inhibiting the NF-κB-mediated activation of Fascin. Oncotarget. 2015;6:22869-79 pubmed
Hünten S, Hermeking H. p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3. Oncotarget. 2015;6:15842-56 pubmed
Pishas K, Adwal A, Neuhaus S, Clayer M, Farshid G, Staudacher A, et al. XI-006 induces potent p53-independent apoptosis in Ewing sarcoma. Sci Rep. 2015;5:11465 pubmed 出版商
Pfister N, Fomin V, Regunath K, Zhou J, Zhou W, Silwal Pandit L, et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev. 2015;29:1298-315 pubmed 出版商
Magnussen G, Emilsen E, Giller Fleten K, Engesæter B, Nähse Kumpf V, Fjær R, et al. Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. BMC Cancer. 2015;15:462 pubmed 出版商
Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal Khoshbeen M, et al. Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget. 2015;6:18558-76 pubmed
Alexandrova E, Yallowitz A, Li D, Xu S, Schulz R, Proia D, et al. Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment. Nature. 2015;523:352-6 pubmed 出版商
Sacco J, Kenyani J, Butt Z, Carter R, Chew H, Cheeseman L, et al. Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget. 2015;6:13757-71 pubmed
Sokka M, Rilla K, Miinalainen I, Pospiech H, Syväoja J. High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation. Nucleic Acids Res. 2015;43:4975-89 pubmed 出版商
Cui H, Guo M, Xu D, Ding Z, Zhou G, Ding H, et al. The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60. Nat Commun. 2015;6:6752 pubmed 出版商
Tan C, Teissier S, Gunaratne J, Quek L, Bellanger S. Stranglehold on the spindle assembly checkpoint: the human papillomavirus E2 protein provokes BUBR1-dependent aneuploidy. Cell Cycle. 2015;14:1459-70 pubmed 出版商
Jahns H, Roos M, Imig J, Baumann F, Wang Y, Gilmour R, et al. Stereochemical bias introduced during RNA synthesis modulates the activity of phosphorothioate siRNAs. Nat Commun. 2015;6:6317 pubmed 出版商
Chen Y, Wright J, Meng X, Leppard K. Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment To Activate Interferon Beta and Interferon-Responsive Gene Expression. Mol Cell Biol. 2015;35:1660-72 pubmed 出版商
Rumpf T, Schiedel M, Karaman B, Roessler C, North B, Lehotzky A, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nat Commun. 2015;6:6263 pubmed 出版商
Brazina J, Svadlenka J, Macurek L, Andera L, Hodny Z, Bartek J, et al. DNA damage-induced regulatory interplay between DAXX, p53, ATM kinase and Wip1 phosphatase. Cell Cycle. 2015;14:375-87 pubmed 出版商
Moretti D, Del Bello B, Allavena G, Corti A, Signorini C, Maellaro E. Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. PLoS ONE. 2015;10:e0117258 pubmed 出版商
de Castro A, Minty F, Hattinger E, Wolf R, Parkinson E. The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. Longev Healthspan. 2014;3:8 pubmed 出版商
Zhao X, Parpart S, Takai A, Roessler S, Budhu A, Yu Z, et al. Integrative genomics identifies YY1AP1 as an oncogenic driver in EpCAM(+) AFP(+) hepatocellular carcinoma. Oncogene. 2015;34:5095-104 pubmed 出版商
Chander H, Brien C, Truesdell P, Watt K, Meens J, Schick C, et al. Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Breast Cancer Res. 2014;16:3413 pubmed 出版商
Xu Y, Liao R, Li N, Xiang R, Sun P. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. 2014;5:12555-72 pubmed
Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, et al. Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014;5:e1580 pubmed 出版商
Müllers E, Silva Cascales H, Jaiswal H, Saurin A, Lindqvist A. Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle. 2014;13:2733-43 pubmed 出版商
Hattori H, Janky R, Nietfeld W, Aerts S, Madan Babu M, Venkitaraman A. p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response. Cell Cycle. 2014;13:2572-86 pubmed 出版商
Botcheva K, McCorkle S. Cell context dependent p53 genome-wide binding patterns and enrichment at repeats. PLoS ONE. 2014;9:e113492 pubmed 出版商
Brachova P, Mueting S, Carlson M, Goodheart M, Button A, Mott S, et al. TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma. Int J Oncol. 2015;46:607-18 pubmed 出版商
Xiao Y, Xiang T, Luo X, Li C, Li Q, Peng W, et al. Zinc-finger protein 545 inhibits cell proliferation as a tumor suppressor through inducing apoptosis and is disrupted by promoter methylation in breast cancer. PLoS ONE. 2014;9:e110990 pubmed 出版商
Chen B, Suen Y, Gu S, Li L, Chan W. A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor. Sci Rep. 2014;4:6413 pubmed 出版商
Hong W, Liang F, Schaak D, Loncar M, Quan Q. Nanoscale label-free bioprobes to detect intracellular proteins in single living cells. Sci Rep. 2014;4:6179 pubmed 出版商
Maya Mendoza A, Merchut Maya J, Bartkova J, Bartek J, Streuli C, Jackson D. Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis. 2014;5:e1351 pubmed 出版商
Zeman M, Lin J, Freire R, Cimprich K. DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis. J Cell Biol. 2014;206:183-97 pubmed 出版商
Davidson B, Rubatt J, Corcoran D, Teoh D, Bernardini M, Grace L, et al. Differential Angiogenic Gene Expression in TP53 Wild-Type and Mutant Ovarian Cancer Cell Lines. Front Oncol. 2014;4:163 pubmed 出版商
Liu X, Yao J, Tripathi D, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene. 2015;34:2450-60 pubmed 出版商
Loughery J, Cox M, Smith L, Meek D. Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters. Nucleic Acids Res. 2014;42:7666-80 pubmed 出版商
Charles J, Fuchs J, Hefter M, Vischedyk J, Kleint M, Vogiatzi F, et al. Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases. Nat Commun. 2014;5:3981 pubmed 出版商
Zuazua Villar P, Rodriguez R, Gagou M, Eyers P, Meuth M. DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B. Cell Death Dis. 2014;5:e1253 pubmed 出版商
Isono T, Chano T, Kitamura A, Yuasa T. Glucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells. PLoS ONE. 2014;9:e96168 pubmed 出版商
Cheung H, Liu X, Canterel Thouennon L, Li L, Edmonson C, Rennert O. Telomerase protects werner syndrome lineage-specific stem cells from premature aging. Stem Cell Reports. 2014;2:534-46 pubmed 出版商
Jung I. Soluble extract from Moringa oleifera leaves with a new anticancer activity. PLoS ONE. 2014;9:e95492 pubmed 出版商
Eisfeld A, Schwind S, Patel R, Huang X, Santhanam R, Walker C, et al. Intronic miR-3151 within BAALC drives leukemogenesis by deregulating the TP53 pathway. Sci Signal. 2014;7:ra36 pubmed 出版商
Jung H, Phillips B, Chan E. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3?. Mol Cancer. 2014;13:80 pubmed 出版商
Zhu Y, Zhou Y, Shi J. Post-slippage multinucleation renders cytotoxic variation in anti-mitotic drugs that target the microtubules or mitotic spindle. Cell Cycle. 2014;13:1756-64 pubmed 出版商
Nordström L, Sernbo S, Edén P, Grønbaek K, Kolstad A, Räty R, et al. SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma--a Nordic Lymphoma Group study. Br J Haematol. 2014;166:98-108 pubmed 出版商
Martinelli V, Kyle W, Kojic S, Vitulo N, Li Z, Belgrano A, et al. ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle. PLoS ONE. 2014;9:e92259 pubmed 出版商
Busch M, Schwindt H, Brandt A, Beier M, Görldt N, Romaniuk P, et al. Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation. Hum Mol Genet. 2014;23:3958-74 pubmed 出版商
Laget S, Miotto B, Chin H, Esteve P, Roberts R, Pradhan S, et al. MBD4 cooperates with DNMT1 to mediate methyl-DNA repression and protects mammalian cells from oxidative stress. Epigenetics. 2014;9:546-56 pubmed 出版商
Huang S, Fang C, Wu C, Tsai C, Lin S, Chen J. Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine. PLoS ONE. 2013;8:e84919 pubmed 出版商
Reamon Buettner S, Sattlegger E, Ciribilli Y, Inga A, Wessel A, Borlak J. Transcriptional defect of an inherited NKX2-5 haplotype comprising a SNP, a nonsynonymous and a synonymous mutation, associated with human congenital heart disease. PLoS ONE. 2013;8:e83295 pubmed 出版商
Valentino T, Palmieri D, Vitiello M, Pierantoni G, Fusco A, Fedele M. PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context. Cell Death Dis. 2013;4:e963 pubmed 出版商
Pozzo F, Dal Bo M, Peragine N, Bomben R, Zucchetto A, Rossi F, et al. Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application. J Hematol Oncol. 2013;6:83 pubmed 出版商
Joshi M, Yao N, Myers K, Li Z. Human serum albumin and p53-activating peptide fusion protein is able to promote apoptosis and deliver fatty acid-modified molecules. PLoS ONE. 2013;8:e80926 pubmed 出版商
Aktary Z, Pasdar M. Plakoglobin represses SATB1 expression and decreases in vitro proliferation, migration and invasion. PLoS ONE. 2013;8:e78388 pubmed 出版商
Benbrook D, Nammalwar B, Long A, Matsumoto H, Singh A, Bunce R, et al. SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres. Invest New Drugs. 2014;32:412-23 pubmed 出版商
Leung T, Rajendran R, Singh S, Garva R, Krstic Demonacos M, Demonacos C. Cytochrome P450 2E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Res. 2013;15:R107 pubmed 出版商
Feldstein O, Nizri T, Doniger T, Jacob J, Rechavi G, Ginsberg D. The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage. Mol Cancer. 2013;12:131 pubmed 出版商
Fan Y, Cheng J, Vasudevan S, Dou J, Patel R, Ma I, et al. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013;4:e867 pubmed 出版商
Vieria Neto L, Wildemberg L, Colli L, Kasuki L, Marques N, Moraes A, et al. ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. PLoS ONE. 2013;8:e77406 pubmed 出版商
Miki T, Matsumoto T, Zhao Z, Lee C. p53 regulates Period2 expression and the circadian clock. Nat Commun. 2013;4:2444 pubmed 出版商
Jacob A, O BRIEN D, Singh R, Comiskey D, Littleton R, Mohammad F, et al. Stress-induced isoforms of MDM2 and MDM4 correlate with high-grade disease and an altered splicing network in pediatric rhabdomyosarcoma. Neoplasia. 2013;15:1049-63 pubmed
Luo C, Li Y, Yang L, Feng Z, Li Y, Long J, et al. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. 2013;14:503-11 pubmed 出版商
Sheren J, Kassenbrock C. RNF38 encodes a nuclear ubiquitin protein ligase that modifies p53. Biochem Biophys Res Commun. 2013;440:473-8 pubmed 出版商
Kaewprag J, Umnajvijit W, Ngamkham J, Ponglikitmongkol M. HPV16 oncoproteins promote cervical cancer invasiveness by upregulating specific matrix metalloproteinases. PLoS ONE. 2013;8:e71611 pubmed 出版商
