产品简要
公司名称 :
圣克鲁斯生物技术
产品类型 :
抗体
产品名称 :
FANCD2(FI17)抗体
目录 :
sc-20022
规格 :
200微克/毫升
价格 :
279美元
克隆性 :
单克隆
宿主 :
小鼠
共轭标签 :
未共轭
克隆名称 :
FI17
反应物种 :
人类
应用 :
免疫印迹, 免疫组化, 免疫细胞化学, 免疫沉淀, 免疫组化-石蜡切片, 其他
更多信息或购买 :
文章摘录数: 52
出版应用/物种/样本/稀释参考文献
  • 免疫印迹; 人类; 图 3h
Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 s1f
Sonego M, Pellarin I, Costa A, Vinciguerra G, Coan M, Kraut A, et al. USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability. Sci Adv. 2019;5:eaav3235 pubmed 出版商
  • 免疫细胞化学; 人类; 图 6C
Vuono E, Mukherjee A, Vierra D, Adroved M, Hodson C, Deans A, et al. The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair. Sci Rep. 2016;6:36439 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 表 s6
Mair B, Konopka T, Kerzendorfer C, Sleiman K, Salic S, Serra V, et al. Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity. PLoS Genet. 2016;12:e1006279 pubmed 出版商
  • 免疫印迹; 人类; 1:100; 图 s3
Liang C, Li Z, Lopez Martinez D, Nicholson W, Venien Bryan C, Cohn M. The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nat Commun. 2016;7:12124 pubmed 出版商
  • 免疫印迹; 人类; 图 2c
Kais Z, Rondinelli B, Holmes A, O Leary C, Kozono D, D Andrea A, et al. FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair. Cell Rep. 2016;15:2488-99 pubmed 出版商
  • 免疫细胞化学; 人类; 图 s2
Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed 出版商
  • 免疫印迹; 人类; 1:1000
Passerini V, Ozeri Galai E, de Pagter M, Donnelly N, Schmalbrock S, Kloosterman W, et al. The presence of extra chromosomes leads to genomic instability. Nat Commun. 2016;7:10754 pubmed 出版商
  • 其他; 人类; 图 st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 4
Wanzel M, Vischedyk J, Gittler M, Gremke N, Seiz J, Hefter M, et al. CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol. 2016;12:22-8 pubmed 出版商
  • 免疫细胞化学; 人类; 图 5a
  • 免疫印迹; 人类; 图 s3
García Rubio M, Pérez Calero C, Barroso S, Tumini E, Herrera Moyano E, Rosado I, et al. The Fanconi Anemia Pathway Protects Genome Integrity from R-loops. PLoS Genet. 2015;11:e1005674 pubmed 出版商
  • 免疫印迹; 人类; 1:200; 图 4a
Fujii N, Evison B, Actis M, Inoue A. A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair. Bioorg Med Chem. 2015;23:6912-21 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Renaud E, Barascu A, Rosselli F. Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells. Nucleic Acids Res. 2016;44:648-56 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Clark D, Tripathi K, Dorsman J, Palle K. FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation. Oncotarget. 2015;6:28816-32 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 3h
Parplys A, Zhao W, Sharma N, Groesser T, Liang F, Maranon D, et al. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Nucleic Acids Res. 2015;43:9817-34 pubmed 出版商
  • 免疫印迹; 人类; 图 3
Yang Y, Liu Z, Wang F, Temviriyanukul P, Ma X, Tu Y, et al. FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress. Nucleic Acids Res. 2015;43:8325-39 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 2
Stoepker C, Ameziane N, van der Lelij P, Kooi I, Oostra A, Rooimans M, et al. Defects in the Fanconi Anemia Pathway and Chromatid Cohesion in Head and Neck Cancer. Cancer Res. 2015;75:3543-53 pubmed 出版商
  • 免疫印迹; 人类; 图 3e
Wang G, Liu Y, Cheng X, Zhou G. Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Sci. 2015;106:902-8 pubmed 出版商
  • 其他; 人类; 1:100; 图 4A
  • 免疫印迹; 人类; 图 s1a
Liang C, Zhan B, Yoshikawa Y, Haas W, Gygi S, Cohn M. UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway. Cell Rep. 2015;10:1947-56 pubmed 出版商
  • 免疫印迹; 人类; 1:1000; 图 2, 3
Raghunandan M, Chaudhury I, Kelich S, Hanenberg H, Sobeck A. FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex. Cell Cycle. 2015;14:342-53 pubmed 出版商
  • 免疫印迹; 人类; 图 4
Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin M, et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 2015;518:258-62 pubmed 出版商
  • 免疫印迹; 人类; 1:500; 图 5
Stoepker C, Faramarz A, Rooimans M, van Mil S, Balk J, Velleuer E, et al. DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. DNA Repair (Amst). 2015;26:54-64 pubmed 出版商
  • 免疫印迹; 人类
Huang Y, Leung J, Lowery M, Matsushita N, Wang Y, Shen X, et al. Modularized functions of the Fanconi anemia core complex. Cell Rep. 2014;7:1849-57 pubmed 出版商
  • 免疫细胞化学; 人类; 1:400
  • 免疫印迹; 人类; 1:750; 图 s5
Liang Q, Dexheimer T, Zhang P, Rosenthal A, Villamil M, You C, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014;10:298-304 pubmed 出版商
  • 免疫印迹; 人类
Stoepker C, Hain K, Schuster B, Hilhorst Hofstee Y, Rooimans M, Steltenpool J, et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 2011;43:138-41 pubmed 出版商
Pouliot G, Degar J, Hinze L, Kochupurakkal B, Vo C, Burns M, et al. Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia. PLoS ONE. 2019;14:e0221288 pubmed 出版商
