产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
ERK 2(D-2)抗体
目录 :
sc-1647
规格 :
200微克/毫升
价格 :
279美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
D-2
反应物种 :
人类, 小鼠, 大鼠, common platanna
应用 :
免疫印迹, 酶联免疫吸附测定, 免疫组化, 免疫细胞化学, 免疫沉淀, 流式细胞仪, 免疫组化-石蜡切片
更多信息或购买 :
文章摘录数: 75
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 小鼠; 图 3g, s7c
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed 出版商
  • 免疫印迹; 小鼠; 1:1000; 图 s7a
Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Asensio Juan E, Fueyo R, PAPPA S, Iacobucci S, Badosa C, Lois S, et al. The histone demethylase PHF8 is a molecular safeguard of the IFNγ response. Nucleic Acids Res. 2017;45:3800-3811 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Takahashi M, Li Y, Dillon T, Stork P. Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP. J Biol Chem. 2017;292:1449-1461 pubmed 出版商
  • 免疫印迹; 人类; 图 1a
Li Y, Dillon T, Takahashi M, Earley K, Stork P. Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. J Biol Chem. 2016;291:21584-21595 pubmed
  • 免疫印迹; 小鼠; 图 1
Hey F, Giblett S, Forrest S, Herbert C, Pritchard C. Phosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse Intestine. PLoS ONE. 2016;11:e0156877 pubmed 出版商
  • 免疫印迹; 人类; 图 5a
Blee A, Liu S, Wang L, Huang H. BET bromodomain-mediated interaction between ERG and BRD4 promotes prostate cancer cell invasion. Oncotarget. 2016;7:38319-38332 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Choi H, Kim M, Choi Y, Shin Y, Cho S, Ko S. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med. 2016;16:122 pubmed 出版商
  • 免疫印迹; 人类; 图 7
Pivonello C, Negri M, De Martino M, Napolitano M, De Angelis C, Provvisiero D, et al. The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma. Oncotarget. 2016;7:9718-31 pubmed 出版商
  • 免疫印迹; 小鼠; 1:2000; 图 s3
Drilon A, Somwar R, Wagner J, Vellore N, Eide C, Zabriskie M, et al. A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer. Clin Cancer Res. 2016;22:2351-8 pubmed 出版商
  • 免疫组化; common platanna; 1:50; 图 5
  • 免疫细胞化学; 小鼠; 1:200; 图 2
  • 免疫印迹; 小鼠; 1:1000; 图 2
Sipieter F, Cappe B, Gonzalez Pisfil M, Spriet C, Bodart J, Cailliau Maggio K, et al. Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms. PLoS ONE. 2015;10:e0140924 pubmed 出版商
  • 免疫印迹; 人类; 1:2000
Davare M, Vellore N, Wagner J, Eide C, Goodman J, Drilon A, et al. Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2015;112:E5381-90 pubmed 出版商
  • 免疫印迹; 小鼠; 图 s4
Wightman S, Uppal A, Pitroda S, Ganai S, Burnette B, Stack M, et al. Oncogenic CXCL10 signalling drives metastasis development and poor clinical outcome. Br J Cancer. 2015;113:327-35 pubmed 出版商
  • 免疫印迹; 人类; 图 1
Chan S, Selth L, Li Y, Nyquist M, Miao L, Bradner J, et al. Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015;43:5880-97 pubmed 出版商
  • 免疫沉淀; 人类; 图 3
  • 免疫细胞化学; 人类; 图 3
  • 免疫印迹; 人类; 图 4
Warren D, Tajsic T, Porter L, Minaisah R, Cobb A, Jacob A, et al. Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageing. Cell Death Differ. 2015;22:1540-50 pubmed 出版商
  • 免疫细胞化学; 人类; 1:200
  • 免疫印迹; 人类
Gonzalez Granado J, Navarro Puche A, Molina Sánchez P, Blanco Berrocal M, Viana R, Font de Mora J, et al. Sorting nexin 6 enhances lamin a synthesis and incorporation into the nuclear envelope. PLoS ONE. 2014;9:e115571 pubmed 出版商
  • 免疫印迹; 人类
Kugel C, Hartsough E, Davies M, Setiady Y, Aplin A. Function-blocking ERBB3 antibody inhibits the adaptive response to RAF inhibitor. Cancer Res. 2014;74:4122-32 pubmed 出版商
  • 免疫印迹; 人类