Okal A, Mossalam M, Matissek K, Dixon A, Moos P, Lim C. A chimeric p53 evades mutant p53 transdominant inhibition in cancer cells. Mol Pharm. 2013;10:3922-33 pubmed 出版商
Takahashi R, Takeshita F, Honma K, Ono M, Kato K, Ochiya T. Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3?. Sci Rep. 2013;3:2474 pubmed 出版商
Massip A, Arcondeguy T, Touriol C, Basset C, Prats H, Lacazette E. E2F1 activates p53 transcription through its distal site and participates in apoptosis induction in HPV-positive cells. FEBS Lett. 2013;587:3188-94 pubmed 出版商
Zou H, Jiang Z, Li R, Jia Y, Yang X, Ni Y, et al. p53 cooperates with Sp1 to regulate breed-dependent expression of glucocorticoid receptor in the liver of preweaning piglets. PLoS ONE. 2013;8:e70494 pubmed 出版商
Yin Y, Kizer N, Thaker P, Chiappinelli K, Trinkaus K, Goodfellow P, et al. Glycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer. Int J Mol Sci. 2013;14:16617-37 pubmed 出版商
Yentrapalli R, Azimzadeh O, Sriharshan A, Malinowsky K, Merl J, Wojcik A, et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation. PLoS ONE. 2013;8:e70024 pubmed 出版商
Niebler M, Qian X, Höfler D, Kogosov V, Kaewprag J, Kaufmann A, et al. Post-translational control of IL-1? via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLoS Pathog. 2013;9:e1003536 pubmed 出版商
Belluti S, Basile V, Benatti P, Ferrari E, Marverti G, Imbriano C. Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-II? by bis-DemethoxyCurcumin in cancer cells. Cell Death Dis. 2013;4:e756 pubmed 出版商
de Oliveira G, Pereira E, Ferretti G, Valente A, Cordeiro Y, Silva J. Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane. J Biol Chem. 2013;288:28331-45 pubmed 出版商
Wu S, Yuan L, Zhang Y, Liu F, Li G, Wen K, et al. Probiotic Lactobacillus rhamnosus GG mono-association suppresses human rotavirus-induced autophagy in the gnotobiotic piglet intestine. Gut Pathog. 2013;5:22 pubmed 出版商
Selvaratnam J, Guan H, Koropatnick J, Yang K. Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction. Am J Physiol Endocrinol Metab. 2013;305:E727-35 pubmed 出版商
Palermo V, Mangiapelo E, Piloto C, Pieri L, Muscolini M, Tuosto L, et al. p53 death signal is mainly mediated by Nuc1(EndoG) in the yeast Saccharomyces cerevisiae. FEMS Yeast Res. 2013;13:682-8 pubmed 出版商
Hyun T, Kim M, Lee H, Kim Y, Kim E, Kim J. Evaluation of anti-oxidant and anti-cancer properties of Dendropanax morbifera Léveille. Food Chem. 2013;141:1947-55 pubmed 出版商
Guo H, Liu Z, Xu B, Hu H, Wei Z, Liu Q, et al. Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage. Aging Cell. 2013;12:1110-21 pubmed 出版商
Asuthkar S, Stepanova V, Lebedeva T, Holterman A, Estes N, Cines D, et al. Multifunctional roles of urokinase plasminogen activator (uPA) in cancer stemness and chemoresistance of pancreatic cancer. Mol Biol Cell. 2013;24:2620-32 pubmed 出版商
Raimondi I, Ciribilli Y, Monti P, Bisio A, Pollegioni L, Fronza G, et al. P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. PLoS ONE. 2013;8:e69152 pubmed 出版商
Burton D, Giribaldi M, Muñoz A, Halvorsen K, Patel A, Jorda M, et al. Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. PLoS ONE. 2013;8:e68003 pubmed 出版商
Liu Y, Xing R, Zhang X, Dong W, Zhang J, Yan Z, et al. miR-375 targets the p53 gene to regulate cellular response to ionizing radiation and etoposide in gastric cancer cells. DNA Repair (Amst). 2013;12:741-50 pubmed 出版商
Li S, Zhang H, Zhang J, Zhang Z, Zhang X, Zhang X, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013;437:325-30 pubmed 出版商
Li Q, Zhang H, Tan C, Peng W, Ren G, Jia B, et al. AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells. Tumour Biol. 2013;34:3569-77 pubmed 出版商
Chen X, Chen J, Gan S, Guan H, Zhou Y, Ouyang Q, et al. DNA damage strength modulates a bimodal switch of p53 dynamics for cell-fate control. BMC Biol. 2013;11:73 pubmed 出版商
Kim H, Roe J, Lee J, Cho E, Youn H. p53 regulates glucose metabolism by miR-34a. Biochem Biophys Res Commun. 2013;437:225-31 pubmed 出版商
Adamski J, Price A, Dive C, Makin G. Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha. PLoS ONE. 2013;8:e65304 pubmed 出版商
Gomez Cabello D, Adrados I, Gamarra D, Kobayashi H, Takatsu Y, Takatsu K, et al. DGCR8-mediated disruption of miRNA biogenesis induces cellular senescence in primary fibroblasts. Aging Cell. 2013;12:923-31 pubmed 出版商
Magnussen G, Hellesylt E, Nesland J, Trope C, Flørenes V, Holm R. High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients. BMC Cancer. 2013;13:288 pubmed 出版商
Orre L, Panizza E, Kaminskyy V, Vernet E, Gräslund T, Zhivotovsky B, et al. S100A4 interacts with p53 in the nucleus and promotes p53 degradation. Oncogene. 2013;32:5531-40 pubmed 出版商
Burger K, Mühl B, Rohrmoser M, Coordes B, Heidemann M, Kellner M, et al. Cyclin-dependent kinase 9 links RNA polymerase II transcription to processing of ribosomal RNA. J Biol Chem. 2013;288:21173-83 pubmed 出版商
Dong Y, Zhao J, Wu C, Zhang L, Liu X, Kang W, et al. Tumor suppressor functions of miR-133a in colorectal cancer. Mol Cancer Res. 2013;11:1051-60 pubmed 出版商
Montero J, Dutta C, Van Bodegom D, Weinstock D, Letai A. p53 regulates a non-apoptotic death induced by ROS. Cell Death Differ. 2013;20:1465-74 pubmed 出版商
Mitterberger M, Lechner S, Mattesich M, Zwerschke W. Adipogenic differentiation is impaired in replicative senescent human subcutaneous adipose-derived stromal/progenitor cells. J Gerontol A Biol Sci Med Sci. 2014;69:13-24 pubmed 出版商
Kleiblova P, Shaltiël I, Benada J, Sevcik J, Pecháčková S, Pohlreich P, et al. Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint. J Cell Biol. 2013;201:511-21 pubmed 出版商
Madar S, Harel E, Goldstein I, Stein Y, Kogan Sakin I, Kamer I, et al. Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta. PLoS ONE. 2013;8:e61353 pubmed 出版商
Long J, Wang Y, Li M, Tong W, Jia J, Huang J. Correlation of TP53 mutations with HCV positivity in hepatocarcinogenesis: identification of a novel TP53 microindel in hepatocellular carcinoma with HCV infection. Oncol Rep. 2013;30:119-24 pubmed 出版商
Fukuda R, Suico M, Koyama K, Omachi K, Kai Y, Matsuyama S, et al. Mild electrical stimulation at 0.1-ms pulse width induces p53 protein phosphorylation and G2 arrest in human epithelial cells. J Biol Chem. 2013;288:16117-26 pubmed 出版商
Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, et al. Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics. 2013;14:224 pubmed 出版商
Schauer I, Zhang J, Xing Z, Guo X, Mercado Uribe I, Sood A, et al. Interleukin-1β promotes ovarian tumorigenesis through a p53/NF-κB-mediated inflammatory response in stromal fibroblasts. Neoplasia. 2013;15:409-20 pubmed
Tang Q, Li G, Wei X, Zhang J, Chiu J, Hasenmayer D, et al. Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma. Cancer Lett. 2013;336:325-37 pubmed 出版商
Szalmás A, Gyöngyösi E, Ferenczi A, László B, Karosi T, Csomor P, et al. Activation of Src, Fyn and Yes non-receptor tyrosine kinases in keratinocytes expressing human papillomavirus (HPV) type 16 E7 oncoprotein. Virol J. 2013;10:79 pubmed 出版商
Simões A, Pereira D, Amaral J, Nunes A, Gomes S, Rodrigues P, et al. Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage. BMC Genomics. 2013;14:181 pubmed 出版商
Huang L, Jin J, Deighan P, Kiner E, McReynolds L, Lieberman J. Efficient and specific gene knockdown by small interfering RNAs produced in bacteria. Nat Biotechnol. 2013;31:350-6 pubmed 出版商
Xie X, Piao L, Bullock B, Smith A, Su T, Zhang M, et al. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene. 2014;33:1037-46 pubmed 出版商
Lee S, Um S, Kim E. CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1. Cancer Lett. 2013;335:397-403 pubmed 出版商
Sachweh M, Drummond C, Higgins M, Campbell J, Lain S. Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression. Cell Death Dis. 2013;4:e533 pubmed 出版商
Furia L, Pelicci P, Faretta M. A computational platform for robotized fluorescence microscopy (II): DNA damage, replication, checkpoint activation, and cell cycle progression by high-content high-resolution multiparameter image-cytometry. Cytometry A. 2013;83:344-55 pubmed 出版商
Farhang Ghahremani M, Goossens S, Nittner D, Bisteau X, Bartunkova S, Zwolinska A, et al. p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway. Cell Death Differ. 2013;20:888-97 pubmed 出版商
Wu S, Chen T, Gmeiner W, Chu E, Schmitz J. Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. Nucleic Acids Res. 2013;41:4650-9 pubmed 出版商
Li W, Anderson R. Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16. Oncogene. 2014;33:928-32 pubmed 出版商
Devany E, Zhang X, Park J, Tian B, Kleiman F. Positive and negative feedback loops in the p53 and mRNA 3' processing pathways. Proc Natl Acad Sci U S A. 2013;110:3351-6 pubmed 出版商
Yentrapalli R, Azimzadeh O, Barjaktarovic Z, Sarioglu H, Wojcik A, Harms Ringdahl M, et al. Quantitative proteomic analysis reveals induction of premature senescence in human umbilical vein endothelial cells exposed to chronic low-dose rate gamma radiation. Proteomics. 2013;13:1096-107 pubmed 出版商
Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS ONE. 2013;8:e53664 pubmed 出版商
Weingarten Gabbay S, Khan D, Liberman N, Yoffe Y, Bialik S, Das S, et al. The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA. Oncogene. 2014;33:611-8 pubmed 出版商
Jia S, Gao X, Lee S, Maira S, Wu X, Stack E, et al. Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 2013;3:44-51 pubmed 出版商
Chee J, Saidin S, Lane D, Leong S, Noll J, Neilsen P, et al. Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9. Cell Cycle. 2013;12:278-88 pubmed 出版商
Pan K, Chen Y, Roth M, Wang W, Wang S, Yee A, et al. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Mol Cell Biol. 2013;33:887-903 pubmed 出版商
Maddocks O, Berkers C, Mason S, Zheng L, Blyth K, Gottlieb E, et al. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. 2013;493:542-6 pubmed 出版商
Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012;13:36 pubmed 出版商