Heijink A, Everts M, Honeywell M, Richards R, Kok Y, de Vries E, et al. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019;28:2345-2357.e5 pubmed 出版商
Rockfield S, Kee Y, Nanjundan M. Chronic iron exposure and c-Myc/H-ras-mediated transformation in fallopian tube cells alter the expression of EVI1, amplified at 3q26.2 in ovarian cancer. Oncogenesis. 2019;8:46 pubmed 出版商
Higgs M, Sato K, Reynolds J, Begum S, Bayley R, Goula A, et al. Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2. Mol Cell. 2018;71:25-41.e6 pubmed 出版商
Velimezi G, Robinson Garcia L, Muñoz Martínez F, Wiegant W, Ferreira da Silva J, Owusu M, et al. Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat Commun. 2018;9:2280 pubmed 出版商
Saha L, Kim S, Kang H, Akter S, Choi K, Sakuma T, et al. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Environ Mol Mutagen. 2018;59:529-538 pubmed 出版商
Mitxelena J, Apraiz A, Vallejo Rodríguez J, García Santisteban I, Fullaondo A, Alvarez Fernandez M, et al. An E2F7-dependent transcriptional program modulates DNA damage repair and genomic stability. Nucleic Acids Res. 2018;46:4546-4559 pubmed 出版商
Thompson E, Yeo J, Lee E, Kan Y, Raghunandan M, Wiek C, et al. FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response. Nucleic Acids Res. 2017;45:11837-11857 pubmed 出版商
Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, et al. Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. Genes Dev. 2017;31:1469-1482 pubmed 出版商
Somasagara R, Spencer S, Tripathi K, Clark D, Mani C, Madeira da Silva L, et al. RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance. Oncogene. 2017;36:6680-6690 pubmed 出版商
Exell J, Thompson M, Finger L, Shaw S, Debreczeni J, Ward T, et al. Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat Chem Biol. 2016;12:815-21 pubmed 出版商
Sundaravinayagam D, Kim H, Wu T, Kim H, Lee H, Jun S, et al. miR146a-mediated targeting of FANCM during inflammation compromises genome integrity. Oncotarget. 2016;7:45976-45994 pubmed 出版商
Cron K, Zhu K, Kushwaha D, Hsieh G, Merzon D, Rameseder J, et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS ONE. 2013;8:e73710 pubmed 出版商
Wang Y, Han X, Wu F, Leung J, Lowery M, Do H, et al. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013;23:1215-28 pubmed 出版商
Knies K, Schuster B, Ameziane N, Rooimans M, Bettecken T, de Winter J, et al. Genotyping of fanconi anemia patients by whole exome sequencing: advantages and challenges. PLoS ONE. 2012;7:e52648 pubmed 出版商
Murai J, Huang S, Das B, Renaud A, Zhang Y, Doroshow J, et al. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer Res. 2012;72:5588-99 pubmed 出版商
Leung J, Wang Y, Fong K, Huen M, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012;109:4491-6 pubmed 出版商
Alexander B, Wang X, Niemierko A, Weaver D, Mak R, Roof K, et al. DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Int J Radiat Oncol Biol Phys. 2012;83:164-71 pubmed 出版商
Harrigan J, Belotserkovskaya R, Coates J, Dimitrova D, Polo S, Bradshaw C, et al. Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol. 2011;193:97-108 pubmed 出版商
Kachnic L, Li L, Fournier L, Ferraiolo N, Dahm Daphi J, Borgmann K, et al. FANCD2 but not FANCA promotes cellular resistance to type II topoisomerase poisons. Cancer Lett. 2011;305:86-93 pubmed 出版商
Alexander B, Sprott K, Farrow D, Wang X, D Andrea A, Schnitt S, et al. DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer. Clin Cancer Res. 2010;16:5796-804 pubmed 出版商
Vaz F, Hanenberg H, Schuster B, Barker K, Wiek C, Erven V, et al. Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet. 2010;42:406-9 pubmed 出版商
Kachnic L, Li L, Fournier L, Willers H. Fanconi anemia pathway heterogeneity revealed by cisplatin and oxaliplatin treatments. Cancer Lett. 2010;292:73-9 pubmed 出版商
Chen C, Kennedy R, Sidi S, Look A, D ANDREA A. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer. 2009;8:24 pubmed 出版商
Cohn M, Kowal P, Yang K, Haas W, Huang T, Gygi S, et al. A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell. 2007;28:786-97 pubmed
Pani E, Stojic L, El Shemerly M, Jiricny J, Ferrari S. Mismatch repair status and the response of human cells to cisplatin. Cell Cycle. 2007;6:1796-802 pubmed
Kennedy R, Chen C, Stuckert P, Archila E, De la Vega M, Moreau L, et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest. 2007;117:1440-9 pubmed
产品信息
产品名称 :
FANCD2(FI17)抗体
基因名称 :
FANCD2
规格 :
200微克/毫升
价格 :
279美元
目录号 :
sc-20022
类型 :
单克隆
宿主 :
小鼠单克隆
抗原 :
FANCD2
反应物种 :
人类
应用 :
免疫印迹, 免疫沉淀, IF, 免疫组化(P)
表位 :
N末端(人类)
交货时间 :
在下午三点前下订单在美国的次日送达;从我们美国的办公室通过国际航运两日后送达;在我们的欧洲办事处下订单次日运抵欧洲客户
更多信息或购买 :
公司信息
圣克鲁斯生物技术
上海浦东新区建业路315号2号楼1-6号
asia@scbio.cn
http://www.scbt.com/zh/
800-820-8626
公司总部: 美国
圣克鲁斯生物技术公司拥有最高的质量承诺和客户服务。