Kardos G, Dai M, Robertson G. Growth inhibitory effects of large subunit ribosomal proteins in melanoma. Pigment Cell Melanoma Res. 2014;27:801-12 pubmed 出版商
  • 免疫印迹; 人类
Li Y, Takahashi M, Stork P. Ras-mutant cancer cells display B-Raf binding to Ras that activates extracellular signal-regulated kinase and is inhibited by protein kinase A phosphorylation. J Biol Chem. 2013;288:27646-57 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Slowik A, Merres J, Elfgen A, Jansen S, Mohr F, Wruck C, et al. Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells. Mol Neurodegener. 2012;7:55 pubmed 出版商
  • 免疫印迹; 人类; 1:500
Brandenburg L, Jansen S, Albrecht L, Merres J, Gerber J, Pufe T, et al. CpG oligodeoxynucleotides induce the expression of the antimicrobial peptide cathelicidin in glial cells. J Neuroimmunol. 2013;255:18-31 pubmed 出版商
  • 免疫组化; 小鼠
Mizrak S, Renault Mihara F, Parraga M, Bogerd J, van de Kant H, Lopez Casas P, et al. Phosphoprotein enriched in astrocytes-15 is expressed in mouse testis and protects spermatocytes from apoptosis. Reproduction. 2007;133:743-51 pubmed
Ohanna M, Cerezo M, Nottet N, Bille K, Didier R, Béranger G, et al. Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype. Genes Dev. 2018;32:448-461 pubmed 出版商
Rubio Patiño C, Bossowski J, De Donatis G, Mondragon L, Villa E, Aira L, et al. Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance. Cell Metab. 2018;27:828-842.e7 pubmed 出版商
Yang Y, Blee A, Wang D, An J, Pan Y, Yan Y, et al. Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion. Cancer Res. 2017;77:6524-6537 pubmed 出版商
Wang Z, Luo Y, Shao Q, Kinlock B, Wang C, Hildreth J, et al. Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. PLoS ONE. 2014;9:e106078 pubmed 出版商
Subramani A, Alsidawi S, Jagannathan S, Sumita K, Sasaki A, Aronow B, et al. The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis. Sci Rep. 2013;3:2392 pubmed 出版商
Botton T, Yeh I, Nelson T, Vemula S, Sparatta A, Garrido M, et al. Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy. Pigment Cell Melanoma Res. 2013;26:845-51 pubmed 出版商
Ahmadiantehrani S, Ron D. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via G??-Erk1/2-dependent induction of Zif268. J Neurochem. 2013;125:193-204 pubmed 出版商
Kaplan F, Kugel C, Dadpey N, Shao Y, Abel E, Aplin A. SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem. 2012;287:41797-807 pubmed 出版商
Lv J, Zhao Z, Chen Y, Wang Q, Tao Y, Yang L, et al. The chinese herbal decoction danggui buxue tang inhibits angiogenesis in a rat model of liver fibrosis. Evid Based Complement Alternat Med. 2012;2012:284963 pubmed 出版商
Jeseta M, Marin M, Tichovska H, Melicharova P, Cailliau Maggio K, Martoriati A, et al. Nitric oxide-donor SNAP induces Xenopus eggs activation. PLoS ONE. 2012;7:e41509 pubmed 出版商
Takahashi N, Sakurai T, Bozdagi Gunal O, Dorr N, Moy J, Krug L, et al. Increased expression of receptor phosphotyrosine phosphatase-?/? is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes. Transl Psychiatry. 2011;1:e8 pubmed 出版商
Amatangelo M, Goodyear S, Varma D, Stearns M. c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial-mesenchymal transition and invasion in prostate cancer. Carcinogenesis. 2012;33:1965-75 pubmed 出版商
Chan S, Li Y, Dehm S. Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem. 2012;287:19736-49 pubmed 出版商
Shao Y, Aplin A. ERK2 phosphorylation of serine 77 regulates Bmf pro-apoptotic activity. Cell Death Dis. 2012;3:e253 pubmed 出版商