Ene C, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, et al. Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization. PLoS ONE. 2012;7:e51407 pubmed 出版商
Madureira P, Hill R, Lee P, Waisman D. Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage. PLoS ONE. 2012;7:e50591 pubmed 出版商
Alonso Castro A, Ortiz Sánchez E, García Regalado A, Ruiz G, Núñez Martínez J, González Sánchez I, et al. Kaempferitrin induces apoptosis via intrinsic pathway in HeLa cells and exerts antitumor effects. J Ethnopharmacol. 2013;145:476-89 pubmed 出版商
Kopp F, Oak P, Wagner E, Roidl A. miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. PLoS ONE. 2012;7:e50469 pubmed 出版商
Yang Y, Wang C, Zhang P, Gao K, Wang D, Yu H, et al. Polycomb group protein PHF1 regulates p53-dependent cell growth arrest and apoptosis. J Biol Chem. 2013;288:529-39 pubmed 出版商
Suzuki H, Miyazono K. p53 actions on microRNA expression and maturation pathway. Methods Mol Biol. 2013;962:165-81 pubmed 出版商
Marcel V, Khoury M, Fernandes K, Diot A, Lane D, Bourdon J. Detecting p53 isoforms at protein level. Methods Mol Biol. 2013;962:15-29 pubmed 出版商
Ohshima S. Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes. Oxid Med Cell Longev. 2012;2012:217594 pubmed 出版商
Venkatesan N, Krishnakumar S, Deepa P, Deepa M, Khetan V, Reddy M. Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells. Mol Vis. 2012;18:2420-37 pubmed
Lambertini E, Lolli A, Vezzali F, Penolazzi L, Gambari R, Piva R. Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells. BMC Cancer. 2012;12:445 pubmed 出版商
Yang H, Zhang W, Pan H, Feldser H, Lainez E, Miller C, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-?B activity. PLoS ONE. 2012;7:e46364 pubmed 出版商
Nylund C, Rappu P, Pakula E, Heino A, Laato L, Elo L, et al. Melanoma-associated cancer-testis antigen 16 (CT16) regulates the expression of apoptotic and antiapoptotic genes and promotes cell survival. PLoS ONE. 2012;7:e45382 pubmed 出版商
Khan D, Sharathchandra A, Ponnuswamy A, Grover R, Das S. Effect of a natural mutation in the 5' untranslated region on the translational control of p53 mRNA. Oncogene. 2013;32:4148-59 pubmed 出版商
Phalke S, Mzoughi S, Bezzi M, Jennifer N, Mok W, Low D, et al. p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res. 2012;40:9534-42 pubmed 出版商
Singh S, Raina V, Chavali P, Dubash T, Kadreppa S, Parab P, et al. Regulation of GAD65 expression by SMAR1 and p53 upon Streptozotocin treatment. BMC Mol Biol. 2012;13:28 pubmed
Guan D, Factor D, Liu Y, Wang Z, Kao H. The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein. Oncogene. 2013;32:3819-28 pubmed 出版商
Létourneau I, Quinn M, Wang L, Portelance L, Caceres K, Cyr L, et al. Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer. BMC Cancer. 2012;12:379 pubmed 出版商
Luo X, Chen L, Dai J, Gao Y, Wang H, Wang N, et al. Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in tumorigenesis and metastasis. BMC Med Genomics. 2012;5:36 pubmed 出版商
Cattelani S, Ferrari Amorotti G, Galavotti S, Defferrari R, Tanno B, Cialfi S, et al. The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform. Neoplasia. 2012;14:634-43 pubmed
Yang M, Yuan F, Li P, Chen Z, Chen A, Li S, et al. Interferon regulatory factor 4 binding protein is a novel p53 target gene and suppresses cisplatin-induced apoptosis of breast cancer cells. Mol Cancer. 2012;11:54 pubmed
Valentino T, Palmieri D, Vitiello M, Simeone A, Palma G, Arra C, et al. Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene. J Cell Physiol. 2013;228:646-53 pubmed 出版商
Kumari R, Li H, Haudenschild D, Fierro F, Carlson C, Overn P, et al. The oncogene LRF is a survival factor in chondrosarcoma and contributes to tumor malignancy and drug resistance. Carcinogenesis. 2012;33:2076-83 pubmed 出版商
Lee Y, Yu Y, Gunawardena H, Xie L, Chen X. BCLAF1 is a radiation-induced H2AX-interacting partner involved in ?H2AX-mediated regulation of apoptosis and DNA repair. Cell Death Dis. 2012;3:e359 pubmed 出版商
Gong J, Zhang J, Li B, Zeng C, You K, Chen M, et al. MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene. 2013;32:3071-9 pubmed 出版商
Hung T, Chen S, Lo L, Li M, Yeh Y, Hsieh T. Increased autophagy in placentas of intrauterine growth-restricted pregnancies. PLoS ONE. 2012;7:e40957 pubmed 出版商
Nikulenkov F, Spinnler C, Li H, Tonelli C, Shi Y, Turunen M, et al. Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis. Cell Death Differ. 2012;19:1992-2002 pubmed 出版商
Ruan J, Liao Y, Lua I, Li M, Hsu C, Chen J. Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells. Breast Cancer Res. 2012;14:R106 pubmed 出版商
Wei X, Zhou L, Hu L, Huang Y. Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells. Oncol Lett. 2012;3:1144-1148 pubmed
Chen H, Wan Y, Zhou S, Lu Y, Zhang Z, Zhang R, et al. Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence. Sci China Life Sci. 2012;55:467-73 pubmed 出版商
Lee J, Kang S, Jeon Y, Park J, You J, Ha S, et al. Protein L-isoaspartyl methyltransferase regulates p53 activity. Nat Commun. 2012;3:927 pubmed 出版商
Magnussen G, Holm R, Emilsen E, Rosnes A, Slipicevic A, Flørenes V. High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapy. PLoS ONE. 2012;7:e38254 pubmed 出版商
Pal D, Sur S, Mandal S, Das S, Panda C. Regular black tea habit could reduce tobacco associated ROS generation and DNA damage in oral mucosa of normal population. Food Chem Toxicol. 2012;50:2996-3003 pubmed 出版商
Pickard A, Cichon A, Menges C, Patel D, McCance D. Regulation of epithelial differentiation and proliferation by the stroma: a role for the retinoblastoma protein. J Invest Dermatol. 2012;132:2691-9 pubmed 出版商
Lafontaine J, Tchakarska G, Rodier F, Mes Masson A. Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress. BMC Cancer. 2012;12:234 pubmed 出版商
Gestl E, Anne Böttger S. Cytoplasmic sequestration of the tumor suppressor p53 by a heat shock protein 70 family member, mortalin, in human colorectal adenocarcinoma cell lines. Biochem Biophys Res Commun. 2012;423:411-6 pubmed 出版商
Michnov O, Solomayer E, Fehm T, Stubenrauch F, Iftner T. Knock down of p53 or its ubiquitin ligase E6AP does not affect the sensitivity of human papillomavirus-positive cervical cancer cells to cisplatin. Am J Cancer Res. 2012;2:309-21 pubmed
Ranganathan P, Yu X, Na C, Santhanam R, Shacham S, Kauffman M, et al. Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia. Blood. 2012;120:1765-73 pubmed 出版商
Masse I, Barbollat Boutrand L, Molina M, Berthier Vergnes O, Joly Tonetti N, Martin M, et al. Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes. Cell Death Dis. 2012;3:e318 pubmed 出版商
Nande R, Di Benedetto A, Aimola P, de Carlo F, Carper M, Claudio C, et al. Targeting a newly established spontaneous feline fibrosarcoma cell line by gene transfer. PLoS ONE. 2012;7:e37743 pubmed 出版商
Yu X, Liu Q, Wang M. [Current applications of high-throughput DNA sequencing technology in antibody drug research]. Yao Xue Xue Bao. 2012;47:322-31 pubmed
Parasramka M, Dashwood W, Wang R, Abdelli A, Bailey G, Williams D, et al. MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res. 2012;56:1259-69 pubmed 出版商
Chen G, Ghosh P, O Farrell T, Munk R, Rezanka L, Sasaki C, et al. Transforming growth factor ?1 (TGF-?1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53. J Biol Chem. 2012;287:23184-95 pubmed 出版商
Das A, Gopalakrishnan B, Voss O, Doseff A, Villamena F. Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling. Biochem Pharmacol. 2012;84:486-97 pubmed 出版商
Fang E, Zhang C, Wong J, Shen J, Li C, Ng T. The MAP30 protein from bitter gourd (Momordica charantia) seeds promotes apoptosis in liver cancer cells in vitro and in vivo. Cancer Lett. 2012;324:66-74 pubmed 出版商
Piovan C, Palmieri D, Di Leva G, Braccioli L, Casalini P, Nuovo G, et al. Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. Mol Oncol. 2012;6:458-72 pubmed 出版商
Fang E, Zhang C, Zhang L, Fong W, Ng T. In vitro and in vivo anticarcinogenic effects of RNase MC2, a ribonuclease isolated from dietary bitter gourd, toward human liver cancer cells. Int J Biochem Cell Biol. 2012;44:1351-60 pubmed 出版商
Bobustuc G, Smith J, Maddipatla S, Jeudy S, Limaye A, Isley B, et al. MGMT inhibition restores ER? functional sensitivity to antiestrogen therapy. Mol Med. 2012;18:913-29 pubmed 出版商
Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, et al. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol. 2012;50:2424-31 pubmed 出版商
Fei J, de Villiers E. Differential regulation of cutaneous oncoprotein HPVE6 by wtp53, mutant p53R248W and ?Np63? is HPV type dependent. PLoS ONE. 2012;7:e35540 pubmed 出版商
Reverdy C, Conrath S, Lopez R, Planquette C, Atmanene C, Collura V, et al. Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chem Biol. 2012;19:467-77 pubmed 出版商
Kim T, Oh S, Shin S, Janknecht R. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS ONE. 2012;7:e34618 pubmed 出版商
Chang L, Eastman A. Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle. 2012;11:1818-26 pubmed 出版商
Shen S, Lee W, Yang L, Tsai H, Yang L, Chen Y. Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes. Exp Dermatol. 2012;21:370-5 pubmed 出版商
Chen H, Yuan Y, Zhang C, Luo A, Ding F, Ma J, et al. Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. J Biol Chem. 2012;287:17109-19 pubmed 出版商
Magnussen G, Ree Rosnes A, Shahzidi S, Dong H, Emilsen E, Engesæter B, et al. Synthetic retinoid CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma. Biochem Biophys Res Commun. 2012;420:516-22 pubmed 出版商
Origanti S, Cai S, Munir A, White L, Piwnica Worms H. Synthetic lethality of Chk1 inhibition combined with p53 and/or p21 loss during a DNA damage response in normal and tumor cells. Oncogene. 2013;32:577-88 pubmed 出版商
Chen S, Evans H, Evans D. FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. PLoS ONE. 2012;7:e32971 pubmed 出版商
Lee S, Park S, Kim W, Moon S. Gleditsia sinensis thorn extract inhibits proliferation and TNF-?-induced MMP-9 expression in vascular smooth muscle cells. Am J Chin Med. 2012;40:373-86 pubmed
Kong Y, Bai P, Sun H, Nan K. Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients. J Mol Neurosci. 2012;47:207-18 pubmed 出版商
Choumessi A, Danel M, Chassaing S, Truchet I, Penlap V, Pieme A, et al. Characterization of the antiproliferative activity of Xylopia aethiopica. Cell Div. 2012;7:8 pubmed 出版商
Hayashi M, Cesare A, Fitzpatrick J, Lazzerini Denchi E, Karlseder J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol. 2012;19:387-94 pubmed 出版商
Yee K, Grochola L, Hamilton G, Grawenda A, Bond E, Taubert H, et al. A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma. Cancer Res. 2012;72:2206-17 pubmed 出版商
Keim A, Muller I, Thiel G. Efficient genetic manipulation of 1321N1 astrocytoma cells using lentiviral gene transfer. J Neurosci Methods. 2012;206:138-42 pubmed 出版商
Wong P, Miranda F, Chan K, Berlato C, Hurst H, Scibetta A. Histone demethylase KDM5B collaborates with TFAP2C and Myc to repress the cell cycle inhibitor p21(cip) (CDKN1A). Mol Cell Biol. 2012;32:1633-44 pubmed 出版商
Gyöngyösi E, Szalmás A, Ferenczi A, Konya J, Gergely L, Veress G. Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes. Virol J. 2012;9:36 pubmed 出版商
Tsapakidis K, Vlachostergios P, Voutsadakis I, Befani C, Patrikidou A, Hatzidaki E, et al. Bortezomib reverses the proliferative and antiapoptotic effect of neuropeptides on prostate cancer cells. Int J Urol. 2012;19:565-74 pubmed 出版商
Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä S, Akesson A, et al. Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci. 2012;127:66-75 pubmed 出版商
Xiang T, Li L, Yin X, Yuan C, Tan C, Su X, et al. The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS ONE. 2012;7:e29783 pubmed 出版商
Keim A, Rössler O, Rothhaar T, Thiel G. Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun. Neuroscience. 2012;206:25-38 pubmed 出版商
Qin X, Fukuda T, Yang L, Zaha H, Akanuma H, Zeng Q, et al. Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells. Cancer Biol Ther. 2012;13:296-306 pubmed 出版商
Patel A, Muñoz A, Halvorsen K, Rai P. Creation and validation of a ligation-independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells. BMC Biotechnol. 2012;12:3 pubmed 出版商
Zhang X, Liu Z, Xu B, Sun Z, Gong Y, Shao C. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization. Eur J Pharmacol. 2012;677:47-54 pubmed 出版商
Liu W, Swetzig W, Medisetty R, Das G. Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS ONE. 2011;6:e29466 pubmed 出版商
Vaughan C, Singh S, Windle B, Sankala H, Graves P, Andrew Yeudall W, et al. p53 mutants induce transcription of NF-?B2 in H1299 cells through CBP and STAT binding on the NF-?B2 promoter and gain of function activity. Arch Biochem Biophys. 2012;518:79-88 pubmed 出版商
Warnock L, Raines S, Milner J. Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53. Cancer Biol Ther. 2011;12:1059-68 pubmed 出版商
Gomes J, Magalhaes A, Michel V, Amado I, Aranha P, Ovesen R, et al. Pteridium aquilinum and its ptaquiloside toxin induce DNA damage response in gastric epithelial cells, a link with gastric carcinogenesis. Toxicol Sci. 2012;126:60-71 pubmed 出版商
Kim T, Shin S, Berry W, Oh S, Janknecht R. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 2012;113:1368-76 pubmed 出版商
Ceteci F, Xu J, Ceteci S, Zanucco E, Thakur C, Rapp U. Conditional expression of oncogenic C-RAF in mouse pulmonary epithelial cells reveals differential tumorigenesis and induction of autophagy leading to tumor regression. Neoplasia. 2011;13:1005-18 pubmed
Shah Z, Ahmed S, Ford J, Allison S, Knight J, Milner J. A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes. Mol Cell Biol. 2012;32:704-16 pubmed 出版商
Srinivas P, Patra C, Bhattacharya S, Mukhopadhyay D. Cytotoxicity of naphthoquinones and their capacity to generate reactive oxygen species is quenched when conjugated with gold nanoparticles. Int J Nanomedicine. 2011;6:2113-22 pubmed 出版商
Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, et al. Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res. 2012;72:460-71 pubmed 出版商
Gagrica S, Brookes S, Anderton E, Rowe J, Peters G. Contrasting behavior of the p18INK4c and p16INK4a tumor suppressors in both replicative and oncogene-induced senescence. Cancer Res. 2012;72:165-75 pubmed 出版商
Lee M, Song S, Jung S, Hur S, Asahara T, Kim H, et al. Effect of ionizing radiation induced damage of endothelial progenitor cells in vascular regeneration. Arterioscler Thromb Vasc Biol. 2012;32:343-52 pubmed 出版商
Grad I, Hibaoui Y, Jaconi M, Chicha L, Bergström Tengzelius R, Sailani M, et al. NANOG priming before full reprogramming may generate germ cell tumours. Eur Cell Mater. 2011;22:258-74; discussio 274 pubmed
Russell P, Hennessy B, Li J, Carey M, Bast R, Freeman T, et al. Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest. Oncogene. 2012;31:2450-60 pubmed 出版商
Abedin Z, Sen S, Field J. Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol. Chem Res Toxicol. 2012;25:113-21 pubmed 出版商
Léveillé N, Elkon R, Davalos V, Manoharan V, Hollingworth D, Oude Vrielink J, et al. Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. Nat Commun. 2011;2:513 pubmed 出版商
Kim H, Cho J, Quan H, Kim J. Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway. FEBS Lett. 2011;585:3569-76 pubmed 出版商
Yuan H, Rossetto D, Mellert H, Dang W, Srinivasan M, JOHNSON J, et al. MYST protein acetyltransferase activity requires active site lysine autoacetylation. EMBO J. 2012;31:58-70 pubmed 出版商
Sivachandran N, Dawson C, Young L, Liu F, Middeldorp J, Frappier L. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. J Virol. 2012;86:60-8 pubmed 出版商
Pandey M, Kaur P, Shukla S, Abbas A, Fu P, Gupta S. Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study. Mol Carcinog. 2012;51:952-62 pubmed 出版商
Tagscherer K, Fassl A, Sinkovic T, Combs S, Roth W. p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737. Apoptosis. 2012;17:187-99 pubmed 出版商
Hsu C, Peng K, Jhang H, Lin C, Wu S, Chiang C, et al. The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription. Oncogene. 2012;31:2335-49 pubmed 出版商
Leskov K, Araki S, Lavik J, Gomez J, Gama V, Gonos E, et al. CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem. 2011;286:40083-90 pubmed 出版商
Euskirchen P, Skaftnesmo K, Huszthy P, Brekkå N, Bjerkvig R, Jacobs A, et al. NUMB does not impair growth and differentiation status of experimental gliomas. Exp Cell Res. 2011;317:2864-73 pubmed 出版商
Fang E, Zhang C, Ng T, Wong J, Pan W, Ye X, et al. Momordica Charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo. Cancer Prev Res (Phila). 2012;5:109-21 pubmed 出版商
Lenos K, de Lange J, Teunisse A, Lodder K, Verlaan de Vries M, Wiercinska E, et al. Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts. Mol Cancer. 2011;10:111 pubmed 出版商
Yew C, Lee P, Chan W, Lim V, Tay S, Tan T, et al. A novel MLL5 isoform that is essential to activate E6 and E7 transcription in HPV16/18-associated cervical cancers. Cancer Res. 2011;71:6696-707 pubmed 出版商
Daviau A, Couture J, Blouin R. Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. Biochem Biophys Res Commun. 2011;413:282-7 pubmed 出版商
Aranha M, Santos D, Sola S, Steer C, Rodrigues C. miR-34a regulates mouse neural stem cell differentiation. PLoS ONE. 2011;6:e21396 pubmed 出版商
Hu R, Peng G, Dai H, Breuer E, Stemke Hale K, Li K, et al. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res. 2011;71:6524-34 pubmed 出版商
Reiser J, Hurst J, Voges M, Krauss P, Münch P, Iftner T, et al. High-risk human papillomaviruses repress constitutive kappa interferon transcription via E6 to prevent pathogen recognition receptor and antiviral-gene expression. J Virol. 2011;85:11372-80 pubmed 出版商
Li Y, Yu Y, Zhang Y, Zhou Y, Li C, Zhu J, et al. MAFIP is a tumor suppressor in cervical cancer that inhibits activation of the nuclear factor-kappa B pathway. Cancer Sci. 2011;102:2043-50 pubmed 出版商
Chavez Perez V, Strasberg Rieber M, Rieber M. Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion. Cancer Biol Ther. 2011;12:647-56 pubmed
Jing K, Song K, Shin S, Kim N, Jeong S, Oh H, et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. Autophagy. 2011;7:1348-58 pubmed 出版商
An J, Kim J, Jang S, Kim C, Kang E, Choi K. Gelsolin negatively regulates the activity of tumor suppressor p53 through their physical interaction in hepatocarcinoma HepG2 cells. Biochem Biophys Res Commun. 2011;412:44-9 pubmed 出版商
Liu J, Uematsu H, Tsuchida N, Ikeda M. Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells. Mol Cancer. 2011;10:95 pubmed 出版商
He H, Yu F, Sun C, Luo Y. CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes. PLoS ONE. 2011;6:e22088 pubmed 出版商
Krzywicka Racka A, Sluder G. Repeated cleavage failure does not establish centrosome amplification in untransformed human cells. J Cell Biol. 2011;194:199-207 pubmed 出版商
He Y, Xu Y, Zhang C, Gao X, Dykema K, Martin K, et al. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal. 2011;4:ra44 pubmed 出版商
Wang X, Wang Y, Wang Y. Ginsenoside Rb1, Rg1 and three extracts of traditional Chinese medicine attenuate ultraviolet B-induced G1 growth arrest in HaCaT cells and dermal fibroblasts involve down-regulating the expression of p16, p21 and p53. Photodermatol Photoimmunol Photomed. 2011;27:203-12 pubmed 出版商
Yoon A, Gao R, Kaul Z, Choi I, Ryu J, Noble J, et al. MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. Nucleic Acids Res. 2011;39:8078-91 pubmed 出版商
Muenyi C, States V, Masters J, Fan T, Helm C, States J. Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC). J Ovarian Res. 2011;4:9 pubmed 出版商
Ling Y, Chen Y, Chen P, Hui H, Song X, Lu Z, et al. Baicalein potently suppresses angiogenesis induced by vascular endothelial growth factor through the p53/Rb signaling pathway leading to G1/S cell cycle arrest. Exp Biol Med (Maywood). 2011;236:851-8 pubmed 出版商
Jalili A, Moser A, Pashenkov M, Wagner C, Pathria G, Borgdorff V, et al. Polo-like kinase 1 is a potential therapeutic target in human melanoma. J Invest Dermatol. 2011;131:1886-95 pubmed 出版商
Bonofiglio D, Cione E, Vizza D, Perri M, Pingitore A, Qi H, et al. Bid as a potential target of apoptotic effects exerted by low doses of PPAR? and RXR ligands in breast cancer cells. Cell Cycle. 2011;10:2344-54 pubmed
Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, et al. Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev. 2011;25:1245-61 pubmed 出版商
Sankala H, Vaughan C, Wang J, Deb S, Graves P. Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance. Arch Biochem Biophys. 2011;512:52-60 pubmed 出版商
Taniue K, Oda T, Hayashi T, Okuno M, Akiyama T. A member of the ETS family, EHF, and the ATPase RUVBL1 inhibit p53-mediated apoptosis. EMBO Rep. 2011;12:682-9 pubmed 出版商
Duan X, Ponomareva L, Veeranki S, Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS ONE. 2011;6:e19532 pubmed 出版商
Wang X, Wang J, Jiang X. MdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination. J Biol Chem. 2011;286:23725-34 pubmed 出版商
Nardiello T, Jungbluth A, Mei A, DiLiberto M, Huang X, Dabrowski A, et al. MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin. Clin Cancer Res. 2011;17:4309-19 pubmed 出版商
Nishioka C, Ikezoe T, Yang J, Udaka K, Yokoyama A. Simultaneous inhibition of DNA methyltransferase and histone deacetylase induces p53-independent apoptosis via down-regulation of Mcl-1 in acute myelogenous leukemia cells. Leuk Res. 2011;35:932-9 pubmed 出版商
Terrinoni A, Pagani I, Zucchi I, Chiaravalli A, Serra V, Rovera F, et al. OTX1 expression in breast cancer is regulated by p53. Oncogene. 2011;30:3096-103 pubmed 出版商
Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res. 2011;9:589-602 pubmed 出版商
Sho T, Tsukiyama T, Sato T, Kondo T, Cheng J, Saku T, et al. TRIM29 negatively regulates p53 via inhibition of Tip60. Biochim Biophys Acta. 2011;1813:1245-53 pubmed 出版商
Tolde O, Folk P. Stress-induced expression of p53 target genes is insensitive to SNW1/SKIP downregulation. Cell Mol Biol Lett. 2011;16:373-84 pubmed 出版商
Ofir M, Hacohen D, Ginsberg D. MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res. 2011;9:440-7 pubmed 出版商
Hömig Hölzel C, van Doorn R, Vogel C, Germann M, Cecchini M, Verdegaal E, et al. Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. EMBO J. 2011;30:1753-65 pubmed 出版商
Li Y, Zhu Z, Zhang S, Yu D, Yu H, Liu L, et al. ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth. PLoS ONE. 2011;6:e17794 pubmed 出版商
Bou Kheir T, Futoma Kazmierczak E, Jacobsen A, Krogh A, Bardram L, Hother C, et al. miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer. 2011;10:29 pubmed 出版商
Tanikawa M, Wada Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, et al. Multifunctional transcription factor TFII-I is an activator of BRCA1 function. Br J Cancer. 2011;104:1349-55 pubmed 出版商
Li M, Xu X, Liu Y. The SET2-RPB1 interaction domain of human RECQ5 is important for transcription-associated genome stability. Mol Cell Biol. 2011;31:2090-9 pubmed 出版商
Dogar A, Towbin H, Hall J. Suppression of latent transforming growth factor (TGF)-beta1 restores growth inhibitory TGF-beta signaling through microRNAs. J Biol Chem. 2011;286:16447-58 pubmed 出版商
Salehi Reyhani A, Kaplinsky J, Burgin E, Novakova M, deMello A, Templer R, et al. A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection. Lab Chip. 2011;11:1256-61 pubmed 出版商
Li Y, Xu S, Giles A, Nakamura K, Lee J, Hou X, et al. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J. 2011;25:1664-79 pubmed 出版商
Sarkari F, Wang X, Nguyen T, Frappier L. The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies. PLoS ONE. 2011;6:e16598 pubmed 出版商
Azzariti A, Bocci G, Porcelli L, Fioravanti A, Sini P, Simone G, et al. Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer. Br J Cancer. 2011;104:769-80 pubmed 出版商
Zakharchenko O, Greenwood C, Lewandowska A, Hellman U, Alldridge L, Souchelnytskyi S. Meta-data analysis as a strategy to evaluate individual and common features of proteomic changes in breast cancer. Cancer Genomics Proteomics. 2011;8:1-14 pubmed
Fan L, Chiang W, Liang C, Tsai Y, Wong T, Chen K, et al. ?-Catulin knockdown induces senescence in cancer cells. Oncogene. 2011;30:2610-21 pubmed 出版商
Srirangam A, Milani M, Mitra R, Guo Z, RODRIGUEZ M, Kathuria H, et al. The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin. J Thorac Oncol. 2011;6:661-70 pubmed 出版商
Singh K, Kumari R, Treas J, DuMond J. Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011;24:340-9 pubmed 出版商
Mittal S, Aslam A, Doidge R, Medica R, Winkler G. The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Mol Biol Cell. 2011;22:748-58 pubmed 出版商
Vrouwe M, Pines A, Overmeer R, Hanada K, Mullenders L. UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways. J Cell Sci. 2011;124:435-46 pubmed 出版商
Heijink D, Fehrmann R, de Vries E, Koornstra J, Oosterhuis D, van der Zee A, et al. A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer. Oncogene. 2011;30:2026-36 pubmed 出版商
Fertey J, Hurst J, Straub E, Schenker A, Iftner T, Stubenrauch F. Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein. J Virol. 2011;85:2918-26 pubmed 出版商
Kasuki Jomori de Pinho L, Vieira Neto L, Armondi Wildemberg L, Gasparetto E, Marcondes J, de Almeida Nunes B, et al. Low aryl hydrocarbon receptor-interacting protein expression is a better marker of invasiveness in somatotropinomas than Ki-67 and p53. Neuroendocrinology. 2011;94:39-48 pubmed 出版商
Bennett K, Mester J, Eng C. Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome. JAMA. 2010;304:2724-31 pubmed 出版商
Kantoh K, Ono M, Nakamura Y, Nakamura Y, Hashimoto K, Sakagami H, et al. Hormetic and anti-radiation effects of tropolone-related compounds. In Vivo. 2010;24:843-51 pubmed
Chen S, Evans H, Evans D. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. J Biol Chem. 2011;286:10201-9 pubmed 出版商
Yu W, Qiu Z, Gao N, Wang L, Cui H, Qian Y, et al. PAK1IP1, a ribosomal stress-induced nucleolar protein, regulates cell proliferation via the p53-MDM2 loop. Nucleic Acids Res. 2011;39:2234-48 pubmed 出版商
Cimica V, Smith M, Zhang Z, Mathur D, Mani S, Kalpana G. Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen. BMC Cancer. 2010;10:634 pubmed 出版商
Scibetta A, Wong P, Chan K, Canosa M, Hurst H. Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter. Cell Cycle. 2010;9:4525-32 pubmed
Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, et al. Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis. PLoS Genet. 2010;6:e1001170 pubmed 出版商
Chu Y, Yang X. SUMO E3 ligase activity of TRIM proteins. Oncogene. 2011;30:1108-16 pubmed 出版商
Luo X, Li L, Deng Q, Yu X, Yang L, Luo F, et al. Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells. Eur J Cancer. 2011;47:316-25 pubmed 出版商
Yang Y, Zhao X, Chen W, Gao Z, Liu A, Guo J, et al. Effects of cidofovir on human papillomavirus-positive cervical cancer cells xenografts in nude mice. Oncol Res. 2010;18:519-27 pubmed
Zhang X, Gao N, Chen R, Xu H, He Q. [Characteristics of boningmycin induced cellular senescence of human tumor cells]. Yao Xue Xue Bao. 2010;45:589-94 pubmed
Larrieu D, Ythier D, Brambilla C, Pedeux R. ING2 controls the G1 to S-phase transition by regulating p21 expression. Cell Cycle. 2010;9:3984-90 pubmed
Giovannelli L, Pitozzi V, Jacomelli M, Mulinacci N, Laurenzana A, Dolara P, et al. Protective effects of resveratrol against senescence-associated changes in cultured human fibroblasts. J Gerontol A Biol Sci Med Sci. 2011;66:9-18 pubmed 出版商
Jiang Y, Rao K, Yang G, Chen X, Wang Q, Liu A, et al. Benzo(a)pyrene induces p73 mRNA expression and necrosis in human lung adenocarcinoma H1299 cells. Environ Toxicol. 2012;27:202-10 pubmed 出版商
Gilmore Hebert M, Ramabhadran R, Stern D. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Mol Cancer Res. 2010;8:1388-98 pubmed 出版商
Uetake Y, Sluder G. Prolonged prometaphase blocks daughter cell proliferation despite normal completion of mitosis. Curr Biol. 2010;20:1666-71 pubmed 出版商
Yu Y, Gu Z, Yin J, Chou W, Kwok C, Qin Z, et al. Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway. Chin Med J (Engl). 2010;123:1915-23 pubmed
Nantajit D, Fan M, Duru N, Wen Y, Reed J, Li J. Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. PLoS ONE. 2010;5:e12341 pubmed 出版商
Jin Z, Wallace L, Harper S, Yang J. PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem. 2010;285:34493-502 pubmed 出版商
Taura M, Suico M, Fukuda R, Koga T, Shuto T, Sato T, et al. MEF/ELF4 transactivation by E2F1 is inhibited by p53. Nucleic Acids Res. 2011;39:76-88 pubmed 出版商
Palozza P, Colangelo M, Simone R, Catalano A, Boninsegna A, Lanza P, et al. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis. 2010;31:1813-21 pubmed 出版商
Welford S, Dorie M, Li X, Haase V, Giaccia A. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol. 2010;30:4595-603 pubmed 出版商
Gomez Sarosi L, Strasberg Rieber M, Rieber M. H(2)O(2) preferentially synergizes with nitroprusside to induce apoptosis associated with superoxide dismutase dysregulation in human melanoma irrespective of p53 status: Antagonism by o-phenanthroline. Chem Biol Interact. 2010;188:134-43 pubmed 出版商
Castle C, Cassimere E, Lee J, Denicourt C. Las1L is a nucleolar protein required for cell proliferation and ribosome biogenesis. Mol Cell Biol. 2010;30:4404-14 pubmed 出版商
Zhang L, Kavanagh B, Thorburn A, Camidge D. Preclinical and clinical estimates of the basal apoptotic rate of a cancer predict the amount of apoptosis induced by subsequent proapoptotic stimuli. Clin Cancer Res. 2010;16:4478-89 pubmed 出版商
Zentner G, Hurd E, Schnetz M, Handoko L, Wang C, Wang Z, et al. CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet. 2010;19:3491-501 pubmed 出版商
Palanichamy J, Mehndiratta M, Bhagat M, Ramalingam P, Das B, Das P, et al. Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization. Mol Cancer Ther. 2010;9:2114-22 pubmed 出版商
Amatori S, Bagaloni I, Macedi E, Formica M, Giorgi L, Fusi V, et al. Malten, a new synthetic molecule showing in vitro antiproliferative activity against tumour cells and induction of complex DNA structural alterations. Br J Cancer. 2010;103:239-48 pubmed 出版商
Lee S, Park K, Ha S, Kim W, Moon S. Gleditsia sinensis thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression. Phytother Res. 2010;24:1870-6 pubmed 出版商