Baens M, Finalet Ferreiro J, Tousseyn T, Urbankova H, Michaux L, de Leval L, et al. t(X;14)(p11.4;q32.33) is recurrent in marginal zone lymphoma and up-regulates GPR34. Haematologica. 2012;97:184-8 pubmed 出版商
Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, et al. BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study. Mol Cancer. 2011;10:118 pubmed 出版商
Menon M, Kotlyarov A, Gaestel M. SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PLoS ONE. 2011;6:e23054 pubmed 出版商
Ohanna M, Giuliano S, Bonet C, Imbert V, Hofman V, Zangari J, et al. Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS). Genes Dev. 2011;25:1245-61 pubmed 出版商
Liu B, Willette Brown J, Liu S, Chen X, Fischer S, Hu Y. IKK? represses a network of inflammation and proliferation pathways and elevates c-Myc antagonists and differentiation in a dose-dependent manner in the skin. Cell Death Differ. 2011;18:1854-64 pubmed 出版商
Hedden L, Benes C, Soltoff S. P2X(7) receptor antagonists display agonist-like effects on cell signaling proteins. Biochim Biophys Acta. 2011;1810:532-42 pubmed 出版商
Majumdar A, Ghosh A, Datta S, Prudner B, Datta B. p67/MetAP2 suppresses K-RasV12-mediated transformation of NIH3T3 mouse fibroblasts in culture and in athymic mice. Biochemistry. 2010;49:10146-57 pubmed 出版商
Horrix C, Raviv Z, Flescher E, Voss C, Berger M. Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells. Cell Mol Life Sci. 2011;68:1269-81 pubmed 出版商
Soltoff S, Asara J, Hedden L. Regulation and identification of Na,K-ATPase alpha1 subunit phosphorylation in rat parotid acinar cells. J Biol Chem. 2010;285:36330-8 pubmed 出版商
Pinto A, Crespo P. Analysis of ERKs' dimerization by electrophoresis. Methods Mol Biol. 2010;661:335-42 pubmed 出版商
Dong Q, Cheng Z, Chang W, Blackman B, Conte F, Hu J, et al. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. J Clin Endocrinol Metab. 2010;95:E245-52 pubmed 出版商
Kim T, Franco H, Jung S, Qin J, Broaddus R, Lydon J, et al. The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene. 2010;29:3770-80 pubmed 出版商
Xia X, Park E, Liu B, Willette Brown J, Gong W, Wang J, et al. Reduction of IKKalpha expression promotes chronic ultraviolet B exposure-induced skin inflammation and carcinogenesis. Am J Pathol. 2010;176:2500-8 pubmed 出版商
Soltoff S, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010;285:13337-48 pubmed 出版商
Lee D, Li Y, Chang S, Zhou J, Ho H, Chiu J, et al. Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway. J Biol Chem. 2010;285:30-42 pubmed 出版商
Warren D, Tajsic T, Mellad J, Searles R, Zhang Q, Shanahan C. Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. J Biol Chem. 2010;285:1311-20 pubmed 出版商
Yeh C, Chiu J, Lee C, Lee P, Shih Y, Sun J, et al. Estrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor-mediated expression of beta1-integrin. J Bone Miner Res. 2010;25:627-39 pubmed 出版商
Ronca R, Gualandi L, Crescini E, Calza S, Presta M, Dell Era P. Fibroblast growth factor receptor-1 phosphorylation requirement for cardiomyocyte differentiation in murine embryonic stem cells. J Cell Mol Med. 2009;13:1489-98 pubmed 出版商
Turchi L, Fareh M, Aberdam E, Kitajima S, Simpson F, Wicking C, et al. ATF3 and p15PAF are novel gatekeepers of genomic integrity upon UV stress. Cell Death Differ. 2009;16:728-37 pubmed 出版商
Greenberg J, Shields D, Barillas S, Acevedo L, Murphy E, Huang J, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature. 2008;456:809-13 pubmed 出版商