Gorjala P, Gary R. Beryllium sulfate induces p21 CDKN1A expression and a senescence-like cell cycle arrest in susceptible cancer cell types. Biometals. 2010;23:1061-73 pubmed 出版商
Pal D, Banerjee S, Mukherjee S, Roy A, Panda C, Das S. Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway. J Dermatol Sci. 2010;59:31-9 pubmed 出版商
Jun J, Lau L. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol. 2010;12:676-85 pubmed 出版商
Bobustuc G, Baker C, Limaye A, Jenkins W, Pearl G, Avgeropoulos N, et al. Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide. Neuro Oncol. 2010;12:917-27 pubmed 出版商
Sharma G, Mirza S, Parshad R, Srivastava A, Gupta S, Pandya P, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87:83-91 pubmed 出版商
Voutsadakis I, Patrikidou A, Tsapakidis K, Karagiannaki A, Hatzidaki E, Stathakis N, et al. Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis. 2010;25:795-804 pubmed 出版商
Damek Poprawa M, Stefanik D, Levin L, Akintoye S. Human bone marrow stromal cells display variable anatomic site-dependent response and recovery from irradiation. Arch Oral Biol. 2010;55:358-64 pubmed 出版商
de Bruijn M, Raats D, Hoogwater F, van Houdt W, Cameron K, Medema J, et al. Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa. Br J Cancer. 2010;102:1254-64 pubmed 出版商
Lui V, Lau C, Cheung C, Ho K, Ng M, Cheng S, et al. An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation. Biochem Pharmacol. 2010;79:1772-80 pubmed 出版商
Soucek K, Gajduskova P, Brazdova M, Hýzd alová M, Kočí L, Vydra D, et al. Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation. Cancer Genet Cytogenet. 2010;197:107-16 pubmed 出版商
Hiraike H, Wada Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, et al. Identification of DBC1 as a transcriptional repressor for BRCA1. Br J Cancer. 2010;102:1061-7 pubmed 出版商
Burger K, Mühl B, Harasim T, Rohrmoser M, Malamoussi A, Orban M, et al. Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J Biol Chem. 2010;285:12416-25 pubmed 出版商
Hwang I, Baguley B, Ching L, Gilchrist C. The ubiquitin-proteasome system is inhibited by p53 protein expression in human ovarian cancer cells. Cancer Lett. 2010;294:82-90 pubmed 出版商
Gwinn M, Leonard S, Sargent L, Lowry D, McKinstry K, Meighan T, et al. The role of p53 in silica-induced cellular and molecular responses associated with carcinogenesis. J Toxicol Environ Health A. 2009;72:1509-19 pubmed 出版商
Li Y, Han N, Gao N, Xu R, Sun C, Li D, et al. Induction of apoptosis by the angucyclinone antibiotic chemomicin in human tumor cells. Oncol Rep. 2010;23:477-83 pubmed
Navaraj A, Finnberg N, Dicker D, Yang W, Matthew E, El Deiry W. Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras. Cancer Biol Ther. 2009;8:2417-44 pubmed
Komissarova E, Rossman T. Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure. Toxicol Appl Pharmacol. 2010;243:399-404 pubmed 出版商
He Y, Shang X, Sun J, Zhang L, Zhao W, Tian Y, et al. Gonadal apoptosis during sex reversal of the rice field eel: implications for an evolutionarily conserved role of the molecular chaperone heat shock protein 10. J Exp Zool B Mol Dev Evol. 2010;314:257-66 pubmed 出版商
Amato A, Schillaci T, Lentini L, Di Leonardo A. CENPA overexpression promotes genome instability in pRb-depleted human cells. Mol Cancer. 2009;8:119 pubmed 出版商
Mirza S, Sharma G, Parshad R, Srivastava A, Gupta S, Ralhan R. Clinical significance of Stratifin, ERalpha and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. Clin Biochem. 2010;43:380-6 pubmed 出版商
Zhang W, Li J, Kanginakudru S, Zhao W, Yu X, Chen J. The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints. Virology. 2010;397:139-44 pubmed 出版商
Sharma G, Mirza S, Yang Y, Parshad R, Hazrah P, Datta Gupta S, et al. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol. 2009;31:487-500 pubmed 出版商
Moriya J, Minamino T, Tateno K, Okada S, Uemura A, Shimizu I, et al. Inhibition of semaphorin as a novel strategy for therapeutic angiogenesis. Circ Res. 2010;106:391-8 pubmed 出版商
Wang J, Wakeman T, Lathia J, Hjelmeland A, Wang X, White R, et al. Notch promotes radioresistance of glioma stem cells. Stem Cells. 2010;28:17-28 pubmed 出版商
Baxter E, Milner J. p53 Regulates LIF expression in human medulloblastoma cells. J Neurooncol. 2010;97:373-82 pubmed 出版商
Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, et al. Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation. Oncogene. 2009;28:4469-79 pubmed 出版商
Ting A, Low G, Gopalakrishnan K, Hande M. Telomere attrition and genomic instability in xeroderma pigmentosum type-b deficient fibroblasts under oxidative stress. J Cell Mol Med. 2010;14:403-16 pubmed 出版商
Lee S, Moon G, Jung K, Kim W, Moon S. c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. Food Chem Toxicol. 2010;48:277-83 pubmed 出版商
Sun C, Zhang M, Shan X, Zhou X, Yang J, Wang Y, et al. Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J Cancer Res Clin Oncol. 2010;136:603-10 pubmed 出版商
Zhang N, Pei F, Wei H, Zhang T, Yang C, Ma G, et al. Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. Exp Toxicol Pathol. 2011;63:33-8 pubmed 出版商
Orjalo A, Bhaumik D, Gengler B, Scott G, Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A. 2009;106:17031-6 pubmed 出版商
Guo Z, Wang J, Yang J, Wu N, Zhang Y, Shen Y. An inhibitory role of p53 via NF-kappaB element on the cyclin D1 gene under heat shock. Biochim Biophys Acta. 2009;1789:758-62 pubmed 出版商
Yun U, Park H, Shin D. p53 prevents immature escaping from cell cycle G2 checkpoint arrest through inhibiting cdk2-dependent NF-Y phosphorylation. Cancer Res Treat. 2006;38:224-8 pubmed 出版商
Rasmussen N, Ditzel H. Scanning the cell surface proteome of cancer cells and identification of metastasis-associated proteins using a subtractive immunization strategy. J Proteome Res. 2009;8:5048-59 pubmed 出版商
Lee S, Kim S, Choi W, Kim W, Moon S. Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys. 2009;490:103-9 pubmed 出版商
Yang A, Shi W, Li Y, Wang Z, Shao R, Li D, et al. Role of prosurvival molecules in the action of lidamycin toward human tumor cells. Biomed Environ Sci. 2009;22:244-52 pubmed 出版商
Park K, Kim S, Kim D. Experimental photodynamic therapy for liver cancer cell-implanted nude mice by an indole-3-acetic acid and intense pulsed light combination. Biol Pharm Bull. 2009;32:1609-13 pubmed
Hu Z, Sun J, Zhu X, Yang D, Zeng Y. ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway. J Transl Med. 2009;7:74 pubmed 出版商
Christoffersen N, Shalgi R, Frankel L, Leucci E, Lees M, Klausen M, et al. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ. 2010;17:236-45 pubmed 出版商
Chen S, Maya Mendoza A, Zeng K, Tang C, Sims P, Loric J, et al. Interaction with checkpoint kinase 1 modulates the recruitment of nucleophosmin to chromatin. J Proteome Res. 2009;8:4693-704 pubmed 出版商
Haughian J, Reno E, Thorne A, Bradford A. Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. Int J Cancer. 2009;125:2556-64 pubmed 出版商
Ferecatu I, Bergeaud M, Rodriguez Enfedaque A, Le Floch N, Oliver L, Rincheval V, et al. Mitochondrial localization of the low level p53 protein in proliferative cells. Biochem Biophys Res Commun. 2009;387:772-7 pubmed 出版商
Suzuki H, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature. 2009;460:529-33 pubmed 出版商
Zhang Z, Gao J, Wang Y, Song T, Zhang J, Wu G, et al. Tanshinone IIA triggers p53 responses and apoptosis by RNA polymerase II upon DNA minor groove binding. Biochem Pharmacol. 2009;78:1316-22 pubmed 出版商
Reamon Buettner S, Ciribilli Y, Traverso I, Kuhls B, Inga A, Borlak J. A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Hum Mol Genet. 2009;18:3567-78 pubmed 出版商
Basile V, Ferrari E, Lazzari S, Belluti S, Pignedoli F, Imbriano C. Curcumin derivatives: molecular basis of their anti-cancer activity. Biochem Pharmacol. 2009;78:1305-15 pubmed 出版商
Bourgarel Rey V, Savry A, Hua G, Carre M, Bressin C, Chacon C, et al. Transcriptional down-regulation of Bcl-2 by vinorelbine: identification of a novel binding site of p53 on Bcl-2 promoter. Biochem Pharmacol. 2009;78:1148-56 pubmed 出版商
Li C, Chen H, Ding F, Zhang Y, Luo A, Wang M, et al. A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway. Biochem J. 2009;422:363-72 pubmed 出版商
Rieber M, Strasberg Rieber M. DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin. Int J Cancer. 2009;125:1604-12 pubmed 出版商
An H, Ryu S, Kim S, Choi H, Chung J, Park S. Age associated high level of major vault protein is p53 dependent. Cell Biochem Funct. 2009;27:289-95 pubmed 出版商
Barradas M, Anderton E, Acosta J, Li S, Banito A, Rodriguez Niedenführ M, et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009;23:1177-82 pubmed 出版商
Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, et al. RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene. 2009;28:2502-12 pubmed 出版商
Nevis K, Cordeiro Stone M, Cook J. Origin licensing and p53 status regulate Cdk2 activity during G(1). Cell Cycle. 2009;8:1952-63 pubmed
Humbert N, Martien S, Augert A, da Costa M, Mauen S, Abbadie C, et al. A genetic screen identifies topoisomerase 1 as a regulator of senescence. Cancer Res. 2009;69:4101-6 pubmed 出版商
Lincová E, Hampl A, Pernicová Z, Starsíchová A, Krcmar P, Machala M, et al. Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs. Biochem Pharmacol. 2009;78:561-72 pubmed 出版商
Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele M, et al. Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009;283:108-17 pubmed 出版商
Shiina M, Lacher M, Christian C, Korn W. RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses. Cancer Gene Ther. 2009;16:810-9 pubmed 出版商
Hu L, Ibrahim S, Liu C, Skaar J, Pagano M, Karpatkin S. Thrombin induces tumor cell cycle activation and spontaneous growth by down-regulation of p27Kip1, in association with the up-regulation of Skp2 and MiR-222. Cancer Res. 2009;69:3374-81 pubmed 出版商
Wu S, Chiang C. Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J. 2009;28:1246-59 pubmed 出版商
Yu X, Riley T, Levine A. The regulation of the endosomal compartment by p53 the tumor suppressor gene. FEBS J. 2009;276:2201-12 pubmed 出版商
Muench P, Hiller T, Probst S, Florea A, Stubenrauch F, Iftner T. Binding of PDZ proteins to HPV E6 proteins does neither correlate with epidemiological risk classification nor with the immortalization of foreskin keratinocytes. Virology. 2009;387:380-7 pubmed 出版商
Shang L, Zhou H, Xia Y, Wang H, Gao G, Chen B, et al. Serum withdrawal up-regulates human SIRT1 gene expression in a p53-dependent manner. J Cell Mol Med. 2009;13:4176-84 pubmed 出版商
Wang W, Bergh A, Damber J. Increased p53 immunoreactivity in proliferative inflammatory atrophy of prostate is related to focal acute inflammation. APMIS. 2009;117:185-95 pubmed 出版商
Zhang Z, Wang Y, Song T, Gao J, Wu G, Zhang J, et al. DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators. Chem Res Toxicol. 2009;22:483-91 pubmed 出版商
Wanzel M, Russ A, Kleine Kohlbrecher D, Colombo E, Pelicci P, Eilers M. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Nat Cell Biol. 2008;10:1051-61 pubmed
Liu Z, Liu Q, Xu B, Wu J, Guo C, Zhu F, et al. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res. 2009;662:75-83 pubmed 出版商
Nobre R, Herráez Hernández E, Fei J, Langbein L, Kaden S, Grone H, et al. E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol. 2009;83:2907-16 pubmed 出版商
Lim S, Hung A, Porter A. Focused PCR screen reveals p53 dependence of nitric oxide-induced apoptosis and up-regulation of maspin and plasminogen activator inhibitor-1 in tumor cells. Mol Cancer Res. 2009;7:55-66 pubmed 出版商
Flanagan J, Funes J, Henderson S, Wild L, Carey N, Boshoff C. Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets. Mol Cancer Ther. 2009;8:249-60 pubmed 出版商
Groskreutz D, Monick M, Babor E, Nyunoya T, Varga S, Look D, et al. Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication. Am J Respir Cell Mol Biol. 2009;41:189-98 pubmed 出版商
Trougakos I, Lourda M, Antonelou M, Kletsas D, Gorgoulis V, Papassideri I, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59 pubmed 出版商
Palozza P, Bellovino D, Simone R, Boninsegna A, Cellini F, Monastra G, et al. Effect of beta-carotene-rich tomato lycopene beta-cyclase ( tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cells. Br J Nutr. 2009;102:207-14 pubmed 出版商
Miao Z, Chang E, Tsai F, Yeh S, Wu C, Wu K, et al. Increased aquaglyceroporin 9 expression disrupts arsenic resistance in human lung cancer cells. Toxicol In Vitro. 2009;23:209-16 pubmed 出版商
Booth N, Sayers T, Brooks A, Thomas C, Jacobsen K, Goncharova E, et al. A cell-based high-throughput screen to identify synergistic TRAIL sensitizers. Cancer Immunol Immunother. 2009;58:1229-44 pubmed 出版商
Zhu C, Li C, Li Y, Zhan Y, Li Y, Xu C, et al. Cell growth suppression by thanatos-associated protein 11(THAP11) is mediated by transcriptional downregulation of c-Myc. Cell Death Differ. 2009;16:395-405 pubmed 出版商
Li Y, Qian H, Li X, Wang H, Yu J, Liu Y, et al. Adenoviral-mediated gene transfer of Gadd45a results in suppression by inducing apoptosis and cell cycle arrest in pancreatic cancer cell. J Gene Med. 2009;11:3-13 pubmed 出版商
Clement J, Kitagaki J, Yang Y, Saucedo C, O Keefe B, Weissman A, et al. Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. Bioorg Med Chem. 2008;16:10022-8 pubmed 出版商
Solier S, Sordet O, Kohn K, Pommier Y. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol Cell Biol. 2009;29:68-82 pubmed 出版商
Ofir Rosenfeld Y, Boggs K, Michael D, Kastan M, Oren M. Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Mol Cell. 2008;32:180-9 pubmed 出版商
Kang S, Lee Y, Kim B, Kim Y, Woo H, Jeon H, et al. Effect of Bupleuri Radix extracts on the toxicity of 5-fluorouracil in HepG2 hepatoma cells and normal human lymphocytes. Basic Clin Pharmacol Toxicol. 2008;103:305-13 pubmed 出版商
Sivachandran N, Sarkari F, Frappier L. Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies. PLoS Pathog. 2008;4:e1000170 pubmed 出版商
Morselli E, Tasdemir E, Maiuri M, Galluzzi L, Kepp O, Criollo A, et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle. 2008;7:3056-61 pubmed
Maduro J, de Vries E, Meersma G, Hougardy B, van der Zee A, de Jong S. Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis. Int J Radiat Oncol Biol Phys. 2008;72:543-52 pubmed 出版商
Warnock L, Knox A, Mee T, Raines S, Milner J. Influence of tetramerisation on site-specific post-translational modifications of p53: comparison of human and murine p53 tumor suppressor protein. Cancer Biol Ther. 2008;7:1481-9 pubmed
Seo H, Park H, Choi H, Hwang S, Park J, Seong Y. BMI-1026 treatment can induce SAHF formation by activation of Erk1/2. BMB Rep. 2008;41:523-8 pubmed
Lee S, Kim J, Jeong M, An J, Jang S, Song K, et al. Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells. FEBS Lett. 2008;582:2826-32 pubmed 出版商
Minty F, Thurlow J, Harrison P, Parkinson E. Telomere dysfunction in human keratinocytes elicits senescence and a novel transcription profile. Exp Cell Res. 2008;314:2434-47 pubmed 出版商
Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008;112:2450-62 pubmed 出版商
Sihn C, Lee Y, Jeong J, Park K, Kim S. CANu1, a novel nucleolar protein, accumulated on centromere in response to DNA damage. Genes Cells. 2008;13:787-96 pubmed 出版商
Wang C, Han M, Zhao X, Wen J. Kruppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J Biochem. 2008;144:313-21 pubmed 出版商
Ouellet V, Zietarska M, Portelance L, Lafontaine J, Madore J, Puiffe M, et al. Characterization of three new serous epithelial ovarian cancer cell lines. BMC Cancer. 2008;8:152 pubmed 出版商
Shiota M, Izumi H, Onitsuka T, Miyamoto N, Kashiwagi E, Kidani A, et al. Twist and p53 reciprocally regulate target genes via direct interaction. Oncogene. 2008;27:5543-53 pubmed 出版商
Chen W, Kang J, Xia J, Li Y, Yang B, Chen B, et al. p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. Int J Mol Med. 2008;21:645-53 pubmed
Kang S, Kim B, Lee Y, Chung H. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen. 2008;49:399-405 pubmed 出版商
Fei J, de Villiers E. Degradation of HPV20E6 by p53: Delta Np63 alpha and mutant p53R248W protect the wild type p53 mediated caspase-degradation. Int J Cancer. 2008;123:108-16 pubmed 出版商
Groll M, Schellenberg B, Bachmann A, Archer C, Huber R, Powell T, et al. A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature. 2008;452:755-8 pubmed 出版商
Chang Y, Jan K, Cheng C, Liao C, Liu Y. Direct involvement of the tumor suppressor p53 in nucleotide excision repair. DNA Repair (Amst). 2008;7:751-61 pubmed 出版商
Reamon Buettner S, Ciribilli Y, Inga A, Borlak J. A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet. 2008;17:1397-405 pubmed 出版商
Li L, Zhou S, Chen X, Guo L, Li Z, Hu D, et al. The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells. FEBS Lett. 2008;582:755-62 pubmed 出版商
Zhao W, Kruse J, Tang Y, Jung S, Qin J, Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature. 2008;451:587-90 pubmed 出版商
Dharel N, Kato N, Muroyama R, Taniguchi H, Otsuka M, Wang Y, et al. Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus. Hepatology. 2008;47:1136-49 pubmed 出版商
Rubio C, Petersson F, Höög A, Jonasson J, Nesi G, Chandanos E, et al. Further studies on serrated neoplasias of the cardia: a review and case report. Anticancer Res. 2007;27:4431-4 pubmed
Weinmann L, Wischhusen J, Demma M, Naumann U, Roth P, Dasmahapatra B, et al. A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ. 2008;15:718-29 pubmed 出版商
Alimirah F, Panchanathan R, Chen J, Zhang X, Ho S, Choubey D. Expression of androgen receptor is negatively regulated by p53. Neoplasia. 2007;9:1152-9 pubmed
Sima N, Wang W, Kong D, Deng D, Xu Q, Zhou J, et al. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis. 2008;13:273-81 pubmed
Augustyn K, Merino E, Barton J. A role for DNA-mediated charge transport in regulating p53: Oxidation of the DNA-bound protein from a distance. Proc Natl Acad Sci U S A. 2007;104:18907-12 pubmed
Zhang P, Jacobs B, Samuel C. Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis. J Virol. 2008;82:840-8 pubmed
Warnock L, Adamson R, Lynch C, Milner J. Crosstalk between site-specific modifications on p53 and histone H3. Oncogene. 2008;27:1639-44 pubmed
Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, et al. Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J. 2008;409:581-9 pubmed
Asadurian Y, Kurilin H, Lichtig H, Jackman A, Gonen P, Tommasino M, et al. Activities of human papillomavirus 16 E6 natural variants in human keratinocytes. J Med Virol. 2007;79:1751-60 pubmed
Oishi N, Shilagardi K, Nakamoto Y, Honda M, Kaneko S, Murakami S. Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Cancer Sci. 2007;98:1540-8 pubmed
Henrich S, Christopherson R. Multiple forms of nuclear p53 formed in human Raji and MEC1 cells treated with fludarabine. Leukemia. 2008;22:657-60 pubmed
Radhakrishnan S, Bhat U, Halasi M, Gartel A. P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents. Oncogene. 2008;27:1306-9 pubmed
Groskreutz D, Monick M, Yarovinsky T, Powers L, Quelle D, Varga S, et al. Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. J Immunol. 2007;179:2741-7 pubmed
Chen Z, Knutson E, Wang S, Martinez L, Albrecht T. Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitination. J Biol Chem. 2007;282:29284-95 pubmed
Sharma R, Jiang H, Zhong L, Tseng J, Gow A. Minimal role for activating transcription factor 3 in the oligodendrocyte unfolded protein response in vivo. J Neurochem. 2007;102:1703-1712 pubmed 出版商
De Castro Arce J, Göckel Krzikalla E, Rösl F. Retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region. J Biol Chem. 2007;282:28520-9 pubmed
Sagulenko E, Savelyeva L, Ehemann V, Sagulenko V, Hofmann W, Arnold K, et al. Suppression of polyploidy by the BRCA2 protein. Cancer Lett. 2007;257:65-72 pubmed
Martin B, Kleiber K, Wixler V, Raab M, Zimmer B, Kaufmann M, et al. FHL2 regulates cell cycle-dependent and doxorubicin-induced p21Cip1/Waf1 expression in breast cancer cells. Cell Cycle. 2007;6:1779-88 pubmed
Schweiger M, Ottinger M, You J, Howley P. Brd4-independent transcriptional repression function of the papillomavirus e2 proteins. J Virol. 2007;81:9612-22 pubmed