Medawar A, Virolle T, Rostagno P, de la Forest Divonne S, Gambaro K, Rouleau M, et al. DeltaNp63 is essential for epidermal commitment of embryonic stem cells. PLoS ONE. 2008;3:e3441 pubmed 出版商
Janes S, Ofstad T, Campbell D, Eddaoudi A, Warnes G, Davies D, et al. PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res. 2009;19:328-39 pubmed 出版商
Soltoff S, Hedden L. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. Am J Physiol Cell Physiol. 2008;295:C590-9 pubmed 出版商
Turchi L, Aberdam E, Mazure N, Pouyssegur J, Deckert M, Kitajima S, et al. Hif-2alpha mediates UV-induced apoptosis through a novel ATF3-dependent death pathway. Cell Death Differ. 2008;15:1472-80 pubmed 出版商
Dufour C, Holy X, Marie P. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab. 2008;294:E794-801 pubmed 出版商
Lee D, Yeh C, Chang S, Lee P, Chien S, Cheng C, et al. Integrin-mediated expression of bone formation-related genes in osteoblast-like cells in response to fluid shear stress: roles of extracellular matrix, Shc, and mitogen-activated protein kinase. J Bone Miner Res. 2008;23:1140-9 pubmed 出版商
Dufour C, Holy X, Marie P. Skeletal unloading induces osteoblast apoptosis and targets alpha5beta1-PI3K-Bcl-2 signaling in rat bone. Exp Cell Res. 2007;313:394-403 pubmed
Hahn C, Wang H, Cho D, Talbot K, Gur R, Berrettini W, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med. 2006;12:824-8 pubmed
Ueda Y, Neel N, Schutyser E, Raman D, Richmond A. Deletion of the COOH-terminal domain of CXC chemokine receptor 4 leads to the down-regulation of cell-to-cell contact, enhanced motility and proliferation in breast carcinoma cells. Cancer Res. 2006;66:5665-75 pubmed
Lien S, Usami S, Chien S, Chiu J. Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal. 2006;18:1270-8 pubmed
Plourde D, Soltoff S. Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity. Am J Physiol Cell Physiol. 2006;290:C702-10 pubmed
Roberts M, Drosopoulos K, Vasileiou I, Stricker M, Taoufik E, Maercker C, et al. Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line. Int J Cancer. 2006;118:616-27 pubmed
Drosopoulos K, Roberts M, Cermak L, Sasazuki T, Shirasawa S, Andera L, et al. Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway. J Biol Chem. 2005;280:22856-67 pubmed
Laurent Matha V, Maruani Herrmann S, Prébois C, Beaujouin M, Glondu M, Noel A, et al. Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J Cell Biol. 2005;168:489-99 pubmed
Calderwood S. Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods. 2005;35:139-48 pubmed
Thyss R, Virolle V, Imbert V, Peyron J, Aberdam D, Virolle T. NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J. 2005;24:128-37 pubmed
Datta B, Datta R, Majumdar A, Ghosh A. The stability of eukaryotic initiation factor 2-associated glycoprotein, p67, increases during skeletal muscle differentiation and that inhibits the phosphorylation of extracellular signal-regulated kinases 1 and 2. Exp Cell Res. 2005;303:174-82 pubmed
Teramoto H, Castellone M, Malek R, Letwin N, Frank B, Gutkind J, et al. Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12. Oncogene. 2005;24:489-501 pubmed
Janes S, Watt F. Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis. J Cell Biol. 2004;166:419-31 pubmed
产品信息
产品名称 :
ERK 2(D-2)抗体
基因名称 :
MAPK1
规格 :
200微克/毫升
价格 :
279美元
目录号 :
sc-1647
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
ERK 2
反应物种 :
m, r, h
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P), FCM, 酶联免疫吸附测定
表位 :
C末端(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。