Jung J, Kwun H, Lee J, Arora P, Jang K. Hepatitis B virus X protein differentially affects the ubiquitin-mediated proteasomal degradation of beta-catenin depending on the status of cellular p53. J Gen Virol. 2007;88:2144-54 pubmed
Gadea G, de Toledo M, Anguille C, Roux P. Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices. J Cell Biol. 2007;178:23-30 pubmed
Sima N, Wang S, Wang W, Kong D, Xu Q, Tian X, et al. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol. 2007;106:299-304 pubmed
Lee J, Beliakoff J, Sun Z. The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Nucleic Acids Res. 2007;35:4523-34 pubmed
Stubenrauch F, Straub E, Fertey J, Iftner T. The E8 repression domain can replace the E2 transactivation domain for growth inhibition of HeLa cells by papillomavirus E2 proteins. Int J Cancer. 2007;121:2284-92 pubmed
Kato Y, Okollie B, Raman V, Vesuna F, Zhao M, Baker S, et al. Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models. Cancer Biol Ther. 2007;6:891-7 pubmed
Sandoval M, Morales M, Tapia R, del Carmen Alarcón L, Sordo M, Ostrosky Wegman P, et al. p53 response to arsenic exposure in epithelial cells: protein kinase B/Akt involvement. Toxicol Sci. 2007;99:126-40 pubmed
Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, et al. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle. 2007;6:1586-93 pubmed
Oh H, Jin X, Kim J, Oh M, Pian X, Kim J, et al. Characteristics of primary and immortalized fibroblast cells derived from the miniature and domestic pigs. BMC Cell Biol. 2007;8:20 pubmed
Feng Z, Hu W, de Stanchina E, Teresky A, Jin S, Lowe S, et al. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res. 2007;67:3043-53 pubmed
Coates S, Lehnert B, Sharma S, Kindell S, Gary R. Beryllium induces premature senescence in human fibroblasts. J Pharmacol Exp Ther. 2007;322:70-9 pubmed
Chen Z, Fu L, Herrero R, Schiffman M, Burk R. Identification of a novel human papillomavirus (HPV97) related to HPV18 and HPV45. Int J Cancer. 2007;121:193-8 pubmed
Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh B, et al. Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem. 2007;282:11722-31 pubmed
Lizama C, Alfaro I, Reyes J, Moreno R. Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat. Apoptosis. 2007;12:499-512 pubmed
Alagbala A, McRiner A, Borstnik K, Labonte T, Chang W, D Angelo J, et al. Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines. J Med Chem. 2006;49:7836-42 pubmed
Kim B, Choi J, Kim Y, Woo H, Chung H. Desferrioxamine (DFX) has genotoxic effects on cultured human lymphocytes and induces the p53-mediated damage response. Toxicology. 2007;229:226-35 pubmed
Choi J, Kim B, Kim Y, Woo H, Chung H. Hypoxia/reoxygenation-induced cytotoxicity in cultured human lymphocytes. Biochem Biophys Res Commun. 2007;352:366-71 pubmed
Coleman C, Rocetes J, Park D, Wallick C, Warn Cramer B, Michel K, et al. Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis. Cell Prolif. 2006;39:599-609 pubmed
Criollo A, Galluzzi L, Maiuri M, Tasdemir E, Lavandero S, Kroemer G. Mitochondrial control of cell death induced by hyperosmotic stress. Apoptosis. 2007;12:3-18 pubmed
Mohan R, Rao A, Gagliardi J, Tini M. SUMO-1-dependent allosteric regulation of thymine DNA glycosylase alters subnuclear localization and CBP/p300 recruitment. Mol Cell Biol. 2007;27:229-43 pubmed
Ortt K, Sinha S. Derivation of the consensus DNA-binding sequence for p63 reveals unique requirements that are distinct from p53. FEBS Lett. 2006;580:4544-50 pubmed
Cisternas P, Moreno R. Comparative analysis of apoptotic pathways in rat, mouse, and hamster spermatozoa. Mol Reprod Dev. 2006;73:1318-25 pubmed
Wu M, Wu X, Li Q, Zheng R. Expression of Egr-1 gene and its correlation with the oncogene proteins in non-irradiated and irradiated esophageal squamous cell carcinoma. Dis Esophagus. 2006;19:267-72 pubmed
Chen C, Chang Y, Liu C, Chang K, Guo I. Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat. 2006;98:121-32 pubmed
Katori H, Nozawat A, Tsukuda M. Relationship between p21 and p53 expression, human papilloma virus infection and malignant transformation in sinonasal-inverted papilloma. Clin Oncol (R Coll Radiol). 2006;18:300-5 pubmed
Baleja J, Cherry J, Liu Z, Gao H, Nicklaus M, Voigt J, et al. Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins. Antiviral Res. 2006;72:49-59 pubmed
Radhakrishnan S, Gartel A. CDK9 phosphorylates p53 on serine residues 33, 315 and 392. Cell Cycle. 2006;5:519-21 pubmed
Radhakrishnan S, Gartel A. A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity. Cancer Res. 2006;66:3264-70 pubmed
Wolcott A, Gerion D, Visconte M, Sun J, Schwartzberg A, Chen S, et al. Silica-coated CdTe quantum dots functionalized with thiols for bioconjugation to IgG proteins. J Phys Chem B. 2006;110:5779-89 pubmed
Zheng Q, Ma L, Zhu W, Zhang Z, Tong T. p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation. J Cell Biochem. 2006;98:1230-48 pubmed
Kherrouche Z, Blais A, Ferreira E, De Launoit Y, Monte D. ASK-1 (apoptosis signal-regulating kinase 1) is a direct E2F target gene. Biochem J. 2006;396:547-56 pubmed
Kim D, Jeon S, Jeong Y, Kim S, Kwon S, Park K. Hydrogen peroxide is a mediator of indole-3-acetic acid/horseradish peroxidase-induced apoptosis. FEBS Lett. 2006;580:1439-46 pubmed
Wadhwa R, Takano S, Kaur K, Deocaris C, Pereira Smith O, Reddel R, et al. Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis. Int J Cancer. 2006;118:2973-80 pubmed
Li X, Zhang S, Safe S. Activation of kinase pathways in MCF-7 cells by 17beta-estradiol and structurally diverse estrogenic compounds. J Steroid Biochem Mol Biol. 2006;98:122-32 pubmed
Lewis J, Meeke K, Osipo C, Ross E, Kidawi N, Li T, et al. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst. 2005;97:1746-59 pubmed
Sanchez Aguilera A, Garcia J, Sanchez Beato M, Piris M. Hodgkin's lymphoma cells express alternatively spliced forms of HDM2 with multiple effects on cell cycle control. Oncogene. 2006;25:2565-74 pubmed
Ranga R, Sowmyalakshmi S, Burikhanov R, Akbarsha M, Chendil D. A herbal medicine for the treatment of lung cancer. Mol Cell Biochem. 2005;280:125-33 pubmed
Ammoun S, Lindholm D, Wootz H, Akerman K, Kukkonen J. G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. J Biol Chem. 2006;281:834-42 pubmed
Feng Z, Jin S, Zupnick A, Hoh J, de Stanchina E, Lowe S, et al. p53 tumor suppressor protein regulates the levels of huntingtin gene expression. Oncogene. 2006;25:1-7 pubmed
Radhakrishnan S, Gierut J, Gartel A. Multiple alternate p21 transcripts are regulated by p53 in human cells. Oncogene. 2006;25:1812-5 pubmed
Palozza P, Sheriff A, Serini S, Boninsegna A, Maggiano N, Ranelletti F, et al. Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad. Apoptosis. 2005;10:1445-56 pubmed
Lentini L, Iovino F, Amato A, Di Leonardo A. Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts. Cancer Lett. 2006;238:153-60 pubmed
Kim S, Kim D, Kwon S, Park E, Huh C, Youn S, et al. Protective effects of EGCG on UVB-induced damage in living skin equivalents. Arch Pharm Res. 2005;28:784-90 pubmed
Wallick C, Gamper I, Thorne M, Feith D, Takasaki K, Wilson S, et al. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene. 2005;24:5606-18 pubmed
He S, Stevens G, Braithwaite A, Eccles M. Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin-induced cytotoxicity. Mol Cancer Ther. 2005;4:996-1003 pubmed
Bernard D, Martinez Leal J, Rizzo S, Martinez D, Hudson D, Visakorpi T, et al. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene. 2005;24:5543-51 pubmed
Westfall M, Joyner A, Barbieri C, Livingstone M, Pietenpol J. Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha. Cell Cycle. 2005;4:710-6 pubmed
Nair A, Schliekelman M, Thomas M, Wakefield J, Jurgensen S, Ramabhadran R. Inhibition of p53 by lentiviral mediated shRNA abrogates G1 arrest and apoptosis in retinal pigmented epithelial cell line. Cell Cycle. 2005;4:697-703 pubmed
Fei J, Wei Q, Angel P, de Villiers E. Differential enhancement of a cutaneous HPV promoter by DeltaNP63alpha, Jun and mutant p53. Cell Cycle. 2005;4:689-96 pubmed
Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa J, Peters G, et al. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res. 2005;65:2179-85 pubmed
Leupin O, Bontron S, Schaeffer C, Strubin M. Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol. 2005;79:4238-45 pubmed
van der Knaap J, Kumar B, Moshkin Y, Langenberg K, Krijgsveld J, Heck A, et al. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. Mol Cell. 2005;17:695-707 pubmed
Magal S, Jackman A, Ish Shalom S, Botzer L, Gonen P, Schlegel R, et al. Downregulation of Bax mRNA expression and protein stability by the E6 protein of human papillomavirus 16. J Gen Virol. 2005;86:611-21 pubmed
Trost T, Lausch E, Fees S, Schmitt S, Enklaar T, Reutzel D, et al. Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells. Cancer Res. 2005;65:840-9 pubmed
Tao Y, Song X, Deng X, Xie D, Lee L, Liu Y, et al. Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1. Exp Cell Res. 2005;303:240-51 pubmed
Hellwinkel O, Muller J, Pollmann A, Kabisch H. Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. J Gene Med. 2005;7:407-19 pubmed
Wu Y, Muldoon L, Neuwelt E. The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. J Pharmacol Exp Ther. 2005;312:424-31 pubmed
Park W, Jung K, Chung D, Nam W, Choi W, Bae Y. Distinct patterns of cleavage and translocation of cell cycle control proteins in CD95-induced and p53-induced apoptosis. J Korean Med Sci. 2003;18:467-72 pubmed
Lee E, Gerhold M, Palmer M, Christen R. p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br J Cancer. 2003;88:754-9 pubmed
Zaika A, Slade N, Erster S, Sansome C, Joseph T, Pearl M, et al. DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors. J Exp Med. 2002;196:765-80 pubmed
Fish K, Schmid S, Damke H. Evidence that dynamin-2 functions as a signal-transducing GTPase. J Cell Biol. 2000;150:145-54 pubmed
产品名称 :
基因名称 :
规格 :
价格 :
目录号 :
类型 :
宿主 :
抗原 :
反应物种 :
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P), FCM
表位 :
交货时间 :
更多信息或购买 :
公司总部: 美国